Download NMR Metabolomics in Cancer Research Ebook PDF

NMR Metabolomics in Cancer Research

NMR Metabolomics in Cancer Research
A Book

by Miroslava Čuperlović-Culf

  • Publisher : Elsevier
  • Release : 2012-12-17
  • Pages : 446
  • ISBN : 1908818263
  • Language : En, Es, Fr & De
GET BOOK

The application of nuclear magnetic resonance (NMR) metabolomics in cancer research requires an understanding of the many possibilities that NMR metabolomics can offer, as well as of the specific characteristics of the cancer metabolic phenotype and the open questions in cancer research. NMR metabolomics in cancer research presents a detailed account of the NMR spectroscopy methods applied to metabolomics mixture analysis along with a discussion of their advantages and disadvantages. Following an overview of the potential use of NMR metabolomics in cancer research, the book begins with an examination of the cancer metabolic phenotype and experimental methodology, before moving on to cover data pre-processing and data analysis. Chapters in the latter part of the book look at dynamic metabolic profiling, biomarker discovery, and the application of NMR metabolomics for different types of cancer, before a concluding chapter discusses future perspectives in the field. Focused description of NMR spectroscopy needed by cancer biologists who are starting to use metabolomics Current overview of knowledge related to the cancer metabolic phenotype from the perspective of metabolomics applications Information about the best practices in NMR metabolomics experimentation and data preprocessing as applied to different sample types

NMR-based Metabolomics

NMR-based Metabolomics

by Hector C Keun

  • Publisher : Royal Society of Chemistry
  • Release : 2018-01-17
  • Pages : 368
  • ISBN : 184973643X
  • Language : En, Es, Fr & De
GET BOOK

This book describes the state of the art in the application of NMR spectroscopy to metabolomics and will be a key title for researchers and practitioners.

Cancer Metabolomics

Cancer Metabolomics
Methods and Applications

by Shen Hu

  • Publisher : Springer Nature
  • Release : 2021-05-03
  • Pages : 312
  • ISBN : 3030516520
  • Language : En, Es, Fr & De
GET BOOK

Cancer metabolomics is a rapidly evolving field that aims for a comprehensive dissection of the metabolic phenotypes and functional network of metabolites in human cancers. State of the art metabolomics tools have been developed and applied to studying cancer metabolism and developing metabolic targets for improved diagnosis, prognosis and therapeutic treatment of human cancers. Chapters are written by subject experts in the field of cancer metabolomics with cross-disciplinary contributions. Coverage includes advanced metabolomics technologies and methodologies, including chemical isotope labelling liquid chromatography - mass spectrometry, capillary ion chromatography - mass spectrometry, 2-D gas chromatography – mass spectrometry, capillary electrophoresis – mass spectrometry, nuclear magnetic resonance spectroscopy, shotgun lipidomics, tracer-based metabolomics, microbial metabolomics, mass spectrometry imaging for single cell metabolomics and functional metabolomics. In addition, the book highlights new discoveries in cancer metabolism such as hypoxia inducible factor pathway, isocitrate dehydrogenase 1 mutation and oncometabolites. Finally, contributors focus on the translational applications of metabolomics in human cancers such as glioma, head and neck cancer, and gastric cancer. This new volume will be a unique reference source for cancer researchers and promote applications of metabolomics in understanding cancer metabolism.

Methodologies for Metabolomics

Methodologies for Metabolomics
Experimental Strategies and Techniques

by Norbert W. Lutz,Jonathan V. Sweedler,Ron A. Wevers

  • Publisher : Cambridge University Press
  • Release : 2013-01-21
  • Pages : 129
  • ISBN : 1139619055
  • Language : En, Es, Fr & De
GET BOOK

Metabolomics, the global characterisation of the small molecule complement involved in metabolism, has evolved into a powerful suite of approaches for understanding the global physiological and pathological processes occurring in biological organisms. The diversity of metabolites, the wide range of metabolic pathways and their divergent biological contexts require a range of methodological strategies and techniques. Methodologies for Metabolomics provides a comprehensive description of the newest methodological approaches in metabolomic research. The most important technologies used to identify and quantify metabolites, including nuclear magnetic resonance and mass spectrometry, are highlighted. The integration of these techniques with classical biological methods is also addressed. Furthermore, the book presents statistical and chemometric methods for evaluation of the resultant data. The broad spectrum of topics includes a vast variety of organisms, samples and diseases, ranging from in vivo metabolomics in humans and animals to in vitro analysis of tissue samples, cultured cells and biofluids.

