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Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
A Book

by Deepak Thassu,Michel Deleers,Yashwant Vishnupant Pathak

  • Publisher : CRC Press
  • Release : 2007-03-30
  • Pages : 376
  • ISBN : 1420008447
  • Language : En, Es, Fr & De
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With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems
A Book

by Jayvadan K. Patel

  • Publisher : Springer Nature
  • Release : 2022
  • Pages : 129
  • ISBN : 303083395X
  • Language : En, Es, Fr & De
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Nanoparticulates as Drug Carriers

Nanoparticulates as Drug Carriers
A Book

by V. P. Torchilin

  • Publisher : Imperial College Press
  • Release : 2006
  • Pages : 724
  • ISBN : 186094907X
  • Language : En, Es, Fr & De
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Written by key experts in the field of nanomedicine, this book provides a broad introduction to the important field of nanomedicine and application of nanotechnology for drug delivery. It covers up-to-date information regarding various nanoparticulate drug delivery systems, describes the various opportunities for the application of nanoparticular drug carriers in different areas of clinical medicine, and analyzes already available information on their clinical applications. This book can be used as an advanced textbook by graduate students and young scientists and clinicians at the early stages of their career. It is also suitable for non-experts from related areas of chemistry, biochemistry, molecular biology, biomedical engineering, physiology, experimental and clinical medicine, and pharmaceutical sciences, who are interested in general problems of drug delivery and drug targeting, as well as in more specialized topics of using nanoparticulate-mediated drug delivery approaches in the individual areas of clinical medicine. Prof Torchilin is an expert in Nanomedicine and a recipient of numerous awards including the Lenin Prize in Science & Technology of the former USSR, membership in the European Academy of Sciences, and AAPS Research Achievement Award in Pharmaceutics and Drug Delivery. He served as an Associate Professor of Radiology at Harvard Medical School before joining Northeastern University as the Chairman of the Department of Pharmaceutical Sciences. Sample Chapter(s). Chapter 1: Introduction. Nanocarriers for Drug Delivery: Needs and Requirements (442 KB). Contents: Nanoparticle Flow: Implications for Drug Delivery (A T Florence); Polymer Micelles as Drug Carriers (E V Batrakova et al.); Lipoproteins as Pharmaceutical Carriers (S Liu et al.); Dendrimers as Nanoparticular Drug Carriers (S Svenson & D A Tomalia); Cells and Cell Ghosts as Drug Carriers (J M Lanao & M L Sayalero); Magnetic Nanoparticles as Drug Carriers (U O Hnfeli & M Chastellain); Liposomal Drug Carriers in Cancer Therapy (A A Gabizon); Delivery of Nanoparticles to the Cardiovascular System (B-A Khaw); Nanoparticles for Targeting Lymphatics (W Phillips); Nanoparticular Carriers for Ocular Drug Delivery (A Sanchez & M J Alonso); and other papers. Readership: Graduate students, academics in nanomedicine, clinicians, pharmacologists, pharmacists, bioengineers, researchers in biotechnology and diagnostic imaging."

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
Strategies, Technologies, and Applications

by Yoon Yeo

  • Publisher : John Wiley & Sons
  • Release : 2013-02-25
  • Pages : 324
  • ISBN : 1118570510
  • Language : En, Es, Fr & De
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Frank discussions of opportunities and challenges point the way to new, more effective drug delivery systems Interest in nanomedicine has grown tremendously, fueled by the expectation that continued research will lead to the safe, efficient, and cost-effective delivery of drugs or imaging agents to human tissues and organs. The field, however, has faced several challenges attempting to translate novel ideas into clinical benefits. With contributions from an international team of leading nanomedicine researchers, this book provides a practical assessment of the possibilities and the challenges of modern nanomedicine that will enable the development of clinically effective nanoparticulate drug delivery products and systems. Nanoparticulate Drug Delivery Systems focuses on the rationales and preclinical evaluation of new nanoparticulate drug carriers that have yet to be thoroughly reviewed in the literature. The first chapter sets the stage with a general overview of targeted nanomedicine. The book then explores new and promising nanoparticulate drug delivery systems, including: Lipid nanoparticles for the delivery of nucleic acids Multifunctional dendritic nanocarriers Polymer drug nanoconjugates Next, the book presents new opportunities and challenges for nanoparticulate drug delivery systems, including: Clearance of nanoparticles during circulation Drug delivery strategies for combatting multiple drug resistance Toxicological assessment of nanomedicine Chapters offer state-of-the-technology reviews with extensive references to facilitate further investigation. Moreover, each chapter concludes with an expert assessment of remaining challenges, pointing the way to solutions and new avenues of research. With its frank discussions of opportunities and challenges, Nanoparticulate Drug Delivery Systems sets a solid foundation for new research leading to the discovery and development of better nanomedicines.

