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NMR Spectroscopy in Pharmaceutical Analysis

NMR Spectroscopy in Pharmaceutical Analysis
A Book

by Iwona Wawer,Bernd Diehl

  • Publisher : Elsevier
  • Release : 2017-07-07
  • Pages : 528
  • ISBN : 008095152X
  • Language : En, Es, Fr & De
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For almost a decade, quantitative NMR spectroscopy (qNMR) has been established as valuable tool in drug analysis. In all disciplines, i. e. drug identification, impurity profiling and assay, qNMR can be utilized. Separation techniques such as high performance liquid chromatography, gas chromatography, super fluid chromatography and capillary electrophoresis techniques, govern the purity evaluation of drugs. However, these techniques are not always able to solve the analytical problems often resulting in insufficient methods. Nevertheless such methods find their way into international pharmacopoeias. Thus, the aim of the book is to describe the possibilities of qNMR in pharmaceutical analysis. Beside the introduction to the physical fundamentals and techniques the principles of the application in drug analysis are described: quality evaluation of drugs, polymer characterization, natural products and corresponding reference compounds, metabolism, and solid phase NMR spectroscopy for the characterization drug substances, e.g. the water content, polymorphism, and drug formulations, e.g. tablets, powders. This part is accompanied by more special chapters dealing with representative examples. They give more detailed information by means of concrete examples. Combines theory, techniques, and concrete applications—all of which closely resemble the laboratory experience Considers international pharmacopoeias, addressing the concern for licensing Features the work of academics and researchers, appealing to a broad readership

NMR Spectroscopy in Drug Development and Analysis

NMR Spectroscopy in Drug Development and Analysis
A Book

by Ulrike Holzgrabe,Iwona Wawer,Bernd Diehl

  • Publisher : John Wiley & Sons
  • Release : 2008-07-11
  • Pages : 312
  • ISBN : 352761365X
  • Language : En, Es, Fr & De
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Since the development of the NMR spectrometer in the 1950s, NMR spectra have been widely used for the elucidation of the 2D structure of newly synthesized and natural compounds. In the 1980s, the high-resolution NMR spectrometer (> 300 Mhz) and 2D experiments were introduced, which opens up the possibility to determine the 3D structure of large molecules, especially biomolecules. However, NMR spectroscopy has been rarely applied to drug analysis. This book illustrates the power and versatility of NMR spectroscopy in the determination of impurities in and the content of drugs, the composition of polymer excipients, the characterization of isomeric drug mixtures, the complexity of drugs with small-size components or ions, and the behavior of drugs in acid and basic solution. In addition, NMR spectroscopy and especially the hyphenated technique with HPLC is shown to be a powerful tool to measure a drug and its metabolites in various body fluids. The solid state NMR technique can give information on the structure, especially the conformation of drugs and excipients in drug formulations. Recently, SAR by NMR, introduced by Fesik, impressively demonstrated the potential of NMR spectroscopy in drug development and in the characterization of the interaction between large molecules and ligands. The complexation between proteins, lipids and cyclodextrins with drugs is described. Finally, NMR imaging (MRI and MRS) can be used to characterize the liberation of drugs from a drug formulation. Furthermore, the distribution of substances in plants, in animals, in tissues and in humans can be visualized by imaging. In short, this book covers all aspects of drug analysis.

Pharmaceutical Analysis

Pharmaceutical Analysis
A Book

by David C Lee,Michael L. Webb

  • Publisher : John Wiley & Sons
  • Release : 2009-02-12
  • Pages : 384
  • ISBN : 1405172991
  • Language : En, Es, Fr & De
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The use of analytical sciences in the discovery, development andmanufacture of pharmaceuticals is wide-ranging. From the analysisof minute amounts of complex biological materials to the qualitycontrol of the final dosage form, the use of analytical technologycovers an immense range of techniques and disciplines. This book concentrates on the analytical aspects of drugdevelopment and manufacture, focusing on the analysis of the activeingredient or drug substance. It provides those joining theindustry or other areas of pharmaceutical research with a source ofreference to a broad range of techniques and their applications,allowing them to choose the most appropriate analytical techniquefor a particular purpose. The volume is directed at analytical chemists, industrialpharmacists, organic chemists, pharmaceutical chemists andbiochemists.

