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Neurobiology of Psychiatric Disorders

Neurobiology of Psychiatric Disorders
A Book

by Thomas E. Schlaepfer,Charles B. Nemeroff

  • Publisher : Elsevier
  • Release : 2012
  • Pages : 760
  • ISBN : 0444520023
  • Language : En, Es, Fr & De
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This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Neurobiology of Brain Disorders

Neurobiology of Brain Disorders
Biological Basis of Neurological and Psychiatric Disorders

by Michael J. Zigmond,Joseph T. Coyle,Lewis P. Rowland

  • Publisher : Elsevier
  • Release : 2014-12-03
  • Pages : 824
  • ISBN : 0123982804
  • Language : En, Es, Fr & De
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Neurobiology of Brain Disorders is the first book directed primarily at basic scientists to offer a comprehensive overview of neurological and neuropsychiatric disease. This book links basic, translational, and clinical research, covering the genetic, developmental, molecular, and cellular mechanisms underlying all major categories of brain disorders. It offers students, postdoctoral fellows, and researchers in the diverse fields of neuroscience, neurobiology, neurology, and psychiatry the tools they need to obtain a basic background in the major neurological and psychiatric diseases, and to discern connections between basic research and these relevant clinical conditions. This book addresses developmental, autoimmune, central, and peripheral neurodegeneration; infectious diseases; and diseases of higher function. The final chapters deal with broader issues, including some of the ethical concerns raised by neuroscience and a discussion of health disparities. Included in each chapter is coverage of the clinical condition, diagnosis, treatment, underlying mechanisms, relevant basic and translational research, and key unanswered questions. Written and edited by a diverse team of international experts, Neurobiology of Brain Disorders is essential reading for anyone wishing to explore the basic science underlying neurological and neuropsychiatric diseases. Links basic, translational, and clinical research on disorders of the nervous system, creating a format for study that will accelerate disease prevention and treatment Covers a vast array of neurological disorders, including ADHD, Down syndrome, autism, muscular dystrophy, diabetes, TBI, Parkinson, Huntington, Alzheimer, OCD, PTSD, schizophrenia, depression, and pain Illustrated in full color Each chapter provides in-text summary points, special feature boxes, and research questions Provides an up-to-date synthesis of primary source material

Neurobiology of Mental Illness

Neurobiology of Mental Illness
A Book

by Dennis S. Charney,Eric J. Nestler,Pamela Sklar,Joseph D. Buxbaum

  • Publisher : Oxford University Press
  • Release : 2013-07-04
  • Pages : 1222
  • ISBN : 0199934959
  • Language : En, Es, Fr & De
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Our understanding of the neurobiological basis of psychiatric disease has accelerated in the past five years. The fourth edition of Neurobiology of Mental Illness has been completely revamped given these advances and discoveries on the neurobiologic foundations of psychiatry. Like its predecessors the book begins with an overview of the basic science. The emerging technologies in Section 2 have been extensively redone to match the progress in the field including new chapters on the applications of stem cells, optogenetics, and image guided stimulation to our understanding and treatment of psychiatric disorders. Sections' 3 through 8 pertain to the major psychiatric syndromes-the psychoses, mood disorders, anxiety disorders, substance use disorders, dementias, and disorders of childhood-onset. Each of these sections includes our knowledge of their etiology, pathophysiology, and treatment. The final section discusses special topic areas including the neurobiology of sleep, resilience, social attachment, aggression, personality disorders and eating disorders. In all, there are 32 new chapters in this volume including unique insights on DSM-5, the Research Domain Criteria (RDoC) from NIMH, and a perspective on the continuing challenges of diagnosis given what we know of the brain and the mechanisms pertaining to mental illness. This book provides information from numerous levels of analysis including molecular biology and genetics, cellular physiology, neuroanatomy, neuropharmacology, epidemiology, and behavior. In doing so it translates information from the basic laboratory to the clinical laboratory and finally to clinical treatment. No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text. The result is an excellent and cutting-edge resource for psychiatric residents, psychiatric researchers and doctoral students in neurochemistry and the neurosciences.

