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The Neurobiology of Disease

The Neurobiology of Disease
Contributions from Neuroscience to Clinical Neurology

by Hugh Bostock,P. A. Kirkwood,A. H. Pullen

  • Publisher : Cambridge University Press
  • Release : 1996-04-18
  • Pages : 443
  • ISBN : 9780521451321
  • Language : En, Es, Fr & De
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Combining the knowledge of distinguished clinicians and scientists, this valuable reference seeks to inspire further understanding of neurological disease.

Neurobiology of Disease

Neurobiology of Disease
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2011-09-06
  • Pages : 1104
  • ISBN : 9780080466385
  • Language : En, Es, Fr & De
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Neurobiology of Disease is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields. Provides cutting edge information about fundamental mechanisms underlying neurological diseases Amply supplied with tables, illustrations and references Includes supporting clinical information putting the mechanisms of disease into perspective

Cingulate Neurobiology and Disease

Cingulate Neurobiology and Disease
A Book

by Brent Vogt

  • Publisher : Oxford University Press
  • Release : 2009-06-04
  • Pages : 829
  • ISBN : 0198566964
  • Language : En, Es, Fr & De
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One of the major neuroscience publications of the past few years, Cingulate Neurobiology and Disease presents the definitive review of the cingulate cortex, explaining its critical role in a host of diseases and illnesses.

University of Utah Program in Neuroscience

University of Utah Program in Neuroscience
Faculty and Research, Developmental Neuroscience

by University of Utah. Medical Center

  • Publisher : Unknown Publisher
  • Release : 1998*
  • Pages : 18
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Neurobiology of Alzheimer's Disease

Neurobiology of Alzheimer's Disease
A Book

by David Dawbarn,Shelley J. Allen

  • Publisher : Oxford University Press, USA
  • Release : 2007
  • Pages : 468
  • ISBN : 9780198566618
  • Language : En, Es, Fr & De
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Alzheimer's disease is the most common form of dementia in the elderly; 450,000 people in the UK and 4.5 million people in the USA suffer with this disease. This 3rd edition of Neurobiology of Alzheimer's Disease gives a comprehensive and readable introduction to the disease, from molecular pathology to clinical practice. The book is intended for readers new to the field, and it also covers an extensive range of themes for those with in-depth knowledge of Alzheimer's disease. It will therefore act either as an introduction to the whole field of neurodegeneration or it will help experienced researchers to access the latest research in specialist topics. Each chapter is written by eminent scientists leading their fields in neuropathology, clinical practice and molecular neurobiology; appendices detail disease-associate proteins, their sequences, familial mutations and known structures. It will be essential reading for students interested in neurodegeneration and for researchers and clinicians, giving a coherent and cohesive approach to the whole area of research, and allowing access at different levels. For those in the pharmaceutical industry it describes the underlying molecular mechanisms involved in the pathogenesis of Alzheimer's disease and explains how current and potential therapeutics may work.

Functional Neurobiology of Aging

Functional Neurobiology of Aging
A Book

by Patrick R. Hof,Charles V. Mobbs

  • Publisher : Academic Press
  • Release : 2001-01-11
  • Pages : 960
  • ISBN : 9780080525587
  • Language : En, Es, Fr & De
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Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. Organized by function, making it easy to find and understand the material Addresses impairments both associated with diseases and not associated with diseases Written by leading researchers in the field Most comprehensive source of information on the neurobiology of aging

Neurobiology of Brain Disorders

Neurobiology of Brain Disorders
Biological Basis of Neurological and Psychiatric Disorders

by Michael J. Zigmond,Joseph T. Coyle,Lewis P. Rowland

  • Publisher : Elsevier
  • Release : 2014-12-03
  • Pages : 824
  • ISBN : 0123982804
  • Language : En, Es, Fr & De
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Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Neurobiology of Huntington’s Disease

