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Nanotoxicity

Nanotoxicity
Prevention and Antibacterial Applications of Nanomaterials

by Susai Rajendran,Anita Mukherjee,Tuan Anh Nguyen,Chandraiah Godugu,Ritesh K. Shukla

  • Publisher : Elsevier
  • Release : 2020-04-09
  • Pages : 504
  • ISBN : 012819944X
  • Language : En, Es, Fr & De
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Nanotoxicity: Prevention, and Antibacterial Applications of Nanomaterials focuses on the fundamental concepts for cytotoxicity and genotoxicity of nanomaterials. It sheds more light on the underlying phenomena and fundamental mechanisms through which nanomaterials interact with organisms and physiological media. The book provides good guidance for toxic prevention methods and management in the manufacture/application/disposal. The book also discusses the potential applications of nanomaterials-based antibiotics. The potential toxic effects of nanomaterials result not only from the type of base materials, but also from their size/ ligands/surface chemical modifications. This book discusses why different classes of nanomaterials display toxic properties, and what can be done to mitigate this toxicity. It also explores how nanomaterials are being used as antimicrobial agents, being used to purify air and water, and counteract a range of infectious diseases. This is an important reference for materials scientists, environmental scientists and biomedical scientists, who are seeking to gain a greater understanding of how nanomaterials can be used to combat toxic agents, and how the toxicity of nanomaterials themselves can best be mitigated. Explains the underlying phenomena and fundamental mechanisms through which nanomaterials interact with organisms and physiological media Outlines major methods for mitigating and prevention of nanotoxicity Discusses the applications of nanomaterials-based antibiotics

Nanotoxicity

Nanotoxicity
From In Vivo and In Vitro Models to Health Risks

by Saura C. Sahu,Daniel A. Casciano

  • Publisher : John Wiley & Sons
  • Release : 2009-08-04
  • Pages : 630
  • ISBN : 047074779X
  • Language : En, Es, Fr & De
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Nanomaterials - substances smaller than 100 nanometers in size - have been added in recent years to an increasing numbers of consumer products used in day-to-day life; in food packaging, medical devices, pharmaceuticals, cosmetics, odor-resistant textiles and household appliances. The extensive application of nanomaterials in a wide range of products for human use poses a potential for toxicity risk to human health and the environment. Such adverse effects of nanomaterials on human health have triggered the development of a new scientific discipline known as “nanotoxicity” – the study of the toxicity of nanomaterials. Nanotoxicity: From in vivo and in vitro Models to Health Risks provides up-to-date state-of-the-art information presented by recognized experts in this emerging new field in toxicology. It discusses the safety evaluation of nanomaterials in foods, drugs, medical devices, cosmetics and other regulated products and its use in risk analysis for potential regulatory use. Topics covered include: biomarkers for nanotoxicity assessment nanotoxicity assessment by gene expression analysis in vivo and in vitro models for nanotoxicity testing mechanisms of nanotoxicity pharmakokinetics of nanomaterials nanotoxicity of foods including food processing, food packaging and food safety nanotoxicity of drugs including drug development and drug delivery nanotoxicity of cosmetics and consumer products health and environmental impact of nanotoxicity safety evaluation of nanomaterials regulatory impact of nanomaterials Nanotoxicity: From in vivo and in vitro Models to Health Risks is a valuable authoritative source of information for readers from a wide range of disciplines such as toxicology, pharmacology, drug toxicity and food and environmental sciences. The book will be useful to the research community in academia, industry, hospitals and government, as well as to government regulators and risk assessors of foods, drugs and environmental and agricultural products.

