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Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability

Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability
A Book

by Carlo Sala,Chiara Verpelli

  • Publisher : Academic Press
  • Release : 2016-04-30
  • Pages : 394
  • ISBN : 0128005335
  • Language : En, Es, Fr & De
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Neuronal and Synaptic Dysfunction in Autism Spectrum Disorder and Intellectual Disability provides the latest information on Autism spectrum disorders (ASDs), the lifelong neurodevelopmental disorders that present in early childhood and affect how individuals communicate and relate to others and their surroundings. In addition, three quarters of ASD patients also manifest severe intellectual disability. Though certain genes have been implicated, ASDs remain largely a mystery, and research looking into causes and cellular deficits are crucial for better understanding of neurodevelopmental disorders. Despite the prevalence and insidious nature of this disorder, this book remains to be an extensive resource of information and background on the state of current research in the field. The book serves as a reference for this purpose, and discusses the crucial role synaptic activity plays in proper brain function. In addition, the volume discusses the neurodevelopmental synaptopathies and serves as a resource for scientists and clinicians in all biomedical science specialties. This research has been crucial for recent studies that have provided a rationale for the development of pharmacological agents able to counteract functional synaptic anomalies and potentially ameliorate some ASD symptoms. Introduces the genetic and non-genetic causes of autism and associated intellectual disabilities Describes the genes implicated in autistic spectrum disorders and their function Considers major individual genetic causes of autism, Rett syndrome, Fragile X syndrome, and other autism spectrum disorders, as well as their classification as synaptopathies Presents a thorough discussion of the clinical aspects of multiple neurodevelopmental disorders and the experimental models that exist to study their pathophysiology in vitro and in vivo, including animal models and patient-derived stem cell culture

Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases

Shankopathies: Shank Protein Deficiency-Induced Synaptic Diseases
A Book

by Elodie Ey,Thomas Bourgeron,Tobias Maria Boeckers,Eunjoon Kim,Kihoon Han

  • Publisher : Frontiers Media SA
  • Release : 2020-03-10
  • Pages : 329
  • ISBN : 2889635678
  • Language : En, Es, Fr & De
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Neural and Synaptic Defects in Autism Spectrum Disorders

Neural and Synaptic Defects in Autism Spectrum Disorders

by Hansen Wang,Laurie C. Doering

  • Publisher : Frontiers Media SA
  • Release : 2015-07-07
  • Pages : 329
  • ISBN : 2889196283
  • Language : En, Es, Fr & De
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Autism spectrum disorders (ASDs) are a group of genetically and clinically heterogeneous neurodevelopmental disorders characterized by impaired reciprocal social interactions and communication, and restricted and repetitive patterns of behaviors and interests. Studies in genetics, neurobiology and systems biology are providing insights into the pathogenesis of ASDs. Investigation of neural and synaptic defects in ASDs not only sheds light on the molecular and cellular mechanisms that govern the function of the central nervous system, but may lead to the discovery of potential therapeutic targets for autism and other cognitive disorders. Our Research Topic which constitutes this e-book documents the recent development and ideas in the study of pathogenesis and treatment of ASDs, with an emphasis on syndromic disorders such as fragile X and Rett syndromes. In addition, model systems and methodological approaches with translational relevance to autism are covered herein. We hope that the Research Topic will enhance the global knowledge base in the autism research community and foster new research directions in autism related biology.

Autism Spectrum Disorders: Developmental Trajectories, Neurobiological Basis, Treatment Update,Volume 2

Autism Spectrum Disorders: Developmental Trajectories, Neurobiological Basis, Treatment Update,Volume 2
A Book

by Roberto Canitano,Yuri Bozzi,Dirk Dhossche

  • Publisher : Frontiers Media SA
  • Release : 2020-07-03
  • Pages : 329
  • ISBN : 2889638693
  • Language : En, Es, Fr & De
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Autism Spectrum Disorders: From Genotypes to Phenotypes

