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Nucleic Acid Nanotheranostics

Nucleic Acid Nanotheranostics
Biomedical Applications

by Marco Filice,Jesús Ruiz-Cabello

  • Publisher : Elsevier
  • Release : 2019-02-26
  • Pages : 491
  • ISBN : 0128144718
  • Language : En, Es, Fr & De
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Nucleic Acid Nanotheranostics: Biomedical Applications offers a comprehensive overview of improvements and new trends in fabrication of nanostructures as theranostic multifunctional carriers in gene therapy. With a strong focus on medical applications (comprising diagnosis, therapy and imaging), the book also examines gene therapy in an individual patient’s cells or tissues to treat genetic diseases. Sections cover Biomedical and Diagnostic applications of Nucleic Acids, Biologic and Synthetic Advanced Nanostructures for nucleic acid delivery, and important considerations of nanomedicine. This book is a valuable guide for materials scientists, physicians, chemists and engineers, but is also ideal for clinicians wishing to expand their knowledge. Provides a unique source of knowledge (theoretical as well as practical) on nanotheranostic materials for gene therapy at all levels and related scientific areas Covers the pros and cons related to viral and nanomaterial-based delivery of nucleic acids in terms of biosafety, carrier selection, synthesis and bioimaging Presents the only book to include an analysis of nanoformulations approved for clinical use

Advances in Nanotheranostics I

Advances in Nanotheranostics I
Design and Fabrication of Theranosic Nanoparticles

by Zhifei Dai

  • Publisher : Springer
  • Release : 2015-12-15
  • Pages : 336
  • ISBN : 3662485443
  • Language : En, Es, Fr & De
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This book highlights the recent advances in nanotheranostics from basic research to potential applications, and discusses the modular design and engineering of multiplex nanoparticles including gold nanostructures, luminescent nanoparticles, dendrimers and liposomes. Each chapter demonstrates multifunctional nanoparticles with topics covering targeting, imaging, delivery, diagnostics, and therapy as new modalities for cancer theranostics. This comprehensive book presents expert views on the latest developments in theranostic nanomedicine. It focuses on potential theranostic applications of multifunctional nanoparticles ranging from identifying noninvasively cancer cells by molecular detection, and visualizing in vivo drug delivery by means of contrast enhanced imaging, to destroying cancer cell s with minimal side effects via selective accumulation at tumor sites, and real-time monitoring therapeutic effectiveness. It also presents an interdisciplinary survey of nanotheranostics and as such is a valuable resource for researchers and students in related fields. Zhifei Dai is a Professor at the Department of Biomedical Engineering, College of Engineering, Peking University, China.

Cancer Nanotheranostics: What Have We Learned So Far?

Cancer Nanotheranostics: What Have We Learned So Far?

by João Conde,Pedro Viana Baptista,Jesús M De La Fuente,Furong Tian

  • Publisher : Frontiers Media SA
  • Release : 2016-03-17
  • Pages : 329
  • ISBN : 288919776X
  • Language : En, Es, Fr & De
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After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.

Nanotheranostics for Cancer Applications

Nanotheranostics for Cancer Applications
A Book

by Prakash Rai,Stephanie A. Morris

  • Publisher : Springer
  • Release : 2018-11-12
  • Pages : 480
  • ISBN : 3030017753
  • Language : En, Es, Fr & De
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This book is the first to focus specifically on cancer nanotheranostics. Each of the chapters that make up this comprehensive volume is authored by a researcher, clinician, or regulatory agency member known for their expertise in this field. Theranostics, the technology to simultaneously diagnose and treat a disease, is a nascent field that is growing rapidly in this era of personalized medicine. As the need for cost-effective disease diagnosis grows, drug delivery systems that can act as multifunctional carriers for imaging contrast and therapy agents could provide unique breakthroughs in oncology. Nanotechnology has enabled the development of smart theranostic platforms that can concurrently diagnose disease, start primary treatment, monitor response and initiate secondary treatments if required. In oncology, chemotherapeutics have been routinely used. Some drugs have proven effective but all carry risks of adverse side effects. There is growing interest in using remotely triggered drug delivery systems to limit cytotoxicity in the diseased area. This book reviews the use of theranostic nanoparticles for cancer applications over the past decade. First, it briefly discusses the challenges and limitations of conventional cancer treatments, and presents an overview of the use of nanotechnology in treating cancer. These introductory chapters are followed by those exploring cancer diagnosis and a myriad of delivery methods for nanotherapeutics. The book also addresses multifunctional platforms, treatment monitoring, and regulatory considerations. As a whole, the book aims to briefly summarize the development and clinical potential of various nanotheranostics for cancer applications, and to delineate the challenges that must be overcome for successful clinical development and implementation of such cancer theranostics.

