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Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia
A Book

by Wilma Wasco,Rudolph Tanzi

  • Publisher : Springer Science & Business Media
  • Release : 1996-11-01
  • Pages : 312
  • ISBN : 1592594719
  • Language : En, Es, Fr & De
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The past decade has witnessed a revolution in the attempts of scientists to under stand the molecular basis of dementia. Although dementia, as defined by global cogni tive decline involving gradual loss of memory, reasoning, judgment, and orientation, presents most commonly in the form of Alzheimer's disease (AD), an assortment of other less common disorders, such as prion and Pick's disease, can also lead to symp toms that are similar to those observed in patients with AD. The primary goal of Molecular Mechanisms of Dementia is to address the various mechanisms and multi faceted approaches currently being employed to more clearly delineate the etiological and pathogenic events responsible for the onset of dementia. Perhaps the greatest boon to obtaining a clearer understanding of the causes of AD has come from genetic and molecular biological studies carried out over the past decade. At the genetic level, it has become increasingly clear that AD is a heteroge neous disorder that can be broadly classified into two categories. "Late onset" (>60 yr) cases, which account for the vast majority of AD, genetically involve "susceptibility" genes representing risk factors for the disease (e. g. , inheritance of the 84 allele of the Apolipoprotein E gene). In many cases, the susceptibility gene can act as a "modifier" that modulates the pathogenic cascade occurring subsequent to a separate etiological event "initiating" or "causing" the disorder.

Molecular Mechanisms of Dementia

Molecular Mechanisms of Dementia
Biomarkers, Neurochemistry, and Therapy

by Akhlaq A. Farooqui

  • Publisher : Academic Press
  • Release : 2019-04-15
  • Pages : 386
  • ISBN : 0128167319
  • Language : En, Es, Fr & De
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Considerable progress has been made in neurochemical and therapeutic aspects of dementia research in recent years. Molecular and Therapeutic Aspects of Dementia presents readers with comprehensive and cutting-edge information on the neurochemical mechanisms of various types of dementias. It provides a clearly written and logically organized and comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia. This book is written for the international audience of neurochemists, neuroscientists, neurologists, neuropharmacologists, and clinicians. The hope is that this discussion will not only integrate and consolidate knowledge in this field, but will jumpstart more studies on molecular mechanisms and therapeutic aspects of dementia. The comprehensive information in this monograph may not only help in early detection of various types of dementia and dementia linked neurological disorders, but also promote discovery of new drugs, which may block or delay the onset of dementia in elderly patients. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy-makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. Provides a comprehensive overview of molecular aspects of risk factors, symptoms, pathogenesis, biomarkers, and therapeutic strategies for various types of dementia Summarizes cutting edge research information on signal transduction processes associated with neurochemistry of dementia Discusses the synthesis, metabolism, and role of lipid mediators in dementia

Molecular Mechanisms of Aging

Molecular Mechanisms of Aging
A Book

by Konrad Beyreuther,Gotthard Schettler

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 206
  • ISBN : 3642842240
  • Language : En, Es, Fr & De
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Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer's Disease and Frontotemporal Dementia

Molecular Mechanisms of Extracellular and Intracellular Proteopaty in Alzheimer's Disease and Frontotemporal Dementia
A Book

by Nicolae-Daniel Pirici

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 215
  • ISBN : 9786061129188
  • Language : En, Es, Fr & De
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Molecular Mechanisms of Neurodegenerative Diseases

Molecular Mechanisms of Neurodegenerative Diseases
A Book

by Marie-Francoise Chesselet

  • Publisher : Springer Science & Business Media
  • Release : 2000-10-19
  • Pages : 410
  • ISBN : 1592590063
  • Language : En, Es, Fr & De
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With the unprecedented identification of new mutation mechanisms in neurodegenerative diseases and the emergence of common mechanisms among diseases that were once considered unrelated, neurobiologists are poised for the development of new therapies based on high throughput screenings and a better understanding of the molecular and cellular mechanisms leading to neurodegeneration. In Molecular Mechanisms of Neurodegenerative Diseases, Marie-Francoise Chesselet, MD, PhD, and a panel of leading researchers and neurologists from industry and academia critically review the most recent advances from different yet complementary points of view. Focusing on Alzheimer's, Parkinson's, and CAG triplet repeat diseases, the authors show how studies of cellular and genetically engineered animal models have enhanced our understanding of the molecular mechanisms of neurodegenerative diseases and may lead to the development of new therapeutics. Topics include the role of Ab toxicity, glial cells, and inflammation in Alzheimer's disease; the formation of abnormal protein fragments across several diseases, the impact of dopamine and mitochondrial dysfunction on neurodegeneration; and the potential of genetics to identify the molecular mechanisms of neurodegenerative diseases. Authoritative and insightful, Molecular Mechanisms of Neurodegenerative Diseases synthesizes the novel ideas and concepts now emerging to create a fresh understanding of neurodegenerative disorders, one that promises to lead to powerful new therapies that prevent, delay the onset, slow the progression, or even cure these cruel diseases.

