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Neurotechnology and Brain Stimulation in Pediatric Psychiatric and Neurodevelopmental Disorders

Neurotechnology and Brain Stimulation in Pediatric Psychiatric and Neurodevelopmental Disorders
A Book

by Lindsay M. Oberman,Peter G. Enticott

  • Publisher : Academic Press
  • Release : 2018-11-27
  • Pages : 368
  • ISBN : 0128127783
  • Language : En, Es, Fr & De
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Neurotechnology and Brain Stimulation in Pediatric Psychiatric and Neurodevelopmental Disorders provides a comprehensive overview of neurotechnological devices as potential treatments for psychiatric and neurodevelopmental disorders in children and adolescents. Many neuropsychiatric disorders are covered such as Autism Spectrum Disorder, ADHD, Depression, Tourette’s Syndrome, and OCD. Different device-based treatments are discussed such as Transcranial Magnetic Stimulation, Transcranial Direct Current Stimulation, Deep Brain Stimulation, Chronotherapy, and Neurofeedback. Provides an overview of neuromodulatory devices as potential treatments for psychiatric and neurodevelopmental disorders in children and adolescents Gives evidence-based recommendations for non-drug interventions that may be effective for treatment options Discusses different neuromodulatory treatment options, including TMS, tDCS, DBS, chronotherapy and neurofeedback

Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders

Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2021-06-22
  • Pages : 408
  • ISBN : 0128223472
  • Language : En, Es, Fr & De
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Non-invasive Brain Stimulation (NIBS) in Neurodevelopmental Disorders, Volume 264 presents the latest updates on recent techniques used to examine the potential treatment of psychiatric and neurological disorders in adults. In this special issue, the book's authors and contributors provide a unique focus on the potential effects of non-invasive brain stimulation. Topics cover a range of reviews, opinions, methodologies, original research articles, and suggestions on how to better translate scientific knowledge into practice. This new release will help guide basic research and the development of therapeutic interventions for children and adolescents who suffer from neurodevelopmental disorders. Covers the effects of brain stimulation on different neurodevelopmental disorders Includes experimental studies in humans, animals and associated theoretical reviews Provides the most accurate and up-to-date coverage from selected international experts

Transcranial Direct Current Stimulation in Neuropsychiatric Disorders

Transcranial Direct Current Stimulation in Neuropsychiatric Disorders
Clinical Principles and Management

by André R. Brunoni

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 3030761363
  • Language : En, Es, Fr & De
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The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders

The Safety and Efficacy of Noninvasive Brain Stimulation in Development and Neurodevelopmental Disorders

by Lindsay M. Oberman,Peter G. Enticott

  • Publisher : Frontiers Media SA
  • Release : 2015-12-03
  • Pages : 129
  • ISBN : 2889196992
  • Language : En, Es, Fr & De
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Noninvasive brain stimulation (including Transcranial Magnetic Stimulation (TMS) and Transcranial Current Brain Stimulation (TCS)) can be used both experimentally and therapeutically. In the experimental domain TMS can be applied in single pulses to depolarize a small population of neurons in a targeted brain region. This protocol can be used, for example, to map cortical motor outputs, study central motor conduction time, or evaluate the cortical silent period (a measure of intracortical inhibition) all of which are relevant to neurodevelopment. TMS can also be applied in pairs of pulses (paired pulse stimulation, ppTMS) where two pulses are presented in rapid succession to study intracortical inhibition and facilitation. Trains of repeated TMS (rTMS) pulses can be applied at various stimulation frequencies and patterns to modulate local cortical excitability beyond the duration of the stimulation itself. Depending on the parameters of stimulation the excitability can be either facilitated or suppressed. TCS (including Transcranial Direct Current Stimulation (tDCS), alternating current (tACS), and random noise current stimulation (tRNS) also have the potential to modulate cortical excitability and have also been used to study and modulate cortical activity in healthy and patient populations. The after-effects of rTMS and TCS are thought to be related to changes in efficacy (in either the positive or negative direction) of synaptic connections of the neurons being stimulated, thus these techniques have been used to study and modulate cortical plasticity mechanisms in a number of populations. Recently, researchers have begun to apply these techniques to the study of neurodevelopmental mechanisms as well as the pathophysiology and development of novel treatments for neurodevelopmental disorders. Though there is much promise, caution is warranted given the vulnerability of pediatric and clinical populations and the potential that these techniques have to modify circuit development in a cortex that is in a very dynamic state. This Research Topic hopes to provide an opportunity to share ideas across areas (human and animal researchers, clinicians and basic scientists). We are particularly interested in papers that address issues of choosing a protocol (intensity, frequency, location, coil geometry etc.), populations where noninvasive brain stimulation may have direct impact on diagnostics and treatment, as well as the safety and ethics of applying these techniques in pediatric populations. As many may not be aware of the potential and limitations of noninvasive brain stimulation and its use for research and treatment in this area, this Research Topic promises to have broad appeal. Submissions for all Frontiers article types are encouraged.