Neurobiology of Psychiatric Disorders E-Book

Neurobiology of Psychiatric Disorders E-Book
A Book

by Charles B. Nemeroff

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 781
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cambridge Medical Reviews: Neurobiology and Psychiatry:

Cambridge Medical Reviews: Neurobiology and Psychiatry:
A Book

by David Dawbarn,James McCulloch,Carol Tammingha

  • Publisher : Cambridge University Press
  • Release : 1993-11-18
  • Pages : 238
  • ISBN : 9780521434836
  • Language : En, Es, Fr & De
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This book was originally published in 1993. At the time of publication, the neurobiological basis of psychiatric disorder was a rapidly expanding field of study, primarily as a result of developments in the basic neurosciences. Neurobiology and Psychiatry served as a regular forum for evaluation and dissemination of information in this fundamental field of biological psychiatry. Topics selected for review illustrated the application of a range of neurobiological techniques to major psychiatric disorders, providing an in-depth review of work in this field. The intended readership included established research workers in the field, postgraduate psychiatrists, psychiatric trainees and other clinical and laboratory workers.

Charney & Nestler's Neurobiology of Mental Illness

Charney & Nestler's Neurobiology of Mental Illness
A Book

by Dennis S. Charney,Pamela B. Sklar

  • Publisher : Oxford University Press
  • Release : 2018-01-12
  • Pages : 1024
  • ISBN : 019068142X
  • Language : En, Es, Fr & De
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Preceded by Neurobiology of mental illness / edited by Dennis S. Charney ... [et al.]. 4th ed. 2013.

Neurobiology of Depression

Neurobiology of Depression
Road to Novel Therapeutics

by Joao Luciano de Quevedo,Andre Ferrer Carvalho,Carlos A. Zarate

  • Publisher : Academic Press
  • Release : 2019-01-03
  • Pages : 471
  • ISBN : 0128133341
  • Language : En, Es, Fr & De
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Neurobiology of Depression: Road to Novel Therapeutics synthesizes the basic neurobiology of major depressive disorder with discussions on the most recent advances in research, including the interacting pathways implicated in the pathophysiology of MDD, omics technologies, genetic approaches, and the development of novel optogenetic approaches that are changing research perspectives and revolutionizing research into depression. These basic foundational understandings on the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research are combined in this book to aid advanced students and researchers in their understanding of MDD. Depression is one of the most common mental-health disorders caused by a variety of genetic, biological, environmental and psychological factors. Major depressive disorder (MDD) is typically treated with first-line antidepressant agents that primarily target monoamine neurotransmission. However, only approximately one-third of patients with MDD achieve remission following a trial with such an antidepressant. Furthermore, MDD is a heterogeneous phenotype, and new frameworks, such as the NIMH Research Domain Criteria (RDoC) may provide a more accurate, biologically based comprehension of the symptomatic heterogeneity of this devastating illness. Aids readers in understanding major depressive disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments, to antidepressants and novel therapeutics Synthesizes discussions on the cellular and molecular mechanisms underlying symptoms with the clinical aspects of depression

Neurobiology of Bipolar Disorder

Neurobiology of Bipolar Disorder
Road to Novel Therapeutics

by Joao Luciano de Quevedo,Andre Ferrer Carvalho,Eduard Vieta

  • Publisher : Academic Press
  • Release : 2020-11-25
  • Pages : 470
  • ISBN : 012819183X
  • Language : En, Es, Fr & De
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The Neurobiology of Bipolar Disorder: Road to Novel Therapeutics combines the basic neurobiology of bipolar disorder with discussions of the most recent advances in research, including the interacting pathways implicated in the pathophysiology of bipolar disorder, genetic approaches and the pharmacogenomics of bipolar disorder. The basic foundational understanding of the neurobiology underlying the disorder, along with a comprehensive summary of the most recent advances in research combine to aid advanced students and researchers in their understanding of bipolar disorder management using novel and fast-acting pharmaceutical and neuromodulatory approaches. Aids readers in understanding bipolar disorder in the context of NIMH Research Domain Criteria (RDoC) recommendations Covers a range of existing and potential pharmacologic and non-pharmacologic treatment options, from lifestyle adjustments to novel therapeutics Synthesizes a discussion of the cellular and molecular mechanisms underlying symptoms with clinical aspects of bipolar disorder

