Download Natural Products and Drug Discovery Ebook PDF

Natural Products

Natural Products
Drug Discovery and Therapeutic Medicine

by Lixin Zhang,Arnold L. Demain

  • Publisher : Springer Science & Business Media
  • Release : 2007-11-17
  • Pages : 386
  • ISBN : 1592599761
  • Language : En, Es, Fr & De
GET BOOK

A fresh examination of the past successes of natural products as medicines and their new future from both conventional and new technologies. High-performance liquid chromatography profiling, combinatorial synthesis, genomics, proteomics, DNA shuffling, bioinformatics, and genetic manipulation all now make it possible to rapidly evaluate the activities of extracts as well as purified components derived from microbes, plants, and marine organisms. The authors apply these methods to new natural product drug discoveries, to microbial diversity, to specific groups of products (Chinese herbal drugs, antitumor drugs from microbes and plants, terpenoids, and arsenic compounds), and to specific sources (the sea, rainforest, and endophytes). These new opportunities show how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be more productive and efficacious.

Pharmacological Advances in Natural Product Drug Discovery

Pharmacological Advances in Natural Product Drug Discovery
A Book

by Guanhua Du

  • Publisher : Academic Press
  • Release : 2020-03
  • Pages : 312
  • ISBN : 0128201851
  • Language : En, Es, Fr & De
GET BOOK

Pharmacological Advances in Natural Product Drug Discovery, Volume 87 in the Advances in Pharmacology series, presents the latest pharmacological research progresses of 8 medicinal compounds from natural products, including salvianolic acid, tanshinone, paeonol, chlorogenic acid, astragaloside, icariin, ganoderan, and febrifugine. Specific chapters to this new release include Potential Role of Paeonol on Atherosclerosis Related Cells, A Review on Salvianolic Acid, Pharmacological Advances of Tanshinones, the Natural Product of Salvia Miltiorrhiza, Pharmacological Action and Potential Targets Analysis of Major Pharmacological Effects of Chlorogenic Acid, Modern TCM: Identifying and Defining the "Medicinal Mix", Pharmacological Advances in Astragaloside IV Derived from Astragalus Membranaceus, and much more. Includes the authority and expertise of leading contributors in natural product pharmacology Provides the latest pharmacological research progresses of eight medicinal compounds from natural products Presents a thorough discussion on the compatibility of traditional medicines

Bioactive Natural products in Drug Discovery

Bioactive Natural products in Drug Discovery
A Book

by Joginder Singh,Vineet Meshram,Mahiti Gupta

  • Publisher : Springer Nature
  • Release : 2020-04-30
  • Pages : 733
  • ISBN : 9811513945
  • Language : En, Es, Fr & De
GET BOOK

This book highlights different natural products that are derived from the plants and microbes that have shown potential as the lead compounds against infectious diseases and cancer. Natural products represent an untapped source of strikingly diverse chemotypes with novel mechanisms of action and the potential to serve as anticancer and anti-infective agents. The book discusses a range of biotechnologically valuable bioactive compounds and secondary metabolites that have been derived from plant and microorganisms from various ecological niches. It also reviews the latest developments in the field of genomics, bioinformatics and industrial fermentation for harnessing the microbial products for commercial applications. In turn, the book’s closing section reviews important biotechnological applications of various natural products. Combining the expertise of specialists in this field, the book’s goal is to promote the further investigation of natural sources for the development of standardized, safe and effective therapies.

Natural Products

Natural Products
Drug Discovery and Therapeutic Medicine

by Lixin Zhang,Arnold L. Demain

  • Publisher : Springer
  • Release : 2005-04-15
  • Pages : 382
  • ISBN : 9781588293831
  • Language : En, Es, Fr & De
GET BOOK

An examination of the past successes of natural products as medicines and their future from both conventional and new technologies. This work shows how research and development trends in the pharmaceutical industry can advance to include both synthetic compounds and natural products, and how this paradigm shift can be productive and efficacious.