The Involvement of Molecular Mechanisms in the Pathogenesis of AIDS Dementia Complex

The Involvement of Molecular Mechanisms in the Pathogenesis of AIDS Dementia Complex
A Book

by Louise Ann Pemberton

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 300
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecular Mechanism of Alzheimer's Disease

Molecular Mechanism of Alzheimer's Disease
A Book

by Ian Macreadie

  • Publisher : MDPI
  • Release : 2019-10-25
  • Pages : 228
  • ISBN : 3039214071
  • Language : En, Es, Fr & De
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Alzheimer’s disease (AD) is an age-related neurological disease that affects tens of millions of people, in addition to their carers. Hallmark features of AD include plaques composed of amyloid beta, as well as neurofibrillary tangles of tau protein. However, despite more than a century of study, the cause of Alzheimer’s disease remains unresolved. The roles of amyloid beta and tau are being questioned and other causes of AD are now under consideration. The contributions of researchers, model organisms, and various hypotheses will be examined in this Special Issue.

Molecular Mechanisms of Extracellular and Intracellular Proteinopathy in Alzheimer's Disease and Frontotemporal Dementia

Molecular Mechanisms of Extracellular and Intracellular Proteinopathy in Alzheimer's Disease and Frontotemporal Dementia
A Book

by Nicolae-Daniel Pirici

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 209
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Alzheimer's Disease

Alzheimer's Disease
Advances in Genetics, Molecular and Cellular Biology

by Sangram S. Sisodia,Rudolph E. Tanzi

  • Publisher : Springer Science & Business Media
  • Release : 2007-02-16
  • Pages : 286
  • ISBN : 0387351353
  • Language : En, Es, Fr & De
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This book examines every major aspect of Alzheimer disease at a time when there has been no scholarly research volume on the subject published in the last 3-5 years. This edition includes expanded coverage of the cellular-level exploration of related dementing disorders, with in-depth presentation of prion diseases, Pick's disease, fronto-temporal disorders, transgenic models, and biochemistry of presenilins.

Neurodegeneration

Neurodegeneration
The Molecular Pathology of Dementia and Movement Disorders

by Dennis Dickson

  • Publisher : John Wiley & Sons
  • Release : 2011-11-07
  • Pages : 477
  • ISBN : 1405196939
  • Language : En, Es, Fr & De
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Most textbooks on neurodegenerative disorders have used a classification scheme based upon either clinical syndromes or anatomical distribution of the pathology. In contrast, this book looks to the future and uses a classification based upon molecular mechanisms, rather than clinical or anatomical boundaries. Major advances in molecular genetics and the application of biochemical and immunocytochemical techniques to neurodegenerative disorders have generated this new approach. Throughout most of the current volume, diseases are clustered according to the proteins that accumulate within cells (e.g. tau, –synuclein and TDP–43) and in the extracellular compartments (e.g. –amyloid and prion proteins) or according to a shared pathogenetic mechanism, such as trinucleotide repeats, that are a feature of specific genetic disorders. Chapters throughout the book conform to a standard lay–out for ease of access by the reader and are written by a panel of International Experts Since the first edition of this book, major advances have been made in the discovery of common molecular mechanisms between many neurodegenerative diseases most notably in the frontotemporal lobar degenerations (FTLD) and motor neuron disease or amyotrophic lateral sclerosis. This book will be essential reading for clinicians, neuropathologists and basic neuroscientists who require the firm up–to–date knowledge of mechanisms, diagnostic pathology and genetics of Neurodegenerative diseases that is required for progress in therapy and management.

Autophagy

Autophagy
Chapter 3. Molecular Mechanisms Underlying the Role of Autophagy in Neurodegenerative Diseases

by S. Tariq Ahmad,Jin-A. Lee

  • Publisher : Elsevier Inc. Chapters
  • Release : 2013-07-29
  • Pages : 360
  • ISBN : 0128069082
  • Language : En, Es, Fr & De
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Autophagy is a highly regulated process that promotes vital cellular homeostasis by allowing bulk non-specific degradation of the cytoplasmic contents, mainly damaged and/or surplus organelles and proteins. Autophagy is ubiquitous in eukaryotes, highly conserved from yeast to mammals, and occurs in all mammalian tissues. Historically, autophagy was characterized as the coping response to limited energy resources (starvation), to generate additional biomolecular raw materials. However, research in the past two decades has demonstrated the indispensible roles of autophagy in eukaryotic physiology and pathology with respect to wide-ranging processes such as development, differentiation, aging, immunity, cancer biology, and neurodegenerative disorders. In this chapter, we will provide an overview of the types of autophagy and mechanisms of the autophagy pathway followed by a discussion of the current understanding of the role of autophagy in neuronal physiology, pathology of neurodegenerative disorders, and potential therapeutic approaches.

Neurodegenerative Diseases

Neurodegenerative Diseases
Molecular Mechanisms and Current Therapeutic Approaches

by Nagehan Ersoy Tunalı

  • Publisher : BoD – Books on Demand
  • Release : 2021-01-20
  • Pages : 178
  • ISBN : 1838801499
  • Language : En, Es, Fr & De
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Neurodegenerative diseases represent a very large group of heterogeneous disorders affecting specific subtypes of neurons in the brain. This book contributes insight both to the awareness of the brain and its neurodegenerative states. The chapters present current knowledge regarding genetics, molecular mechanisms, and new therapeutic strategies against neurodegenerative disorders. The book is intended to serve as a source to aid clinicians and researchers in the field, and also life science readers to increase their understanding and awareness of the clinical correlations, genetic aspects, neuropathological findings, and current therapeutic interventions in neurodegenerative diseases. I believe that this book will enlighten the curiosity for neurodegeneration and also encourage researchers to work on potentially effective molecular therapies for still mysterious neurodegenerative disorders.

Protein Misfolding, Aggregation and Conformational Diseases

Protein Misfolding, Aggregation and Conformational Diseases
Part B: Molecular Mechanisms of Conformational Diseases

by Vladimir N. Uversky,Anthony Fink

  • Publisher : Springer Science & Business Media
  • Release : 2007-05-26
  • Pages : 538
  • ISBN : 0387365346
  • Language : En, Es, Fr & De
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The second volume continues to fill the gap in protein review and protocol literature. It does this while summarizing recent achievements in the understanding of the relationships between protein misfoldings, aggregation, and development of protein deposition disorders. The focus of Part B is the molecular basis of differential disorders.

Metal-Based Neurodegeneration

Metal-Based Neurodegeneration
From Molecular Mechanisms to Therapeutic Strategies

by Robert Crichton,Roberta Ward

  • Publisher : John Wiley & Sons
  • Release : 2013-09-04
  • Pages : 440
  • ISBN : 1118553519
  • Language : En, Es, Fr & De
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Neurodegenerative diseases of the human brain appear in variousforms, resulting in disorders of movement and coordination,cognitive deterioration and psychiatric disturbances. Many of thekey factors leading to neurodegenerative diseases are similar,including the dysfunction of metal ion homeostasis, redox-activemetal ions generating oxidative stress, and intracellular inclusionbodies. Metal-based Neurodegeneration presents a detailed surveyof the molecular origins of neurodegenerative diseases. Eachchapter is dedicated to a specific disease, presenting the latestscientific findings, including details of their biochemicalactors (proteins or peptides), their normal and pathologicalconformations, and a description of the diseases characteristics,with an emphasis on the role of metal-induced oxidative stress,which can result in the production of intracellular aggregates oftarget proteins and peptides. Topics covered include: Brain function, physiology and the blood-brain barrier Immune system and neuroinflammation Aging and mild cognitive impairment, MCI Parkinson’s Disease Alzheimer’s Disease Creutzfelt-Jakob and related prion diseases Alcoholic Brain Damage Therapeutic strategies to combat the onset and progression ofneurological diseases This extensively updated, full colour, second edition ofMetal-based Neurodegeneration is an essential text forresearch scientists and clinicians working in gerontology,neuropathology, neurochemistry, and metalloprotein mechanisms.

Molecular Mechanism and Epochal Therapeutics of Ischemic Stroke and Dementia

Molecular Mechanism and Epochal Therapeutics of Ischemic Stroke and Dementia
Invited Papers from the International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke Dementia, Held in Okayama, Japan 18 to 20 October 2002

by Kōji Abe

  • Publisher : Elsevier Science Health Science Division
  • Release : 2003
  • Pages : 506
  • ISBN : 9780444512222
  • Language : En, Es, Fr & De
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The International Symposium on Molecular Mechanism and Epochal Therapeutics of Ischemic Stroke and Dementia was held in Okayama on October 18-20, 2002. This proceeding covers topics relating to the molecular mechanism and therapeutics of these diseases, including: the role of intracellular signaling in cerebral ischemia; genes and genetic models of cerebral ischemia; neuroprotection with hypothermia and against inflammation; molecular mechanisms and therapy for ischemic brain damage; neurotrophic factors and gene therapy for stroke; imaging of brain function; molecular mechanisms of Alzheimer's disease and therapeutic potentials; activation of stem cells in the ischemic brain; and stem cell therapy for the ischemic brain--Preface.

Diabetes Mellitus

Diabetes Mellitus
A risk factor for Alzheimer's Disease

by Yusaku Nakabeppu,Toshiharu Ninomiya

  • Publisher : Springer
  • Release : 2019-05-06
  • Pages : 248
  • ISBN : 9811335400
  • Language : En, Es, Fr & De
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This book describes the precise mechanisms by which insulin resistance and diabetes mellitus (DM) act as risk factors for Alzheimer’s disease (AD). It opens by discussing the de novo synthesis of insulin in the brain and its functional significance with regard to glucose metabolism and maintenance of neuronal function in the brain. The epidemiological evidence that DM is a risk factor for the development of dementia, including AD as well as vascular dementia, is then examined. Subsequent chapters explore in depth the mechanisms involved in this relationship, including abnormal protein processing, dysregulated glucose metabolism, impaired insulin signaling, and mitochondrial dysfunction. The molecular interactions between diabetes and AD are fully discussed, highlighting the pathological molecular mechanisms induced by diabetes that promote and accelerate AD pathology. Finally, diagnostic biomarkers and potential therapeutic approaches for AD are considered on the basis of the presented evidence. In providing answers to the critical questions of whether and why DM is a risk factor for AD, this book will hold appeal for a wide interdisciplinary audience.

Metabolic Syndrome

Metabolic Syndrome
An Important Risk Factor for Stroke, Alzheimer Disease, and Depression

by Akhlaq A. Farooqui

  • Publisher : Springer Science & Business Media
  • Release : 2013-06-14
  • Pages : 412
  • ISBN : 1461473187
  • Language : En, Es, Fr & De
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Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.

Molecular Mechanisms and Therapeutic Strategies in C9orf72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Molecular Mechanisms and Therapeutic Strategies in C9orf72 Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
A Book

by Rubika Balendra

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Tau Protein

Tau Protein
Methods and Protocols

by Caroline Smet-Nocca

  • Publisher : Humana Press
  • Release : 2018-07-07
  • Pages : 432
  • ISBN : 9781493982462
  • Language : En, Es, Fr & De
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This detailed volume gathers basic and advanced methods and protocols from in vitro assays and in vivo models to address the molecular and functional aspects of tau physiopathology. Divided into five parts that illustrate the underlying molecular mechanisms of Tau functions and dysfunctions in Alzheimer’s disease and other dementia referred to as tauopathies, this volume discusses timely topics such as: conformational studies of native tau protein and investigation of its physiological function in microtubules binding and tubulin polymerization; in vitro methods of formation and detection of tau oligomers and PHF-like fibrils; characterization and in vitro introduction of post-translational modifications on tau proteins for further functional studies; analytical tools for the detection of tau proteins, their modifications and cellular interactions, and MAPT gene mutations in various biological samples; and cellular and in vivo models for the investigations of tau physiopathology. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and cutting-edge, Tau Protein: Methods and Protocols is a valuable resource that addresses the most recent aspects of Alzheimer’s disease research related to Tau protein and state-of-the-art experimental techniques. It targets a broad scientific audience including molecular biologists and biochemists, as well as all researchers interested in exploring the functions of tau proteins.

Molecular Mechanisms of the Aging Process and Rejuvenation

Molecular Mechanisms of the Aging Process and Rejuvenation
A Book

by Naofumi Shiomi

  • Publisher : BoD – Books on Demand
  • Release : 2016-08-31
  • Pages : 126
  • ISBN : 9535125680
  • Language : En, Es, Fr & De
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Numerous studies had been performed to elucidate the mechanisms of aging and to achieve rejuvenation, with some success reported in recent years. However, at present, the findings from those studies are not sufficient to resolve the issue of aging. This book presents an overview of recent topics on cellular aging and rejuvenation. In the early chapters, the molecular mechanisms of aging via the activities of clock and ion channel proteins, in addition to overall aspects, are discussed. In the latter part, the aging of the skin, immune system, and brain is discussed. This book will prove useful for those studying or developing new drugs to counter the aging process and will encourage the development of novel ideas for rejuvenation.