Coupling of Capillary Electrophoresis with Nuclear Magnetic Resonance Spectroscopy for the Analysis of Pharmaceutical and Environmental Relevant Compounds

Coupling of Capillary Electrophoresis with Nuclear Magnetic Resonance Spectroscopy for the Analysis of Pharmaceutical and Environmental Relevant Compounds
A Book

by Joana Diekmann

  • Publisher : GRIN Verlag
  • Release : 2011-03-21
  • Pages : 107
  • ISBN : 3640873394
  • Language : En, Es, Fr & De
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Master's Thesis from the year 2009 in the subject Chemistry - Analytical Chemistry, grade: 1,0, University of Hannover (Anorganische Chemie), language: English, abstract: Separation and identification of mass-limited chemical samples is the key to understand the complex nature of pharmaceutical and environmental systems. High efficiency separation techniques, such as capillary electrophoresis (CE), coupled to a non-destructive, information-rich detection, such as nuclear magnetic resonance (NMR) spectroscopy, have revolutionized the ability to separate and identify components in small sample volumes. Using this hyphenated system, structure elucidation of analytes separated during an electrophoretic process can be performed using NMR as an on-line detector. Although sensitivity remains an issue for on-line NMR detection, capillary NMR spectroscopy using microcoils has emerged as a major breakthrough for increasing the mass-sensitivity of NMR spectroscopy, because the limit of detection is proportional to the coil diameter. A further development is the miniaturization of the magnet enabling the possibility of a truly portable NMR system. This portable, low-cost NMR sensor, coupled to the rapid CE separation system could enable high-throughput and on-site identification of nanoliter amounts of solution. Furthermore, CE can provide on-line pre-concentration via electrokinetic injection or other stacking techniques to increase the sample concentration. In this research, coupling CE to a laboratory-scale NMR and to a portable NMR system are investigated, with the emphasis on the development of the miniaturized system. For the experiments with the large-scale 1H NMR system, a group of selected uric acids and xan- thines are studied since those compounds are representative of various classes of therapeutical drugs. The portable NMR instrument incorporates lithographically patterned microcoils and a small 1.8 T permanent magnet to measure 19F NMR spectra for the analysis of trifluoroacetic acid (TFA) and longer chain perfluorinated carboxylic acids (PFCAs). Our results demonstrate that coupling CE to a portable NMR system is feasible and can provide a low cost method to obtain structural information about the samples of interest. The results confirm that it was possible to acquire congruent sample data using the ultraviolet/visible (UV/VIS) detector of the CE and the 19F NMR detector. To obtain data, CE and NMR conditions were optimized and different modes of data acquisition were investigated.

Spectroscopic Analyses

Spectroscopic Analyses
Developments and Applications

by Eram Sharmin,Fahmina Zafar

  • Publisher : BoD – Books on Demand
  • Release : 2017-12-06
  • Pages : 240
  • ISBN : 9535136275
  • Language : En, Es, Fr & De
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The book presents developments and applications of these methods, such as NMR, mass, and others, including their applications in pharmaceutical and biomedical analyses. The book is divided into two sections. The first section covers spectroscopic methods, their applications, and their significance as characterization tools; the second section is dedicated to the applications of spectrophotometric methods in pharmaceutical and biomedical analyses. This book would be useful for students, scholars, and scientists engaged in synthesis, analyses, and applications of materials/polymers.