Drug Delivery with Targeted Nanoparticles

Drug Delivery with Targeted Nanoparticles
In Vitro and In Vivo Evaluation Methods

by Yılmaz Çapan,Adem Sahin,Hayrettin Tonbul

  • Publisher : CRC Press
  • Release : 2021-11-30
  • Pages : 790
  • ISBN : 1000375307
  • Language : En, Es, Fr & De
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Nanotechnology has the potential to change every part of our lives. Today, nanotechnology-based products are used in many areas, and one of the most important areas is drug delivery. Nanoparticulate drug delivery systems not only provide controlled delivery of drugs and improved drug solubility but also improve drug efficiency and reduce side effects via targeting mechanisms. However, compared with conventional drug delivery systems, few nanoparticle-based products are on the market and almost all are nontargeted or only passively targeted systems. In addition, obtaining targeted nanoparticle systems is quite complex and requires several evaluation mechanisms. This book discusses the production, characterization, regulation, and currently marketed targeted nanoparticle systems in a broad framework. It provides an overview of targeted nanoparticles’ (i) in vitro characterization, such as particle size, stability, ligand density, and type; (ii) in vivo behavior for different targeting areas, such as tumor, brain, and vagina; and (iii) current advances in this field, including clinical trials and regulation processes.

Nanoparticulate Drug Delivery System

Nanoparticulate Drug Delivery System
An Overview

by Kamal Singh Rathore,Shreya Patel,Naisarg Pujara

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2013
  • Pages : 72
  • ISBN : 9783659482205
  • Language : En, Es, Fr & De
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Nanoparticles hold tremendous potential as an effective drug delivery system. In this overview we discussed recent developments in nanotechnology for drug delivery. To overcome the problems of gene and drug delivery, nanotechnology has gained interest in recent years. Nanosystems with different compositions and biological properties have been extensively investigated for drug and gene delivery applications. To achieve efficient drug delivery it is important to understand the interactions of nanomaterials with the biological environment, targeting cell-surface receptors, drug release, multiple drug administration, stability of therapeutic agents and molecular mechanisms of cell signaling involved in pathobiology of the disease under consideration. Several anti-cancer drugs including paclitaxel, doxorubicin, 5-fluorouracil and dexamethasone have been successfully formulated using nanomaterials. Quantom dots, chitosan, Polylactic/glycolic acid (PLGA) and PLGA based nanoparticles have also been used for in vitro RNAi delivery. The use of nanomaterials including peptide-based nanotubes is a new approach to control disease progression.

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems

Pharmacokinetics and Pharmacodynamics of Nanoparticulate Drug Delivery Systems
A Book

by Jayvadan K. Patel,Yashwant V. Pathak

  • Publisher : Springer
  • Release : 2022-04-08
  • Pages : 438
  • ISBN : 9783030833947
  • Language : En, Es, Fr & De
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A reference is needed that addresses the recent progress in aspects of PK/PD methods and developments of nanoparticles for novel drug delivery systems. No other consolidated published reference discusses the PK/PD study of nanoparticle drug delivery systems. This book discusses the advantages of nanoparticle drug delivery systems (NPDDS) in enhancing the pharmacokinetics of many drugs that are not easily metabolized or that obtain the desired therapeutic effect with minimum toxicity. The authors provide an overview of biodistribution with a focus on polymer and lipid nanoparticles. This thorough reference is divided into three parts: Modelling, Specific carries and their potential to treat specific diseases.

