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Neurotherapeutics in the Era of Translational Medicine

Neurotherapeutics in the Era of Translational Medicine
A Book

by Richard A. Smith,Brian K. Kaspar,Clive N. Svendsen

  • Publisher : Academic Press
  • Release : 2020-11-28
  • Pages : 518
  • ISBN : 0128172746
  • Language : En, Es, Fr & De
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For the first time in history, there is now hope for treating neurological disorders that had previously been considered untreatable. The remarkable confluence of events that has heralded this is the focus of Neurotherapeutics in the Era of Translational Medicine. This anthology, written by many of the prominent scientists and researchers in the field of biotechnology, recounts the breathtaking advances that are revolutionizing treatment for disorders such as amyotrophic lateral sclerosis‎, spinal muscular atrophy, multiple sclerosis, Parkinson’s disease, myasthenia gravis, migraine, and glioblastoma. The "story behind the story" of these translational efforts is told, with authors depicting the ups and downs encountered on the path of their drug discovery and development effort. In parallel with this path, advances in identifying novel biomarkers and disease models are summarized, as are contemporary issues focusing on clinical trial design, bioethics, innovative funding strategies, and collaborations between government and academia in an effort to facilitate breakthrough treatments. The book is written by members of the biotech and pharmaceutical ecosystem for those who belong to it and aspire to become part of it. Comprehensive review on the progress of translational research in neurotherapeutics for neurologic disorders Discusses important issues in clinical trials such as design and ethical issues Written for neuroscientists, neurologists and pharmacologists

NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE.

NEUROTHERAPEUTICS IN THE ERA OF TRANSLATIONAL MEDICINE.
A Book

by RICHARD A. SMITH

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 329
  • ISBN : 9780323907262
  • Language : En, Es, Fr & De
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Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2007: Testimony of members of Congress and other interested individuals and organizations

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2007: Testimony of members of Congress and other interested individuals and organizations
A Book

by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Mind Fixers: Psychiatry's Troubled Search for the Biology of Mental Illness

Mind Fixers: Psychiatry's Troubled Search for the Biology of Mental Illness
A Book

by Anne Harrington

  • Publisher : W. W. Norton & Company
  • Release : 2019-04-16
  • Pages : 384
  • ISBN : 1324001976
  • Language : En, Es, Fr & De
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Mind Fixers tells the history of psychiatry’s quest to understand the biological basis of mental illness and asks where we need to go from here. In Mind Fixers, Anne Harrington, author of The Cure Within, explores psychiatry’s repeatedly frustrated struggle to understand mental disorder in biomedical terms. She shows how the stalling of early twentieth century efforts in this direction allowed Freudians and social scientists to insist, with some justification, that they had better ways of analyzing and fixing minds. But when the Freudians overreached, they drove psychiatry into a state of crisis that a new “biological revolution” was meant to alleviate. Harrington shows how little that biological revolution had to do with breakthroughs in science, and why the field has fallen into a state of crisis in our own time. Mind Fixers makes clear that psychiatry’s waxing and waning biological enthusiasms have been shaped not just by developments in the clinic and lab, but also by a surprising range of social factors, including immigration, warfare, grassroots activism, and assumptions about race and gender. Government programs designed to empty the state mental hospitals, acrid rivalries between different factions in the field, industry profit mongering, consumerism, and an uncritical media have all contributed to the story as well. In focusing particularly on the search for the biological roots of schizophrenia, depression, and bipolar disorder, Harrington underscores the high human stakes for the millions of people who have sought medical answers for their mental suffering. This is not just a story about doctors and scientists, but about countless ordinary people and their loved ones. A clear-eyed, evenhanded, and yet passionate tour de force, Mind Fixers recounts the past and present struggle to make mental illness a biological problem in order to lay the groundwork for creating a better future, both for those who suffer and for those whose job it is to care for them.