NMR in Pharmaceutical Science

NMR in Pharmaceutical Science
A Book

by Jeremy R. Everett,Robin K. Harris,John C. Lindon,Ian D. Wilson

  • Publisher : John Wiley & Sons
  • Release : 2015-08-24
  • Pages : 504
  • ISBN : 1118660234
  • Language : En, Es, Fr & De
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NMR in Pharmaceutical Sciences is intended to be a comprehensive source of information for the many individuals that utilize MR in studies of relevance to the pharmaceutical sector. The book is intended to educate and inform those who develop and apply MR approaches within the wider pharmaceutical environment, emphasizing the toolbox that is available to spectroscopists and radiologists. This book is structured on the key processes in drug discovery, development and manufacture, but underpinned by an understanding of fundamental NMR principles and the unique contribution that NMR (including MRI) can provide. After an introductory chapter, which constitutes an overview, the content is organised into five sections. The first section is on the basics of NMR theory and relevant experimental methods. The rest follow a sequence based on the chronology of drug discovery and development, firstly 'Idea to Lead' then 'Lead to Drug Candidate', followed by 'Clinical Development', and finally 'Drug Manufacture'. The thirty one chapters cover a vast range of topics from analytical chemistry, including aspects involved in regulatory matters and in the prevention of fraud, to clinical imaging studies. Whilst this comprehensive volume will be essential reading for many scientists based in pharmaceutical and related industries, it should also be of considerable value to a much wider range of academic scientists whose research is related to the various aspects of pharmaceutical R&D; for them it will supply vital understanding of pharmaceutical industrial concerns and the basis of key decision making processes. About eMagRes Handbooks eMagRes (formerly the Encyclopedia of Magnetic Resonance) publishes a wide range of online articles on all aspects of magnetic resonance in physics, chemistry, biology and medicine. The existence of this large number of articles, written by experts in various fields, is enabling the publication of a series of eMagRes Handbooks on specific areas of NMR and MRI. The chapters of each of these handbooks will comprise a carefully chosen selection of eMagRes articles. In consultation with the eMagRes Editorial Board, the eMagRes handbooks are coherently planned in advance by specially-selected Editors, and new articles are written to give appropriate complete coverage. The handbooks are intended to be of value and interest to research students, postdoctoral fellows and other researchers learning about the scientific area in question and undertaking relevant experiments, whether in academia or industry. Have the content of this handbook and the complete content of eMagRes at your fingertips! Visit: www.wileyonlinelibrary.com/ref/eMagRes

Quantitative NMR Spectroscopy in Pharmaceuticals

Quantitative NMR Spectroscopy in Pharmaceuticals
Method Development and Validation of Some Pharmaceuticals by Modern Analytical Techniques

by Kalpesh S. Parikh,Hemant H. Gadape

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2012-03
  • Pages : 268
  • ISBN : 9783845478845
  • Language : En, Es, Fr & De
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Over the past fifty years nuclear magnetic resonance spectroscopy, commonly referred to as NMR, has become the preeminent technique for structure determination of organic compounds. With developments in both methodology and instrumentation in the past two decades, NMR has become one of the most powerful and versatile spectroscopic techniques for characterization and quantification. An increasing concern with the well being of individuals and life in general has led to initiatives for improvements in medicine and the world environment, and in these areas analytical chemistry has particularly vital roles to play. Where new drugs or materials with potential commercial value are synthesized, a complete chemical characterization may be required involving considerable analytical work. More than any other analytical method the NMR spectroscopy provides information about the chemical structure and the dynamics of organic molecules. NMR spectroscopy is by definition a quantitative spectroscopic tool because the intensity of a resonance line is directly proportional to the number of resonant nuclei (spins). This fact enables accurate and precise determinations of the amount of substance.