Diagnosis, Management and Modeling of Neurodevelopmental Disorders

Diagnosis, Management and Modeling of Neurodevelopmental Disorders
The Neuroscience of Development

by Colin R. Martin,Victor R. Preedy,Rajkumar Rajendram

  • Publisher : Academic Press
  • Release : 2021-05-29
  • Pages : 624
  • ISBN : 0128179899
  • Language : En, Es, Fr & De
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Diagnosis, Management and Modeling of Neurodevelopmental Disorders: The Neuroscience of Development is a comprehensive reference on the diagnosis and management of neurodevelopment and associated disorders. The book discusses the mechanisms underlying neurological development and provides readers with a detailed introduction to the neural connections and complexities in biological circuitries, as well as the interactions between genetics, epigenetics and other micro-environmental processes. In addition, the book also examines the pharmacological and non-pharmacological interventions of development-related conditions. Provides the most comprehensive coverage of the broad range of topics relating to the neuroscience of aging Features sections on the genetics that influences aging and diseases of aging Contains an abstract, key facts, a mini dictionary of terms, and summary points in each chapter Focuses on neurological diseases and conditions linked to aging, environmental factors and clinical recommendations Includes more than 500 illustrations and tables

Frontiers in Brain Based Therapeutic Interventions and Biomarker Research in Child and Adolescent Psychiatry

Frontiers in Brain Based Therapeutic Interventions and Biomarker Research in Child and Adolescent Psychiatry
A Book

by Paul E. Croarkin,Stephanie H. Ameis

  • Publisher : Frontiers Media SA
  • Release : 2016-08-05
  • Pages : 107
  • ISBN : 2889199541
  • Language : En, Es, Fr & De
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Developmental neuroscience research is on the cusp of unprecedented advances in the understanding of how variations in brain structure and function within neural circuits confer risk for symptoms of childhood psychiatric disorders. Novel dimensional approaches to illness classification, the availability of non-invasive, diverse and increasingly sophisticated methods to measure brain structure and function in humans in vivo, and advances in genetics, animal model and multimodal research now place brain-based biomarkers within reach in the field of psychiatry. These advances hold great promise for moving neuroscience research into the clinical realm. One exciting new area of translational research in child and adolescent psychiatry, is in the use of a variety of neuroscience research tools to track brain response to clinical intervention. Examples of this include: using longitudinal neuroimaging techniques to track changes in white matter microstructure following a training intervention for children with poor reading skills, or using functional imaging to compare brain activity before and after children with bipolar disorder begin taking psychotropic medication treatment. Brain stimulation is another cutting-edge research area where brain response to therapeutic intervention can be closely tracked with electroencephalography or other brain imaging modalities. Research using neuroscience tools to track brain response to clinical interventions is beginning to yield novel insights into the etiopathogenesis of psychiatric illness, and is providing preliminary feedback around how therapeutic interventions work in the brain to bring about symptom improvement. Using these novel approaches, neuroscience research may soon move into the clinical realm to target early pathophysiology, and tailor treatments to both individuals and specific neurodevelopmental trajectories, in an effort to alter the course of development and mitigate risk for a lifetime of morbidity and ineffective treatments. Excitement and progress in these areas must be tempered with safety and ethical considerations for these vulnerable populations. This research topic focuses on efforts to use neuroscience research tools to identify brain-based biomarkers of therapeutic response in child and adolescent psychiatry.

Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences

Non Invasive Brain Stimulation in Psychiatry and Clinical Neurosciences
A Book

by Bernardo Dell'Osso,Giorgio Di Lorenzo

  • Publisher : Springer Nature
  • Release : 2020-09-01
  • Pages : 370
  • ISBN : 3030433560
  • Language : En, Es, Fr & De
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This book presents the state of the art regarding the use of non-invasive brain stimulation (TMS and tDCS) in the research and treatment of neuropsychiatric disorders. The contributions, all of which were prepared by internationally recognized experts in the field, are divided into two main sections (for TMS and tDCS, respectively) across diagnoses, following an introductory section on the mechanisms of action and neurophysiological background. Neuropsychological perspectives and approaches are provided as well. The book is ultimately intended to offer a unique, integrated approach to the use of non-invasive brain stimulation across the clinical neurosciences, providing a comprehensive and updated perspective that will benefit psychiatrists, neurologists, clinical psychologists and neurophysiologists alike.

Neuropsychiatry, An Issue of Psychiatric Clinics of North America, E-Book

Neuropsychiatry, An Issue of Psychiatric Clinics of North America, E-Book
A Book

by Vassilis E Koliatsos

  • Publisher : Elsevier Health Sciences
  • Release : 2020-05-26
  • Pages : 240
  • ISBN : 0323789528
  • Language : En, Es, Fr & De
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This issue of Psychiatric Clinics, guest edited by Dr. Vassilis E. Koliatsos will cover Neuropsychiatry. This issue is one of four each year selected by our series consulting editor, Dr. Harsh Trivedi of Sheppard Pratt Health System. Topics in this issue include: The clinical neurobiology of autism spectrum disorders; New developments in impulse control disorders; Schizophrenia as a neurodevelopmental phenotype; Neuropsychiatric Aspects of Epilepsy; New developments in addiction; The clinical neuroscience of acquired brain injury; New developments in frontotemporal dementia; Lewy body degenerations as neuropsychiatric disorders; Neuropsychiatric challenges in Alzheimer’s disease; and New pharmacological approaches in Neuropsychiatry, among others.

At Risk for Neuropsychiatric Disorders: An Affective Neuroscience Approach to Understanding the Spectrum

At Risk for Neuropsychiatric Disorders: An Affective Neuroscience Approach to Understanding the Spectrum

by Raymond C. K. Chan,Morten L. Kringelbach

  • Publisher : Frontiers Media SA
  • Release : 2016-11-17
  • Pages : 129
  • ISBN : 2889450260
  • Language : En, Es, Fr & De
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Neuropsychiatric disorders such as schizophrenia, bipolar disorder, depression, anxiety disorders, and other mental disorders constitute about 13% of the global burden of disease surpassing both cardiovascular disease and cancer. The total cost worldwide of these diseases is estimated to exceed 100 million disability-adjusted life years. In order to begin to address this important problem, the present Research Topic brings together a group of leading affective neuroscience researchers to present their state-of-the-art findings using an affective neuroscience approach to investigate the spectrum of neuropsychiatric disorders from patients to those at risk. They focus on different aspects of the emotional and social cognitive disturbances which are core features of neuropsychiatric disorders. While progress has been slow over last couple of decades, we are finally beginning to glimpse some of the underlying neural mechanisms of the emotional and social cognitive disturbances in patients and those at risk. With the technological advances in affective neuroscience and neuroimaging presented in this volume, we hope that progress will be much swifter in the coming years such that we can provide better care for patients and those at risk.

Neuroimaging in Developmental Clinical Neuroscience

Neuroimaging in Developmental Clinical Neuroscience
A Book

by Judith M. Rumsey,Monique Ernst

  • Publisher : Cambridge University Press
  • Release : 2009-02-19
  • Pages : 453
  • ISBN : 0521883571
  • Language : En, Es, Fr & De
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Covers normative structural and functional brain maturation and mechanisms underlying basic developmental processes through neuroimaging.

