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Nervous System Drug Delivery

Nervous System Drug Delivery
Principles and Practice

by Russell R. Lonser,Malisa Sarntinoranont,Kristof Bankiewicz

  • Publisher : Academic Press
  • Release : 2019-06-25
  • Pages : 556
  • ISBN : 0128139986
  • Language : En, Es, Fr & De
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Nervous System Drug Delivery: Principles and Practice helps users understand the nervous system physiology affecting drug delivery, the principles that underlie various drug delivery methods, and the appropriate application of drug delivery methods for drug- and disease-specific treatments. Researchers developing nervous system putative therapeutic agents will use this book to optimize drug delivery during preclinical assessment and to prepare for regulatory advancement of new agents. Clinicians will gain direct insights into pathophysiologic alterations that impact drug delivery and students and trainees will find this a critical resource for understanding and applying nervous system drug delivery techniques. Offers an up-to-date, comprehensive resource on drug delivery to the nervous system Provides a bridge for understanding across nervous system delivery-related physiology, drug delivery principles. and the methodologies that underlie the various methods of drug distribution (with clinical application) Written for a broad audience of researchers, clinicians and advanced graduate students in neuroscience, neurology, neurosurgery, pharmacology, radiology and psychiatry

Drug Delivery to the Central Nervous System

Drug Delivery to the Central Nervous System
A Book

by Kewal K. Jain

  • Publisher : Humana Press
  • Release : 2009-12-21
  • Pages : 324
  • ISBN : 9781607615286
  • Language : En, Es, Fr & De
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Playing an important role in the treatment of neurological disorders, the delivery of drugs to central nervous system (CNS), both administered directly and administered systematically for targeted action, encounters a major challenge in the form of the blood-brain barrier (BBB), which limits the access of drugs to the brain substance. In Drug Delivery to the Central Nervous System, experts in the field present essential methods used to deliver therapeutics across the BBB, both in experimental animals and in humans. In addition to those methods, several overviews of innovative methods and their applications are presented in order to give a glimpse of the future of this research. As a volume in the successful Neuromethods series, this book presents its protocols with the kind of detailed description and implementation advice that is crucial for getting optimal results. Authoritative and cutting-edge, Drug Delivery to the Central Nervous System serves as an ideal guide to scientists continuing to pursue knowledge of the delicate interactions between pharmaceuticals and the brain.

New Advances in Drug Delivery to the Central Nervous System

New Advances in Drug Delivery to the Central Nervous System
A Book

by Timothy Tankosic

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Blood-Brain Barrier and Drug Delivery to the CNS

The Blood-Brain Barrier and Drug Delivery to the CNS
A Book

by Michael Bradbury,David Begley,Jorg Kreuter

  • Publisher : Informa Health Care
  • Release : 2000-05-16
  • Pages : 264
  • ISBN : 9780824703943
  • Language : En, Es, Fr & De
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This timely and compact monograph addresses how to determine drug permeability across the blood-brain barrier more effectively. Focusing on the physiological mechanisms that influence the passage of agents into the brain, the book covers the latest research on the blood-brain barrier, the current problems of and solutions to drug delivery to the central nervous system (CNS), existing strategies, and prospects for future research. Avoid excessive in vivo experimentation and utilize timesaving in vitro techniques. A concise reference with reviews from nearly 40 international specialists in diverse fields, The Blood-Brain Barrier and Drug Delivery to the CNS assesses the properties of the blood-brain barrier to determine and measure drug permeability in animals and humans presents techniques to predict successful drug uptake through in vitro systems or by computation of physicochemical parameters examines the multidrug resistance protein P-glycoprotein as a natural transporter analyzes current drug designs to known requirements for transport looks at drug delivery systems for the brain and much more! Densely packed with over 800 literature references, drawings, photographs, x-rays, tables, and equations, The Blood-Brain Barrier and Drug Delivery to the CNS is a vital addition to the bookshelves of biochemists, pharmacists, clinical and research pharmacologists, neuroscientists and neurologists, and graduate and medical school students in these disciplines.

Blood-Brain Barrier

Blood-Brain Barrier
Drug Delivery and Brain Pathology

by David Kobiler,Shlomo Lustig,Shlomo Shapira

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 434
  • ISBN : 1461505798
  • Language : En, Es, Fr & De
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The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.

Drug and Gene Delivery to the Central Nervous System for Neuroprotection

Drug and Gene Delivery to the Central Nervous System for Neuroprotection
Nanotechnological Advances

by Hari S. Sharma,Dafin F. Muresanu,Aruna Sharma

  • Publisher : Springer
  • Release : 2017-06-14
  • Pages : 228
  • ISBN : 9783319576954
  • Language : En, Es, Fr & De
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This book summarizes the latest research on drug and gene delivery to the central nervous system (CNS). The chapters address safety concerns regarding the nanotechnology that is needed to develop nanomedicine for clinical practice. Particular focus is given to new technologies that have emerged in recent years to deliver therapeutic materials, such as genes, drugs, and other agents using nanotechnologies of diverse origin. This is an ideal book for students, teachers, researchers, and clinicians interested in a deeper understanding of nanotechnological advances in therapeutic medicine. This book also: Broadens readers’ understanding of viral vector gene delivery to the brain for treating neurogenetic diseases as well as targeted gene delivery into the brain using microbubble-facilitated focused ultrasound Covers in detail the latest developments in delivering therapeutic materials, such as siRNA delivery to the brain for treating neurological diseases, neuroprotective effects of gelatin nanoparticles in stroke, and nanowired drug delivery for brain diseases, heat stroke, and CNS injury Enriches understanding of new technologies for delivering therapeutic materials treating Alzheimer’s Disease, including targeted nanodrug delivery through the blood-brain barrier and the superior neuroprotective effects of nanowired drug delivery in Alzheimer’s Disease