Neurobiology of Huntington’s Disease
Applications to Drug Discovery

by Donald C. Lo,Robert E. Hughes

  • Publisher : CRC Press
  • Release : 2010-07-02
  • Pages : 338
  • ISBN : 1420008250
  • Language : En, Es, Fr & De
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In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene. Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume: Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology
Neurotransmitter Systems

by E. S. Vizi,Abel Lajtha

  • Publisher : Springer Science & Business Media
  • Release : 2008-04-15
  • Pages : 465
  • ISBN : 0387303510
  • Language : En, Es, Fr & De
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Understanding the biology of brain function is a great challenge and a major goal of modern science. The brain is one of the last great frontiers in science, and the unraveling of its mysteries is comparable in complexity to efforts in space exploration. A fundamental goal of neuroscience is to understand how neurons generate behavior and the pathophysiology of different mental and neurological diseases. The aim of this book is to describe recent discoveries about the basic operations of the brain and to provide an introduction to the adaptations for specific types of information processing.

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome

The Neurobiology of Aging and Alzheimer Disease in Down Syndrome
A Book

by Elizabeth Head,Ira Lott

  • Publisher : Academic Press
  • Release : 2021-08-31
  • Pages : 352
  • ISBN : 0128188464
  • Language : En, Es, Fr & De
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The Neurobiology of Aging and Alzheimer Disease in Down Syndrome provides a multidisciplinary approach to the understanding of aging and Alzheimer disease in Down syndrome that is synergistic and focused on efforts to understand the neurobiology as it pertains to interventions that will slow or prevent disease. The book provides detailed knowledge of key molecular aspects of aging and neurodegeneration in Down Syndrome by bringing together different models of the diseases and highlighting multiple techniques. Additionally, it includes case studies and coverage of neuroimaging, neuropathological and biomarker changes associated with these cohorts. This is a must-have resource for researchers who work with or study aging and Alzheimer disease either in the general population or in people with Down syndrome, for academic and general physicians who interact with sporadic dementia patients and need more information about Down syndrome, and for new investigators to the aging and Alzheimer/Down syndrome arena. Discusses the complexities involved with aging and Alzheimer’s disease in Down syndrome Summarizes the neurobiology of aging that requires management in adults with DS and leads to healthier aging and better quality of life into old age Serves as learning tool to orient researchers to the key challenges and offers insights to help establish critical areas of need for further research

Recent Advances in Parkinsons Disease

Recent Advances in Parkinsons Disease
Part II: Translational and Clinical Research

by Anonim

  • Publisher : Elsevier
  • Release : 2010-10-13
  • Pages : 368
  • ISBN : 9780444537515
  • Language : En, Es, Fr & De
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This second volume follows on from Part I by reviewing the variety of animal models of PD current available (from drosophila to rodents to non-human primate species) and their specific contributions to PD research. This is followed by comprehensive coverage of functional neuroimaging studies that explore different pathophysiological questions and evaluate treatment outcome in PD patients. Different areas of experimental therapeutics and outstanding challenges to PD treatment are presented in a concluding group of articles. Complete overview of hot topics and approaches to current PD research, from molecules, to brain circuits, to clinical and therapeutic applications Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Metal Related Neurodegenerative Disease

Metal Related Neurodegenerative Disease
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2013-11-07
  • Pages : 434
  • ISBN : 0124105351
  • Language : En, Es, Fr & De
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This issue reviews the role of metals in neurodegenerative diseases; including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders. An update on advances in neuroimaging and pathology of metal related disease is also presented. This volume of International Review of Neurobiology brings together cutting-edge research on metal related neurodegenerative disease It reviews the role of metals in neurodegenerative diseases, including Parkinson’s and Huntington’s disease; restless leg syndrome and NBIA disorders; and Wilson’s disease and manganese and calcium accumulation disorders An update on advances in neuroimaging and pathology of metal related disease is also presented

Behavioral Neurobiology of Aging

Behavioral Neurobiology of Aging
A Book

by Marie-Christine Pardon,Mark W. Bondi

  • Publisher : Springer Science & Business Media
  • Release : 2012-04-15
  • Pages : 362
  • ISBN : 3642238750
  • Language : En, Es, Fr & De
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This volume discusses the current state of research findings related to healthy brain aging by integrating human clinical studies and translational research in animal models. Several chapters offer a unique overview of successful aging, age-related cognitive decline and its associated structural and functional brain changes, as well as how these changes are influenced by reproductive aging. Insights provided by preclinical studies in mouse models and advanced neuroimaging techniques in humans are also presented.