The Role of Natural Products in Drug Discovery

The Role of Natural Products in Drug Discovery
A Book

by J. Mulzer,R. Bohlmann

  • Publisher : Springer
  • Release : 2013-10-03
  • Pages : 351
  • ISBN : 9783662040447
  • Language : En, Es, Fr & De
GET BOOK

Natural Products have been important sources of useful drugs from prehistoric times to the present. This book gives an overview about this field and provides important recent contributions to the discovery of new drugs generated by research on natural products. Total synthesis of natural products with interesting biological activities is paving the way for the preparation of new and improved analogs. The methods of combinatorial chemistry permit the selection of the best drug from a large number of candidates. Beyond synthesis and evaluation of organic molecules a number of new bioorganic methods are coming to the fore and will be discucced in this isue of the ERnst schering Research Foundation workshop proceedings.

Drug Discovery from Nature

Drug Discovery from Nature
A Book

by S. Grabley,R. Thiericke

  • Publisher : Springer Science & Business Media
  • Release : 1998-11-26
  • Pages : 347
  • ISBN : 9783540648444
  • Language : En, Es, Fr & De
GET BOOK

This book is unique in covering the present status and future potential of natural products in drug discovery. It provides readers with recent information regarding the impact on drug discovery, development and strategies, technical and automation aspects, and methods based on biochemistry as well as molecular biology, highlighting compounds from natural sources. Special emphasis is placed on the various strategies to gain access to natural compounds and combinatorial approaches by making use of both synthetic and biological methods.

Bioassay Methods in Natural Product Research and Drug Development

Bioassay Methods in Natural Product Research and Drug Development
A Book

by Lars Bohlin,Jan G. Bruhn

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 203
  • ISBN : 9401148104
  • Language : En, Es, Fr & De
GET BOOK

Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Natural Products and Cancer Drug Discovery

Natural Products and Cancer Drug Discovery
A Book

by Frank E. Koehn

  • Publisher : Springer Science & Business Media
  • Release : 2012-11-09
  • Pages : 244
  • ISBN : 1461446546
  • Language : En, Es, Fr & De
GET BOOK

This volume will cover the natural products as they relate to cancer chemotherapy. The topics will include history and current status , recent launches, new clinical candidates and approved drugs directly derived from natural products, current and future cancer target opportunities for natural products, leveraging natural products as tools for new target generation , new approaches to cancer drug discovery through natural products based lead generation, and enabling technologies which leverage the unique attributes of natural products.

Natural Products and Drug Discovery

Natural Products and Drug Discovery
An Integrated Approach

by Subhash C. Mandal,Vivekananda Mandal,Tetsuya Konishi

  • Publisher : Elsevier
  • Release : 2018-02-16
  • Pages : 776
  • ISBN : 0081021046
  • Language : En, Es, Fr & De
GET BOOK

Natural Products and Drug Discovery: An Integrated Approach provides an applied overview of the field, from traditional medicinal targets, to cutting-edge molecular techniques. Natural products have always been of key importance to drug discovery, but as modern techniques and technologies have allowed researchers to identify, isolate, extract and synthesize their active compounds in new ways, they are once again coming to the forefront of drug discovery. Combining the potential of traditional medicine with the refinement of modern chemical technology, the use of natural products as the basis for drugs can help in the development of more environmentally sound, economical, and effective drug discovery processes. Natural Products & Drug Discovery: An Integrated Approach reflects on the current changes in this field, giving context to the current shift and using supportive case studies to highlight the challenges and successes faced by researchers in integrating traditional medicinal sources with modern chemical technologies. It therefore acts as a useful reference to medicinal chemists, phytochemists, biochemists, pharma R&D professionals, and drug discovery students and researchers. Reviews the changing role of natural products in drug discovery, integrating traditional knowledge with modern molecular technologies Highlights the potential future role of natural products in preventative medicine Supported by real world case studies throughout

Natural Product Chemistry for Drug Discovery

Natural Product Chemistry for Drug Discovery
A Book

by Antony D. Buss,Mark S. Butler,Royal Society of Chemistry (Great Britain)

  • Publisher : Royal Society of Chemistry
  • Release : 2010
  • Pages : 440
  • ISBN : 0854041931
  • Language : En, Es, Fr & De
GET BOOK

This up-to-date summary of natural product chemistry in drug discovery will appeal to scientists, professionals, postgraduates and industrial chemists.