Cancer Metabolomics 2018

Cancer Metabolomics 2018
A Book

by Paula Guedes De Pinho,Márcia Carvalho,Joana Pinto

  • Publisher : MDPI
  • Release : 2019-09-03
  • Pages : 184
  • ISBN : 3039213458
  • Language : En, Es, Fr & De
GET BOOK

The metabolomics approach, defined as the study of all endogenously-produced low-molecular-weight compounds, appeared as a promising strategy to define new cancer biomarkers. Information obtained from metabolomic data can help to highlight disrupted cellular pathways and, consequently, contribute to the development of new-targeted therapies and the optimization of therapeutics. Therefore, metabolomic research may be more clinically translatable than other omics approaches, since metabolites are closely related to the phenotype and the metabolome is sensitive to many factors. Metabolomics seems promising to identify key metabolic pathways characterizing features of pathological and physiological states. Thus, knowing that tumor metabolism markedly differs from the metabolism of normal cells, the use of metabolomics is ideally suited for biomarker research. Some works have already focused on the application of metabolomic approaches to different cancers, namely lung, breast and liver, using urine, exhaled breath and blood. In this Special Issue we contribute to a more complete understanding of cancer disease using metabolomics approaches.

Proteomic and Metabolomic Approaches to Biomarker Discovery

Proteomic and Metabolomic Approaches to Biomarker Discovery
A Book

by Haleem J. Issaq,Timothy D. Veenstra

  • Publisher : Academic Press
  • Release : 2019-10-24
  • Pages : 504
  • ISBN : 0128197889
  • Language : En, Es, Fr & De
GET BOOK

Proteomic and Metabolomic Approaches to Biomarker Discovery, Second Edition covers techniques from both proteomics and metabolomics and includes all steps involved in biomarker discovery, from study design to study execution. The book describes methods and presents a standard operating procedure for sample selection, preparation and storage, as well as data analysis and modeling. This new standard effectively eliminates the differing methodologies used in studies and creates a unified approach. Readers will learn the advantages and disadvantages of the various techniques discussed, as well as potential difficulties inherent to all steps in the biomarker discovery process. This second edition has been fully updated and revised to address recent advances in MS and NMR instrumentation, high-field NMR, proteomics and metabolomics for biomarker validation, clinical assays of biomarkers and clinical MS and NMR, identifying microRNAs and autoantibodies as biomarkers, MRM-MS assay development, top-down MS, glycosylation-based serum biomarkers, cell surface proteins in biomarker discovery, lipodomics for cancer biomarker discovery, and strategies to design studies to identify predictive biomarkers in cancer research. Addresses the full range of proteomic and metabolomic methods and technologies used for biomarker discovery and validation Covers all steps involved in biomarker discovery, from study design to study execution Serves as a vital resource for biochemists, biologists, analytical chemists, bioanalytical chemists, clinical and medical technicians, researchers in pharmaceuticals and graduate students

An Omics Perspective on Cancer Research

An Omics Perspective on Cancer Research
A Book

by William C.S. Cho

  • Publisher : Springer Science & Business Media
  • Release : 2010-04-07
  • Pages : 269
  • ISBN : 9789048126750
  • Language : En, Es, Fr & De
GET BOOK

Omics is an emerging and exciting area in the field of science and medicine. Numerous promising developments have been elucidated using omics (including genomics, transcriptomics, epigenomics, proteomics, metabolomics, interactomics, cytomics and bioinformatics) in cancer research. The development of high-throughput technologies that permit the solution of deciphering cancer from higher dimensionality will provide a knowledge base which changes the face of cancer understanding and therapeutics. This is the first book to provide such a comprehensive coverage of a rapidly evolving area written by leading experts in the field of omics. It complies and details cutting-edge cancer research that covers the broad advances in the field and its application from cancer-associated gene discovery to drug target validation. It also highlights the potential of using integration approach for cancer research. This unique and timely book provides a thorough overview of developing omics, which will appeal to anyone involved in cancer research. It will be a useful reference book for graduate students of different subjects (medicine, biology, engineering, etc) and senior scientists interested in the fascinating area of advanced technologies in cancer research. Readership: This is a precious book for all types of readers – cancer researchers, oncologists, pathologists, biologists, clinical chemists, pharmacologists, pharmaceutical specialists, biostatisticians, and bioinformaticists who want to expand their knowledge in cancer research.

