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Nanotechnology for Oral Drug Delivery

Nanotechnology for Oral Drug Delivery
From Concept to Applications

by João Pedro Martins, MSc Biom. Eng.,Hélder A. Santos

  • Publisher : Academic Press
  • Release : 2020-08-17
  • Pages : 534
  • ISBN : 0128180382
  • Language : En, Es, Fr & De
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Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. Highlights the relevance of oral drug delivery in the clinical setting Covers the most recent advances in the field of nanotechnology for oral drug delivery Provides the scientific community with data that can facilitate and guide their research

Nanotechnology for Oral Drug Delivery

Nanotechnology for Oral Drug Delivery
From Concept to Applications

by João Pedro Martins,Hélder A. Santos

  • Publisher : Academic Press
  • Release : 2020-07-30
  • Pages : 534
  • ISBN : 0128180390
  • Language : En, Es, Fr & De
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Nanotechnology for Oral Drug Delivery: From Concept to Applications discusses the current challenges of oral drug delivery, broadly revising the different physicochemical barriers faced by nanotechnolgy-based oral drug delivery systems, and highlighting the challenges of improving intestinal permeability and drug absorption. Oral delivery is the most widely used form of drug administration due to ease of ingestion, cost effectiveness, and versatility, by allowing for the accommodation of different types of drugs, having the highest patient compliance. In this book, a comprehensive overview of the most promising and up-to-date engineered and surface functionalized drug carrier systems, as well as opportunities for the development of novel and robust delivery platforms for oral drug administration are discussed. The relevance of controlling the physicochemical properties of the developed particle formulations, from size and shape to drug release profile are broadly reviewed. Advances in both in vitro and in vivo scenarios are discussed, focusing on the possibilities to study the biological-material interface. The industrial perspective on the production of nanotechnology-based oral drug delivery systems is also covered. Nanotechnology for Oral Drug Delivery: From Concept to Applications is essential reading for researchers, professors, advanced students and industry professionals working in the development, manufacturing and/or commercialization of nanotechnology-based systems for oral drug delivery, targeted drug delivery, controlled drug release, materials science and biomaterials, in vitro and in vivo testing of potential oral drug delivery technologies. Highlights the relevance of oral drug delivery in the clinical setting Covers the most recent advances in the field of nanotechnology for oral drug delivery Provides the scientific community with data that can facilitate and guide their research

Application of Nanotechnology in Drug Delivery

Application of Nanotechnology in Drug Delivery
A Book

by Ali Demir Sezer

  • Publisher : BoD – Books on Demand
  • Release : 2014-07-25
  • Pages : 554
  • ISBN : 9535116282
  • Language : En, Es, Fr & De
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This book collects reviews and original articles from eminent experts working in the interdisciplinary arena of nanotechnology use in drug delivery. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of nanotechnology application of drug delivery. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Nanoparticles in Life Sciences and Biomedicine

Nanoparticles in Life Sciences and Biomedicine
A Book

by Ana Rute Neves,Salette Reis

  • Publisher : CRC Press
  • Release : 2018-02-13
  • Pages : 552
  • ISBN : 1351207334
  • Language : En, Es, Fr & De
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The creation of new and more efficient therapies for improving human health greatly depends on drug delivery systems. Nanotechnology has emerged as a powerful strategy for the development of nanoparticles, such as nanoemulsions, liposomes, nanocrystals, and nanocomplexes, applied in the diagnosis, treatment, or theranostics of several pathologies and diseases. This book reviews the most recent research and development in nanotechnology and, following a multidisciplinary approach, presents new strategies for drug delivery, including aspects from chemistry, physics, biology, and imaging methodologies and exploiting several administration routes, internalization pathways, site-specific delivery strategies, and the potential cytotoxicity of nanoparticles. Beginning with a description of the importance and application of nanotechnology for enhancing existing therapy, the book moves on to detailing oral, topical, pulmonary, brain, cancer, and anti-inflammatory drug delivery approaches; gene delivery approaches; theranostic approaches; and nanoparticle cytotoxicity. Practical and user friendly, it is suitable for advanced undergraduate, graduate, and postgraduate students of nanoscience and nanotechnology; researchers in nanoscience, nanotechnology, chemistry, biology, biochemistry, pharmaceutical sciences, medicine, and bioengineering, especially those with an interest in drug delivery or theranostics; and academia and university readership.