Nanoparticulate Drug Delivery

Nanoparticulate Drug Delivery
Perspectives on the Transition from Laboratory to Market

by Vandana Patravale,Prajakta Dandekar,Ratnesh Jain

  • Publisher : Elsevier
  • Release : 2012-10-31
  • Pages : 244
  • ISBN : 1908818190
  • Language : En, Es, Fr & De
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Nanotechnology-based therapeutics, operating at scales of billionths of a metre, have great potential for future expansion in altering the scale and methods of drug delivery. The availability of these novel formulations to once-inaccessible areas of the body has greatly expanded the therapeutic window of existing drug molecules. Nanoparticulate drug delivery highlights and examines the transition of nanoparticulate drug delivery systems from the laboratory into a commercially viable sector. The first chapters of the book provide an overview of the use and characterization of nanoparticulate systems as drug carriers, including the assessment of their morphology, sterility and potential toxicity. In the latter part of the book, chapters cover nanotoxicology, regulatory aspect and clinical trials, ending with an overview of several case studies and a look towards future developments. Discusses the issues surrounding nanoparticulate products, based on personal experience of their formulation Provides an overview of new application areas, including RNA interference Outlines the pros and cons of nanoparticulate products, and discusses how these may influence their route into the commercial sector

Ocular Drug Delivery Systems

Ocular Drug Delivery Systems
Barriers and Application of Nanoparticulate Systems

by Deepak Thassu,Gerald J. Chader

  • Publisher : CRC Press
  • Release : 2012-10-02
  • Pages : 473
  • ISBN : 1439848009
  • Language : En, Es, Fr & De
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Drug discovery for ocular diseases has taken great strides in the last two decades. From cornea to choroid, new drugs have been formulated to address a great variety of ocular diseases. Yet without good drug delivery systems, these drugs are less effective than they might be or could even cause serious side effects. Ocular Drug Delivery Systems: Barriers and Application of Nanoparticulate Systems presents research on the development of currently marketed devices and recent trends in the topical delivery of drugs to the posterior of the eye. With contributions from leading pharmaceutical researchers and industry experts, eye researchers, surgeons, pharmacologists from academia, the National Eye Institute, and leading ophthalmic companies such as Pfizer, Allergan, and Novartis, the book presents the state of the art in the use of nanoparticles in ocular drug delivery systems and also sets the stage for future developments. This volume provides both a current evaluation and a future roadmap for developments in ocular drug delivery. The subjects range from biological needs to material challenges and finally to clinical applications for improving drug delivery for conditions where treatments already exist. It also explores areas where effective drugs may be currently available but yet need a safe, efficient, and efficacious delivery vehicle.

Drug Delivery Nanoparticles Formulation and Characterization

Drug Delivery Nanoparticles Formulation and Characterization
A Book

by Yashwant Pathak,Deepak Thassu

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 416
  • ISBN : 1420078054
  • Language : En, Es, Fr & De
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Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na