Neurobiology of Psychiatric Disorders

Neurobiology of Psychiatric Disorders
A Book

by Thomas E Schlaepfer,Charles B. Nemeroff

  • Publisher : Elsevier
  • Release : 2012-09-01
  • Pages : 762
  • ISBN : 0444535004
  • Language : En, Es, Fr & De
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This new volume in the Handbook of Clinical Neurology presents a comprehensive review of the fundamental science and clinical treatment of psychiatric disorders. Advances in neuroscience have allowed for dramatic advances in the understanding of psychiatric disorders and treatment. Brain disorders, such as depression and schizophrenia, are the leading cause of disability worldwide. It is estimated that over 25% of the adult population in North America are diagnosed yearly with at least one mental disorder and similar results hold for Europe. Now that neurology and psychiatry agree that all mental disorders are in fact, "brain diseases," this volume provides a foundational introduction to the science defining these disorders and details best practices for psychiatric treatment. Provides a comprehensive review of the scientific foundations of psychiatric disorders and psychiatric treatment Includes detailed results from genetics, molecular biology, brain imaging, and neuropathological, immunological, epidemiological, metabolic, therapeutic and historical aspects of the major psychiatric disorders A "must have" reference and resource for neuroscientists, neurologists, psychiatrists, and clinical psychologists as well as all research scientists investigating disorders of the brain

Personalized Psychiatry

Personalized Psychiatry
A Book

by Bernhard Baune

  • Publisher : Academic Press
  • Release : 2019-10-16
  • Pages : 604
  • ISBN : 0128131772
  • Language : En, Es, Fr & De
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Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective

Psychopathology in the Genome and Neuroscience Era

Psychopathology in the Genome and Neuroscience Era
A Book

by Charles F. Zorumski,Eugene H. Rubin,American Psychopathological Association

  • Publisher : American Psychiatric Pub
  • Release : 2007-05-03
  • Pages : 256
  • ISBN : 1585627178
  • Language : En, Es, Fr & De
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The fascinating Psychopathology in the Genome and Neuroscience Era brings together selected topics in psychiatric genetics, epidemiology and prevention, and neuroscience and education. This key reference integrates this information across the fields of genetics, epidemiology, and neuroscience to arrive at an understanding of where recent advances in genetics and neuroscience -- advances that promise to enhance our understanding of human behavior and psychopathology -- are likely to influence psychopathology research and education in the near future. How will the field of psychopathology incorporate the coming avalanche of information generated by these recent advances? The answer will influence not only how mental health professionals diagnose and treat patients but also how the next generation of professionals is trained. Chapters in this exciting compilation are based on individual talks by 20 international experts at the conceptual forefront of their respective fields given at the March 2003 American Psychopathological Association annual meeting. Organized into four main sections -- the future of psychiatric genetics, diagnosis and prevention of psychiatric disorders, neurobiology and psychiatric disorders, and the future of psychiatric education -- Psychopathology in the Genome and Neuroscience Era focuses on a broad range of topics: The importance of a conceptual shift from identifying major genes for mental disorders to gaining an understanding of the role of which genes in which contexts, both biological and environmental, confer susceptibility to or protection from mental disorders or components thereof Historical perspective of gene susceptibility to mental disorders, with the same possibilities for use and misuse of genotype data as now exist for significantly heritable traits such as intelligence, and for borderline traits such as criminal behavior and alcoholism Reconceptualization of medicine and medical diagnoses to include molecular genetic components, including the importance of cell loss and neurogenesis in mood disorders Major phenotypic problems inherent in all attempts to measure psychopathology, starting with how to achieve reliability, and how to advance from reliability to validity in future revisions of DSM and ICD classifications Brain structural abnormalities in mood disorders; physiological cell death and whether or not this natural phenomenon can be converted into a pathological process, including the importance of cell loss and neurogenesis in mood disorders The influence of scientific advances, workforce issues, and educational trends on psychiatric training Psychopathology in the Genome and Neuroscience Era is a must-read reference work for anyone -- practitioners, residents, and students alike -- interested in the future of psychiatric genetics, epidemiology, and education.