The Study and Exploration about Nanotoxicity of Oxide Nanoparticles on Escherichia Coli and Exiguobacterium Sibiricum

The Study and Exploration about Nanotoxicity of Oxide Nanoparticles on Escherichia Coli and Exiguobacterium Sibiricum
A Book

by Yu Yang

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 340
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanotoxicity

Nanotoxicity
Methods and Protocols

by Joshua Reineke

  • Publisher : Humana Press
  • Release : 2012-09-14
  • Pages : 414
  • ISBN : 9781627030014
  • Language : En, Es, Fr & De
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The field of nanotechnology has developed very rapidly over the past decade lending great promise to medical applications in drug delivery, therapeutics, and biological imaging. Due to the great promise, rapid development, and broad application of nanomaterials, it is imperative that researchers from development through application seek a thorough understanding of nanotoxicity. Nanotoxicity: Methods and Protocols address the special considerations when applying toxicity studies to nanomaterials and detail newly developed methods for the study of nanotoxicity. These diverse methods span in vitro cell culture, model tissues, in situ exposure, in vivo models, analysis in plants, and mathematical modeling, proving to be relevant to pharmaceutical scientists, material scientists, bioengineers, toxicologists, environmentalists, immunologists, and cellular and molecular biologists, to name a few. As part of the highly successful Methods in Molecular BiologyTM, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Nanotoxicity: Methods and Protocols aims to diversify the capabilities of current researchers involved in nanotoxicology and to enable researchers in related fields to expand their knowledge of how nanomaterials interface with the biological environment.

Nanotoxicity

Nanotoxicity
Methods and Protocols

by Qunwei Zhang

  • Publisher : Humana Press
  • Release : 2019-02-04
  • Pages : 371
  • ISBN : 9781493989157
  • Language : En, Es, Fr & De
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This volume explores the latest techniques used to investigate nanotoxicity. The protocols covered in this book range from routine nanotoxicity assays to genomic and proteomic approaches in vivo and in vitro. The chapters discuss specific topics such as preparation and utilization of 3D human liver microtissue models; assessment of ovarian granulosa cells with exposure to nanoparticles; DNA methylation analysis; evaluation of genotoxicity of nanoparticles in mouse models; and studying nanotoxicity using embryonic zebrafish. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Nanotoxicity: Methods and Protocols is a valuable resource for researchers and postgraduate students in the fields of toxicology, environmental science, pharmacological sciences, and clinical medicine. This volume also serves as a starting point for researchers interested in learning more about this developing field.

Modeling of Nanotoxicity

Modeling of Nanotoxicity
Molecular Interactions of Nanomaterials with Bionanomachines

by Ruhong Zhou

  • Publisher : Springer
  • Release : 2015-09-04
  • Pages : 189
  • ISBN : 331915382X
  • Language : En, Es, Fr & De
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This book provides a comprehensive overview of the fundamentals of nanotoxicity modeling and its implications for the development of novel nanomedicines. It lays out the fundamentals of nanotoxicity modeling for an array of nanomaterial systems, ranging from carbon-based nanoparticles to noble metals, metal oxides, and quantum dots. The author illustrates how molecular (classical mechanics) and atomic (quantum mechanics) modeling approaches can be applied to bolster our understanding of many important aspects of this critical nanotoxicity issue. Each chapter is organized by types of nanomaterials for practicality, making this an ideal book for senior undergraduate students, graduate students, and researchers in nanotechnology, chemistry, physics, molecular biology, and computer science. It is also of interest to academic and industry professionals who work on nanodrug delivery and related biomedical applications, and aids readers in their biocompatibility assessment efforts in the coming age of nanotechnology. This book also provides a critical assessment of advanced molecular modeling and other computational techniques to nanosafety, and highlights current and future biomedical applications of nanoparticles in relation to nanosafety.

Nanotoxicity: A Proteoliposome Method for Assessing Nanotoxicity on Synaptic Fusion and Membrane Integrity (Small Methods 11/2017).

Nanotoxicity: A Proteoliposome Method for Assessing Nanotoxicity on Synaptic Fusion and Membrane Integrity (Small Methods 11/2017).
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract : An in vitro vesicle system that mimics neuronal exocytosis is employed for nanotoxicity testing by Jiajie Diao and co‐workers in article number1700207 . The experimental scheme consists of leakage and content‐mixing experiments to test the effects of nanomaterials on membrane integrity and synaptic fusion, respectively. The results demonstrate the potential of this system as a novel in vitro platform for assessing the biocompatibility of nanomaterials, drug molecules, and other substances. These leakage and content‐mixing experiments may offer a faster and easier approach for measuring nanotoxicity.