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles
A Book

by Pavan Muttil,Nitesh K. Kunda

  • Publisher : Springer Nature
  • Release : 2020-03-18
  • Pages : 277
  • ISBN : 3030359107
  • Language : En, Es, Fr & De
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Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Nanostructures for Oral Medicine

Nanostructures for Oral Medicine
A Book

by Ecaterina Andronescu,Alexandru Mihai Grumezescu

  • Publisher : Elsevier
  • Release : 2017-04-11
  • Pages : 1034
  • ISBN : 0323477216
  • Language : En, Es, Fr & De
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Nanostructures for Oral Medicine presents an up-to-date examination of the applications and effects of nanostructured materials in oral medicine, with each chapter addressing recent developments, specific applications, and uses of nanostructures in the oral administration of therapeutic agents in dentistry. The book also includes coverage of the biocompatibility of nanobiomaterials and their remarkable potential in improving human health and in reducing environmental pollution. Emerging advances, such as Dr. Franklin Tay's concept of a new nanotechnology process of growing extremely small, mineral-rich crystals and guiding them into the demineralized gaps between collagen fibers to prevent the aging and degradation of resin-dentin bonding is also discussed. This work will be of great value to those who work in oral medicine, providing them with a resource to gain a greater understanding of how nanotechnology can help them create more efficient, cost-effective products. In addition, it will be of great interest to those who work in materials science who wish to gain a greater appreciation of how nanostructured materials are applied in this field. Outlines the major uses of nanostructured materials for oral medicine, including the properties of each material discussed and how it should best be applied Explores how nanostructured materials enable the creation of more effective drug delivery systems in oral medicine Discusses how novel uses of nanostructured materials may be applied in oral medicine to create more effective devices

Nanomaterials for Drug Delivery and Therapy

Nanomaterials for Drug Delivery and Therapy
A Book

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2019-03-14
  • Pages : 580
  • ISBN : 0128166290
  • Language : En, Es, Fr & De
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Nanomaterials for Drug Delivery and Therapy presents recent advances in the field of nanobiomaterials and their important applications in drug delivery, therapy and engineering. The book offers pharmaceutical perspectives, exploring the development of nanobiomaterials and their interaction with the human body. Chapters show how nanomaterials are used in treatments, including neurology, dentistry and cancer therapy. Authored by a range of contributors from global institutions, this book offers a broad, international perspective on how nanotechnology-based advances are leading to novel drug delivery and treatment solutions. It is a valuable research resource that will help both practicing medics and researchers in pharmaceutical science and nanomedicine learn more on how nanotechnology is improving treatments. Assesses the opportunities and challenges of nanotechnology-based drug delivery systems Explores how nanotechnology is being used to create more efficient drug delivery systems Discusses which nanomaterials make the best drug carriers

Nanotechnology and Drug Delivery, Volume One

Nanotechnology and Drug Delivery, Volume One
Nanoplatforms in Drug Delivery

by José L. Arias

  • Publisher : CRC Press
  • Release : 2014-08-04
  • Pages : 380
  • ISBN : 1466599472
  • Language : En, Es, Fr & De
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Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes
A Book

by Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer

  • Publisher : Academic Press
  • Release : 2017-05-23
  • Pages : 552
  • ISBN : 0128097183
  • Language : En, Es, Fr & De
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Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Nanoengineered Biomaterials for Advanced Drug Delivery

Nanoengineered Biomaterials for Advanced Drug Delivery
A Book

by Masoud Mozafari

  • Publisher : Elsevier
  • Release : 2020-06-17
  • Pages : 820
  • ISBN : 0081029861
  • Language : En, Es, Fr & De
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Nanoengineered Biomaterials for Advanced Drug Delivery explores the latest advances in the applications of nanoengineered biomaterials in drug delivery systems. The book covers a wide range of biomaterials and nanotechnology techniques that have been used for the delivery of different biological molecules and drugs in the human body. It is an important resource for biomaterials scientists and engineers working in biomedicine and those wanting to learn more on how nanoengineered biomaterials are being used to enhance drug delivery for a variety of diseases. Nanoengineered biomaterials have enhanced properties that make them more effective than conventional biomaterials as both drug delivery agents, and in the creation of new drug delivery systems. As nanoengineering becomes more cost-effective, nanoengineered biomaterials have become more widely used within biomedicine. Offers an informed overview on how nanoengineering biomaterials enhance their properties for drug delivery applications Discusses the major applications of nanoengineered biomaterials for drug delivery Outlines the major challenges for successfully implementing nanoengineered biomaterials into existing drug delivery systems

Nanotechnology in Drug Delivery

Nanotechnology in Drug Delivery
A Book

by Melgardt M. de Villiers,Pornanong Aramwit,Glen S. Kwon

  • Publisher : Springer Science & Business Media
  • Release : 2008-10-29
  • Pages : 662
  • ISBN : 9780387776682
  • Language : En, Es, Fr & De
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The reader will be introduced to various aspects of the fundamentals of nanotechnology based drug delivery systems and the application of these systems for the delivery of small molecules, proteins, peptides, oligonucleotides and genes. How these systems overcome challenges offered by biological barriers to drug absorption and drug targeting will also be described.