Cambridge Medical Reviews: Neurobiology and Psychiatry:

Cambridge Medical Reviews: Neurobiology and Psychiatry:
A Book

by David Dawbarn,James McCulloch,Carol Tammingha

  • Publisher : Cambridge University Press
  • Release : 1995-06-29
  • Pages : 194
  • ISBN : 9780521453653
  • Language : En, Es, Fr & De
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This book was originally published in 1995. At the time of publication, the neurobiological basis of psychiatric disorder was a rapidly expanding field of study, primarily as a result of developments in the basic neurosciences. Neurobiology and Psychiatry served as a regular forum for evaluation and dissemination of information in this fundamental field of biological psychiatry. Topics selected for review illustrated the application of a range of neurobiological techniques to major psychiatric disorders, providing an in-depth review of work in this field. The intended readership included established research workers in the field, postgraduate psychiatrists, psychiatric trainees and other clinical and laboratory workers.

The Neurobiology of Childhood

The Neurobiology of Childhood
A Book

by Susan L. Andersen,Daniel S. Pine

  • Publisher : Springer
  • Release : 2014-05-13
  • Pages : 370
  • ISBN : 3642549136
  • Language : En, Es, Fr & De
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During the past years there has been rapid progress in the understanding of how early life stress impacts psychopathology in children. The first two parts of this book present the basic principles of brain development and describe the most important neuronal systems. This includes systems involved in emotion processing, cognitive control, and social processes. These first two general sections are followed by an overview about recent research on various neuronal and psychiatric disorders, where environmental exposures and altered brain development play an important role: sleep, autism, ADHD and other developmental forms of psychopathology.

Molecular Neurobiology for the Clinician

Molecular Neurobiology for the Clinician
A Book

by Dennis S. Charney

  • Publisher : American Psychiatric Pub
  • Release : 2008-05-20
  • Pages : 272
  • ISBN : 158562733X
  • Language : En, Es, Fr & De
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In this authoritative volume you'll find today's most important molecular neurobiological advances and their relevance to clinicians treating patients with mental illness. Molecular Neurobiology for the Clinician, Review of Psychiatry, Volume 22, will update you on the latest findings -- and their impact on psychiatry. You'll learn about Discoveries with the potential to revolutionize your clinical approach by changing the ways in which you diagnose and treat patients The effects on psychiatry of advances in the molecular basis of neuronal network function, particularly in relation to abnormalities in cognitive and emotional regulation, and the identification of novel molecular targets for drug development How to apply these discoveries to diagnosing and treating major psychiatric disorders, including childhood- and adolescent-onset disorders, schizophrenia, drug addiction, and severe mood and anxiety disorders Molecular Neurobiology for the Clinician is an outstanding compilation of the best research by top names in the field. Psychiatrists, psychologists, psychiatric residents, and graduate students in neuroscience, psychiatry, and psychology will gain knowledge, understanding, and techniques for better diagnosis and treatment.

