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Nanopharmaceuticals

Nanopharmaceuticals
Volume 1: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Elsevier
  • Release : 2020-01-10
  • Pages : 244
  • ISBN : 0128177799
  • Language : En, Es, Fr & De
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Nanopharmaceuticals reviews advances in the drug delivery field via nanovehicles or nanocarriers that offer benefits like targeted therapy and serves as a single dose magic bullet for multiple drug delivery with improved drug efficiency at a lower dose, transportation of the drug across physiological barriers as well as reduced drug-related toxicity. The chapters are written by a diverse group of international researchers from industry and academia. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Other volumes in the Expectations and Realities of Multifunctional Drug Delivery Systems book series: Delivery of Drugs, Volume 2, 9780128177761 Drug Delivery Trends, Volume 3, 9780128178706 Drug Delivery Aspects, Volume 4, 9780128212226 Encompasses functional aspects of nanocarriers Discusses Intellectual Property landscapes of micro-nano drug carriers Contains in-depth investigation of specific aspects of drug delivery systems

Nanopharmaceuticals: Principles and Applications Vol. 3

Nanopharmaceuticals: Principles and Applications Vol. 3
A Book

by Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse

  • Publisher : Springer Nature
  • Release : 2020-08-19
  • Pages : 340
  • ISBN : 3030471209
  • Language : En, Es, Fr & De
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This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Emerging Nanotechnologies in Immunology

Emerging Nanotechnologies in Immunology
The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines

by Ranjita Shegokar,Eliana B. Souto

  • Publisher : William Andrew
  • Release : 2018-05-17
  • Pages : 290
  • ISBN : 0323401139
  • Language : En, Es, Fr & De
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Emerging Nanotechnologies in Immunology: The Design, Applications and Toxicology of Nanopharmaceuticals and Nanovaccines aims to deliver a systematic and comprehensive review of data concerning the nature of interaction and nano-related risks between the nanopharmaceuticals currently in the pipeline of S&T development for skin, ocular and nasal drug delivery, including absorption, toxicity, and the ability to distribute after systemic exposure. The book's contributors address a representative set of the broad spectrum of nanopharmaceutics presently being used, including cationic lipid nanoparticles, polymeric PLGA, PLA nanoparticles, biomacromolecules-based nanoparticles, and other scaffolds tissue-engineered skin substitutes. In addition, regulation and risk are also covered since the safety of these nanopharmaceuticals still represents a barrier to their wide and innovative use. Provides a thorough knowledge of the safety aspects of nanopharmaceuticals currently under research Focuses on the characterization and quantification of nanopharmaceutics to allow readers to understand the correlation between the nature of the materials and their potential nanotoxicological effects Includes a thorough overview of legal and regulatory aspects and a discussion of the ethical issues related to the R&D of nanopharmaceuticals

Nanopharmaceuticals: Principles and Applications Vol. 1

Nanopharmaceuticals: Principles and Applications Vol. 1
A Book

by Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse

  • Publisher : Springer Nature
  • Release : 2020-07-14
  • Pages : 381
  • ISBN : 3030449254
  • Language : En, Es, Fr & De
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This book discusses the biological, technical and study-design challenges of Nanopharmaceuticals. Chapters of this book are dedicated to supermagentic iron oxide nanoparticles for the diagnosis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It also includes a brief introduction to magnetic resonance imaging and ends with the future prospective of iron oxide nanoparticles in cancer detection. The book also provides a critical discussion on ‘Computational sequence design for DNA nanostructures’ and gives a brief introduction about the skin delivery. A detailed discussion has been included about the different types of nanocarriers such as micells, microemulsions, nanoemulsions, polymeric and lipid based nanoparticles. Focussing on the safety concerns of nanomedicine it also covers the safety issues, clinical benefits, ecotoxicity and regulatory frame work of nanopharmaceuticals.