Biocompatibility and Nanotoxicity of Layered Two‐Dimensional Nanomaterials

Biocompatibility and Nanotoxicity of Layered Two‐Dimensional Nanomaterials
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract: Layered two‐dimensional (2D) nanomaterials, such as graphene, transition metal dichalcogenides (TMDs), layered metal oxides (LMOs), black phosphorus (BP), and hexagonal boron nitride (hBN), have attracted tremendous interest recently owing to their unique structural morphologies and outstanding physicochemical properties. Consequently, these nanomaterials have been actively explored for different biological and biomedical applications, such as tissue engineering, drug delivery, bioimaging, and biosensing. As increasing efforts have been focused on identifying the potential bioapplications of layered 2D nanomaterials, one of the fundamental aspects that is of considerable interest and ought to be studied in greater depth is their biocompatibility and nanotoxicity. In addition, as the elucidation and understanding of the physicochemical properties of this new class of nanomaterials are still in their infancy, information on both in vitro and in vivo biocompatibility and nanotoxicity is still scarce and remains poorly understood. As such, there is an immediate need to explore and establish the biocompatibility and nanotoxicological profiles of these nanomaterials in order to develop and optimize them for specific bioapplications. Here, in this Focus Review, we will provide a broad overview of recent advances on the biocompatibility and nanotoxicity of layered 2D nanomaterials. First, a wide range of established and emerging layered 2D nanomaterials actively investigated for bioapplications will be introduced. Next, the different physicochemical aspects governing the biocompatibility and nanotoxicity of these nanomaterials, such as lateral size, concentration, exposure time, number of layers, and chemical composition and surface functionalization, will be evaluated. Finally, we will summarize the review and provide our perspectives on the challenges and opportunities facing this important field. Abstract : Layered 2D nanomaterials have been extensively explored for biological and biomedical applications, such as tissue engineering, drug delivery, bioimaging, and biosensing. For such applications, some of the most important considerations that ought to be studied in great depth is their biocompatibility and nanotoxicity.

Nanotoxicity of Oxide-derived Engineered Nanomaterials

Nanotoxicity of Oxide-derived Engineered Nanomaterials
Impact on Cell Viability and Function, with Conventional Assays and Evaluation of Novel Eicosanoid Profiling

by Elizabeth F. Garrison

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanotoxicology in Caenorhabditis elegans

Nanotoxicology in Caenorhabditis elegans
A Book

by Dayong Wang

  • Publisher : Springer
  • Release : 2018-05-22
  • Pages : 274
  • ISBN : 9811302332
  • Language : En, Es, Fr & De
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This book focuses on the toxicity of engineered nanomaterials (ENMs) and their underlying physicochemical, cellular, physiological, and molecular mechanisms. Further, it covers ENMs’ translocation and their targeted organ toxicology, and discusses chemical and pharmacological strategies used to combat nanotoxicity. Engineered nanomaterials (ENMs) are defined as materials with one or more dimensions of less than 100 nm, and have shown considerable promise in several areas of development. At the same time, the potential toxicity of ENMs for human health and environmental organisms is increasingly attracting attention. In addition to the typical properties of model animals, Caenorhabditis elegans is extremely sensitive to environmental toxicants, which makes it the ideal in vivo assay system for toxicological studies. C. elegans has been widely used in toxicity assessment and toxicological studies of environmental toxicants and stresses. This book provides a comprehensive summary of nanotoxicology research on C. elegans.

The Role of Substrate Mechanics in Nanotoxicity Mediated by Endocytosis

The Role of Substrate Mechanics in Nanotoxicity Mediated by Endocytosis
A Book

by Robert C. Boehm

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 41
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Presented in this work is the development of a novel variable modulus, porous PDMS-membrane based ALI cell culture model to assess cell growth under tissue matched stiffness conditions, tight-junction formation, and response to nanoparticle (NP) exposures. Using Sylgard 184 and 527 polydimethylsiloxane (PDMS) and corn syrup emulsions, produced 5 micron thick, highly porous membranes. Membranes spanning 1 kPa-1000 kPa have been achieved, modeling both healthy and fibrotic physiological lung tissue stiffness respectively. Scaffold microstructure and mechanics, cellular proliferation and viability under submerged and ALI conditions, were assessed. The viability was assessed using a Guava 12HT flow cytometer with Viacount reagent. Submerged exposure to 30 nm tannic acid stabilized gold or zinc oxide will be conducted for 8, 24, and 48 hours at 0, 1, 5, 10, 20, and 100 æg/ml. Inductively coupled plasma-mass spectrometry (ICP-MS) will be performed on the apical supernatants. A model system capable of capturing the unique mechanics and membrane properties found at the alveolar-endothelial interface could better predict toxicity, safe levels of exposure, and provide a rapid-means to assess new materials, pharmacologics, or potentially hazard chemicals.