Molecular Neurobiology of Alzheimer Disease and Related Disorders

Molecular Neurobiology of Alzheimer Disease and Related Disorders
A Book

by Masatoshi Takeda,Toshihisa Tanaka,Ramón Cacabelos

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2004
  • Pages : 297
  • ISBN : 380557603X
  • Language : En, Es, Fr & De
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Alzheimers disease affects 6-10% of the elderly population, causing impairment in cognitive functions and significant disability in daily living for more than ten years. Neurofibrillary tangles, amyloid deposits and neuronal loss are the three hallmarks of Alzheimers disease. Due to insolubility of these unique structures in Alzheimer brain tissue, they were very difficult to study by usual biochemical methods in the past. Active research is now going on to elucidate the pathogenesis of Alzheimers disease. Major topics of neurobiological study of Alzheimers disease include the unraveling of the molecular mechanism of neurofibrillary tangle formation in neuronal and glial cells, the molecular processing of amyloid precursor protein in intracellular organella and in extra-cellular space, and the molecular mechanism of neuronal loss. The articles in this book were selected from contributions presented by leading scientists in this field at the international symposium which took place in Osaka in 2002. This publication is essential reading for all researchers, clinicians, basic and social scientists, neurologists and psychiatrists to promote the understanding of this formidable disease.

Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease

Behavioral Neurobiology of Huntington's Disease and Parkinson's Disease
A Book

by Hoa Huu Phuc Nguyen,M. Angela Cenci

  • Publisher : Springer
  • Release : 2015-05-23
  • Pages : 397
  • ISBN : 366246344X
  • Language : En, Es, Fr & De
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Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms of PD. With their identification, a plethora of genetic animal models has been generated and has revolutionized the understanding of the pathobiology and pathophysiology of these disorders. The models allow us to study the earliest manifestations of the diseases behaviorally and neuropathologically and help us understand how they progress over time. Additionally, neurotoxic animal models are still of high interest to the PD field, as they are being used to study e.g. mitochondrial dysfunction in PD. This book focuses on animal models of both diseases and how they have helped and will continue to help understand the behavioral neurobiology in these disorders.

Neurobiology of Learning and Memory

Neurobiology of Learning and Memory
A Book

by Joe L. Martinez, Jr.,Raymond P. Kesner

  • Publisher : Elsevier
  • Release : 1998-06-29
  • Pages : 456
  • ISBN : 9780080537405
  • Language : En, Es, Fr & De
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Neurobiology of Learning and Memory provides an excellent overview of current information on this fast-growing field of neurobiology. The contents have been structured for use as a course text or as a handy resource for researchers in neuro- and cognitive psychology. It discusses learning and memory from developmental, pharmacological, and psychobiological perspectives, as well as changes in learning and memory with age. Neurobiology of Learning and Memory also includes research on invertebrates and vertebrates, presenting basics in anatomy and development along with computational models. It is written in an easy-to-follow format with summaries at the end of each chapter. Key Features * Provides an overview of information on the neurobiology of learning and memory * Discusses learning and memory from developmental, pharmacological, and psychobiological perspectives, and changes in learning and memory with age * Includes research on invertebrates and vertebrates * Gives basics on anatomy and development * Written for easy comprehension with chapter summaries