Encyclopedia of Tissue Engineering and Regenerative Medicine

Encyclopedia of Tissue Engineering and Regenerative Medicine
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-06-03
  • Pages : 1418
  • ISBN : 0128137002
  • Language : En, Es, Fr & De
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Encyclopedia of Tissue Engineering and Regenerative Medicine provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

Monoclonal Antibodies in Headache

Monoclonal Antibodies in Headache
From Bench to Patient

by Antoinette Maassen van den Brink

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 3030690326
  • Language : En, Es, Fr & De
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From Symptom to Synapse

From Symptom to Synapse
A Neurocognitive Perspective on Clinical Psychology

by Jan Mohlman,Thilo Deckersbach,Adam Weissman

  • Publisher : Routledge
  • Release : 2015-01-30
  • Pages : 400
  • ISBN : 1135046662
  • Language : En, Es, Fr & De
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This edited volume bridges the gap between basic and applied science in understanding the nature and treatment of psychiatric disorders and mental health problems. Topics such as brain imaging, physiological indices of emotion, cognitive enhancement strategies, neuropsychological and cognitive training, and related techniques as tools for increasing our understanding of anxiety, depression, addictions, schizophrenia, ADHD, and other disorders are emphasized. Mental health professionals will learn how to integrate a neurocognitive perspective into their clinical research and practice of psychotherapy.

Brain Mapping

Brain Mapping
An Encyclopedic Reference

by Anonim

  • Publisher : Academic Press
  • Release : 2015-02-14
  • Pages : 2658
  • ISBN : 0123973163
  • Language : En, Es, Fr & De
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Brain Mapping: A Comprehensive Reference offers foundational information for students and researchers across neuroscience. With over 300 articles and a media rich environment, this resource provides exhaustive coverage of the methods and systems involved in brain mapping, fully links the data to disease (presenting side by side maps of healthy and diseased brains for direct comparisons), and offers data sets and fully annotated color images. Each entry is built on a layered approach of the content – basic information for those new to the area and more detailed material for experienced readers. Edited and authored by the leading experts in the field, this work offers the most reputable, easily searchable content with cross referencing across articles, a one-stop reference for students, researchers and teaching faculty. Broad overview of neuroimaging concepts with applications across the neurosciences and biomedical research Fully annotated color images and videos for best comprehension of concepts Layered content for readers of different levels of expertise Easily searchable entries for quick access of reputable information Live reference links to ScienceDirect, Scopus and PubMed

Neural Regenerative Nanomedicine

Neural Regenerative Nanomedicine
A Book

by Mehdi Razavi

  • Publisher : Academic Press
  • Release : 2020-07-21
  • Pages : 318
  • ISBN : 012820446X
  • Language : En, Es, Fr & De
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Neural Regenerative Nanomedicine presents novel, significant, experimental results relating to nanoscience and nanotechnology in neural regeneration. As current research is at the forefront of healing the nervous system, the content in the book focuses on basic, translational and clinical research in neural repair and regeneration. Chapters focus on stem cell biology to advance medical therapies for devastating disorders, the complex, delicate structures that make up the nervous system, and neurodegenerative diseases that cause progressive deterioration, including Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis and multiple system atrophy. Presents a multidisciplinary focus on all research areas surrounding the applications of nanotechnology in neural regeneration Provides a guide for physician and scientists, including necessary expertise for bioengineers, materials engineers, those in biomaterials and nanoengineering, stem cell biologists, and chemists Covers many disciplines, including bioengineering, biomaterials, tissue engineering, regenerative medicine, neural regenerative medicine, and nanomedicine

Mapping Psychopathology with fMRI and Effective Connectivity Analysis

Mapping Psychopathology with fMRI and Effective Connectivity Analysis

by Baojuan Li,Adeel Razi,Karl J. Friston

  • Publisher : Frontiers Media SA
  • Release : 2017-06-22
  • Pages : 329
  • ISBN : 2889452077
  • Language : En, Es, Fr & De
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There is a growing appreciation that many psychiatric (and neurological) conditions can be understood as functional disconnection syndromes – as reflected in aberrant functional integration and synaptic connectivity. This Research Topic considers recent advances in understanding psychopathology in terms of aberrant effective connectivity – as measured noninvasively using functional magnetic resonance imaging (fMRI). Recently, there has been increasing interest in inferring directed connectivity (effective connectivity) from fMRI data. Effective connectivity refers to the influence that one neural system exerts over another and quantifies the directed coupling among brain regions – and how they change with pathophysiology. Compared to functional connectivity, effective connectivity allows one to understand how brain regions interact with each other in terms of context sensitive changes and directed coupling – and therefore may provide mechanistic insights into the neural basis of psychopathology. Established models of effective connectivity include psychophysiological interaction (PPI), structural equation modeling (SEM) and dynamic causal modelling (DCM). DCM is unique because it explicitly models the interaction among brain regions in terms of latent neuronal activity. Moreover, recent advances in DCM such as stochastic and spectral DCM, make it possible to characterize the interaction between different brain regions both at rest and during a cognitive task.