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases

Discovery and Development of Therapeutics from Natural Products Against Neglected Tropical Diseases
A Book

by Goutam Brahmachari

  • Publisher : Elsevier
  • Release : 2019-04-15
  • Pages : 458
  • ISBN : 0128157240
  • Language : En, Es, Fr & De
GET BOOK

Discovery and Development of Therapeutics from Natural Products against Neglected Tropical Diseases draws together research on medicinal agents from natural sources as starting points for the design of drugs against Neglected Tropical Diseases (NTDs). From the prediction of promising leads and identification of active agents, to the extraction of complex molecules, the book explores novel, economical and efficacious therapeutics for these diseases. It describes current research and the role of natural products, antimalarial compounds from marine natural products and sesquiterpene lactones, natural antileprotic agents, natural products with potential against Leishmaniasis, Trypanosomiasis and Dengue, and more. In addition, Quinoline and Isoquinoline alkaloids for developing new antiprotozoal agents are discussed, alongside anti-trypanosomatid heterocyclic compounds as structures for development. Combining the expertise of specialists from around the world, this volume aims to support and encourage researchers in the investigation of natural sources as starting points for the development of novel, safe and effective agents for use against neglected tropical diseases. Includes chapters written by active researchers and leading global experts deeply engaged in the research field of natural product chemistry for drug discovery Draws together cutting-edge research advances in natural product chemistry that are targeted at neglected tropical diseases Highlights the future potential of natural products as sources of novel medicinal compounds against neglected tropical diseases

Natural Products in Drug Discovery

Natural Products in Drug Discovery
A Book

by Silvio Roggo

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 66
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Discovery and Development of Antidiabetic Agents from Natural Products

Discovery and Development of Antidiabetic Agents from Natural Products
Natural Product Drug Discovery

by Goutam Brahmachari

  • Publisher : Elsevier
  • Release : 2016-10-11
  • Pages : 332
  • ISBN : 0128096926
  • Language : En, Es, Fr & De
GET BOOK

Discovery and Development of Antidiabetic Agents from Natural Products brings together global research on the medicinal chemistry of active agents from natural sources for the prevention and treatment of diabetes and associated disorders. From the identification of promising leads, to the extraction and synthesis of bioactive molecules, this book explores a range of important topics to support chemists in the discovery and development of safer, more economical therapeutics that are desperately needed in response to this emerging global epidemic. Beginning with an overview of bioactive chemical compounds from plants with anti-diabetic properties, the book goes on to outline the identification and extraction of anti-diabetic agents and antioxidants from natural sources. It then explores anti-diabetic plants from specific regions before looking more closely at the background, isolation, and synthesis of key therapeutic compounds and their derivatives, including Mangiferin, Resveratrol, natural saponins, and alpha-glucosidase enzyme inhibitors. The book concludes with a consideration of current and potential future applications. Combining the expertise of specialists from around the world, this volume aims to support and encourage medicinal chemists investigating natural sources as starting points for the development of standardized, safe, and effective antidiabetic therapeutics. Contains chapters written by active researchers and leading global experts who are deeply engaged in the research field of natural product chemistry for drug discovery Provides comprehensive coverage of cutting-edge research advances in the design of medicinal natural products with potential as preventives and therapeutics for diabetes and related metabolic issues Presents a practical review of the identification, isolation, and extraction techniques that help support medicinal chemists in the lab

Plant Bioactives and Drug Discovery

Plant Bioactives and Drug Discovery
Principles, Practice, and Perspectives

by Valdir Cechinel-Filho

  • Publisher : John Wiley & Sons
  • Release : 2012-05-22
  • Pages : 565
  • ISBN : 047058226X
  • Language : En, Es, Fr & De
GET BOOK