Nanotoxicology

Nanotoxicology
Toxicity Evaluation, Risk Assessment and Management

by Vineet Kumar,Nandita Dasgupta,Shivendu Ranjan

  • Publisher : CRC Press
  • Release : 2018-03-12
  • Pages : 684
  • ISBN : 1351138197
  • Language : En, Es, Fr & De
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As the application of nanotechnology in the myriad disciplines of science and engineering--from agriculture, pharmaceuticals, material science, and biotechnology to sensors, electronics, and mechanical and electrical engineering--brings benefits it also can produce serious threats to human health and the environment that must be evaluated. The unique properties of nanomaterials make them different from their bulk counterparts. In addition to such unique properties, the nanometric size of nanomaterials can invite some detrimental effects on the health and well-being of living organisms and the environment. Thus, it is important to distinguish nanomaterials with such ill effects from nanomaterials with no or minimum toxicity. Nanotoxicology: Toxicity Evaluation, Risk Assessment and Management covers issues such as the basic principles of nanotoxicity, methods used for nanotoxicity evaluation, risk assessment and its management for nanomaterial toxicity with a focus on current trends, limitations, challenges, and future directions of nanotoxicity evaluation. Various experts from different countries discuss these issues in detail in this book. This will be helpful to researchers, educators, and students who are interested in research opportunities for avoiding the environmental and health hazards of nanomaterials. This book will also be useful for industrial practitioners, policy makers, and other professionals in the fields of toxicology, medicine, pharmacology, food, drugs, and other regulatory sciences.

Nanotoxicology and Nanoecotoxicology Vol. 1

Nanotoxicology and Nanoecotoxicology Vol. 1
A Book

by Vineet Kumar

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 3030632415
  • Language : En, Es, Fr & De
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Assessment of Nano-toxicity and Safety Profiles of Silver Nanoparticles

Assessment of Nano-toxicity and Safety Profiles of Silver Nanoparticles
A Book

by Yasemin Budama-Kilinc

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanotoxicology, which is related with toxic potentials of nanoparticles (NPs) and their adverse effects on living organisms and environment, is a sub-branch of toxicology discipline. Nano-toxicity of NPs depends on their doses, unique chemical, and physical properties. Nowadays, silver (Ag) NPs are used in many consumer and scientific applications such as antimicrobial and pharmaceutical applications, water purification systems, textile industry, and food packaging processes. However, the information that about their nano-toxic potentials is still not complete, and it is considered that several parameters of Ag NPs such as size, shape, surface, and stability affect the toxic potential in different ways. Nano-toxic potentials of Ag NPs were mentioned as in vivo, in vitro, and in silico the studies. In this chapter, it was evaluated the common unique properties of NPs are related with nanotoxicology such as size, surface area and modifications, shape, agglomeration status, and dose.

Biointeractions of Nanomaterials

Biointeractions of Nanomaterials
A Book

by Vijaykumar B. Sutariya,Yashwant Pathak

  • Publisher : CRC Press
  • Release : 2014-07-29
  • Pages : 480
  • ISBN : 1466582391
  • Language : En, Es, Fr & De
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An examination of the widespread application of nano materials in biology, medicine, and pharmaceuticals and the accompanying safety concerns, Bio-interactions of Nano Materials addresses the issues related to toxicity and safety of nano materials and nano systems. It covers the interactions in biological systems and presents various tools and meth