Neurodegenerative Diseases

Neurodegenerative Diseases
Neurobiology, Pathogenesis and Therapeutics

by M. Flint Beal,Anthony E. Lang,Albert C. Ludolph

  • Publisher : Cambridge University Press
  • Release : 2005-06-02
  • Pages : 129
  • ISBN : 1139443453
  • Language : En, Es, Fr & De
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Neurodegenerative diseases are major contributors to disability and disease, with Alzheimer's and Parkinson's diseases the most prevalent. This major reference reviews the rapidly advancing knowledge of pathogenesis and treatment of neurodegenerative diseases in the context of a comprehensive survey of each disease and its clinical features. The editors and contributors are among the leading experts in the field internationally. Covering basic science, diagnostic tools and therapeutic approaches, the book focuses on all aspects of neurodegenerative disease, including the normal aging process. The dementias, prion diseases, Parkinson's disease and atypical parkinsonisms, neurodegenerative ataxias, motor neuron diseases, degenerative diseases with chorea, iron and copper disorders, and mitochondrial diseases, are all methodically presented and discussed, with extensive illustrations. In each case the underlying genetics, neuropathological and clinical issues are fully reviewed, making this the most complete as well as the most authoritative reference available to clinicians and neuroscientists.

Handbook of Neurochemistry and Molecular Neurobiology

Handbook of Neurochemistry and Molecular Neurobiology
Development and Aging Changes in the Nervous System

by Abel Lajtha,Regino Perez-Polo,Steffen Roßner

  • Publisher : Springer Science & Business Media
  • Release : 2008-06-06
  • Pages : 324
  • ISBN : 0387326707
  • Language : En, Es, Fr & De
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In the animal nervous system, a very high metabolic turnover, fragile but steep ionic gradients, and morphological and structural constraints - dictated by the necessity for prompt neuronal transmission of electrical impulses and necessary plasticity - result in a highly fragile organ system. Here, we address a small sampling of major constituents of neural function at the cellular and molecular level that play important roles in development and aging, two endogenous processes that embody features of allostasis or the dynamic shifts in set points for specific homeostatic mechanisms associated with development and aging. These chapters stress the dynamic features of neuronal responses to internal (developmental) cues or the more harmful external events (injury and disease) in a modern perspective.