Neuroscience: Exploring the Brain, Enhanced Edition

Neuroscience: Exploring the Brain, Enhanced Edition
Exploring the Brain, Enhanced Edition

by Mark Bear,Barry Connors,Michael A. Paradiso

  • Publisher : Jones & Bartlett Learning
  • Release : 2020-03-25
  • Pages : 975
  • ISBN : 1284211282
  • Language : En, Es, Fr & De
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Acclaimed for its clear, friendly style, excellent illustrations, leading author team, and compelling theme of exploration, Neuroscience: Exploring the Brain, Fourth Edition takes a fresh, contemporary approach to the study of neuroscience, emphasizing the biological basis of behavior. The authors’ passion for the dynamic field of neuroscience is evident on every page, engaging students and helping them master the material. In just a few years, the field of neuroscience has been transformed by exciting new technologies and an explosion of knowledge about the brain. The human genome has been sequenced, sophisticated new methods have been developed for genetic engineering, and new methods have been introduced to enable visualization and stimulation of specific types of nerve cells and connections in the brain. The Fourth Edition has been fully updated to reflect these and other rapid advances in the field, while honoring its commitment to be student-friendly with striking new illustrati

The Oxford Handbook of Clinical Child and Adolescent Psychology

The Oxford Handbook of Clinical Child and Adolescent Psychology
A Book

by Thomas H. Ollendick,Susan W. White,Bradley A. White

  • Publisher : Oxford University Press
  • Release : 2018-11-13
  • Pages : 960
  • ISBN : 0190669764
  • Language : En, Es, Fr & De
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At the founding in 1896 of the first psychological clinic dedicated to children and adolescents, the study of the psychological treatment of young people lagged behind that of adults, and the basic psychopathology underlying mental disorders in this population was largely ignored. Since those early days, the field has evolved steadily and, in recent years, exponentially. The Oxford Handbook of Clinical Child and Adolescent Psychology is a state-of-the-science volume providing comprehensive coverage of the psychological problems and disorders of childhood. International in scope and penned by the discipline's most eminent scientists and practitioners, the handbook begins with a section on conceptual and empirical issues, followed by exceptional content on specific psychiatric disorders such as intellectual disability, externalizing and internalizing disorders, communication disorders, schizophrenia and bipolar disorder, personality disorders, and many more. The third section offers chapters on special problems in childhood and adolescence, including divorce, the incarceration of parents, suicide and non-suicidal self-injury, bullying, and medical illness. A fourth section covers delivery of clinical services in diverse settings, such as schools and prisons, and the handbook concludes with several chapters on emerging trends and future directions for the field. Conceptually rich and evidence-based, this handbook is an essential resource for students, practitioners, and researchers, providing a cutting-edge compendium of the latest theoretical and empirical developments by leaders of the discipline.

The Genetics of Neurodevelopmental Disorders

The Genetics of Neurodevelopmental Disorders
A Book

by Kevin J. Mitchell

  • Publisher : John Wiley & Sons
  • Release : 2015-07-21
  • Pages : 368
  • ISBN : 1118524993
  • Language : En, Es, Fr & De
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Neurodevelopmental disorders arise from disturbances to various processes of brain development, which can manifest in diverse ways. They encompass many rare genetic syndromes as well as common, heritable conditions such as intellectual disability, autism, ADHD, schizophrenia and many types of epilepsy. The Genetics of Neurodevelopmental Disorders examines recent revolutionary advances in our understanding of the genetics of these disorders, exploring both basic discoveries and the translation of new findings into the clinical setting. The book begins by examining the genetic architecture and etiology of neurodevelopmental disorders. It describes the striking recent progress in identifying pathogenic mutations, which are grouped here based on the neurodevelopmental processes impacted. Subsequent chapters consider the use of cellular and animal models to elucidate the cascading consequences of such mutations, from molecular and cellular levels to emergent effects on neural circuits, brain systems and subsequent psychological development. The text concludes by examining the important clinical implications of the recent advances in the field, from recognition of the genetic causes in individual patients to development of new treatments and interventions. A timely synthesis, The Genetics of Neurodevelopmental Disorders is a unique and essential resource for neuroscientists, geneticists, neurologists and psychiatrists and an accessible and up-to-date overview for medical and science students.

Application of Basic Neuroscience to Child Psychiatry

Application of Basic Neuroscience to Child Psychiatry
A Book

by S.I. Deutsch,A. Weizman,R. Weizman

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 420
  • ISBN : 146130525X
  • Language : En, Es, Fr & De
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The idea for this book developed during the course of several discussions among the editors while we were working together as staff scientists in the laboratories of the Clinical Neuro science Branch of the National Institute of Mental Health. It was a happy coincidence that the three of us, child psychiatrists with predominantly clinical interests, selected a collaborative bench research project involving neurotransmitter receptor characterization and regulation. We appreciated the relevance of our work to child psychiatry and wished for a forum to share the excitement we enjoyed in the laboratory with our clinical colleagues. Moreover, it seemed to us that much of the pharmacological research in child psychiatry proceeded on an empirical basis, often without a compelling neurochemical rationale. This could reflect the paucity of neurochemical data that exists in child psychiatry and the very limited understanding of the pathophysiology in most psychiatric disorders that occur in childhood. Also, we bemoaned the fact that there was a virtual absence of meaningful interchange between clinical investigators in child psychiatry and their colleagues in the neurosciences. We believed that an edited book appealing to clinicians and basic scientists could serve as an initial effort to foster interchange between them. The editors wish to emphasize that this book is viewed as only a beginning in the process of interchange that must take place.