Nanotechnology in Regenerative Medicine and Drug Delivery Therapy

Nanotechnology in Regenerative Medicine and Drug Delivery Therapy
A Book

by Haiyan Xu,Ning Gu

  • Publisher : Springer Nature
  • Release : 2020-07-21
  • Pages : 482
  • ISBN : 9811553866
  • Language : En, Es, Fr & De
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The book focuses on the application of nanotechnologies in scaffold-guided tissue regeneration and in drug delivery systems for use in immunotherapy and overcoming drug resistance in cancer treatment. It covers a variety of topics, including nanomaterials for immunomodulation and immnunotherapy; molecular studies on self-assembly for peptides and DNA and related applications in tumor diagnosis and therapeutics and against human pathogenic bacteria; magnetic and conductive scaffolds for guiding tissue regeneration; multiple functions of magnetic nanoparticles in drug delivery and regenerative medicine; and re-purposing of traditional medicine in nano-formulations. In addition, it discusses common effects of nanomaterials, including reactive oxygen species and protein corona. Providing valuable insights and the presenting the latest research advances, the book allows readers to gain a systematic understanding of the topic.

Drug Delivery Trends

Drug Delivery Trends
Volume 3: Expectations and Realities of Multifunctional Drug Delivery Systems

by Ranjita Shegokar

  • Publisher : Elsevier
  • Release : 2020-03-01
  • Pages : 246
  • ISBN : 012817871X
  • Language : En, Es, Fr & De
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Drug Delivery Trends examines a drift in the pharmaceutical field across the wide range of dosage forms, drug delivery systems (micro and nanoparticulate), at the regulatory front and on new types of therapies in the market. This volume additionally covers the challenges on drug delivery systems in terms of preclinical and current ways of determining quality and the options to solve the challenges associated with this. Most small-medium scale industries and academics struggle with initial regulatory challenges so a detailed discussion on regulatory trend covers the necessary basic understanding of regulatory procedures and provides the required guidance. The series Expectations and Realities of Multifunctional Drug Delivery Systems examines the fabrication, optimization, biological aspects, regulatory and clinical success of wide range of drug delivery carriers. This series reviews multifunctionality and applications of drug delivery systems, industrial trends, regulatory challenges and in vivo success stories. Throughout the volumes discussions on diverse aspects of drug delivery carriers, such as clinical, engineering, and regulatory, facilitate insight sharing across expertise area and form a link for collaborations between industry-academic scientists and clinical researchers. Expectations and Realities of Multifunctional Drug Delivery Systems connects formulation scientists, regulatory experts, engineers, clinical experts and regulatory stake holders. The wide scope of the book ensures it as a valuable reference resource for researchers in both academia and the pharmaceutical industry who want to learn more about drug delivery systems. Encompasses trends in drug delivery systems and selected dosage forms Illustrates regulatory, preclinical and quality principles Contains in-depth investigation of upcoming types of drug delivery systems

Nanomedicine for Drug Delivery and Therapeutics

Nanomedicine for Drug Delivery and Therapeutics
A Book

by Ajay Kumar Mishra

  • Publisher : John Wiley & Sons
  • Release : 2013-02-01
  • Pages : 536
  • ISBN : 1118635841
  • Language : En, Es, Fr & De
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This book describes a broad area of nanomedicine which involves mainly applications, diseases, and diagnostics. The comprehensive coverage provides researchers, academics, and health specialists with a great tool, that includes techniques applicable to various uses.

Nanotechnology and Drug Delivery, Volume One

Nanotechnology and Drug Delivery, Volume One
Nanoplatforms in Drug Delivery

by José L. Arias

  • Publisher : CRC Press
  • Release : 2014-08-04
  • Pages : 380
  • ISBN : 1466599480
  • Language : En, Es, Fr & De
GET BOOK

Pharmacotherapy is often limited by the inefficient activity and severe toxicity of drug molecules. Nanotechnology offers a revolutionary and definitive approach for the efficient delivery of drug molecules to non-healthy tissues and cells. This first volume of a series of two volumes analyzes the basics in the development of drug-loaded nanoplatforms, the so-called nanomedicines. Special attention is given to physicochemical engineering, pharmacokinetics, biocompatibility and biodegradability, representative nanoplatforms (based on lipids, polymers, cyclodextrins, metals, carbon, silica, iron oxides, etc.), and advanced nano-engineering strategies for passive, ligand-mediated, and/or stimuli-sensitive drug delivery and release.