Nanopharmaceuticals: Principles and Applications Vol. 2

Nanopharmaceuticals: Principles and Applications Vol. 2
A Book

by Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse

  • Publisher : Springer Nature
  • Release : 2020-07-14
  • Pages : 366
  • ISBN : 3030449211
  • Language : En, Es, Fr & De
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This book presents the comprehensive description of basic principles, methodologies, similarities and differences of nano-liposomes and -phytosomes. It focuses on the implications of these nano carriers in drug delivery and also includes detailed classification of nanoinonized drug particles, polymeric nanoparticles and hydrophobic nanoparticles. This book concludes with the biological, technical and study-design challenges of Nanopharmaceuticals and presents critical viewpoints of smart DNA nanostructures. The risk factors and regulatory concerns have also been kept in focus and the book includes the toxicity and application of different types of ionic liquids for humans and environment. It also critically describes characteristics, applications and regulatory gaps of nanoparticle-ionic liquid combined systems.

21st Century Nanoscience – A Handbook

21st Century Nanoscience – A Handbook
Nanopharmaceuticals, Nanomedicine, and Food Nanoscience (Volume Eight)

by Klaus D. Sattler

  • Publisher : CRC Press
  • Release : 2020-04-22
  • Pages : 332
  • ISBN : 1000702537
  • Language : En, Es, Fr & De
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This 21st Century Nanoscience Handbook will be the most comprehensive, up-to-date large reference work for the field of nanoscience. Handbook of Nanophysics by the same editor published in the fall of 2010 and was embraced as the first comprehensive reference to consider both fundamental and applied aspects of nanophysics. This follow-up project has been conceived as a necessary expansion and full update that considers the significant advances made in the field since 2010. It goes well beyond the physics as warranted by recent developments in the field. This eighth volume in a ten-volume set covers nanopharmaceuticals, nanomedicine, and food nanoscience. Key Features: Provides the most comprehensive, up-to-date large reference work for the field. Chapters written by international experts in the field. Emphasises presentation and real results and applications. This handbook distinguishes itself from other works by its breadth of coverage, readability and timely topics. The intended readership is very broad, from students and instructors to engineers, physicists, chemists, biologists, biomedical researchers, industry professionals, governmental scientists, and others whose work is impacted by nanotechnology. It will be an indispensable resource in academic, government, and industry libraries worldwide. The fields impacted by nanophysics extend from materials science and engineering to biotechnology, biomedical engineering, medicine, electrical engineering, pharmaceutical science, computer technology, aerospace engineering, mechanical engineering, food science, and beyond.

Nanopharmaceuticals: A New Perspective of Drug Delivery System

Nanopharmaceuticals: A New Perspective of Drug Delivery System
A Book

by Shahid Nazir Wani,Janmajoy Banerjee

  • Publisher : Unknown Publisher
  • Release : 2017-08-11
  • Pages : 92
  • ISBN : 9783330331020
  • Language : En, Es, Fr & De
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Nanopharmaceutical Advanced Delivery Systems

Nanopharmaceutical Advanced Delivery Systems
A Book

by Vivek Dave,Nikita Gupta,Srija Sur

  • Publisher : John Wiley & Sons
  • Release : 2020-12-29
  • Pages : 512
  • ISBN : 1119711673
  • Language : En, Es, Fr & De
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The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Nanopharmaceuticals

Nanopharmaceuticals
A Book

by Raj Bawa

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 20
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanopharmaceutical Advanced Delivery Systems

Nanopharmaceutical Advanced Delivery Systems
A Book

by Vivek Dave,Nikita Gupta,Srija Sur

  • Publisher : John Wiley & Sons
  • Release : 2020-12-29
  • Pages : 512
  • ISBN : 1119711681
  • Language : En, Es, Fr & De
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The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Emerging Nanopharmaceuticals for Non-parenteral Application Routes

Emerging Nanopharmaceuticals for Non-parenteral Application Routes
Edited by Jelena Filipović-Grčić, Aleš Mrhar and Hans E. Junginger

by Emerging Nanopharmaceuticals for Non-parenteral Application Routes

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 160
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Ethical Challenges of Emerging Medical Technologies