Autism Spectrum Disorders: From Genotypes to Phenotypes

by Valsamma Eapen,Andrew J. Whitehouse,Charles Claudianos,Rudi Crncec

  • Publisher : Frontiers Media SA
  • Release : 2015-12-10
  • Pages : 329
  • ISBN : 2889196801
  • Language : En, Es, Fr & De
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This Research Topic covers the pathogenetic processes in Autism Spectrum Disorder (ASD) that underpin the translation of genetic vulnerability to clinically significant symptoms. Available research data in ASD suggests that it is a neural connectivity disorder and that the social communication and related neurobehavioural symptoms result from reduced synchronization between key "social brain" regions. These interconnected neural systems can be understood through the relationship between functionally relevant anatomic areas and neurochemical pathways, the programming of which are genetically modulated during neurodevelopment and mediated through a range of epigenetic and environmental modulators. Elucidating the underlying molecular mechanisms can provide an invaluable window for understanding the neural wiring that regulates higher brain functions and consequent clinical phenotypes. In keeping with the multi modal and diverse origins of ASD, this Research Topic explores the genetic underpinnings and environmental modulation in the aetiology; neural substrates, biomarkers and endophenotypes that underlie clinical characteristics; as well as neurochemical pathways and pathophysiological mechanisms that pave the way for therapeutic interventions. Furthermore, since genetically mediated deficits and consequent functional impairments involve activity-dependent synapse development that depends on postnatal learning and experience, the trajectory towards the final clinical expression could be modulated by early interventions that exploit the neuronal maturation and brain plasticity. However, identifying these diverse pathogenetic processes and tailoring interventions would require subtyping ASD into homogeneous subgroups. In this regard, this topic covers the current state of evidence in the literature through topic reviews as well as ongoing original work that provides tangible hypotheses and directions for future research.

Principles of Neural Science, Sixth Edition

Principles of Neural Science, Sixth Edition
A Book

by Eric R. Kandel,Thomas M. Jessell,Steven A. Siegelbaum

  • Publisher : McGraw Hill Professional
  • Release : 2021-04-05
  • Pages : 1760
  • ISBN : 1259642240
  • Language : En, Es, Fr & De
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The gold standard of neuroscience texts—updated with hundreds of brand-new images and fully revised content in every chapter With 300 new illustrations, diagrams, and radiology studies including PET scans, Principles of Neural Science, 6th Edition is the definitive guide for neuroscientists, neurologists, psychiatrists, students, and residents. Highly detailed chapters on stroke, Parkinson’s, and MS build your expertise on these critical topics. Radiological studies the authors have chosen explain what’s most important to know and understand for each type of stroke, progressive MS, or non-progressive MS. Features 2,200 images, including 300 new color illustrations, diagrams, and radiology studies (including PET scans) NEW: This edition now features only two contributors per chapter and are mostly U.S.-based NEW: Number of chapters streamlined down from 67 to 60 NEW: Chapter on Navigation and Spatial Memory NEW: New images in every chapter!

The Autisms

The Autisms
Molecules to Model Systems

by Craig M. Powell,Lisa M. Monteggia

  • Publisher : Oxford University Press
  • Release : 2012-11-22
  • Pages : 405
  • ISBN : 0199744319
  • Language : En, Es, Fr & De
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The science of autism has seen tremendous breakthroughs in the past few decades. A multitude of relatively rare mutations have been identified to explain around 15 % of autism cases with many of these genetic causes systematically examined in animal models. This marriage of human genetics and basic neurobiology has led to major advances in our understanding of how these genetic mutations alter brain function and help to better understand the human disease. These scientific approaches are leading to the identification of potential therapeutic targets for autism that can be tested in the very same genetic models and hopefully translated into novel, rational therapies. The Autisms: Molecules to Model Systems provides a roadmap to many of these genetic causes of autism and clarifies what is known at the molecular, cellular, and circuit levels. Focusing on tractable genetic findings in human autism and painstakingly dissecting the underlying neurobiology, the book explains, is the key to understanding the pathophysiology of autism and ultimately to identifying novel treatments.

Capute & Accardo's Neurodevelopmental Disabilities in Infancy and Childhood: Neurodevelopmental diagnosis and treatment

Capute & Accardo's Neurodevelopmental Disabilities in Infancy and Childhood: Neurodevelopmental diagnosis and treatment
A Book

by Pasquale J. Accardo,Arnold J. Capute

  • Publisher : Brookes Pub
  • Release : 2008
  • Pages : 822
  • ISBN : 9781557667564
  • Language : En, Es, Fr & De
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The first of two volumes comprising the third edition of the core text for certification in neurodevelopmental disabilities in pediatrics, this definitive resource prepares future clinicians to skillfully assess and treat a range of neurodevelopmental dis

Advances in X-Linked Mental Retardation Research and Treatment: 2011 Edition

Advances in X-Linked Mental Retardation Research and Treatment: 2011 Edition
ScholarlyPaper

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 25
  • ISBN : 1464950660
  • Language : En, Es, Fr & De
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Advances in X-Linked Mental Retardation Research and Treatment: 2011 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about X-Linked Mental Retardation in a compact format. The editors have built Advances in X-Linked Mental Retardation Research and Treatment: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about X-Linked Mental Retardation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in X-Linked Mental Retardation Research and Treatment: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Pharmacotherapy: A Pathophysiologic Approach, Eleventh Edition