An in-depth exploration of the applications of plant bioactive metabolites in drug research and development Highlighting the complexity and applications of plant bioactive metabolites in organic and medicinal chemistry, Plant Bioactives and Drug Discovery: Principles, Practice, and Perspectives provides an in-depth overview of the ways in which plants can inform drug research and development. An edited volume featuring multidisciplinary international contributions from acclaimed scientists researching bioactive natural products, the book provides an incisive overview of one of the most important topics in pharmaceutical studies today. With coverage of strategic methods of natural compound isolation, structural manipulation, natural products in clinical trials, quality control, and more, and featuring case studies on medicinal plants, the book serves as a definitive guide to the field of plant biodiversity as it relates to medicine. In addition, chapters on using natural products as drugs that target specific disease areas, including neurological disorders, inflammation, infectious diseases, and cancer, illustrate the myriad possibilities for therapeutic applications. Wide ranging and comprehensive, Plant Bioactives and Drug Discovery also includes important information on marketing, regulations, intellectual property rights, and academic-industry collaboration as they relate to plant-based drug research, making it an essential resource for advanced students and academic and industry professionals working in biochemical, pharmaceutical, and related fields.

Proceedings of 4th International Conference and Exhibition on Natural Products, Medicinal Plants & Marine Drugs 2018

Proceedings of 4th International Conference and Exhibition on Natural Products, Medicinal Plants & Marine Drugs 2018
Journal of Natural Products Chemistry & Research : Volume 6

by ConferenceSeries

  • Publisher : ConferenceSeries
  • Release : 2021
  • Pages : 98
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

June 11-12, 2018 Rome, Italy Key Topics : Natural Products, Development of Marine Drugs and Natural Products, Natural Products Chemistry, Natural Products Drug Discovery, Phytomedicine and Phytochemistry, Medicinal Natural Products, Natural Products as Anti-Cancer Drugs, Marine: The Ultimate Source of Bioactives and Drug Metabolites, Marine Biotechnology, New Sources and Approaches to Natural Products, Marine Natural Products Drug Discovery, Bioactive Natural Products, Bioactive Natural Products from Marine Bacteria, Marine Probiotics and Prebiotics, A Promising Future for Marine Drugs and Natural Products, Medicinal Chemistry & Drug Discovery, Anti-cancer agents in Medicinal Plants, Therapeutic Drugs and Personalized Medicines,

Drug Discovery & Development

Drug Discovery & Development
Traditional Medicine and Ethnopharmacology

by Bhushan Patwardhan

  • Publisher : New India Publishing
  • Release : 2007
  • Pages : 362
  • ISBN : 9788189422295
  • Language : En, Es, Fr & De
GET BOOK

While biotechnological advances, genomics and high throughput screenings or combinatorial and asymmetric syntheses are opening new opportunities in drug discovery, the industry is facing serious innovation deficit. The total number of new molecules registered per year has dropped in contrast to expected increase. Post marketing failures of blockbuster drugs have become major concerns of industries. On the other side, globally there is a major shift to sue of traditional medicine involving complementary and alternative therapies. Ethnopharmacology and traditional medicines have contributed in past significantly in the process of natural product drug discovery. There are two clear tracks where ethnopharmacology has potential to contribute in future drug research. First, as a discovery engine to provide new targets, leads, and second, use of quality assured and standardized traditional medicines. In this scenario, it is important to understand the mechanisms of drug discovery and pharmaceutical development with a focus on herbal drugs and neutraceutical. This book provides historical perspective, future prospects and significance of ethnopharmacology in drug research. It also provides important steps in botanical drug discovery and development including bioprospecting, quality control, standardization, pharmaceutics, stability, pharmacokinetics, and bioavailability with examples from ethnopharmacology and herbal medicine. One of the important feature of this book is to give an excellent insight to Good Laboratory and Good Clinical Practices along with very useful summary steps involved in filing IND or NDA of botanical products. The book also gives Regulators' perspective of validating claims and how ethnopharmacological or traditional medicines need different approach.