Child and Adolescent Psychiatry

Child and Adolescent Psychiatry
Asian Perspectives

by Savita Malhotra,Paramala Santosh

  • Publisher : Springer
  • Release : 2016-11-25
  • Pages : 488
  • ISBN : 813223619X
  • Language : En, Es, Fr & De
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This is a comprehensive volume on issues and concerns relating to child and adolescent mental health in Asia, which includes contributions from experts in child psychiatry from Asia and other parts of the world. The chapters provide accurate and detailed accounts of the current state of knowledge integrating research approaches and findings from clinical studies. Each chapter discusses existing information, emphasizes areas of growth and provides fresh insights on a particular topic especially as these might relate to Asian populations. The book integrates various clinical and scientific perspectives on psychiatric disorders in children and adolescents with a focus on Asia. The various sections deal with important topics in child and adolescent psychiatry: the current understanding of mental disorders and the ways in which possible influences might work in the development of psychopathology; substance use disorders, their neurobiological correlates and implications for the developing brain; early environmental influences in the psychopathology of psychiatric disorders in children; issues of parenting, child rearing and cultural practices in Asia, which influence personality development and adaptation; life-long impact of early parental loss; early diagnosis and intervention in recognizing and treating psychopathology; psychopharmacology of neurodevelopmental disorders in children; non-pharmacological treatments for children; mental health gap, and telepsychiatry as an innovative model to provide services for children; and a pressing need for a comprehensive child mental health policy across nations.

Cognitive Neuroscience

Cognitive Neuroscience
A Book

by Marie T. Banich,Rebecca J. Compton

  • Publisher : Cambridge University Press
  • Release : 2018-04-05
  • Pages : 129
  • ISBN : 110854875X
  • Language : En, Es, Fr & De
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Updated fully, this accessible and comprehensive text highlights the most important theoretical, conceptual and methodological issues in cognitive neuroscience. Written by two experienced teachers, the consistent narrative ensures that students link concepts across chapters, and the careful selection of topics enables them to grasp the big picture without getting distracted by details. Clinical applications such as developmental disorders, brain injuries and dementias are highlighted. In addition, analogies and examples within the text, opening case studies, and 'In Focus' boxes engage students and demonstrate the relevance of the material to real-world concerns. Students are encouraged to develop the critical thinking skills that will enable them to evaluate future developments in this fast-moving field. A new chapter on Neuroscience and Society considers how cognitive neuroscience issues relate to the law, education, and ethics, highlighting the clinical and real-world relevance. An expanded online package includes a test bank.

Developmental Disorders of the Brain

Developmental Disorders of the Brain
A Book

by Nicole J. Rinehart,John L. Bradshaw,Peter G. Enticott

  • Publisher : Psychology Press
  • Release : 2016-10-14
  • Pages : 378
  • ISBN : 1317432665
  • Language : En, Es, Fr & De
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Developmental Disorders of the Brain: Brain and Behaviour addresses disabilities that occur or have their roots in the early, developmental phase of life which are of utmost concern to parents, siblings, carers and teachers. This text describes the latest clinical and behavioral findings of disorders which largely or entirely involve the frontostriatal (basal ganglia) system including Tourette’s, Obsessive-Compulsive and Attention-Deficit-Hyperactivity disorders, Schizophrenia, Autism, gambling and addiction, depression, and Conduct, Developmental Motor Co-ordination, and language disorders. Examples of disorders involving the frontocerebellar are also described such as Asperger’s disorder, Williams, Fragile X, and Cerebellar Cognitive Affective syndromes, and Friedreich Ataxia. This book also discusses the relevant anatomy, physiology and pathology, and some of the major functions mediated by affected or relevant structures, together with accounts of the latest recording, brain imaging and stimulating techniques related to these kinds of disorders. Covering both frontostriatal and frontocerebellar, systems which control and direct normal behavior, and which can fail with often distressing consequences during development, as well as addressing behavioural, clinical, pathophysiological and technical aspects, this text is vital to understanding, diagnosis and management of developmental disorders of the brain. This text will be of great interest to clinicians, researchers, teachers and parents.