Cambridge Medical Reviews: Neurobiology and Psychiatry: Volume 2

Cambridge Medical Reviews: Neurobiology and Psychiatry: Volume 2
A Book

by David Dawbarn,James McCulloch,Carol Tammingha

  • Publisher : Cambridge University Press
  • Release : 1993-11-18
  • Pages : 238
  • ISBN : 0521434831
  • Language : En, Es, Fr & De
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The neurobiological basis of psychiatric disorder is a rapidly expanding field of study. Cambridge Medical Reviews in Neurobiology and Psychiatry is a regular series of high quality up-to-date reviews on the application of state-of-the-art neuroscience methods to the understanding of psychiatric disorder. This volume addresses such issues as molecular genetics and the major psychoses, the B-amyloid precursor protein and the biochemistry of tau proteins in Alzheimer's disease, cytoarchitectonic and developmental aspects of schizophrenia, immunological and genetic factors in schizophrenia, neuroendocrine developments in psychiatric research, the role of neurotrophins in neurodegenerative disease, the biology of mental handicap, HIV infection and the brain, and applications to psychiatry of magnetic resonance spectroscopy.

Neurobiology of Exceptionality

Neurobiology of Exceptionality
A Book

by Con Stough

  • Publisher : Springer Science & Business Media
  • Release : 2006-09-28
  • Pages : 220
  • ISBN : 0306486490
  • Language : En, Es, Fr & De
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Nurture or nature? Biology or environment? Why are some people intelligent, or personable, or creative and others obtuse, or shy, or unimaginative? Although each human being is a unique mixture of positive and negative traits and behaviors, the question remains: What is the neurobiological basis for each individual’s makeup? For example, why does one person suffer from a disorder (e.g., ADHD, autism, mental retardation) and another lives free of maladies? These are just some of the issues addressed in detail in Neurobiology of Exceptionality. The introductory chapter provides a broad-based overview of current neurobiological techniques (i.e., terms, procedures, and technologies), which are followed by chapters that offer in-depth examination of the neurobiological bases for: • Impulsive sensation seeking • Creativity • Intelligence • Antisociality • Autism, mental retardation, and Down Syndrome • ADHD • Savant Syndrome This volume provides a one-stop source for clinical psychologists and other allied mental health professionals to access information on a wide range of research on the neurobiology of psychological and psychiatric traits. It is designed to give readers an overview of the current knowledge base of the biological processes for each trait. It is unlikely that any one book could cover all human traits, but the Neurobiology of Exceptionality addresses a wide range of exceptional psychological traits and psychiatric disorders.

Cambridge Medical Reviews: Neurobiology and Psychiatry:

Cambridge Medical Reviews: Neurobiology and Psychiatry:
A Book

by David Dawbarn,James McCulloch,Carol Tammingha

  • Publisher : Cambridge University Press
  • Release : 2011-04-28
  • Pages : 236
  • ISBN : 9780521203517
  • Language : En, Es, Fr & De
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This book was originally published in 1993. At the time of publication, the neurobiological basis of psychiatric disorder was a rapidly expanding field of study, primarily as a result of developments in the basic neurosciences. Neurobiology and Psychiatry served as a regular forum for evaluation and dissemination of information in this fundamental field of biological psychiatry. Topics selected for review illustrated the application of a range of neurobiological techniques to major psychiatric disorders, providing an in-depth review of work in this field. The intended readership included established research workers in the field, postgraduate psychiatrists, psychiatric trainees and other clinical and laboratory workers.

Demystifying Schizophrenia for the General Practitioner

Demystifying Schizophrenia for the General Practitioner
A Book

by Steven J. Siegel,LaRiena Ralph

  • Publisher : Jones & Bartlett Learning
  • Release : 2010-09-15
  • Pages : 266
  • ISBN : 0763758655
  • Language : En, Es, Fr & De
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Schizophrenia is devastating psychiatric disorder that is often misunderstood. Demystifying Schizophrenia for the General Practitioner is an essential manual for clinicians illustrating how schizophrenia affects patients, their families and society using poignant real world examples to explain its onset, progression and prognosis. This book includes criteria for diagnosing schizophrenia based on the Diagnostic Statistical Manual (DSM). Special emphasis is placed on differential diagnosis, co-morbidities, medications, and additional treatment options. The authors provide expert guidance on helping patients to cope with family and cultural issues for this highly complex disorder.