Nanomedicine in Drug Delivery

Nanomedicine in Drug Delivery
A Book

by Arun Kumar,Heidi M. Mansour,Adam Friedman,Eric R. Blough

  • Publisher : CRC Press
  • Release : 2013-06-05
  • Pages : 469
  • ISBN : 1466506164
  • Language : En, Es, Fr & De
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There is a clear need for innovative technologies to improve the delivery of therapeutic and diagnostic agents in the body. Recent breakthroughs in nanomedicine are now making it possible to deliver drugs and therapeutic proteins to local areas of disease or tumors to maximize clinical benefit while limiting unwanted side effects. Nanomedicine in Drug Delivery gives an overview of aspects of nanomedicine to help readers design and develop novel drug delivery systems and devices that build on nanoscale technologies. Featuring contributions by leading researchers from around the world, the book examines: The integration of nanoparticles with therapeutic agents The synthesis and characterization of nanoencapsulated drug particles Targeted pulmonary nanomedicine delivery using inhalation aerosols The use of biological systems—bacteria, cells, viruses, and virus-like particles—as carriers to deliver nanoparticles Nanodermatology and the role of nanotechnology in the diagnosis and treatment of skin disease Nanoparticles for the delivery of small molecules, such as for gene and vaccine delivery The use of nanotechnologies to modulate and modify wound healing Nanoparticles in bioimaging, including magnetic resonance, computed tomography, and molecular imaging Nanoparticles to enhance the efficiency of existing anticancer drugs The development of nanoparticle formulations Nanoparticles for ocular drug delivery Nanoparticle toxicity, including routes of exposure and mechanisms of toxicity The use of animal and cellular models in nanoparticles safety studies With its practical focus on the design, synthesis, and application of nanomedicine in drug delivery, this book is a valuable resource for clinical researchers and anyone working to tackle the challenges of delivering drugs in a more targeted and efficient manner. It explores a wide range of promising approaches for the diagnosis and treatment of diseases using cutting-edge nanotechnologies.

Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
Nanoparticles Loaded Temperature Induced in Situ Gel

by Jaya Raja Kumar Kalaimani,Kanagambikai Maivizhi Selvi,Ai Lee Leng Liow Hin Teng

  • Publisher : Unknown Publisher
  • Release : 2016-04-09
  • Pages : 108
  • ISBN : 9783659860898
  • Language : En, Es, Fr & De
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Nanoparticle Drug Delivery Systems for Cancer Treatment

Nanoparticle Drug Delivery Systems for Cancer Treatment
A Book

by Hala Gali-Muhtasib,Racha Chouaib

  • Publisher : CRC Press
  • Release : 2020-02-19
  • Pages : 326
  • ISBN : 1000680878
  • Language : En, Es, Fr & De
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In recent years, nanoparticles—bionanomaterials with specific physicochemical properties—have gained a great deal of scientific interest owing to their unique structure. Nanoparticle-based drugs are now widely regarded as a safer, more precise, and more effective mode of cancer therapy, considering their ability to enhance drug bioavailability, improve site-specific drug delivery, and protect nontarget tissues from toxic therapeutic drugs. This book compiles and details cutting-edge research in nanomedicine from an interdisciplinary team of international cancer researchers who are currently revolutionizing drug delivery techniques through the development of nanomedicines and nanotheranostics. Edited by Hala Gali-Muhtasib and Racha Chouaib, two prominent cancer researchers, this book will appeal to anyone involved in nanotechnology, cancer therapy, or drug delivery research.

Surface Modification of Nanoparticles for Targeted Drug Delivery

Surface Modification of Nanoparticles for Targeted Drug Delivery
A Book

by Yashwant V Pathak

  • Publisher : Springer
  • Release : 2019-03-11
  • Pages : 499
  • ISBN : 3030061159
  • Language : En, Es, Fr & De
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This unique book is the only one to discuss various new techniques developed to enhance the application of nanoparticulate drug delivery systems using surface modification of nanoparticles. The understanding of the surface characteristics nano-particles is growing significantly with the advent of new analytical techniques. Polymer chemistry is contributing to the development of many new versatile polymers which have abilities to accommodate many different, very reactive chemical groups, and can be used as a diagnostic tool, for better targeting, for more effective therapeutic results as well as for reducing the toxic and side effects of the drugs. Surface modification of such polymeric nanoparticles has been found by many scientists to enhance the application of nanoparticles and also allows the nano particles to carry specific drug molecule and disease /tumor specific antibodies which refine and improve drug delivery. Surface Modification of Nanoparticles for Targeted Drug Delivery is a collection essential information with various applications of surface modification of nanoparticles and their disease specific applications for therapeutic purposes.