Drug Repositioning

Drug Repositioning
Approaches and Applications for Neurotherapeutics

by Joel Dudley,Laura Berliocchi

  • Publisher : CRC Press
  • Release : 2017-07-14
  • Pages : 313
  • ISBN : 1482220849
  • Language : En, Es, Fr & De
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Nervous system diseases represent a major health concern worldwide. Although important financial and professional investment, their etiology and pathophysiology still remain mostly elusive. Moreover, the clinical need of disease-modifying therapies is still unmet. In the last decades, traditional R&D has failed in identifying new effective therapies in many medical areas and drug repositioning has recently emerged as a promising alternative strategy to de novo drug discovery to improve and accelerate therapeutic development. For the first time, Drug Repositioning: Approaches and Applications for Neurotherapeutics reviews history and advances in drug repositioning, with a special focus on therapeutics for nervous system diseases. International experts from Academia, Industry and Non-profit organisations will provide different views on drug repositioning advantages, challenges and specific applications, which will be covered for nervous system diseases including Alzheimer's, Parkinson's, Huntington's diseases, Amyotrophic Lateral Sclerosis, Spinal Muscular Atrophy, ischemic stroke, and psychiatric disorders. This book provides a balanced overview and synthesis of drug repositioning concept, methods and applications for neurotherapeutics. It represents a valuable resource for students, scientists and clinicians working in academic settings, industry and government agencies within the fields of neuroscience, pharmacology, neurology, pharmaceutical sciences, drug discovery and development.

Advancing Gene-Targeted Therapies for Central Nervous System Disorders

Advancing Gene-Targeted Therapies for Central Nervous System Disorders
Proceedings of a Workshop

by National Academies of Sciences, Engineering, and Medicine,Health and Medicine Division,Board on Health Sciences Policy,Forum on Neuroscience and Nervous System Disorders

  • Publisher : National Academies Press
  • Release : 2019-10-31
  • Pages : 92
  • ISBN : 0309495873
  • Language : En, Es, Fr & De
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On April 23 and 24, 2019 the Forum on Neuroscience and Nervous System Disorders convened a workshop titled "Advancing Gene-Targeted Therapies for Central Nervous System Disorders" in Washington, DC. This public workshop brought together experts and key stakeholders from academia, government, industry, philanthropic foundations, and disease/patient-focused nonprofit organizations to explore approaches for advancing the development of gene-targeted therapies for central nervous system (CNS) disorders, and implications of developing these therapies. Participants explored lessons learned from both successful and unsuccessful clinical development programs; new knowledge about the genetic underpinnings of brain disorders; the current status and future potential of gene-targeted therapies for CNS disorders; challenges and potential solutions for translating preclinical findings to approved therapies; and patient and caregiver perspectives. They also discussed what will be needed to develop these therapies for common disorders such as Alzheimer's and Parkinson's disease, as well as neuropsychiatric and neurodevelopmental disorders such as schizophrenia and autism. The workshop included approaches that target both DNA and RNA, as well as gene products using viral vectors, antisense oligonucleotides, and RNA interference. This publication summarizes the presentations and discussion of the workshop.

Direct Nose-to-Brain Drug Delivery

Direct Nose-to-Brain Drug Delivery
Mechanism, Technological Advances, Applications, and Regulatory Updates

by Chandrakantsing Pardeshi,Eliana Souto

  • Publisher : Academic Press
  • Release : 2021-06-25
  • Pages : 554
  • ISBN : 0128225238
  • Language : En, Es, Fr & De
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Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates provides the reader with precise knowledge about the strategies and approaches for enhanced nose to brain drug delivery. It highlights the development of novel nanocarrier-based drug delivery systems for targeted drug delivery to the brain microenvironments with a focus on the technological advances in the development of the novel drug delivery devices for intranasal administration, including special emphasis on brain targeting through nose. This book explores the various quantification parameters to assess the brain targeting efficiency following intranasal administration, includes an overview on the toxicity aspects of the various materials used to develop the direct nose to brain drug delivery vehicles and of the regulatory aspects including patents and current clinical status of the potential neurotherapeutics for the effective management of neuro-ailments. Technological advances in new drug delivery systems with diverse applications in pharmaceutical, biomedical, biomaterials, and biotechnological fields are also explained. Direct Nose to Brain Drug Delivery: Mechanism, Technological Advances, Applications and Regulatory Updates is a crucial source that will assist the veteran scientists, industrial technologists, and clinical research professionals to develop new drug delivery systems, and novel drug administration devices for the treatment of neuro-ailments. Explains the targeting approaches for enhanced brain targeting following intranasal drug administration Explores the various nanocarriers developed to date for neurotherapeutic delivery via nose to brain Discusses pharmaceutical and biomedical applications after nose to brain delivery of therapeutic pharmaceuticals and biologicals

Undoing Monogamy

Undoing Monogamy
The Politics of Science and the Possibilities of Biology

by Angela Willey

  • Publisher : Duke University Press
  • Release : 2016-05-13
  • Pages : 216
  • ISBN : 0822374218
  • Language : En, Es, Fr & De
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In Undoing Monogamy Angela Willey offers a radically interdisciplinary exploration of the concept of monogamy in U.S. science and culture, propelled by queer feminist desires for new modes of conceptualization and new forms of belonging. She approaches the politics and materiality of monogamy as intertwined with one another such that disciplinary ways of knowing themselves become an object of critical inquiry. Refusing to answer the naturalization of monogamy with a naturalization of nonmonogamy, Willey demands a critical reorientation toward the monogamy question in the natural sciences, social sciences, and humanities. The book examines colonial sexual science, monogamous voles, polyamory, and the work of Alison Bechdel and Audre Lorde to show how challenging the lens through which human nature is seen as monogamous or nonmonogamous forces us to reconsider our investments in coupling and in disciplinary notions of biological bodies.

Fragile X Syndrome

Fragile X Syndrome
From Genetics to Targeted Treatment

by Rob Willemsen,Frank Kooy

  • Publisher : Academic Press
  • Release : 2017-05-26
  • Pages : 498
  • ISBN : 0128045078
  • Language : En, Es, Fr & De
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Fragile X Syndrome: From Genetics to Targeted Treatment provides a structured overview of the molecular and clinical background of the disorder as well as treatment options. The book discusses the detailed molecular information on each of the pathways involved with sufficient details for all whose research touches this pathway. It provides a state-of-the-art update on all clinical aspects associated with this syndrome, including phenotype, diagnostics and epidemiology. It also includes an overview of the lessons learned from the preclinical research and pioneering trials on the fragile X syndrome for the investigators involved in clinical trials of neurodevelopmental disorders. This book is written for academic researchers, pharmaceutical investigators, and clinicians in the field who work on the disorder, and for researchers involved in clinical trials of the fragile X syndrome or related disorders. Provides a comprehensive overview of the molecular genetics, clinical trials, and treatment of Fragile X Syndrome Written for academic researchers, pharmaceutical investigators, and clinicians in the field Edited by international leaders in the field who have contributed greatly to the study of Fragile X Syndrome Directs the reader through complex issues surrounding FXS and draws the literature together for researchers and clinicians