Functionalized Nanomaterials I

Functionalized Nanomaterials I
Fabrications

by Vineet Kumar,Praveen Guleria,Nandita Dasgupta,Shivendu Ranjan

  • Publisher : CRC Press
  • Release : 2020-08-10
  • Pages : 318
  • ISBN : 1351021605
  • Language : En, Es, Fr & De
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Nanomaterials contain some unique properties compared to their bulk. Their unique properties are due to the chemical nature of the material, small size, and surface functionalization. Along with control over size, the functionalization of nanomaterials also affects their compatibility to the environment and living organisms. This book provides a detailed account of nanomaterials functionalization along with a brief overview of their application. This book serves as a reference for scientific investigators including doctoral and postdoctoral scholars and undergradate and graduate students who need to have knowledge of the basics of nanomaterial functionalization, recent advancements, challenges, and opportunities in this field. This book will also provide critical and comparative data for nano-technologists and may be beneficial for industry personnel, journalists, policy makers, and the general public to help understand functionalized nanomaterials in detail and in depth. Features: This book is comprehensive and covers all aspects of functionalized nanotechnology. It describes the challenges and methods of functionalized nanomaterials synthesis for different applications. It discusses the recent findings and cutting-edge global research trends on the functionalization of nanomaterials. It emphasizes the products and market, safety, and regulatory issues of functionalized nanomaterials. It contains contributions from international experts and will be a valuable resource for researchers.

Nanomedicine

Nanomedicine
Basic and Clinical Applications in Diagnostics and Therapy

by Christoph Alexiou

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2011
  • Pages : 201
  • ISBN : 3805598181
  • Language : En, Es, Fr & De
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A meeting report of the 2nd international Else Kr ner-Fresenius Symposium on Nanomedicine Nanomedicine -- the application of nanotechnology to human health -- is a promising field of research at the interface of physical, chemical, biological, and medical science. Recent advances have made it possible to analyze biological systems at cellular and subcellular levels, offering numerous promising approaches to improve medical diagnosis and therapy. It is expected that nanomedicine will have a great impact especially on drug delivery and imaging. In this context, the development of targeted, highly specific nanoparticles is of pivotal importance. The results of these advances will offer personalized diagnostic tools and treatments in the future. Based on the 2nd Else Kr ner-Fresenius-Symposium, this book presents a broad spectrum of topics ranging from nanoscale drug delivery/drug design to nanotoxicity and from diagnostics and imaging to therapeutic applications including antibody therapies. The contributions are authored by leading experts in the field and provide an excellent overview of the current knowledge in nanomedicine. Due to the interdisciplinary nature of the subject area this volume will be of special interest to physicians, biologists, chemists, engineers, and physicists as well as to students in the respective fields.

Parliamentary Debates (Hansard).

Parliamentary Debates (Hansard).
Senate

by Australia. Parliament. Senate

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicology of Nanomaterials

Toxicology of Nanomaterials
A Book

by Yuliang Zhao

  • Publisher : John Wiley & Sons
  • Release : 2016-12-12
  • Pages : 432
  • ISBN : 3527337970
  • Language : En, Es, Fr & De
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This book provides the reader with a comprehensive view of analytical methods for nanotoxicology studies. After an introduction to nanomaterials and toxicological studies, the book discusses various characterization methods of nanomaterials and continues with the detection of nanoparticles in vivo as well as in vitro. A variety of techniques in molecular toxicology of nanomaterials is presented, followed by a detailed explanation of interaction between nanoparticles and biomacromolecules, including the structure-toxicity relationships of nanomaterials. Finally, the book concludes with the advantages and challenges of the analytical methods for nanotoxicology.

Nanosensors for Environment, Food and Agriculture Vol. 1

Nanosensors for Environment, Food and Agriculture Vol. 1
A Book

by Vineet Kumar,Praveen Guleria,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse

  • Publisher : Springer Nature
  • Release : 2021-04-16
  • Pages : 265
  • ISBN : 3030632458
  • Language : En, Es, Fr & De
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Nanosensors enable us to specifically detect pollutants that can adversely affect the quality of life. This book covers the design, application and safety aspects of nanomaterial-based sensors. The focus is on nanosensors useful for application in Environment, Food and Agriculture. It discusses in detail the advances in nanosensor design and application. It also emphasizes on the strategies for toxicity assessment and safe use of nanosensors.