Nanoparticulate Systems for Drug Delivery

Nanoparticulate Systems for Drug Delivery
A Book

by Daan J. A. Crommelin

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 138
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
A Book

by Raj K. Keservani,Anil K. Sharma

  • Publisher : CRC Press
  • Release : 2019-01-23
  • Pages : 422
  • ISBN : 1351137247
  • Language : En, Es, Fr & De
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Focusing on nanoparticulate nanocarriers and recent advances in the field of drug delivery, the volume begins with chapters that provide an informative introduction to polymeric nanoparticles—their general physicochemical features and characteristics, their applications in drug delivery systems, and the challenges involved. Specific applications are discussed, with attention paid to treatment of particular diseases and disorders and the targeting of specific organs. Part 2 looks at more specific applications and techniques of nanoparticulate nanocarriers for drug delivery, such as the use of magnetic nanoparticles, gold nanoparticles in therapeutics, and superparamagnetic iron oxide nanoparticles (SPIONs) for the treatment of cancer. Part 3 discusses lipid-based nanoparticulates for various applications, including skin care. The last section of the book explores some of the newer nanoarchitectures, including dendrimers in gene delivery and carbon nanotubes for drug delivery. Together, the insightful research presented here provides valuable information for those involved in this area, including scientists and researchers and faculty and upper-level students, as well as for industry professionals.

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems
A Focus on Nanotechnology and Nanoparticulates

by Huile Gao,Xiaoling Gao

  • Publisher : Academic Press
  • Release : 2018-09-20
  • Pages : 499
  • ISBN : 012814002X
  • Language : En, Es, Fr & De
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Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Nanoparticulate Drug Delivery

Nanoparticulate Drug Delivery
Novel Approach for Drug Delivery

by Kinjal P. Shukla,Balkrushna K. Patel,Bhuvan P. Raval

  • Publisher : Unknown Publisher
  • Release : 2012-02
  • Pages : 60
  • ISBN : 9783848408672
  • Language : En, Es, Fr & De
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Any drug given in the form of parenteral dosage form like emulsion, suspension, solution etc. it is not best suited for the long time therapy. Long time drug release profile in controlled manner achieved by nano particle which is difficult by parenteral suspension or parenteral solution. Nano particulate drug delivery is the novel concept now a days. Nano particulate drug delivery is used to get maximum bio-availability for the potent drug with minimal side effect. Nano particulate drug delivery is also useful for maintaining the drug concentration in therapeutic window for the drug having narrow therapeutic window. Nano particulate drug delivery having disadvantage like cost effective even though it is widely useful because of its ease of preparation and suitability with most of drugs and excipients.

Nanoparticles for Drug Delivery

Nanoparticles for Drug Delivery
A Book

by Joshy K. S.,Sabu Thomas,Vijay Kumar Thakur

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 207
  • ISBN : 9811621195
  • Language : En, Es, Fr & De
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This book introduces the reader to drug delivery with specific emphasis on the use of nanoparticles. It covers properties, characterization, and preparation of different types of nanoparticles and discusses recent advances in their structural design and biomedical application, as well as the issues and challenges associated with their design and use. Some of the topics covered include the potential application of nanoparticles in biomedical fields, hazards associated with use of nanoparticles for drug delivery, size-dependent factors in drug delivery applications, different organic, inorganic and their hybrid systems used in drug delivery, etc. It also highlights use of nanoparticles in controlled and targeted drug delivery, and their application in stimuli-responsive, especially pH-responsive, drug release. Additionally, it also focuses on biomimetic nanoparticles, challenges faced in the designing of nanoparticles for drug delivery in cancer, viral and bacterial diseases. The contents of this volume will be useful to researchers and professionals working on advances in targeted drug delivery systems.

Nanotherapeutics

Nanotherapeutics
Drug Delivery Concepts in Nanoscience

by Alf Lamprecht

  • Publisher : Pan Stanford Publishing
  • Release : 2009
  • Pages : 279
  • ISBN : 9814241024
  • Language : En, Es, Fr & De
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This timely book provides an overview of possible therapeutic applications. The first part of the book highlights general properties of and phenomena observed with nanoparticles, and the subsequent consequences for applications in drug delivery. The second part focuses on the therapeutic approaches that are possible through the use of nanoparticles, with each chapter discussing a specific disease (e.g., diabetes, cancer, inflammation) and the relevant therapeutic approaches based on the design of nanoparticulate drug delivery systems. From this concise book, readers will gain an insight into the basics of nanoparticle preparation and find a more detailed account of what is therapeutically feasible by using nanoparticle approaches.