Pharmacotherapy: A Pathophysiologic Approach, Eleventh Edition
A Book

by Joseph T. DiPiro,Gary C. Yee,L. Michael Posey

  • Publisher : McGraw Hill Professional
  • Release : 2020-07-03
  • Pages : 2512
  • ISBN : 1260116824
  • Language : En, Es, Fr & De
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Publisher's Note: Products purchased from Third Party sellers are not guaranteed by the publisher for quality, authenticity, or access to any online entitlements included with the product. 25+ additional chapters available online! The classic guide to driving optimal patient outcomes using evidence-based medication therapies—updated with the latest advances and guidelines Presented in full color, Pharmacotherapy: A Pathophysiologic Approach, 11th Edition helps you deliver the highest-quality patient care through evidence-based medication therapy derived from sound pharmacotherapeutic principles. It takes you beyond drug indications and dosages, showing how to properly select, administer, and monitor drugs—everything you need to provide safe, effective drug therapy across all therapeutic categories. With all-new monitoring tables and authoritative content from 300 expert contributors, this new edition has been fully updated to reflect the latest evidence-based information and recommendations. You’ll find Key Concepts at the beginning of each chapter, Clinical Presentation tables that summarize disease signs and symptoms, and Clinical Controversies boxes that examine the complicated issues faced by students and clinicians in providing drug therapy. Why Pharmacotherapy: A Pathophysiologic Approach is perfect for students, pharmacists, and other healthcare providers: • All chapters provide the most current, reliable, and relevant information available. • Key concepts kick off every chapter. • Clinical Presentation Tables summarize disease signs and symptoms. • The majority of sections include personalized pharmacotherapy content. • Clinical Controversies Boxes clarify the most complex drug therapy issues you’ll face. • Diagnostic flow diagrams, treatment algorithms, dosing recommendations, and monitoring approaches have been updated in full color to distinguish treatment pathways. • Most disease-oriented chapters are enhanced by updated evidence-based treatment guidelines, which often include ratings of the level of evidence to support key therapeutic approaches. • Instructors who adopt this text are eligible for a PowerPoint presentation of all images and answers to Self-Assessment Questions! The most trusted guide of its kind for decades, Pharmacotherapy: A Pathophysiologic Approach is the go-to text for students and practitioners seeking clear, objective coverage of core pathophysiologic and therapeutic elements.

Developmental Disabilities in Infancy and Childhood: The spectrum of developmental disabilities

Developmental Disabilities in Infancy and Childhood: The spectrum of developmental disabilities
A Book

by Arnold J. Capute,Pasquale J. Accardo

  • Publisher : Paul H Brookes Publishing Company
  • Release : 1996
  • Pages : 529
  • ISBN : 9781557661944
  • Language : En, Es, Fr & De
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Volume II: The Spectrum of Developmental Disabilities explores a range of specific disorders, their effects from infancy through adolescence, and assessment and intervention strategies for each.

Issues in Neuroscience Research and Application: 2011 Edition

Issues in Neuroscience Research and Application: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 3141
  • ISBN : 1464963606
  • Language : En, Es, Fr & De
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Issues in Neuroscience Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neuroscience Research and Application. The editors have built Issues in Neuroscience Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neuroscience Research and Application in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neuroscience Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Society for Neuroscience Abstracts

Society for Neuroscience Abstracts
Volume 24, 28th Annual Meeting, Los Angeles, Calif., November 7-12, 1998

by Society for Neuroscience. Meeting

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition

Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 2915
  • ISBN : 1464963665
  • Language : En, Es, Fr & De
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Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Clinical Psychology, Psychiatry, and Counseling. The editors have built Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Clinical Psychology, Psychiatry, and Counseling in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Neurology Research and Practice: 2011 Edition

Issues in Neurology Research and Practice: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 3208
  • ISBN : 1464963568
  • Language : En, Es, Fr & De
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Issues in Neurology Research and Practice / 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Neurology Research and Practice. The editors have built Issues in Neurology Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Neurology Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Neurology Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Advances in Physiology Research and Application: 2011 Edition

Advances in Physiology Research and Application: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 1690
  • ISBN : 1464920702
  • Language : En, Es, Fr & De
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Advances in Physiology Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Physiology. The editors have built Advances in Physiology Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Physiology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Physiology Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in General Science and Scientific Theory and Method: 2011 Edition

Issues in General Science and Scientific Theory and Method: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 3278
  • ISBN : 1464963479
  • Language : En, Es, Fr & De
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Issues in General Science and Scientific Theory and Method: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about General Science and Scientific Theory and Method. The editors have built Issues in General Science and Scientific Theory and Method: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about General Science and Scientific Theory and Method in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in General Science and Scientific Theory and Method: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Biological and Life Sciences Research: 2011 Edition

Issues in Biological and Life Sciences Research: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 5106
  • ISBN : 1464963355
  • Language : En, Es, Fr & De
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Issues in Biological and Life Sciences Research: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Biological and Life Sciences Research. The editors have built Issues in Biological and Life Sciences Research: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Biological and Life Sciences Research in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biological and Life Sciences Research: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.