Natural Products in Drug Discovery and Human Health

Natural Products in Drug Discovery and Human Health
Book of Abstracts

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 293
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
GET BOOK

Natural Products and Drug Discovery

Natural Products and Drug Discovery
A Book

by Pinarosa Avato

  • Publisher : MDPI
  • Release : 2020-04-22
  • Pages : 392
  • ISBN : 303928746X
  • Language : En, Es, Fr & De
GET BOOK

Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Discovery and Development of Anti-inflammatory Agents from Natural Products

Discovery and Development of Anti-inflammatory Agents from Natural Products
A Book

by Goutam Brahmachari

  • Publisher : Elsevier
  • Release : 2019-07-11
  • Pages : 332
  • ISBN : 0128169931
  • Language : En, Es, Fr & De
GET BOOK

Discovery and Development of Anti-inflammatory Agents from Natural Products, the latest volume in the Natural Product Drug Discovery series, presents cutting-edge research advances in the field of bioactive natural products and natural drug formulations, with this volume focusing on molecules of natural origin and their synthetic analogues that have the potential to act against the pathogens responsible for inflammatory diseases. All aspects of each are covered, including isolations and structure elucidations, in vitro and in vivo biological activity, synthetic optimization, investigations of pharmacodynamics and kinetics, and the structure-activity relationships of anti-inflammatory natural products. Written by active researchers and leading experts, this book brings together an overview of current discoveries and trends in this field. It will be a valuable resource for researchers working to discover promising leads for the development of pharmaceuticals in the prevention and treatment of anti-inflammatory diseases. Features contributions from active researchers and leading experts working in medicinal natural products and herbal formulations Includes recent, cutting-edge advances on medicinal natural products, along with preventative therapies for different kinds of inflammation-directed diseases Offers an authoritative source of information on the industrial application of natural products for medicinal purposes

Handbook on Drugs from Natural Sources

Handbook on Drugs from Natural Sources
A Book

by H. Panda

  • Publisher : ASIA PACIFIC BUSINESS PRESS Inc.
  • Release : 2010-10-01
  • Pages : 480
  • ISBN : 8178331330
  • Language : En, Es, Fr & De
GET BOOK

Natural products have played an important role throughout the world in treating and preventing human diseases. Natural product medicines have come from various materials including terrestrial plants, terrestrial microorganisms, organisms etc. Historical experiences with plants as therapeutic tools have helped to introduce single chemical entries in modern medicine. About 40% of the drugs used are derived from natural sources. Most are pure substances which are isolated from various organisms & used directly or after chemical modification. Natural products will continue to be important in three areas of drug discovery: as targets for production by biotechnology as a source of new lead compounds of novel chemical structure and as the active ingredients of useful treatments derived from traditional systems. Biotechnology will contribute more new natural products for medicinal use. Plants provide a fertile source of natural products many of which are clinically important medicinal agents. Natural products have traditionally provided most of the drugs in use. Despite the achievements of synthetic chemistry and the advances towards rational drug design, natural products continue to be essential in providing medicinal compounds and as starting points for the development of synthetic analogues. With the increasing power of screening programs and the increasing interest in the reservoir of untested natural products, many future drug developments will be based, at least in part, on natural products. The major contents of the book are plant products produced in cell culture , application of genetic engineering to the production of pharmaceuticals , anti transpirants and plant growth regulators based , the potential and the problems of marine natural products, marine sterols, plants as a source of anti-inflammatory substances, anti hepatotoxic principles in oriental medicinal plants, immune stimulants of fungi and higher plants, amanita muscaria in medicinal chemistry, ergot alkaloids and their derivatives in medicinal chemistry and therapy, development of drugs from cannabinoids, etc. This book contains development of new drugs from plants, work on some Thai medicinal plants, plant growth based on Jasmonates, marine sterols, bleomycin and its derivatives, drugs from cannabinoids, bioactive compounds from nature, fungi and higher plants, biological active compounds from British Marine, microbial phytotoxins as herbicides and many more. This book will be very helpful to its readers, upcoming entrepreneurs, scientists, existing industries, technical institutions, druggist etc.