Applications of NMR Spectroscopy; Vol. 6

Applications of NMR Spectroscopy; Vol. 6
A Book

by Atta-ur- Rahman,M. Iqbal Choudhary

  • Publisher : Bentham Science Publishers
  • Release : 2017-12-04
  • Pages : 240
  • ISBN : 1681084392
  • Language : En, Es, Fr & De
GET BOOK

Applications of NMR Spectroscopy is a book series devoted to publishing the latest advances in the applications of nuclear magnetic resonance (NMR) spectroscopy in various fields of organic chemistry, biochemistry, health and agriculture. The sixth volume of the series features reviews focusing on NMR spectroscopic techniques for studying tautomerism, applications in medical diagnosis, in food chemistry and identifying secondary metabolites.

Cell-wide Metabolic Alterations Associated with Malignancy

Cell-wide Metabolic Alterations Associated with Malignancy
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2014-06-07
  • Pages : 384
  • ISBN : 0128014830
  • Language : En, Es, Fr & De
GET BOOK

This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo. Malignant cells exhibit metabolic changes when compared to their normal counterparts, owing to both genetic and epigenetic alterations. Although such a metabolic rewiring has recently been indicated as "yet another" general hallmark of cancer, accumulating evidence suggests that the metabolic alterations of each neoplasm rather represent a molecular signature that intimately accompanies, and hence cannot be severed from, all facets of malignant transformation. Continues the legacy of this premier serial with quality chapters authored by leaders in the field Covers research methods in biomineralization science Contains sections on such topics providing a a theoretical overview on metabolic alterations of cancer cells and a series of protocols that can be employed to study oncometabolism, in vitro, ex vivo and in vivo.

Metabolomics: From Fundamentals to Clinical Applications

Metabolomics: From Fundamentals to Clinical Applications
A Book

by Alessandra Sussulini

  • Publisher : Springer
  • Release : 2017-01-28
  • Pages : 350
  • ISBN : 3319476564
  • Language : En, Es, Fr & De
GET BOOK

This book provides a comprehensive view of metabolomics, from the basic concepts, through sample preparation and analytical methodologies, to data interpretation and applications in medicine. It is the first volume to cover metabolomics clinical applications while also emphasizing analytical and statistical features. Moreover, future trends and perspectives in clinical metabolomics are also presented. For researches already experienced in metabolomics, the book will be useful as an updated definitive reference. For beginners in the field and graduate students, the book will provide detailed information about concepts and experimental aspects in metabolomics, as well as examples and perspectives of applications of this strategy to clinical questions.

Practical Applications of Computational Biology & Bioinformatics, 15th International Conference (PACBB 2021)

Practical Applications of Computational Biology & Bioinformatics, 15th International Conference (PACBB 2021)
A Book

by Miguel Rocha,Florentino Fdez-Riverola,Mohd Saberi Mohamad,Roberto Casado-Vara

  • Publisher : Springer Nature
  • Release : 2021-08-27
  • Pages : 176
  • ISBN : 3030862585
  • Language : En, Es, Fr & De
GET BOOK

This book features novel research papers spanning many different subfields in bioinformatics and computational biology, presenting the latest research on the practical applications to promote fruitful interactions between young researchers in different areas related to the field. Clearly, biology is increasingly becoming a science of information, requiring tools from the computational sciences. To address these challenges, we have seen the emergence of a new generation of interdisciplinary scientists with a strong background in the biological and computational sciences. PACBB'21 expects to contribute to this effort by encouraging a successful collaboration of researchers in different areas related to bioinformatics. The PACBB'21 technical program included 17 papers covering many different subfields in bioinformatics and computational biology. Therefore, this conference, held in Salamanca (Spain), definitely promotes the collaboration of scientists from different research groups and with different backgrounds (computer scientists, mathematicians, biologists) to reach breakthrough solutions for these challenges.

Principles of Clinical Cancer Research

Principles of Clinical Cancer Research
A Book

by Loren K. Mell, MD,Phuoc T. Tran, MD, PhD,James B. Yu, MD, MHS,Qiang (Ed) Zhang, PhD

  • Publisher : Springer Publishing Company
  • Release : 2018-11-28
  • Pages : 576
  • ISBN : 1617052396
  • Language : En, Es, Fr & De
GET BOOK