Brain Targeted Drug Delivery Systems

Brain Targeted Drug Delivery Systems
A Focus on Nanotechnology and Nanoparticulates

by Huile Gao,Xiaoling Gao

  • Publisher : Academic Press
  • Release : 2018-09-20
  • Pages : 499
  • ISBN : 012814002X
  • Language : En, Es, Fr & De
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Brain Targeted Drug Delivery Systems: A Focus on Nanotechnology and Nanoparticulates provides a guide on nanoparticulates to both academic and industry researchers. The book discusses key points in the development of brain targeted drug delivery, summarizes available strategies, and considers the main problems and pitfalls evidenced in current studies on brain targeted drug delivery systems. As the brain is the most important organ in the human body, and disorders of the central nervous system (CNS) are the most serious threat to human life, this book highlights advances and new research in drug delivery methods to the brain. Provides an overview of brain targeting drug delivery that is useful to both academic and industry-based researchers Discusses key points in developing brain targeting drug delivery systems Summarizes and presents currently available strategies for brain targeting drug delivery Covers not only current studies and their strengths, but also gives insight into the pitfalls of current research

Nanoparticles for Brain Drug Delivery

Nanoparticles for Brain Drug Delivery
A Book

by Carla Vitorino,Andreia Jorge,Alberto A. C. C. Pais

  • Publisher : Jenny Stanford Publishing
  • Release : 2021-01-28
  • Pages : 504
  • ISBN : 9789814877312
  • Language : En, Es, Fr & De
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In an era wherein nanotechnology has sparked a huge research interest, brain drug delivery is not an exception. Aiming at fighting several central nervous system (CNS) conditions, tailored nanoparticles open new avenues to address several challenges in the fields of drug delivery and brain targeting. This book gathers contributions from experts in different, complementary fields, having in common their interest in developing new strategies for brain delivery based on nanotechnologies. The book encompasses general aspects pertaining to fundamental development, including tripartite in silico-in vitro-in vivo approaches. It also covers a diversity of nanomedicines applied in treatment and/or diagnosis and monitoring of CNS disorders. Aspects concerning their translation from the bench to clinical practice are also seamlessly discussed. This book will inspire readers to discover possible approaches to holistically delivering drugs into the brain. Edited by Carla Vitorino, Andreia Jorge and Alberto Pais, this book will appeal to anyone involved in nanomedicine, pharmaceutics, neurological and cancer therapies, drug delivery research and computational and regulatory sciences.

Handbook of Traumatic Brain Injury and Neurodegeneration

Handbook of Traumatic Brain Injury and Neurodegeneration
A Book

by R.J. Castellani

  • Publisher : IOS Press
  • Release : 2020-04-24
  • Pages : 504
  • ISBN : 164368065X
  • Language : En, Es, Fr & De
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Holbourne’s theory that rotational head movement and shear strains were limiting factors in producing acute parenchymal brain damage was a watershed moment in understanding traumatic brain injury (TBI). Long term effects, and in particular neurodegenerative proteinopathy subsequent to TBI, remain theoretical, notwithstanding the poorly understood ‘punch drunk’ syndrome of the early and mid-20th century, and the 21st century concept of chronic traumatic encephalopathy. This book, the Handbook of Traumatic Brain Injury and Neurodegeneration, has as its theme the marriage between neurodegenerative disease and neurotrauma through TBI surrogates such as sport, military service, and experimental models, and the legitimacy of that marriage. In the 32 contributions included here, this handbook not only explores the deleterious effects of genuine TBI, but also, and more importantly, the relationship between TBI and neurodegeneration. Controversy notwithstanding, there is much to be learned about the biological effects of TBI, substrates for long-term sequelae, the relationship between TBI and diverse neuropsychiatric disorders, and targets for therapy. The overall message to the neuroscience community from these papers may be a cautionary tale. The null hypothesis, that there is no causal relationship between TBI and progressive neurodegenerative disease, appears to be very much in play, and the book will be of interest to all those working in the field.

Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems

Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems
A Book

by Loyd V. Allen,Nicholas G. Popovich,Howard C. Ansel

  • Publisher : Unknown Publisher
  • Release : 2011
  • Pages : 710
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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"Thanks to its comprehensive coverage, clear explanations, and logical organization, Ansel's Pharmaceutical Dosage Forms and Drug Delivery Systems has been a core pharmaceutics text in the pharmacy curriculum for more than 40 years. As you progress through this thoroughly updated Ninth Edition, you'll master all the principles, practices, and technologies essential for the preparation of pharmaceutical dosage forms and drug delivery systems. The text's integrated approach will help you understand the interrelationships among pharmaceutical and biopharmaceutical principles, product design, formulation, manufacturing, compounding, and the clinical application of dosage forms for effective patient care." --Book Jacket.

Advances in Drug Delivery Systems, 4

Advances in Drug Delivery Systems, 4
Proceedings of the Fourth International Symposium on Recent Advances in Drug Delivery Systems, SaltLake City, UT, U.S.A., February 21-24, 1989

by James M. Anderson,Sung Wan Kim,Kristine Knutson

  • Publisher : Elsevier Science Limited
  • Release : 1990
  • Pages : 359
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This symposium provided a setting in which scientists could gather to discuss recent advances and state-of-the-art technology in drug delivery. Speakers included pharmaceutical scientists, polymer chemists, bioengineers, pharmacologists and physicians who were considered to be leaders in the field of research and development of drug delivery systems. Perspectives on drug delivery systems and development have changed markedly since the first symposium on this subject was held. Focus on biological mechanisms and interactions important to drug delivery systems has increased. This changing emphasis is reflected in the five major topics discussed: transport mechanisms across membranes, proteins and macromolecular drug delivery, new developments in drug delivery, pharmacokinetics and pharmacodynamics in controlled drug delivery, and targeting and site-specific delivery. The breadth of topics covered illustrates the interdisciplinary and multifaceted nature of drug delivery systems.

Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems
A Symposium

by Academy of Pharmaceutical Sciences. Industrial Pharmaceutical Technology Section

  • Publisher : Unknown Publisher
  • Release : 1980
  • Pages : 137
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Layer-by-layer Assembled Multilayers and Polymeric Nanoparticles for Drug Delivery in Tissue Engineering Applications

Layer-by-layer Assembled Multilayers and Polymeric Nanoparticles for Drug Delivery in Tissue Engineering Applications
A Book

by Sumit Mehrotra

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 564
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanoparticulate Drug Delivery Systems

Nanoparticulate Drug Delivery Systems
A Book

by Deepak Thassu,Michel Deleers,Yashwant Vishnupant Pathak

  • Publisher : CRC Press
  • Release : 2007-03-30
  • Pages : 376
  • ISBN : 9781420008449
  • Language : En, Es, Fr & De
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With the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. Nanoparticulate Drug Delivery Systems addresses the scientific methodologies, formulation, processing, applications, recent trends, and e

Temporal Control of Drug Delivery

Temporal Control of Drug Delivery
A Book

by William Hrushesky,William J. M. Hrushesky,Robert S. Langer,Felix Theeuwes,New York Academy of Sciences

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 641
  • ISBN : 9780897666336
  • Language : En, Es, Fr & De
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Blood-Brain Barrier in Drug Discovery

Blood-Brain Barrier in Drug Discovery
Optimizing Brain Exposure of CNS Drugs and Minimizing Brain Side Effects for Peripheral Drugs

by Li Di,Edward H. Kerns

  • Publisher : John Wiley & Sons
  • Release : 2015-02-02
  • Pages : 600
  • ISBN : 1118788354
  • Language : En, Es, Fr & De
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Focused on central nervous system (CNS) drug discovery efforts, this book educates drug researchers about the blood-brain barrier (BBB) so they can affect important improvements in one of the most significant – and most challenging – areas of drug discovery. • Written by world experts to provide practical solutions to increase brain penetration or minimize CNS side-effects • Reviews state-of-the-art in silico, in vitro, and in vivo tools to assess brain penetration and advanced CNS drug delivery strategies • Covers BBB physiology, medicinal chemistry design principles, free drug hypothesis for the BBB, and transport mechanisms including passive diffusion, uptake/efflux transporters, and receptor-mediated processes • Highlights the advances in modelling BBB pharmacokinetics and dynamics relationships (PK/PD) and physiologically-based pharmacokinetics (PBPK) • Discusses case studies of successful CNS and non-CNS drugs, lessons learned and paths to the market

The Role of Insulin-like Growth Factors in the Nervous System

The Role of Insulin-like Growth Factors in the Nervous System
A Book

by Mohan K. Raizada,Derek LeRoith

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 336
  • ISBN : 9780897667906
  • Language : En, Es, Fr & De
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Some 50 papers from a conference in Arlington, Virginia, in November 1992 discuss insulin-like growth factors in the nervous system from such perspectives as the molecular aspects, localization, binding proteins, receptors, their role in tissue and central-nervous-system function, biological functio

Regional Antineoplastic Drug Delivery in the Management of Malignant Disease

Regional Antineoplastic Drug Delivery in the Management of Malignant Disease
A Book

by Maurie Markman

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 143
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Excerpta medica. Section 30. Pharmacology and toxicology

Excerpta medica. Section 30. Pharmacology and toxicology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1978
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioavailability Control by Drug Delivery System Design

Bioavailability Control by Drug Delivery System Design
A Book

by Victor F. Smolen,LuAnn Ball

  • Publisher : Wiley-Interscience
  • Release : 1985
  • Pages : 438
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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