Structure-activity Relationship Studies in Drug Development by NMR Spectroscopy

Structure-activity Relationship Studies in Drug Development by NMR Spectroscopy
Volume 1

by Atta-ur- Rahman,M. Iqbal Choudhary

  • Publisher : Bentham Science Publishers
  • Release : 2011
  • Pages : 214
  • ISBN : 1608051641
  • Language : En, Es, Fr & De
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"NMR (Nuclear Magnetic Resonance) Spectroscopy has found significant applications in drug discovery based on its capacity to map molecular interactions at the atomic level. Chemical shifts, cross relaxation, and exchange of protons are among the NMR parame"

Process Analytical Technology

Process Analytical Technology
Spectroscopic Tools and Implementation Strategies for the Chemical and Pharmaceutical Industries

by Katherine A. Bakeev

  • Publisher : John Wiley & Sons
  • Release : 2010-04-01
  • Pages : 576
  • ISBN : 0470689609
  • Language : En, Es, Fr & De
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Process Analytical Technology explores the concepts of PAT and its application in the chemical and pharmaceutical industry from the point of view of the analytical chemist. In this new edition all of the original chapters have been updated and revised, and new chapters covering the important topics of sampling, NMR, fluorescence, and acoustic chemometrics have been added. Coverage includes: Implementation of Process Analytical Technologies UV-Visible Spectroscopy for On-line Analysis Infrared Spectroscopy for Process Analytical Applications Process Raman Spectroscopy Process NMR Spectrscopy: Technology and On-line Applications Fluorescent Sensing and Process Analytical Applications Chemometrics in Process Analytical Technology (PAT) On-Line PAT Applications of Spectroscopy in the Pharmaceutical Industry Future Trends for PAT for Increased Process Understanding and Growing Applications in Biomanufacturing NIR Chemical Imaging This volume is an important starting point for anyone wanting to implement PAT and is intended not only to assist a newcomer to the field but also to provide up-to-date information for those who practice process analytical chemistry and PAT. It is relevant for chemists, chemical and process engineers, and analytical chemists working on process development, scale-up and production in the pharmaceutical, fine and specialty chemicals industries, as well as for academic chemistry, chemical engineering, chemometrics and pharmaceutical science research groups focussing on PAT. Review from the First Edition “The book provides an excellent first port of call for anyone seeking material and discussions to understand the area better. It deserves to be found in every library that serves those who are active in the field of Process Analytical Technology.”—Current Engineering Practice

Natural Products Analysis

Natural Products Analysis
Instrumentation, Methods, and Applications

by Vladimir Havlicek,Jaroslav Spizek

  • Publisher : John Wiley & Sons
  • Release : 2014-09-17
  • Pages : 624
  • ISBN : 1118876024
  • Language : En, Es, Fr & De
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This book highlights analytical chemistry instrumentation andpractices applied to the analysis of natural products and theircomplex mixtures, describing techniques for isolating andcharacterizing natural products. • Applies analytical techniques to natural productsresearch – an area of critical importance to drugdiscovery • Offers a one-stop shop for most analytical methods:x-ray diffraction, NMR analysis, mass spectrometry, and chemicalgenetics • Includes coverage of natural products basics andhighlights antibacterial research, particularly important asefforts to combat drug resistance gain prominence • Covers instrumental techniques with enough detail forboth current practitioners and beginning researchers

Pharmaceutical Drug Analysis

Pharmaceutical Drug Analysis
A Book

by Ashutosh Kar

  • Publisher : New Age International
  • Release : 2005-12
  • Pages : 554
  • ISBN : 9788122415827
  • Language : En, Es, Fr & De
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About the Book: During the past two decades, there have been magnificent and significant advances in both analytical instrumentation and computerized data handling devices across the globe. In this specific context the remarkable proliferation of windows

Analysis of Drug Impurities

Analysis of Drug Impurities
A Book

by Richard J. Smith,Michael L. Webb

  • Publisher : John Wiley & Sons
  • Release : 2008-04-15
  • Pages : 288
  • ISBN : 0470994223
  • Language : En, Es, Fr & De
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A key component of the overall quality of a pharmaceutical is control of impurities, as their presence, even in small amounts, may affect drug safety and efficacy. The identification and quantification of impurities to acceptable standards presents a significant challenge to the analytical chemist. Analytical science is developing rapidly and provides increasing opportunity to identify the structure, and therefore the origin and safety implications of these impurities, and the challenges of their measurement drives the development of modern quantitative methods. Written for both practicing and student analytical chemists, Analysis of Drug Impurities provides a detailed overview of the challenges and the techniques available to permit accurate identification and quantification of drug impurities.