The Neuropsychology of Psychopathology

The Neuropsychology of Psychopathology
A Book

by Chad A. Noggle, PhD, ABN,Raymond S. Dean, PhD, ABPP, ABN, ABPdN

  • Publisher : Springer Publishing Company
  • Release : 2012-11-26
  • Pages : 536
  • ISBN : 082610701X
  • Language : En, Es, Fr & De
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This clinical reference book presents state-of-the-science knowledge about the neurobiology and genetics of the major mental disorders and how this corresponds with their psychiatric features and neuropsychological traits. The text demonstrates how the application of neuropsychology to these disorders provides a more comprehensive foundation for greater accuracy in assessment, diagnosis, and treatment. The book focuses on the neuropathological and pathophysiological basis of the various symptoms, emphasizing the biological basis of each disorder. This approach stresses the importance of looking at the other functional impacts of these manifestations (for example, cognitive deficits secondary to depression). The text compares adult versus child presentation of psychiatric disorders and covers the major forms of psychopathology including ADHD; Learning Disabilities; Pervasive Developmental Disorders; Mood, Anxiety, Personality, and Schizophrenic Disorders; Cortical and Subcortical Dementias; and Delirium. The book is written for clinical professionals to increase diagnostic accuracy and intervention success and to provide a way to approach psychopathologies as disorders of the neurological system. Key Features: Provides state-of-the-science knowledge about the application of neuropsychological practice to the major forms of psychopathology Examines neurological and neuropsychological features of the major forms of psychopathology Demonstrates how the application of neurobiology and genetics to psychiatric disorders can increase accuracy of assessment, diagnosis, and treatment Considers adult versus child presentation of psychiatric disorders

Computational Psychiatry

Computational Psychiatry
New Perspectives on Mental Illness

by A. David Redish,Joshua A. Gordon

  • Publisher : MIT Press
  • Release : 2016-12-09
  • Pages : 424
  • ISBN : 0262035421
  • Language : En, Es, Fr & De
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Psychiatrists and neuroscientists discuss the potential of computational approaches to address problems in psychiatry including diagnosis, treatment, and integration with neurobiology. Modern psychiatry is at a crossroads, as it attempts to balance neurological analysis with psychological assessment. Computational neuroscience offers a new lens through which to view such thorny issues as diagnosis, treatment, and integration with neurobiology. In this volume, psychiatrists and theoretical and computational neuroscientists consider the potential of computational approaches to psychiatric issues. This unique collaboration yields surprising results, innovative synergies, and novel open questions. The contributors consider mechanisms of psychiatric disorders, the use of computation and imaging to model psychiatric disorders, ways that computation can inform psychiatric nosology, and specific applications of the computational approach. Contributors Susanne E. Ahmari, Huda Akil, Deanna M. Barch, Matthew Botvinick, Michael Breakspear, Cameron S. Carter, Matthew V. Chafee, Sophie Denève, Daniel Durstewitz, Michael B. First, Shelly B. Flagel, Michael J. Frank, Karl J. Friston, Joshua A. Gordon, Katia M. Harlé, Crane Huang, Quentin J. M. Huys, Peter W. Kalivas, John H. Krystal, Zeb Kurth-Nelson, Angus W. MacDonald III, Tiago V. Maia, Robert C. Malenka, Sanjay J. Mathew, Christoph Mathys, P. Read Montague, Rosalyn Moran, Theoden I. Netoff, Yael Niv, John P. O'Doherty, Wolfgang M. Pauli, Martin P. Paulus, Frederike Petzschner, Daniel S. Pine, A. David Redish, Kerry Ressler, Katharina Schmack, Jordan W. Smoller, Klaas Enno Stephan, Anita Thapar, Heike Tost, Nelson Totah, Jennifer L. Zick