Neurobiology of the Axon in Health and Disease

Neurobiology of the Axon in Health and Disease
A Book

by Maren Engelhardt,Vann Bennett

  • Publisher : Frontiers Media SA
  • Release : 2019-11-04
  • Pages : 134
  • ISBN : 2889194884
  • Language : En, Es, Fr & De
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Ever since Santiago Ramón y Cajal sketched his captivating panels of the microscopic structure of the brain with its vast diversity of neuronal morphology over a century ago, scientists have been drawn to this seemingly chaotic network of neurites and processes to uncover how structure relates to function. During the course of a century, we have moved from merely describing neuronal and glial morphology to furthering our understanding of such intricate processes as organelle and factor transport, cellular compartmentalization, neuronal polarity, cytoskeleton dynamics, neurite pathfinding, and the impact of pathophysiological insult on these structures and events. Yet to this day, and likely for the foreseeable future, much work remains to be done to fully grasp the exceptional role of neurites for the function of larger neuronal ensembles and networks. While the somatodendritic domain of neurons has been in the focus of attention for many years, mostly because of its great dynamic remodeling capacity during events of plasticity (e.g. learning), the axonal domain has somehow remained in the background despite the fact that especially recent comprehensive studies from various fields of research underline the axon’s contribution to dynamic plasticity processes. Consequently, this Research Topic focuses on the many exciting aspects of axonal neurobiology – ranging from membrane composition and molecular determination during development to axonal domain specialization and physiology in health and disease. In Chapter 1 “Axons in the PNS”, Bombeiro et al. use immunodeficient mice to study the role of lymphocytes during the regeneration of peripheral nerves, showing that the modulation of immune responses after injury can be an efficient approach to enhance nerve regeneration in the PNS. Using a DRG model, Berbusse et al. identify the onset of damage to mitochondrial structure and dynamics as a key event during early axon degeneration and provide evidence that Nmnat1, a member of the family of nicotinamide-nucleotide adenylyltransferases, can have protective effects by preserving normal mitochondrial integrity and dynamics. In another study of PNS nerve regeneration, Law et al. use proteomics approaches via Mass Spectrometry to provide evidence that rosovitine, a synthetic purine nucleoside analog, can successfully promote PNS axon regeneration. In Chapter 2 “Axonal development in the central nervous system”, Yoshimura et al. analyze specialized axonal domains, namely the axon initial segment and nodes of Ranvier, with regards to their expression profiles of the major scaffolding protein ßIV-spectrin. Super resolution microscopy reveals a potential developmental switch of spectrin isoforms at both axonal domains. In a related study, also using super resolution microscopy, Leterrier et al. examine a potential reciprocal role of membrane partners in ankyrin-G targeting and stabilization at the axonal membrane during development. The authors demonstrate a tight and precocious association of ankyrin-G with its membrane partners. Höfflin et al. address the question of axon initial segment morphology across different cell classes in cortical organotypic slice cultures and find a surprising heterogeneity especially between pyramidal cells and interneurons in primary visual cortex. In a major step towards establishing a successful live label of the axon initial segment, Dumitrescu et al. report the development of a genetically-encoded construct consisting of a voltage-gated sodium channel intracellular domain fused to yellow fluorescent protein (YFP-NaVII-III). Nelson and Jenkins then provide a comprehensive Review article on the axon initial segment and nodes of Ranvier with a special focus on the various scaffolding protein isoforms and their role in human disease. In Chapter 3 “Axonal physiology and plasticity”, Nikitin et al. investigate fast onset dynamics of action potentials during neuronal development in vitro, showing that encoding of high frequencies improves upon culture maturation, accompanied by the development of passive electrophysiological properties and action potential generation. Using pharmacological and RNA interference approaches, Tapia et al. provide evidence that cannabinoid receptors and their ligands can modulate dendritic morphology and thus, indirectly, also affect ankyrin-G accumulation at the axon initial segment. A Mini Review by Zbili et al. discusses the potential impact of subthreshold changes in presynaptic membrane potential before action potential initiation on neurotransmitter release, and which significant impact such mechanisms could have on information processing in neuronal circuits. Yamada and Kuba close this chapter with a Mini Review on axon initial segment plasticity with a particular focus on ion channels and the biophysics of excitability. In Chapter 4 “Axon degeneration and regeneration”, Hamada et al. investigate the often overlooked question to which extent myelin loss affects action potential propagation along distal branch points and axon collaterals. Using the cuprizone demyelination model and optical voltage-sensitive dye imaging, the authors uncover functional consequences of demyelination that reach well beyond the main axon. In a model of mild traumatic brain injury, Vascak et al. demonstrate complex aspects of this injury type on neocortical circuit function, including changes in inhibitory perisomatic input and axon initial segment-driven output in affected layer V neurons. In a Mini Review, Grosch et al. discuss recent advances in the field of Parkinson’s disease with a focus on early degeneration in dopaminergic and serotonergic neurons of the basal ganglia. The last two articles cover the topic of axonal regeneration. Li et al. investigate the role of activated astrocytes in spinal cord lesion and how their functional downregulation via an inhibitor of mitochondrial fission, Mdivi-1, could potentially have positive impact on lesion scar formation and axonal regeneration. In a final Review, Liu et al. highlight recent advances in the development of biomaterial scaffolds and cell transplantation strategies to combine two promising therapeutic approaches for spinal cord injury.

Neurobiology of Psychiatric Disorders

Neurobiology of Psychiatric Disorders
A Book

by Thomas E. Schlaepfer,Charles B. Nemeroff

  • Publisher : Elsevier
  • Release : 2012
  • Pages : 760
  • ISBN : 0444520023
  • Language : En, Es, Fr & De
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This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain