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Multiscale Biomechanical Modeling of the Brain

Multiscale Biomechanical Modeling of the Brain
A Book

by Mark F. Horstemeyer,Raj K. Prabhu

  • Publisher : Academic Press
  • Release : 2021-10-27
  • Pages : 276
  • ISBN : 0128181451
  • Language : En, Es, Fr & De
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Multiscale Biomechanical Modeling of the Brain discusses the constitutive modeling of the brain at various length scales (nanoscale, microscale, mesoscale, macroscale and structural scale). In each scale, the book describes the state-of-the- experimental and computational tools used to quantify critical deformational information at each length scale. Then, at the structural scale, several user-based constitutive material models are presented, along with real-world boundary value problems. Lastly, design and optimization concepts are presented for use in occupant-centric design frameworks. This book is useful for both academia and industry applications that cover basic science aspects or applied research in head and brain protection. The multiscale approach to this topic is unique, and not found in other books. It includes meticulously selected materials that aim to connect the mechanistic analysis of the brain tissue at size scales ranging from subcellular to organ levels. Presents concepts in a theoretical and thermodynamic framework for each length scale Teaches readers not only how to use an existing multiscale model for each brain but also how to develop a new multiscale model Takes an integrated experimental-computational approach and gives structured multiscale coverage of the problems

Biomechanical Analysis of Blast-induced Traumatic Brain Injury Using Multiscale Brain Modeling

Biomechanical Analysis of Blast-induced Traumatic Brain Injury Using Multiscale Brain Modeling
A Book

by Mahdi Sotudeh Chafi

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 408
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Multiscale Modeling in Biomechanics and Mechanobiology

Multiscale Modeling in Biomechanics and Mechanobiology
A Book

by Suvranu De,Wonmuk Hwang,Ellen Kuhl

  • Publisher : Springer
  • Release : 2014-10-10
  • Pages : 286
  • ISBN : 1447165993
  • Language : En, Es, Fr & De
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Presenting a state-of-the-art overview of theoretical and computational models that link characteristic biomechanical phenomena, this book provides guidelines and examples for creating multiscale models in representative systems and organisms. It develops the reader's understanding of and intuition for multiscale phenomena in biomechanics and mechanobiology, and introduces a mathematical framework and computational techniques paramount to creating predictive multiscale models. Biomechanics involves the study of the interactions of physical forces with biological systems at all scales – including molecular, cellular, tissue and organ scales. The emerging field of mechanobiology focuses on the way that cells produce and respond to mechanical forces – bridging the science of mechanics with the disciplines of genetics and molecular biology. Linking disparate spatial and temporal scales using computational techniques is emerging as a key concept in investigating some of the complex problems underlying these disciplines. Providing an invaluable field manual for graduate students and researchers of theoretical and computational modelling in biology, this book is also intended for readers interested in biomedical engineering, applied mechanics and mathematical biology.

Mathematical Modelling and Biomechanics of the Brain

Mathematical Modelling and Biomechanics of the Brain
A Book

by Corina Drapaca,Siv Sivaloganathan

  • Publisher : Springer Nature
  • Release : 2019-09-06
  • Pages : 155
  • ISBN : 1493998102
  • Language : En, Es, Fr & De
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This monograph aims to provide a rigorous yet accessible presentation of some fundamental concepts used in modeling brain mechanics and give a glimpse of the insights and advances that have arisen as a result of the nascent interaction of the mathematical and neurosurgical sciences. It begins with some historical perspective and a brief synopsis of the biomedical/biological manifestations of the clinical conditions/diseases considered. Each chapter proceeds with a discussion of the various mathematical models of the problems considered, starting with the simplest models and proceeding to more complex models where necessary. A detailed list of relevant references is provided at the end of each chapter. With the beginning research student in mind, the chapters have been crafted to be as self-contained as possible while addressing different clinical conditions and diseases. The book is intended as a brief introduction to both theoreticians and experimentalists interested in brain mechanics, with directions and guidance for further reading, for those who wish to pursue particular topics in greater depth. It can also be used as a complementary textbook in a graduate level course for neuroscientists and neuroengineers.

Practical Aspects of Computational Chemistry

Practical Aspects of Computational Chemistry
Methods, Concepts and Applications

by Jerzy Leszczynski,Manoj Shukla

  • Publisher : Springer Science & Business Media
  • Release : 2009-10-03
  • Pages : 465
  • ISBN : 9048126878
  • Language : En, Es, Fr & De
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"Practical Aspects of Computational Chemistry" presents contributions on a range of aspects of Computational Chemistry applied to a variety of research fields. The chapters focus on recent theoretical developments which have been used to investigate structures and properties of large systems with minimal computational resources. Studies include those in the gas phase, various solvents, various aspects of computational multiscale modeling, Monte Carlo simulations, chirality, the multiple minima problem for protein folding, the nature of binding in different species and dihydrogen bonds, carbon nanotubes and hydrogen storage, adsorption and decomposition of organophosphorus compounds, X-ray crystallography, proton transfer, structure-activity relationships, a description of the REACH programs of the European Union for chemical regulatory purposes, reactions of nucleic acid bases with endogenous and exogenous reactive oxygen species and different aspects of nucleic acid bases, base pairs and base tetrads.

Seeing Beyond the Eye: The Brain Connection

Seeing Beyond the Eye: The Brain Connection
A Book

by Christine Nguyen,Monica Liliana Acosta,Silvia Di Angelantonio,Thomas Salt

  • Publisher : Frontiers Media SA
  • Release : 2021-09-02
  • Pages : 129
  • ISBN : 2889712591
  • Language : En, Es, Fr & De
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Computer Methods in Biomechanics and Biomedical Engineering

Computer Methods in Biomechanics and Biomedical Engineering
Proceedings of the 14th International Symposium CMBBE, Tel Aviv, Israel, 2016

by Amit Gefen,Daphne Weihs

  • Publisher : Springer
  • Release : 2017-08-29
  • Pages : 263
  • ISBN : 3319597647
  • Language : En, Es, Fr & De
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This edited volume collects the research results presented at the 14th International Symposium on Computer Methods in Biomechanics and Biomedical Engineering, Tel Aviv, Israel, 2016. The topical focus includes, but is not limited to, cardiovascular fluid dynamics, computer modeling of tissue engineering, skin and spine biomechanics, as well as biomedical image analysis and processing. The target audience primarily comprises research experts in the field of bioengineering, but the book may also be beneficial for graduate students alike.

Tumors of the Central Nervous System, Volume 12

Tumors of the Central Nervous System, Volume 12
Molecular Mechanisms, Children's Cancer, Treatments, and Radiosurgery

by M.A. Hayat

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-12
  • Pages : 386
  • ISBN : 9400772173
  • Language : En, Es, Fr & De
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As in the case of its eleven predecessors in the series Tumors of the Central Nervous System, this volume is distinguished for its thorough approach, its roster of 92 distinguished contributors representing 11 different countries and its detailed examination of leading-edge technology and methods. Volume 12: Molecular Mechanisms, Children’s Cancer, Treatments, and Radiosurgery offers a comprehensive review of the diagnosis, therapy and prognosis of brain and spinal cord tumors. Coverage extends to a large number of tumor types, including neuroblastoma, medulloblastoma, meningioma and chordoma. Molecular profiling of brain tumors to select appropriate therapy in clinical trials of brain tumors is discussed in detail, as is the classification/diagnosis of brain tumors based on function analysis. CDK6 as the molecular regulator of neuronal differentiation in the adult brain, and the role of aquaporins in human brain tumor growth are explained. Discussion also includes tumors affecting children, including neuroblastoma and medulloblastoma. A full chapter is devoted to the role of molecular genetic alterations in medulloblastoma, and another examines survival differences between children and adults with medulloblastoma. The use of various types of imaging methods to diagnose brain tumors is explained. In-depth discussion of treatment options includes stereotactic radiosurgery, endoscopic neurosurgery, electrochemotherapy, transsphenoidal surgery, focal ablation, whole brain radiation therapy and recraniotomy.

Multiscale Modeling of Cancer

Multiscale Modeling of Cancer
An Integrated Experimental and Mathematical Modeling Approach

by Vittorio Cristini,John Lowengrub

  • Publisher : Cambridge University Press
  • Release : 2010-09-09
  • Pages : 129
  • ISBN : 1139491504
  • Language : En, Es, Fr & De
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Mathematical modeling, analysis and simulation are set to play crucial roles in explaining tumor behavior, and the uncontrolled growth of cancer cells over multiple time and spatial scales. This book, the first to integrate state-of-the-art numerical techniques with experimental data, provides an in-depth assessment of tumor cell modeling at multiple scales. The first part of the text presents a detailed biological background with an examination of single-phase and multi-phase continuum tumor modeling, discrete cell modeling, and hybrid continuum-discrete modeling. In the final two chapters, the authors guide the reader through problem-based illustrations and case studies of brain and breast cancer, to demonstrate the future potential of modeling in cancer research. This book has wide interdisciplinary appeal and is a valuable resource for mathematical biologists, biomedical engineers and clinical cancer research communities wishing to understand this emerging field.

Military Injury Biomechanics

Military Injury Biomechanics
The Cause and Prevention of Impact Injuries

by Melanie Franklyn,Peter Vee Sin Lee

  • Publisher : CRC Press
  • Release : 2017-06-12
  • Pages : 418
  • ISBN : 1498742831
  • Language : En, Es, Fr & De
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Military Injury Biomechanics: The Cause and Prevention of Impact Injuries is a reference manual where information and data from a large number of sources, focussing on injuries related to military events, has been critically reviewed and discussed. The book covers the cause and prevention of impact injuries to all the major body regions, while topics such as the historical background of military impact biomechanics, the history and use of anthropomorphic test devices for military applications and the medical management of injuries are also discussed. An international team of experts have been brought together to examine and review the topics. The book is intended for researchers, postgraduate students and others working or studying defence and impact injuries.

Biomechanics of the Cerebrum at Finite Strain

Biomechanics of the Cerebrum at Finite Strain
A Tissue and Cell Level Study

by Thibault Philippe Prévost

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 124
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The present study addresses the large strain nonlinear mechanical response of the cerebral cortex at the macroscopic tissue level and at the microscopic cell level. Unconfined uniaxial compression tests were conducted in vitro on cortical samples of porcine brains. The tests consisted of load-unload and relaxation segments to 50% nominal deformation at 0.01 to 10 s-1 strain rates. The tissue exhibited moderate volumetric compressibility, marked hysteretic features, and substantial nonlinearities. Indentation tests - with displacement histories mirroring those imposed in compression - were performed on the cortex of porcine brains in vivo, in situ and in vitro, in order to assess and contrast the mechanical properties of the live and dead tissue. The tissue response shared similar qualitative nonlinear viscoelastic features under all testing conditions, although, quantitatively, the response was found to be significantly stiffer in situ than in vivo. Test protocols were also developed at the neuronal cell level using atomic force microscopy. The response of individual somata to cyclic load-unload and relaxation test sequences was found to be nonlinear with time dependencies and hysteretic patterns similar to those measured at the tissue level. A large strain kinematics nonlinear continuum model was proposed to capture the features of the tissue and cell responses. The model was numerically implemented into a three-dimensional finite-element framework. The continuum formulation was found to successfully account for the main experimental observations gathered in vitro at the tissue and cell levels. The present study provides novel insights into the tissue rheology in vivo, in situ and in vitro, at large strains, in the quasi-static and dynamic strain rate regime and reports the first body of observations on the large strain nonlinear viscoelastic properties of brain tissue in vivo. These observations could be directly compared to those pertaining to the tissue response in situ and in vitro, thereby providing a unique quantitative basis for further refinements of existing biomechanical models relying only on in vitro/situ measurements. The consistent set of mechanical data collected, and the constitutive framework proposed at the tissue and cell levels might support the development of multiscale numerical models to study traumatic brain injury.

Computer Models in Biomechanics

Computer Models in Biomechanics
From Nano to Macro

by Gerhard A. Holzapfel,Ellen Kuhl

  • Publisher : Springer Science & Business Media
  • Release : 2012-10-16
  • Pages : 416
  • ISBN : 9400754647
  • Language : En, Es, Fr & De
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This book contains a collection of papers that were presented at the IUTAM Symposium on “Computer Models in Biomechanics: From Nano to Macro” held at Stanford University, California, USA, from August 29 to September 2, 2011. It contains state-of-the-art papers on: - Protein and Cell Mechanics: coarse-grained model for unfolded proteins, collagen-proteoglycan structural interactions in the cornea, simulations of cell behavior on substrates - Muscle Mechanics: modeling approaches for Ca2+–regulated smooth muscle contraction, smooth muscle modeling using continuum thermodynamical frameworks, cross-bridge model describing the mechanoenergetics of actomyosin interaction, multiscale skeletal muscle modeling - Cardiovascular Mechanics: multiscale modeling of arterial adaptations by incorporating molecular mechanisms, cardiovascular tissue damage, dissection properties of aortic aneurysms, intracranial aneurysms, electromechanics of the heart, hemodynamic alterations associated with arterial remodeling following aortic coarctation, patient-specific surgery planning for the Fontan procedure - Multiphasic Models: solutes in hydrated biological tissues, reformulation of mixture theory-based poroelasticity for interstitial tissue growth, tumor therapies of brain tissue, remodeling of microcirculation in liver lobes, reactions, mass transport and mechanics of tumor growth, water transport modeling in the brain, crack modeling of swelling porous media - Morphogenesis, Biological Tissues and Organs: mechanisms of brain morphogenesis, micromechanical modeling of anterior cruciate ligaments, mechanical characterization of the human liver, in vivo validation of predictive models for bone remodeling and mechanobiology, bridging scales in respiratory mechanics

Computational Biomechanics for Medicine

Computational Biomechanics for Medicine
Deformation and Flow

by Poul M.F. Nielsen,Adam Wittek,Karol Miller

  • Publisher : Springer Science & Business Media
  • Release : 2012-05-02
  • Pages : 140
  • ISBN : 1461431727
  • Language : En, Es, Fr & De
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One of the greatest challenges for mechanical engineers is to extend the success of computational mechanics to fields outside traditional engineering, in particular to biology, biomedical sciences, and medicine. This book is an opportunity for computational biomechanics specialists to present and exchange opinions on the opportunities of applying their techniques to computer-integrated medicine. Computational Biomechanics for Medicine: Deformation and Flow collects the papers from the Medical Image Computing and Computer Assisted Intervention conference (MICCAI 2011) dedicated to research in the field of medical image computing and computer assisted medical interventions. The topics covered include: medical image analysis, image-guided surgery, surgical simulation, surgical intervention planning, disease prognosis and diagnostics, injury mechanism analysis, implant and prostheses design, and medical robotics.

Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries

Brainlesion: Glioma, Multiple Sclerosis, Stroke and Traumatic Brain Injuries
6th International Workshop, BrainLes 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 4, 2020, Revised Selected Papers, Part I

by Alessandro Crimi,Spyridon Bakas

  • Publisher : Springer Nature
  • Release : 2021-03-26
  • Pages : 529
  • ISBN : 3030720845
  • Language : En, Es, Fr & De
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This two-volume set LNCS 12658 and 12659 constitutes the thoroughly refereed proceedings of the 6th International MICCAI Brainlesion Workshop, BrainLes 2020, the International Multimodal Brain Tumor Segmentation (BraTS) challenge, and the Computational Precision Medicine: Radiology-Pathology Challenge on Brain Tumor Classification (CPM-RadPath) challenge. These were held jointly at the 23rd Medical Image Computing for Computer Assisted Intervention Conference, MICCAI 2020, in Lima, Peru, in October 2020.* The revised selected papers presented in these volumes were organized in the following topical sections: brain lesion image analysis (16 selected papers from 21 submissions); brain tumor image segmentation (69 selected papers from 75 submissions); and computational precision medicine: radiology-pathology challenge on brain tumor classification (6 selected papers from 6 submissions). *The workshop and challenges were held virtually.