Applications of NMR Spectroscopy:

Applications of NMR Spectroscopy:
A Book

by Atta-ur-Rahman,M. Iqbal Choudhary

  • Publisher : Elsevier
  • Release : 2015-12-11
  • Pages : 280
  • ISBN : 1681080621
  • Language : En, Es, Fr & De
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Applications of NMR Spectroscopy, Volume 3 presents the latest developments in the field of NMR spectroscopy, including the analysis of the structure-property relationship of polyphenols, breast cancer diagnosis, drug discovery and formulation, protein confirmation analysis using Fluorine NMR, and enaminone studies. The well-illustrated chapters contain comprehensive references to the recent literature. The content is ideal for readers who are seeking reviews and updates, as it consolidates scientific articles of a diverse nature into a single volume. The book is organized into sections based on disciplines such as food science and medical diagnostics, with each chapter written by eminent experts in the field. The applications presented cover a wide range of the field, such as drug development, medical imaging and diagnostics, food science, mining, petrochemical, process control, materials science, and chemical engineering, making this resource a multi-disciplinary reference. Consolidates the latest developments in NMR spectroscopy into a single volume Authored and edited by world-leading experts in spectroscopy Features comprehensive references to the most recent related literature More than 75 illustrations aid in the retention of key concepts

Annual Reports on NMR Spectroscopy

Annual Reports on NMR Spectroscopy
A Book

by Graham A. Webb

  • Publisher : Academic Press
  • Release : 2014-07-22
  • Pages : 376
  • ISBN : 0128003278
  • Language : En, Es, Fr & De
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Nuclear magnetic resonance (NMR) is an analytical tool used by chemists and physicists to study the structure and dynamics of molecules. In recent years, no other technique has gained such significance as NMR spectroscopy. It is used in all branches of science in which precise structural determination is required and in which the nature of interactions and reactions in solution is being studied. Annual Reports on NMR Spectroscopy has established itself as a premier means for the specialist and non-specialist alike to become familiar with new techniques and applications of NMR spectroscopy. This volume of Annual Reports on NMR Spectroscopy focuses on the analytical tools used by chemists and physicists, taken together with other volumes of this series, an excellent account of progress in NMR and its many applications is provided and anyone using NMR will find interest in this Serial

Implementation of Solution and Solid Sate Nuclear Magnetic Resonance (NMR) Spectroscopic Techniques for Quantitative and Qualitative Analysis of Molecular Species

Implementation of Solution and Solid Sate Nuclear Magnetic Resonance (NMR) Spectroscopic Techniques for Quantitative and Qualitative Analysis of Molecular Species
A Book

by Abrar S. Alnafisah

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 205
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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In this dissertation, spectroscopy has been used to solve a variety of problems in different domains of science. Therefore, each chapter consists of different examples that have been addressed using different concepts of spectroscopy. The objective of part I (application of solution state NMR spectroscopy in pharmaceutical sciences) is to apply NMR techniques in different pharmaceutical projects. In chapter 3, a real-time quantification of in vitro Bortezomib (BTZ) release from alginate microparticles using a solution state quantitative boron nuclear magnetic resonance (11B qNMR) method is presented. The method was validated according to International Conference on Harmonization (ICH) guidelines. Therefore, several analytical performance parameters were discussed such as limit of detection (LOD), limit of quantification (LOQ), linearity, specificity, accuracy, precision and robustness. The 11B qNMR method was applied to the in vitro release study of a model drug, bortezomib (BTZ) from alginate microparticles and results were compared to a commonly used dialysis method. Throughout the release study, the dialysis method consistently underestimated the level of drug released, probably due to the separating membrane that can interfere with the real-time drug transport process. Overall, compared to the dialysis method, the direct 11B qNMR method was accurate and provided a direct and real-time quantification of BTZ for an effective study of drug release kinetics. Similarly, in chapter 4, a 19F qNMR method was developed and validated and then applied to study the real-time release of maraviroc from a microparticle formulation in a vaginal and seminal stimulated environment. Different possibilities were discussed to control the release profile such as the crosslinking process and a pH sensitive polymer. In chapter 5, the project is a collaborative effort between the department of Chemistry and School of Pharmacy. Our contributions in that project are to utilize 11B NMR spectroscopy technique as a characterization tool for the reaction progression. Moreover, to perform theoretical and experimental calculations and compare them to each other in order to trace the reaction mechanism. The overall motivation of the project is to test an assumption about phenylboronic acid (PBA) to prevent HIV transmission. It has been found that phenylboronic acid can form boronic acid in the presence of cis-diol, like the one found in HIV-gp120 glycoproteins. In order to exam the proposed hypothesis, a derivative of phenylboronic acid was synthesized. The synthetic scheme and the spectroscopic results are presented and discussed in detail. The objective of part II (applications of solid-state NMR spectroscopy) is to apply SSNMR spectroscopy experiments in two projects to gain significant information about specific materials. In chapter 6, some main concepts of SSNMR spectroscopy are discussed as well as some basic SSNMR experiments. In chapter 7, boron carbide thin films were grown using plasma enhanced chemical vapor deposition (PECVD) under different growth conditions. Different possible spectroscopic techniques were discussed in order to discover the local physical structure of boron carbide thin films. However, most of these techniques have shown a lack of an ability to demonstrate the internal structure of thin films. SSNMR spectroscopy was successfully employed to reveal information about the internal structure of boron carbide thin films. In chapter 8, the optical properties of titanium oxide TiO2 were modified by introducing a hydrazine molecule. SSNMR spectroscopy was implemented to monitor the reaction progression of TiO2 to improve its optical properties.

Annual Reports on NMR Spectroscopy

Annual Reports on NMR Spectroscopy
A Book

by Graham A. Webb

  • Publisher : Academic Press
  • Release : 2021-06-04
  • Pages : 268
  • ISBN : 0323850987
  • Language : En, Es, Fr & De
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Annual Reports on NMR Spectroscopy, Volume 103, the latest release in a series that has established itself as a premier resource for both specialists and non-specialists interested in new techniques and applications pertaining to NMR spectroscopy includes a variety of updated chapters covering Recent Applications of 17O Solid State NMR in Biochemistry, NMR Studies of Ferromagnetic Materials, Very Fast MAS Solid State NMR Studies of Pharmaceuticals, Recent Advances in Benchtop NMR and Applications, Ultra-Fast Magic Angle Spinning Nuclear Magnetic Resonance. Serves as the premier resource for learning new techniques and applications in NMR spectroscopy Provides a key reference for chemists and physicists using NMR spectroscopy to study the structure and dynamics of molecules Covers all aspects of molecular science, including MRI (Magnetic Resonance Imaging)