The Ethical Challenges of Emerging Medical Technologies
A Book

by Arthur L. Caplan,Brendan Parent

  • Publisher : Routledge
  • Release : 2020-09-10
  • Pages : 482
  • ISBN : 1000151999
  • Language : En, Es, Fr & De
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This collection of essays emphasizes society’s increasingly responsible engagement with ethical challenges in emerging medical technology. Expansion of technological capacity and attention to patient safety have long been integral to improving healthcare delivery but only relatively recently have concepts like respect, distributive justice, privacy, and autonomy gained some power to shape the development, use, and refinement of medical tools and techniques. Medical ethics goes beyond making better medicine to thinking about how to make the field of medicine better. These essays showcase several ways in which modern ethical thinking is improving safety, efficacy and efficiency of medical technology, increasing access to medical care, and empowering patients to choose care that comports with their desires and beliefs. Included are complimentary ethical approaches as well as compelling counter-arguments. Together, the articles demonstrate how improving the quality of medical technology relies on every stakeholder -- not just medical researchers and scientists -- to assess each given technology’s strengths and pitfalls. This collection also portends one of the next major issues in the ethics of medical technology: developing the requisite moral framework to accompany shifts toward patient-centred personalized healthcare.

Delivery of Chemotherapeutics by Metal-organic Nanopharmaceuticals

Delivery of Chemotherapeutics by Metal-organic Nanopharmaceuticals
A Book

by Benjamin Steinborn

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Inorganic Frameworks as Smart Nanomedicines

Inorganic Frameworks as Smart Nanomedicines
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2018-04-09
  • Pages : 726
  • ISBN : 0128136626
  • Language : En, Es, Fr & De
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Inorganic Frameworks as Smart Nanocarriers for Drug Delivery brings together recent research in the area of inorganic frameworks for drug delivery. Different types of nanocarriers are presented and discussed in detail, providing an up-to-date overview on inorganic nanoparticles with pharmaceutical applications. Written by a diverse range of international academics, this book is a valuable reference resource for researchers in biomaterials, the pharmaceutical industry, and those who want to learn more about the current applications of inorganic smart nanocarriers. Includes assembly methods for a variety of smart nanocarrier systems, also showing how they are applied Highlights how metal-oxide nanoparticles are effectively used in drug delivery Assesses the pros and cons of different metallic nanomaterials as drug carriers

Marine-Derived Biomaterials for Tissue Engineering Applications

Marine-Derived Biomaterials for Tissue Engineering Applications
A Book

by Andy H. Choi,Besim Ben-Nissan

  • Publisher : Springer
  • Release : 2019-07-08
  • Pages : 550
  • ISBN : 9811388555
  • Language : En, Es, Fr & De
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This book presents the latest advances in marine structures and related biomaterials for applications in both soft- and hard-tissue engineering, as well as controlled drug delivery. It explores marine structures consisting of materials with a wide variety of characteristics that warrant their use as biomaterials. It also underlines the importance of exploiting natural marine resources for the sustainable development of novel biomaterials and discusses the resulting environmental and economic benefits. The book is divided into three major sections: the first covers the clinical application of marine biomaterials for drug delivery in tissue engineering, while the other two examine the clinical significance of marine structures in soft- and hard-tissue engineering, respectively. Focusing on clinically oriented applications, it is a valuable resource for dentists, oral and maxillofacial surgeons, orthopedic surgeons, and students and researchers in the field of tissue engineering.

Nanomedicine

Nanomedicine
Principles and Perspectives

by Yi Ge,Songjun Li,Shenqi Wang,Richard Moore

  • Publisher : Springer
  • Release : 2014-12-01
  • Pages : 413
  • ISBN : 1461421403
  • Language : En, Es, Fr & De
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Increasing demand for and awareness of the applications of nanotechnology in medicine has resulted in the emergence of a new fast-growing multidisciplinary area - nanomedicine. This book offers comprehensive knowledge of and diverse perspectives on nanomedicine through two independent volumes. It aims to bridge the gap between nanotechnology and medicine through contributions by world-renowned experts from wide range of backgrounds including academia, industry, professional consultancy, and government agencies. Each contribution integrates knowledge from a wide range of areas to present the fundamentals of new applications and products of nanomedicine, as well as an outlook for the future. This book can well serve as a reference and guide for students, academics, researchers, scientists, engineers, clinicians, government researchers, and healthcare professionals.

