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Molecular Evolutionary Models in Drug Discovery

Molecular Evolutionary Models in Drug Discovery
A Book

by Juan Bueno

  • Publisher : Academic Press
  • Release : 2020-01-22
  • Pages : 192
  • ISBN : 0128189290
  • Language : En, Es, Fr & De
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Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings. Examines the integration and application of evolutionary models in the pharmaceutical industry to create new drug development platforms Investigates the biotechnological prospecting of secondary metabolites and their potential use in the discovery of new drugs Evaluates the ecosystem of living beings and how its molecular adaptation might improve the success of therapies

Adaptive Systems in Drug Design

Adaptive Systems in Drug Design
A Book

by Gisbert Schneider,Sung-Sau So

  • Publisher : Eurekah.Com Incorporated
  • Release : 2003
  • Pages : 173
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Major concepts in the field of drug design are described in this book, with a strong focus on complex adaptive systems. Special emphasis is placed on neural network applications and evolutionary algorithms. The book is meant to complement a text on computational chemistry and bioinformatices and to present some new challenging ideas. A conceptual framework is presented for the use of adaptive systems and evolutionary algorithms, then the concept of chemical space is discussed and numerous examples of algorithms for classical unsupervised projection methods are given. The use of evolutionary algorithms and artificial neural networks in quantitative structure- activity relationships is discussed, and the drug-likeness concepts is explained. A final chapter examines the utility of evolutionary method in de novo molecular design. Schneider teaches cheminformatics at Johann Wolfgang Goethe University in Germany. So is affiliated with F. Hoffman-La Roche, Inc. Annotation copyrighted by Book News, Inc., Portland, OR

Molecular Modelling and Drug Design

Molecular Modelling and Drug Design
A Book

by K Anand Solomon

  • Publisher : MJP Publisher
  • Release : 2019-06-05
  • Pages : 242
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecular modelling is the scientific art of simulating chemicalor biological systems, so that computational methods can beapplied to understand the process concerned. Models usingcomputers are generated using mathematical equations and areevolved based on experimental information that is taken intoconsideration during model building. This book is anintroduction to the field of molecular modelling and drug designin which biological molecules effective in treating diseases arediscovered using in silico methods.

Genome Research

Genome Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Directory of Graduate Research

Directory of Graduate Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.

S&T Today

S&T Today
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstracts, 18th Annual Meetings, April 3-April 24, 1989

Abstracts, 18th Annual Meetings, April 3-April 24, 1989
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 328
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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EMBASE List of Journals Indexed

EMBASE List of Journals Indexed
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II
A Book

by John B. Taylor,D. J. Triggle

  • Publisher : Elsevier Science Ltd
  • Release : 2007
  • Pages : 7200
  • ISBN : 9780080445137
  • Language : En, Es, Fr & De
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The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Abstracts of Papers Presented at the 1999 Meeting on Genome Sequencing & Biology

Abstracts of Papers Presented at the 1999 Meeting on Genome Sequencing & Biology
May 19-May 23, 1999

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 269
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Model Organisms in Drug Discovery

Model Organisms in Drug Discovery
A Book

by Pamela M. Carroll,Kevin Fitzgerald

  • Publisher : John Wiley & Sons
  • Release : 2003-11-21
  • Pages : 288
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Fruit flies are "little people with wings" goes the saying in the scientific community, ever since the completion of the Human Genome Project and its revelations about the similarity amongst the genomes of different organisms. It is humbling that most signalling pathways which "define" humans are conserved in Drosophila, the common fruit fly. Feed a fruit fly caffeine and it has trouble falling asleep; feed it antihistamines and it cannot stay awake. A C. elegans worm placed on the antidepressant flouxetine has increased serotonin levels in its tiny brain. Yeast treated with chemotherapeutics stop their cell division. Removal of a single gene from a mouse or zebrafish can cause the animals to develop Alzheimer’s disease or heart disease. These organisms are utilized as surrogates to investigate the function and design of complex human biological systems. Advances in bioinformatics, proteomics, automation technologies and their application to model organism systems now occur on an industrial scale. The integration of model systems into the drug discovery process, the speed of the tools, and the in vivo validation data that these models can provide, will clearly help definition of disease biology and high-quality target validation. Enhanced target selection will lead to the more efficacious and less toxic therapeutic compounds of the future. Leading experts in the field provide detailed accounts of model organism research that have impacted on specific therapeutic areas and they examine state-of-the-art applications of model systems, describing real life applications and their possible impact in the future. This book will be of interest to geneticists, bioinformaticians, pharmacologists, molecular biologists and people working in the pharmaceutical industry, particularly genomics.

Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery

Burger's Medicinal Chemistry and Drug Discovery, Drug Discovery
A Book

by Donald J. Abraham

  • Publisher : Wiley-Interscience
  • Release : 2003
  • Pages : 968
  • ISBN : 9780471270904
  • Language : En, Es, Fr & De
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This is Volume 1: Drug Discovery, of Burger's Medicinal Chemistry and Drug Discovery, 6th Edition. This new volume contains critical new chapters on Virtual Screening, Bioinformatics and Chemical Information Computing Systems in Drug Discovery. To purchase the entire 6 volume set, please refer to ISBN 0-471-37032-0. For a complete list of articles and contributors as well as FREE sample chapters from this new 6th Edition please visit: www.mrw.interscience.wiley.com/bmcdd

Science

Science
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Journal of the American Statistical Association

Journal of the American Statistical Association
A Book

by American Statistical Association

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Parasites, Molecular Biology, Drug and Vaccine Design

Parasites, Molecular Biology, Drug and Vaccine Design
Proceedings of a UCLA Symposium Held at Keystone, Colorado, April 3-10, 1989

by Nina Agabian,Anthony Cerami

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 504
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This wide-ranging collection of edited papers examines the many mechanisms that allow parasites to survive and interact in a host environment. The research explains how a more knowledgeable understanding of host-parasite interactions aids in the development of unique strategies for vaccine design and applied research in clinical diagnostics and therapeutics. Divided into five parts, the text covers gene expression during parasite differentiation and development; the potential for molecular genetics in parasite systems; molecules of the parasite membrane; molecular modeling and parasite drug design; and vaccines.

Preclinical Evaluation of Antimicrobial Nanodrugs

Preclinical Evaluation of Antimicrobial Nanodrugs
A Book

by Juan Bueno

  • Publisher : Springer Nature
  • Release : 2020-05-08
  • Pages : 117
  • ISBN : 3030438554
  • Language : En, Es, Fr & De
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Translational medicine addresses the gap between research and the clinical application of new discoveries. To efficiently deliver new drugs to care centers, a preclinical evaluation, both in vitro and in vivo, is required to ensure that the most active and least toxic compounds are selected as well as to predict clinical outcome. Antimicrobial nanomedicines have been shown to have higher specificity in their therapeutic targets and the ability to serve as adjuvants, increasing the effectiveness of pre-existing immune compounds. The design and development of new standardized protocols for evaluating antimicrobial nanomedicines is needed for both the industry and clinical laboratory. These protocols must aim to evaluate laboratory activity and present models of pharmacokinetic-pharmacodynamic and toxicokinetic behavior that predict absorption and distribution. Likewise, these protocols must follow a theranostics approach, be able to detect promising formulations, diagnose the infectious disease, and determine the correct treatment to implement a personalized therapeutic behavior. Given the possibilities that nanotechnology offers, not updating to new screening platforms is inadequate as it prevents the correct application of discoveries, increasing the effect of the valley of death between innovations and their use. This book is structured to discuss the fundamentals taken into account for the design of robust, reproducible and automatable evaluation platforms. These vital platforms should enable the discovery of new medicines with which to face antimicrobial resistance (RAM), one of the great problems of our time.

International Journal of Oriental Medicine

International Journal of Oriental Medicine
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Methods and Techniques in Drug Discovery

Methods and Techniques in Drug Discovery
A Book

by John Sterling,Ellyn J. T. D. Kerr,Shannon Simons

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 266
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Aerospace Medicine and Biology

Aerospace Medicine and Biology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1987
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A selection of annotated references to unclassified reports and journal articles that were introduced into the NASA scientific and technical information system and announced in Scientific and technical aerospace reports (STAR) and International aerospace abstracts (IAA).

Timetable

Timetable
A Book

by University of Illinois at Urbana-Champaign

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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