New Applications of NMR in Drug Discovery and Development

New Applications of NMR in Drug Discovery and Development
A Book

by Leoncio Garrido,Nicolau Beckmann

  • Publisher : Royal Society of Chemistry
  • Release : 2013-07-18
  • Pages : 304
  • ISBN : 1849737665
  • Language : En, Es, Fr & De
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This book presents a review of recent developments in NMR applications in pharmaceutical research. Consideration is given to consolidated and emerging techniques and methods in NMR, many of which are not widely applied but are likely to provide new opportunities for drug design. The first part of the book is dedicated to the description of NMR as a tool for the analysis of chemicals and interaction with targets. Particular emphasis is put on applications with unexploited potential for drug discovery and development. The next seven chapters describe NMR approaches to investigate in vivo models of interest in drug discovery and development, with the attention focused on anatomy, function, metabolism and molecular-cellular aspects. Finally, consideration is given to the application of in vivo NMR to the identification and characterization of biomarkers with the aim of monitoring the outcome of therapeutic intervention in selected human diseases, including the study of drug metabolism and toxicity. Aimed at NMR spectroscopists and pharmaceutical scientists, this title will be invaluable at putting NMR within context in its role in drug discovery and development. This resource will be essential reading for those both new and already active in these areas.

On-line LC-NMR and Related Techniques

On-line LC-NMR and Related Techniques
A Book

by Klaus Albert

  • Publisher : John Wiley & Sons
  • Release : 2003-02-14
  • Pages : 306
  • ISBN : 0470854812
  • Language : En, Es, Fr & De
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This book gives a comprehensive overview of the basis and the current applications of LC-NMR and related techniques. It deals with the practical aspects of the hardware and software set-up for a successful performance of on-line coupling experiments. It covers the solution of real-word problems from the fields of biomedical, pharmaceutical and environmental studies as well as the analysis of natural products and polymeric compounds. Thus guidelines for an efficient application of the powerful hyphenated technique LC-NMR in combination with LC-MS are presented. Besides LC-NMR, important techniques such as the on-line coupling of gel permeation chromatography and supercritical fluid chromatography, together with 1H NMR spectroscopy, are described in detail. Fascinating further aspects, such as the application of capillary separation techniques either in the single or parallel detection mode, together with the possibilities of direct 13C monitoring of chromatographic events, are also discussed. Key features include: * Up-to-date information on the theoretical and experimental methodology * Coverage of applications in biomedical, pharmaceutical and natural product analysis, as well as environmental polymer and related hyphenated techniques * Information appropriate for researchers in organic, pharmaceutical and medical chemistry Overall, this book is a requirement for all researchers and staff members dealing with structure elucidation problems in separation science.

Pharmaceutical Excipients

Pharmaceutical Excipients
Characterization by IR, Rahman, and NMR Spectroscopy

by David E. Bugay,W. Paul Findlay

  • Publisher : CRC Press
  • Release : 1999-02-23
  • Pages : 688
  • ISBN : 9780824793739
  • Language : En, Es, Fr & De
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Meeting the need for a hands-on guide elucidating the role of molecular spectroscopy in the physical characterization of pharmaceutical solids, two experts from the industry gather theoretical discussions of infrared, Raman, and nuclear magnetic resonance spectroscopy. They provide recommendations on spectral data acquisition techniques and include 600 spectra for 300 of the most commonly used excipients. Complete with references, equations, tables, and a CAS registry number index, the book covers the drug development process, including chemical identification of substances, investigative studies, competitor analysis, problem solving activities, reproduction of spectral data, and more.

LC-NMR and Other Hyphenated NMR Techniques

LC-NMR and Other Hyphenated NMR Techniques
Overview and Applications

by Maria V. Silva Elipe

  • Publisher : John Wiley & Sons
  • Release : 2011-12-20
  • Pages : 256
  • ISBN : 1118135385
  • Language : En, Es, Fr & De
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This practical guide provides a basic overview of the pros and cons of NMR spectroscopy as both a hyphenated and non-hyphenated technique. The book begins with a description of basic NMR concepts for the structural elucidation of organic compounds and then details the historical development of NMR and hyphenated NMR in the structural elucidation world, followed by applications of hyphenated NMR as LC-NMR and LC-MS-NMR in industry and academia. It also contains updated information on the latest advancements and applications of LC-NMR in such areas as degradation products, drug metabolism, food analysis, and drug discovery. An essential resource for scientists in industry and academia who work in the areas of organic chemistry, medicinal chemistry, process chemistry, and analytical chemistry.