Drug Efficacy, Safety, and Biologics Discovery

Drug Efficacy, Safety, and Biologics Discovery
Emerging Technologies and Tools

by Sean Ekins,Jinghai J. Xu

  • Publisher : John Wiley & Sons
  • Release : 2009-01-28
  • Pages : 400
  • ISBN : 0470431806
  • Language : En, Es, Fr & De
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Drug Efficacy, Safety, and Biologics Discovery: Emerging Technologies and Tools covers key emerging technologies in pharmaceutical R & D and how they have substantially impacted (or are currently impacting) drug discovery. The cross-disciplinary collaborations implicit in integrating these technologies with drug discovery operations will fuel the engine for future innovations. This book cuts across the multiple areas of drug discovery, each chapter authored by pioneers in that field, making for a broad appeal to the chemical and biological scientists and technologists involved in drug discovery and development.

Characterization and Biology of Nanomaterials for Drug Delivery

Characterization and Biology of Nanomaterials for Drug Delivery
Nanoscience and Nanotechnology in Drug Delivery

by Shyam Mohapatra,Shivendu Ranjan,Nandita Dasgupta,Raghvendra Kumar Mishra,Sabu Thomas

  • Publisher : Elsevier
  • Release : 2018-10-05
  • Pages : 682
  • ISBN : 0128140321
  • Language : En, Es, Fr & De
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Characterization and Biology of Nanomaterials for Drug Delivery: Nanoscience and Nanotechnology in Drug Delivery describes the techniques successfully employed for the application of nanocarriers loaded with the antioxidant enzyme, catalase, and thus targeted to endothelial cells. Methods of nanocarrier synthesis, loading within various systems, and the characterization of nanocarriers for targeting activities are covered, as are their advantages, disadvantages and applications. Reflecting the interdisciplinary nature of the subject matter, this book includes contributions by experts from different fields, all with various backgrounds and expertise. It will appeal to researchers and students from different disciplines, such as materials science, technology and various biomedical fields. Enables readers from different fields to access recent research and protocols across traditional boundaries Focuses on protocols and techniques, as well as the knowledge base of the field, thus enabling those in R&D to learn about, and successfully deploy, cutting-edge techniques Explores both current and emerging classes of nanomaterials, along with their fundamentals and applications

Nanobiomaterials in Drug Delivery

Nanobiomaterials in Drug Delivery
Applications of Nanobiomaterials

by Alexandru Mihai Grumezescu

  • Publisher : William Andrew
  • Release : 2016-04-26
  • Pages : 618
  • ISBN : 0323428894
  • Language : En, Es, Fr & De
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Nanobiomaterials in Drug Delivery: Applications of Nanobiomaterials presents novel approaches regarding nanostructured drug delivery systems, revealing the most investigated materials for the development of particular nanobioshuttles. This book brings the results of current research to reach those who wish to use this knowledge in an applied setting, providing one coherent text, with focused chapters and easily accessible information. At its core, it is a collection of titles, bringing together many of the novel applications these materials have in biology, also discussing the advantages and disadvantages of each application and the perspectives of the technologies based on these findings. At the moment, there is no other comparable book series covering all the subjects approached in this set of titles. Provides up-to-date and well-structured reference material for students, researchers, and practitioners working in the biomedical, biotechnological, and engineering fields Presents a valuable guide to recent scientific progress, along with most known applications of nanomaterials in the biomedical area Proposes novel opportunities and ideas for developing or improving technologies in nanomedicine/nanobiology

Chitin and Chitosan

Chitin and Chitosan
Physicochemical Properties and Industrial Applications

by Mohammed Berrada

  • Publisher : BoD – Books on Demand
  • Release : 2021-09-29
  • Pages : 290
  • ISBN : 178984424X
  • Language : En, Es, Fr & De
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Chitin and Chitosan - Physicochemical Properties and Industrial Applications provides an overview of the extraction, modification, characterization, and application of chitin and chitosan derivatives from crustacean byproducts and their physicochemical properties. It presents and explains important studies and develops new and innovative methods of biological and physicochemical analysis in the fields of organic and mineral environmental pollution, corrosion inhibitors, drug delivery systems, superabsorbent materials, nanotechnology, textiles, biotechnology, and biomedical sciences.

Pharmaceutical Nanotechnology

Pharmaceutical Nanotechnology
Innovation and Production, 2 Volumes

by Jean Cornier

  • Publisher : John Wiley & Sons
  • Release : 2017-02-06
  • Pages : 775
  • ISBN : 3527340548
  • Language : En, Es, Fr & De
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With its focus on concrete methods and recent advances in applying nanotechnology to develop new drug therapies and medical diagnostics, this book provides an overall picture of the field, from the fundamentals of nanopharmacy with the characterisation and manufacturing methods to the role of nanoparticles and substances. Actual examples of utilization include drug development issues, translation to the clinic, market prospects, and industrial commercialization aspects. The applications described are taken from cancer treatment as well as other major therapeutic areas, such as infectious diseases and dermatology. An in-depth discussion on safety, regulatory, and societal aspects rounds off the book. Written by a top team of editors and authors composed of the leading experts in Europe and the USA who have pioneered the field of nanopharmacy!