Posthuman Cyberware

Posthuman Cyberware
Blurring the Boundaries of Mind, Body, and Computer

by Matthew E. Gladden

  • Publisher : Mnemoclave
  • Release : 2017-08-20
  • Pages : 40
  • ISBN : 1944373179
  • Language : En, Es, Fr & De
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You don’t know how far you can trust what you see or feel or remember, because it could all just be a byproduct of your neural implant or illusions fabricated by a neurohacker. Self-evolving computer viruses and stray nanorobotic swarms have taken up residence in the components of your robotic prosthetic arm. Battles over access to neurocybernetic enhancement, life-extension biotech, and immersive VR paradises are fragmenting humanity into new strata of haves and have-nots. You can never tell whether the full-body cyborgs that you see in the street belong to military units, megacorps, or bands of hackers-for-hire… or maybe all three at once. Such near-future cyberdystopias provide the perfect setting for a hard-SF roleplaying game campaign. But how much reality lies beneath their surface? Could a human mind really learn how to operate a full cyborg body that has wheels or wings or dozens of robotic tentacles, or would it be too ‘alien’? If relatively small changes in brain temperature can cause behavioral impacts (or even brain damage), is it advisable to implant a heat-spewing miniaturized supercomputer in someone’s cranium? A neural jack that lets you instantly download new skills sounds great, but could such a thing actually work? And which of your cognitive functions could a hacker take control of by compromising such a device? If you’ve ever thought about any of these questions when designing or running an adventure, then Mnemoclave’s Posthuman Cyberware Sourcebook series is meant for you. It’s designed especially for GMs who want to give their campaigns a grittier edge and loads of surprises that’ll keep their players on their toes – and for serious gamers who want to map out the potential and limitations of their characters’ cyberware from a new perspective. This first volume in the series offers an introduction to the use of neuroprostheses for sensory, cognitive, and motor enhancement and explores distinctions between posthuman and transhuman cyberware. It’s not simply a tale of artificial eyes with telescopic night vision or combat-grade cyberlimbs but also a blueprint for the development of neuroprosthetically enhanced imagination, emotions, and conscience and the creation of human-synthetic hive minds. The volume considers neuroprosthetic devices’ human hosts in their three roles as sapient minds, embodied organisms, and social and economic actors to explain how cyberware can be employed either as tools for personal empowerment and liberation or mechanisms of enslavement and zombification. The book serves as a resource for designing campaigns or one-off adventures set in worlds with a cyberpunk, postcyberpunk, or biopunk milieu in which posthumanizing cyberware exists and societies are tilting toward the dystopian. The text includes dozens of special inserts with plot hooks, character traits, equipment descriptions, and ideas regarding setting and atmosphere that help you incorporate the material directly into your game, regardless of which rule system you’re running.

Oxford Textbook of Neurological Surgery

Oxford Textbook of Neurological Surgery
A Book

by Ramez Kirollos,Peter Hutchinson,Adel Helmy,Simon Thomson

  • Publisher : Oxford University Press, USA
  • Release : 2019-09-05
  • Pages : 1176
  • ISBN : 0198746709
  • Language : En, Es, Fr & De
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Neurosurgery is a rapidly developing and technically demanding branch of surgery that requires a detailed knowledge of the basic neuro-sciences and a thorough clinical approach. The Oxford Textbook of Neurological Surgery is an up-to-date, objective and readable text that covers the full scope of neurosurgical practice. It is part of the Oxford Textbooks in Surgery series, edited by Professor Sir Peter Morris. The book is split into 20 overarching sections (Principles of Neurosurgery, Neuro-oncology of Intrinsic Tumours; Extra-axial Tumours and Skull Lesions; Cerebro-Pontine Angle Tumours; Sellar and Supra-Sellar Tumours; Posterior Fossa Tumours; Pineal tumours; Uncommon Tumours and Tumour Syndromes; Neurotrauma and Intensive Care; Vascular Neurosurgery; Principles of Spinal Surgery; Spinal Pathology; Spinal Trauma; Peripheral Nerve Surgery; Functional Neurosurgery; Epilepsy; Paediatric Neurosurgery; Neurosurgery for Cerebrospinal Fluid Disorders and Neurosurgical Infection). Each section takes a dual approach with, 'Generic Surgical Management' chapters that focus on specific clinical problems facing the neurosurgeon (e.g. sellar/supra-sellar tumour, Intradural Spina Tumours etc.) and 'Pathology-Specific' chapters (e.g. Glioma, Meningeal Tumours, Scoliosis and Spinal Deformity, Aneurysm etc.). Where appropriate, this division provides the reader with easily accessible information for both clinical problems which present in a regional fashion and specific pathologies. The generic chapters cover aspects such as operative approaches, neuroanatomy and nuances. Specifically each chapter in the book incorporates several strands. Firstly the fundamental neuroscience (anatomy, pathology, genetics etc.) that underlies the clinical practice. Secondly, a review of the requisite clinical investigations (e.g. angiography, electrodiagnostics, radiology). Thirdly, a thorough evidence based review of clinical practice. Following this a consideration of the key debates and controversies in the field with 'pro-' and 'con-' sections (e.g. minimally invasive spine surgery, microsurgical treatment of aneurysms) is provided. A summary of the key papers and clinical scales relevant to neurosurgery form the concluding part. The book is a 'one-stop' text for trainees and consultants in neurosurgery, residents, those preparing for sub-specialty exams and other professionals allied to surgery who need to gain an understanding of the field. It acts as both a point of reference to provide a focussed refresher for the experienced neurosurgeon as well as a trusted training resource.