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
A Book

by Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon

  • Publisher : Springer Science & Business Media
  • Release : 2008-10-29
  • Pages : 662
  • ISBN : 9780387776682
  • Language : En, Es, Fr & De
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Nanopharmaceutical for Improved Anti-HIV Therapy

Nanopharmaceutical for Improved Anti-HIV Therapy
A Book

by Li Wan

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 191
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Curing HIV-1 infection has remained elusive due to low and fluctuating drug levels, arising from poor absorption, viral reservoirs and sanctuary sites, toxicity and patient non-adherence. The theme of the current study is to investigate the value of combining AIDS drugs and modifiers of cellular uptake into macromolecular nanocarriers having novel pharmacological properties for improving current anti-HIV therapy. Nanopharmaceuticals were prepared from different combinations of saquinavir (SQV), R.I. CK-Tat9 and the polymeric nanocarrier polyethylene glycol. Anti-HIV activities were measured in MT-2 cells while parallel studies were performed in uninfected cells to determine cellular toxicity. Flow cytometry and confocal microscopy studies suggested that variations in intracellular uptake and intracellular localization, as well as synergistic inhibitory effects of SQV and Tat peptides, contributed to the unexpected and substantial differences in antiviral activity. Our results demonstrate that highly potent multi-drug nanopharmaceuticals with low non-specific toxicity can be produced by combining moieties with anti-HIV agents for different targets onto macromolecules having improved delivery properties. The present study also addressed the issue of insufficient drug exposure of viral reservoirs in macrophages. Macrophages are a key target and primary cellular reservoir for HIV, and are believed to be responsible for the viral rebound effect observed upon the discontinuation of therapy. In this study, multiple copies of N-formyl-Met-Leu-Phe (fMLF), a known chemo-attractant for macrophages, were conjugated to multifunctional nanocarrier derived from commercially available or novel peptide-based PEGs. The results of uptake studies indicated that appending only two copies of fMLF to the nanocarrier is sufficient for optimal binding and the optimal size of the nanocarrier was about 20 kDa. Further pharmacokinetics and biodistribution studies demonstrated that the attachment of fMLF increased accumulation of PEG nanocarriers in major macrophage-residing tissues such as liver, kidneys and spleen. Taken together, these results demonstrated the feasibility of using macrophage-targeted nanocarriers for enhancing drug uptake in human macrophage-like cells in vitro or macrophages residing in tissues in vivo. These results indicate great promise for enhancing targeted drug delivery to HIV-infected macrophages, which may eventually improve current anti-HIV therapy by improving therapeutic efficacy, minimizing systemic toxicity and simplifying administration regimens.

Multifunctional Pharmaceutical Nanocarriers

Multifunctional Pharmaceutical Nanocarriers
A Book

by Vladimir Torchilin

  • Publisher : Springer Science & Business Media
  • Release : 2008-03-21
  • Pages : 474
  • ISBN : 0387765549
  • Language : En, Es, Fr & De
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The editors have brought together leading experts in multifunctional nanopharmaceuticals to provide cutting edge information; a critical overview of the field; and analysis of current and potential future developments to speed the subject’s rapid development.

Handbook of Clinical Nanomedicine

Handbook of Clinical Nanomedicine
Nanoparticles, Imaging, Therapy, and Clinical Applications

by Raj Bawa,Gerald F. Audette,Israel Rubinstein

  • Publisher : CRC Press
  • Release : 2016-02-22
  • Pages : 1708
  • ISBN : 9814669210
  • Language : En, Es, Fr & De
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This handbook (55 chapters) provides a comprehensive roadmap of basic research in nanomedicine as well as clinical applications. However, unlike other texts in nanomedicine, it not only highlights current advances in diagnostics and therapeutics but also explores related issues like nomenclature, historical developments, regulatory aspects, nanosim