Principles of Clinical Cancer Research provides comprehensive coverage of the fundamentals of clinical cancer research, including the full spectrum of methodologies used in the field. For those involved in research or considering research careers, this book offers a mix of practical advice and analytical tools for effective training in theoretical principles as well as specific, usable teaching examples. The clinical oncologist or trainee will find a high-yield, practical guide to the interpretation of the oncology literature and the application of data to real-world settings. Valuable for both researchers and clinicians who wish to sharpen their skills, this book contains all of the cornerstones and explanations needed to produce and recognize quality clinical science in oncology. Written from the physician-scientist’s perspective, the book lays a strong foundation in preclinical sciences that is highly relevant to careers in translational oncology research along with coverage of population and outcomes research and clinical trials. It brings together fundamental principles in oncology with the statistical concepts one needs to know to design and interpret studies successfully. With each chapter including perspectives of both clinicians and scientists or biostatisticians, Principles of Clinical Cancer Research provides balanced, instructive, and high-quality topic overviews and applications that are accessible and thorough for anyone in the field. KEY FEATURES: Gives real-world examples and rationales behind which research methods to use when and why Includes numerous tables featuring key statistical methods and programming commands used in everyday clinical research Contains illustrative practical examples and figures in each chapter to help the reader master concepts Provides tips and pointers for structuring a career, avoiding pitfalls, and achieving success in the field of clinical cancer research Access to fully downloadable eBook

Updates in Liver Cancer

Updates in Liver Cancer
A Book

by Hesham Abdeldayem

  • Publisher : BoD – Books on Demand
  • Release : 2017-04-05
  • Pages : 222
  • ISBN : 9535130633
  • Language : En, Es, Fr & De
GET BOOK

Liver cancers result in considerable amount of financial and social burden. On the other hand, researches and clinical studies related to liver cancers continue to advance at a rapid pace. The chapters in this book provide state-of-the-art reviews on the current knowledge and advances in research and management of liver cancers. It includes the most recent advances in that field, particularly, hepatocarcinogenesis and the potential role of intestinal microbiota, nonalcoholic steatohepatitis, cancer stem cells, aldehyde dehydrogenase-1, and hepatitis B virus. This book also discusses the methods of diagnosis of HCC, the minimally invasive therapies for liver cancers, living donor liver transplantation for HCC, surgical management of liver metastases from colorectal cancers, and assessment and optimization for the future liver remnant.

The Handbook of Metabonomics and Metabolomics

The Handbook of Metabonomics and Metabolomics
A Book

by John C. Lindon,Jeremy K. Nicholson,Elaine Holmes

  • Publisher : Elsevier
  • Release : 2011-08-11
  • Pages : 572
  • ISBN : 9780080468006
  • Language : En, Es, Fr & De
GET BOOK

Molecular biology operates at three levels – genes, proteins and metabolites. This book is unique in that it provides a comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies (genomics and proteomics). These "omics" methods form the basis for understanding biology at a systems level. The Handbook of Metabonomics and Metabolomics aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification, encompassing the fields of metabonomics and metabolomics. It covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications. * comprehensive description of an approach (metabonomics) to characterise the endogenous metabolites in a living system, complementing gene and protein studies * aims to be the definitive work on the rapidly expanding subjects of metabolic profiling, metabolite and biomarker identification * covers the principles of the subject, the analytical and statistical techniques used and the wide variety of applications.

Biomechanics of Cells and Tissues

Biomechanics of Cells and Tissues
Experiments, Models and Simulations

by Paola Lecca

  • Publisher : Springer Science & Business Media
  • Release : 2013-01-18
  • Pages : 168
  • ISBN : 9400758901
  • Language : En, Es, Fr & De
GET BOOK

The application of methodological approaches and mathematical formalisms proper to Physics and Engineering to investigate and describe biological processes and design biological structures has led to the development of many disciplines in the context of computational biology and biotechnology. The best known applicative domain is tissue engineering and its branches. Recent domains of interest are in the field of biophysics, e.g.: multiscale mechanics of biological membranes and films and filaments; multiscale mechanics of adhesion; biomolecular motors and force generation. Modern hypotheses, models, and tools are currently emerging and resulting from the convergence of the methods and phylosophycal apporaches of the different research areas and disciplines. All these emerging approaches share the purpose of disentangling the complexity of organisms, tissues, and cells and mimiking the function of living systems. The contributions presented in this book are current research highlights of six challenging and representative applicative domains of phyisical, engineering, and computational approaches in medicine and biology, i.e tissue engineering, modelling of molecular structures, cell mechanics and cell adhesión processes, cancer physics, and physico-chemical processes of metabolic interactions. Each chapter presents a compendium or a review of the original results achieved by authors in the last years. Furthermore, the book also wants to pinpoint the questions that are still open and that could propel the future research.