New Frontiers in Noninvasive Brain Stimulation: Cognitive, Affective and Neurobiological Effects of Transcutaneous Vagus Nerve Stimulation

New Frontiers in Noninvasive Brain Stimulation: Cognitive, Affective and Neurobiological Effects of Transcutaneous Vagus Nerve Stimulation
A Book

by Mathias Weymar,Tino Zaehle

  • Publisher : Frontiers Media SA
  • Release : 2021-07-27
  • Pages : 129
  • ISBN : 2889710831
  • Language : En, Es, Fr & De
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Bradley's Neurology in Clinical Practice E-Book

Bradley's Neurology in Clinical Practice E-Book
A Book

by Joseph Jankovic,John C. Mazziotta,Scott L Pomeroy,Nancy J. Newman

  • Publisher : Elsevier Health Sciences
  • Release : 2021-03-23
  • Pages : 2400
  • ISBN : 0323642624
  • Language : En, Es, Fr & De
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A practical, dynamic resource for practicing neurologists, clinicians and trainees, Bradley and Daroff's Neurology in Clinical Practice, Eighth Edition, offers a straightforward style, evidence-based information, and robust interactive content supplemented by treatment algorithms and images to keep you up to date with all that’s current in this fast-changing field. This two-volume set is ideal for daily reference, featuring a unique organization by presenting symptom/sign and by specific disease entities—allowing you to access content in ways that mirror how you practice. More than 150 expert contributors, led by Drs. Joseph Jankovic, John C. Mazziotta, Scott L. Pomeroy, and Nancy J. Newman, provide up-to-date guidance that equips you to effectively diagnose and manage the full range of neurological disorders. Covers all aspects of today’s neurology in an easy-to-read, clinically relevant manner. Allows for easy searches through an intuitive organization by both symptom and grouping of diseases. Features new and expanded content on movement disorders, genetic and immunologic disorders, tropical neurology, neuro-ophthalmology and neuro-otology, palliative care, pediatric neurology, and new and emerging therapies. Offers even more detailed videos that depict how neurological disorders manifest, including EEG and seizures, deep brain stimulation for PD and tremor, sleep disorders, movement disorders, ocular oscillations, EMG evaluation, cranial neuropathies, and disorders of upper and lower motor neurons, as well as other neurologic signs.

New Oxford Textbook of Psychiatry

New Oxford Textbook of Psychiatry
A Book

by John R. Geddes,Nancy C. Andreasen,Guy M. Goodwin

  • Publisher : Oxford University Press
  • Release : 2020-03-25
  • Pages : 1472
  • ISBN : 0192514024
  • Language : En, Es, Fr & De
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Over its two editions, The New Oxford Textbook of Psychiatry has come to be regarded as one of the most popular and trusted standard psychiatry texts among psychiatrists and trainees. Bringing together 146 chapters from the leading figures in the discipline, it presents a comprehensive account of clinical psychiatry, with reference to its scientific basis and to the patient's perspective throughout. The New Oxford Textbook of Psychiatry, Third Edition has been extensively re-structured and streamlined to keep pace with the significant developments that have taken place in the fields of clinical psychiatry and neuroscience since publication of the second edition in 2009. The new edition has been updated throughout to include the most recent versions of the two main classification systems—-the DSM-5 and the ICD-11—-used throughout the world for the diagnosis of mental disorders. In the years since publication of the first edition, many new and exciting discoveries have occurred in the biological sciences, which are having a major impact on how we study and practise psychiatry. In addition, psychiatry has fostered closer ties with philosophy, and these are leading to healthy discussions about how we should diagnose and treat mental illness. This new edition recognises these and other developments. Throughout, accounts of clinical practice are linked to the underlying science, and to the evidence for the efficacy of treatments. Physical and psychological treatments, including psychodynamic approaches, are covered in depth. The history of psychiatry, ethics, public health aspects, and public attitudes to psychiatry and to patients are all given due attention.