Clinical Image-Based Procedures. Translational Research in Medical Imaging

Clinical Image-Based Procedures. Translational Research in Medical Imaging
4th International Workshop, CLIP 2015, Held in Conjunction with MICCAI 2015, Munich, Germany, October 5, 2015. Revised Selected Papers

by Cristina Oyarzun Laura,Raj Shekhar,Stefan Wesarg,Miguel Ángel González Ballester,Klaus Drechsler,Yoshinobu Sato,Marius Erdt,Marius George Linguraru

  • Publisher : Springer
  • Release : 2016-03-29
  • Pages : 132
  • ISBN : 331931808X
  • Language : En, Es, Fr & De
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This book constitutes revised selected papers from the 4th International Workshop on Clinical Image-Based Procedures, CLIP 2015, held in conjunction with MICCAI 2015 in Munich, Germany, in October 2015. The 15 papers presented in this volume were carefully reviewed and selected from 22 submissions. CLIP focuses on translational research; therefore, the goal of the works presented in this workshop is to bring basic research methods closer to the clinical practice. A highlight of this workshop is the subject of strategies for personalized medicine to enhance diagnosis, treatment and interventions.

Combining Simulations, Theory, and Experiments into Multiscale Models of Biological Events

Combining Simulations, Theory, and Experiments into Multiscale Models of Biological Events
A Book

by Fabio Trovato,Peter J. Bond,Joanna Trylska,Peter Guy Wolynes

  • Publisher : Frontiers Media SA
  • Release : 2022-01-11
  • Pages : 129
  • ISBN : 2889740250
  • Language : En, Es, Fr & De
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Concussive Brain Trauma

Concussive Brain Trauma
Neurobehavioral Impairment & Maladaptation, Second Edition

by Rolland S. Parker

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 879
  • ISBN : 1000654362
  • Language : En, Es, Fr & De
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Focusing on a public health problem affecting millions of people of all ages, the second edition of Concussive Brain Trauma: Neurobehavioral Impairment and Maladaptation reflects Dr. Rolland S. Parker's more than 25 years of neuropsychological practice and research in traumatic brain injury and stress, and his prior experience as a clinical psychol

Biomechanical Principles and Applications in Sports

Biomechanical Principles and Applications in Sports
A Book

by Jani Macari Pallis,Jill L. McNitt-Gray,George K. Hung

  • Publisher : Springer Nature
  • Release : 2019-09-11
  • Pages : 321
  • ISBN : 3030134679
  • Language : En, Es, Fr & De
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This book provides an overview of biomedical applications in sports, including reviews of the current state-of-the art methodologies and research areas. Basic principles with specific case studies from different types of sports as well as suggested student activities and homework problems are included. Equipment design and manufacturing, quantitative evaluation methods, and sports medicine are given special focus. Biomechanical Principles and Applications in Sports can be used as a textbook in a sports technology or sports engineering program, and is also ideal for graduate students and researchers in biomedical engineering, physics, and sports physiology. It can also serve as a useful reference for professional athletes and coaches interested in gaining a deeper understanding of biomechanics and exercise physiology to improve athletic performance.

Handbook of Imaging in Biological Mechanics

Handbook of Imaging in Biological Mechanics
A Book

by Corey P. Neu,Guy M. Genin

  • Publisher : CRC Press
  • Release : 2014-10-24
  • Pages : 579
  • ISBN : 1466588144
  • Language : En, Es, Fr & De
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Emerging imaging techniques have opened new fronts to investigate tissues, cells, and proteins. Transformative technologies such as microCT scans, super-resolution microscopy, fluorescence-based tools, and other methods now allow us to study the mechanics of cancer, dissect the origins of cellular force regulation, and examine biological specimens

Biomechanical Systems Technology

Biomechanical Systems Technology
A Book

by Cornelius T. Leondes

  • Publisher : World Scientific
  • Release : 2007
  • Pages : 344
  • ISBN : 9812709843
  • Language : En, Es, Fr & De
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Because of rapid developments in computer technology and computational techniques, advances in a wide spectrum of technologies, coupled with cross-disciplinary pursuits between technology and its application to human body processes, the field of biomechanics continues to evolve. Many areas of significant progress include dynamics of musculoskeletal systems, mechanics of hard and soft tissues, mechanics of bone remodeling, mechanics of blood and air flow, flow-prosthesis interfaces, mechanics of impact, dynamics of man-machine interaction, and more. Thus, the great breadth and significance of the field in the international scene require a well integrated set of volumes to provide a complete coverage of the exciting subject of biomechanical systems technology. World-renowned contributors tackle the latest technologies in an in-depth and readable manner.