Issues in Biochemistry and Biomaterials: 2013 Edition

Issues in Biochemistry and Biomaterials: 2013 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-05-01
  • Pages : 1200
  • ISBN : 1490108645
  • Language : En, Es, Fr & De
GET BOOK

Issues in Biochemistry and Biomaterials / 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Molecular Biotechnology. The editors have built Issues in Biochemistry and Biomaterials: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Biotechnology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Biochemistry and Biomaterials: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Bioinformatics

Bioinformatics
Concepts, Methodologies, Tools, and Applications

by Information Resources Management Association

  • Publisher : IGI Global
  • Release : 2013-03-31
  • Pages : 1246
  • ISBN : 146663605X
  • Language : En, Es, Fr & De
GET BOOK

"Bioinformatics: Concepts, Methodologies, Tools, and Applications highlights the area of bioinformatics and its impact over the medical community with its innovations that change how we recognize and care for illnesses"--Provided by publisher.

The Funding of Biopharmaceutical Research and Development

The Funding of Biopharmaceutical Research and Development
A Book

by David R Williams

  • Publisher : Elsevier
  • Release : 2013-10-31
  • Pages : 284
  • ISBN : 1908818387
  • Language : En, Es, Fr & De
GET BOOK

The funding of biopharmaceutical research and development provides a comprehensive critical review of the funding of research and development (R&D) in the human biopharmaceutical market sector. It addresses both private and public funding sources available in the US and internationally. The biopharmaceutical market is among the most research-intensive market sectors globally. Clinical researchers face a multitude of public and private funding options with respect to bringing their idea or innovation to market. These funding options are continually changing and complex, and are expected to decrease in the near future. A lack of understanding of the scale, scope, and inner workings of the funding aspects of R&D can, at times, act as a barrier for all involved, and can slow down or even eliminate the R&D process. The book lessens these barriers by describing the theoretical underpinnings, present practice, and trends in R&D funding in this market sector, both in the US and internationally. This includes a review and discussion of public-private partnership activity and their inner-workings, noting the complementary relationship between public and private funding. The book also contains an overview of the inner-workings of strategic alliance activity, including the advantages and disadvantages for each party. It goes on to provide an outline of venture capital activity, detailing the methods by which venture capital firms raise capital and are organized, a description of the venture capital-entrepreneur arrangement, and the effects of this arrangement. The book also presents an overview of the IPO process and the various fates of firms going public. Presents a comprehensive view of the funding issues of R&D in this market sector, adopting a theory-to-practice approach A comprehensive and analytical review of the biopharmaceutical R&D literature and practice An overview of the various and competing/complementary theories of the firm and valuation methods as they apply to biopharmaceutical R&D

Imaging of Brain Tumors, An Issue of Magnetic Resonance Imaging Clinics of North America,

Imaging of Brain Tumors, An Issue of Magnetic Resonance Imaging Clinics of North America,
A Book

by Rivka R. Colen

  • Publisher : Elsevier Health Sciences
  • Release : 2016-10-15
  • Pages : 129
  • ISBN : 0323459765
  • Language : En, Es, Fr & De
GET BOOK

This issue of MRI Clinics of North America focuses on Imaging of Brain Tumors, and is edited by Dr. Rivka Colen. Articles will include: Multiparametric Imaging Analysis: MR Spectroscopy; Genomics and MicroRNAs in Glioma; Metabolomics and Hyperpolarization MRI in Brain Tumors; Imaging Genomics in Glioma; Radiomics and Big Data in Imaging; RANO Criteria and Clinical Endpoints; Gliomas: The New WHO Brain Tumor Pathological/Molecular Classification and Clinical and Radiographic Classifications; Liposomal Contrast Agents and Nanoparticles in Brain Tumor Imaging; Multiparametric Imaging Analysis: Perfusion, and more!

Applications of NMR Spectroscopy:

Applications of NMR Spectroscopy:
A Book

by Atta-ur-Rahman,M. Iqbal Choudhary

  • Publisher : Elsevier
  • Release : 2015-12-11
  • Pages : 280
  • ISBN : 1681080621
  • Language : En, Es, Fr & De
GET BOOK

Applications of NMR Spectroscopy, Volume 3 presents the latest developments in the field of NMR spectroscopy, including the analysis of the structure-property relationship of polyphenols, breast cancer diagnosis, drug discovery and formulation, protein confirmation analysis using Fluorine NMR, and enaminone studies. The well-illustrated chapters contain comprehensive references to the recent literature. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. The book is organized into sections based on disciplines such as food science and medical diagnostics, with each chapter written by eminent experts in the field. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference. Consolidates the latest developments in NMR spectroscopy into a single volume Authored and edited by world-leading experts in spectroscopy Features comprehensive references to the most recent related literature More than 75 illustrations aid in the retention of key concepts