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine
A Book

by Yusuf Tutar

  • Publisher : Bentham Science Publishers
  • Release : 2020-06-08
  • Pages : 198
  • ISBN : 9811456895
  • Language : En, Es, Fr & De
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Nanotheranostics is a recent medical field which integrates diagnostic imaging protocols and therapeutic functions to monitor real time drug release in the body and distribution to the target site. The combined processes allow technicians to observe the effectiveness of a specifically designed drug candidate and predict its possible side effects. All these features help clinicians in optimizing treatment options for cancer and other diseases for the individual patient. Current research is tailored to individual therapy because each drug may display a variety of responses depending on variations in an individual’s genetics and subsequently, their clinical biochemistry. Many tumors are still challenging for therapists in terms of available treatment and nanotheranostic strategies may help them to combat cancer more efficiently. Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine presents information about current theranostic technologies in use at clinics and recent research on nanotheranostic applications, with a focus on cancer treatment. Information is presented in seven organized chapters that cover the basics of cancer nanotheranostics, tumor microenvironmental factors, gene therapy and gene delivery concepts, and the combined application of diagnostic imaging with cancer chemotherapy. A chapter focusing on the role of non-coding MRNAs in breast cancer carcinogenesis is also included, giving readers a glimpse of the complexities in the molecular biology of cancer which drive the need for new theranostic technologies. The book is of interest to medical professionals (including oncologists and specialists in internal medicine), diagnostic imaging technicians, and researchers in the fields of pharmacology, molecular biology and nuclear medicine.

Nanotheranostics

Nanotheranostics
Applications and Limitations

by Mahendra Rai,Bushra Jamil

  • Publisher : Springer Nature
  • Release : 2019-11-22
  • Pages : 409
  • ISBN : 3030297683
  • Language : En, Es, Fr & De
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This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.

Nanotheranostics for Personalized Medicine

Nanotheranostics for Personalized Medicine
A Book

by Simona Mura,Patrick Couvreur

  • Publisher : World Scientific
  • Release : 2016-02-22
  • Pages : 348
  • ISBN : 9814713546
  • Language : En, Es, Fr & De
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The application of nanotechnology in the biomedical field, known as nanomedicine, has gained much interest in the recent past as a versatile strategy for selective drug delivery and diagnostic purposes. The nanotheranostic approach, which aims to combine both therapeutic and imaging/diagnostic functionalities, is characterized by a strong pluridisciplinarity where the chemistry of materials, bioconjugate chemistry, pharmaceutical technology, drug delivery, imaging, and pharmacology, work together. Nanotheranostics combine simultaneous non-invasive diagnosis and treatment of diseases with the exciting possibility to monitor drug release and distribution in real time; thus offering the opportunity to optimize treatment outcomes in cancer and other severe diseases. Clinical applications of nanotheranostics would enable earlier detection and treatment of diseases, and earlier assessment of the response, thus allowing to identify patients which would potentially respond to therapy and have higher possibilities of a favorable outcome. Nanotheranostics for Personalized Medicine presents an integrated and transdisciplinary description of nanotheranostics. It provides principles of imaging techniques and concrete examples of advances and challenges in the development of nanotheranostics for personalized medicine. This book is written for students (Bachelors to Doctoral level) as well as experienced researchers, in academia or the industry, interested in this emerging concept in the nanomedicine field. Contents:Combining Imaging and Drug Delivery for the Treatment of Severe Diseases (Simona Mura and Patrick Couvreur)Increased Sensitivity for Medical Imaging Using Non-Ionizing Nanomedicine as Contrast Agents (Cyrille Richard, Bich-Thuy Doan and Nathalie Mignet)MRI T2 Weighted Theranostic Nanodevices and Chemotherapy (Sophie Laurent, Luce Vander Elst, Dimitri Stanicki and Robert N Muller)MRI T1 Weighted Theranostic Nanodevices (Lucie Sancey, François Lux, Géraldine Le Duc, Sabin Carme and Olivier Tillement)Optical Imaging and Chemotherapy (Guillaume Bort, Simona Mura and Patrick Couvreur)Plasmonic Nanoparticles-Coated Microbubbles for Theranostic Applications (Mark A Borden, Jacob D Dove and Todd W Murray)Contribution of Nuclear Medicine to Cancer Nanotheranostics (Thomas Lars Andresen, Anncatrine L Petersen, Anders E Hansen and Jonas R Henriksen)Nanotheranostics in Gene Therapy (Madhura Deshpande, Shravan Kumar Sriraman and Vladimir Torchilin)Nanotheranostics in Cardiovascular Diseases (Maya Juenet, Mariana Varna, Cédric Chauvierre and Didier Letourneur)Stimuli-Responsive Nanotheranostics (Basit Yameen, Jun Wu, Critian Vilos, Andrew Whyte David Werstler, Lori Pollit and Omid C Farokhzad)Advancing the Practical Clinical Utility in Personalized Medicine: Capabilities and Lessons Learned for Pharmacology and Pharmaceutics (Ioannis S Vizirianakis, Christina Karavasili, Elsa P Amanatiadou and Dimitrios G Fatouros) Readership: Advanced undergraduates, graduates, as well as experimental researchers in academia or the industry with an interest in this emerging concept in the nanomedicine world. Key Features:This book presents an integrated and transdisciplinary description of an emerging concept in the world of nanomedicine: nanotheranosticsThis work is one of the few dedicated to nanotheranostics and its applicationsWritten by well-recognized experts in academia, this book would offer to the reader a clear overview of the progresses in the field of nanotheranostics and their fundamental contribution to the field of personalized medicineReading this book would open the way to further improvements and to the possible clinical translation of the nanotheranostics concept in the not-too-distant futureKeywords:Bioengineering;Nanomedicine & Nanobiology;Biomedical Engineering;Medical Imaging;Therapy

Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials

Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials
A Book

by Kirill A. Afonin

  • Publisher : MDPI
  • Release : 2019-08-06
  • Pages : 186
  • ISBN : 3039212591
  • Language : En, Es, Fr & De
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This book is a printed edition of the Special Issue Nucleic Acid Architectures for Therapeutics, Diagnostics, Devices and Materials that was published in Nanomaterials

Biopolymer-Based Composites

Biopolymer-Based Composites
Drug Delivery and Biomedical Applications

by Sougata Jana,Sabyasachi Maiti,Subrata Jana

  • Publisher : Woodhead Publishing
  • Release : 2017-06-15
  • Pages : 422
  • ISBN : 0081019157
  • Language : En, Es, Fr & De
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Biopolymer-Based Composites: Drug Delivery and Biomedical Applications presents a comprehensive review on recent developments in biopolymer-based composites and their use in drug delivery and biomedical applications. The information contained in this book is critical for the more efficient use of composites, as detailed up-to-date information is a pre-requirement. The information provided brings cutting-edge developments to the attention of young investigators to encourage further advances in the field of bio-composite research. Currently, biopolymers are being investigated for the design of various drug delivery and biomedical devices due to their non-toxic, biodegradable and biocompatible nature. Mostly, biopolymer-based solid orals, gels, hydrogel beads, and transdermal matrices have been designed in order to control drug/protein release in simulated bio-fluids. Presents the most updated information in the field of pharmaceutical and biological sciences Contains color figures and illustrations to help users understand key topics Useful guide for young researchers working towards new innovations Includes chapters covered by eminent scientists in the field

Nanobiosensors for Biomolecular Targeting

Nanobiosensors for Biomolecular Targeting
A Book

by Subash C.B. Gopinath,Thangavel Lakshmipriya

  • Publisher : Elsevier
  • Release : 2018-10-26
  • Pages : 352
  • ISBN : 0128139013
  • Language : En, Es, Fr & De
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Nanobiosensors for Bio-molecular Targeting presents the latest analytical methods for the detection of different substances in the range of small molecules to whole cells, exploring the advantages and disadvantages of each method. Biosensors combine the component of biological origin and physicochemical detector to show the presence of analytes in a given sample. The use of bionanotechnology has led to a significant advancement in the progression of nanobiosensors and has been effectively used for biomedical diagnosis. Explains the detection techniques used by nanosensors, exploring the strengths and weaknesses of each for the detection of disease Shows how biosensors are used to detect various types of biomolecules Demonstrates how the use of nanomaterials makes biosensors both cheaper and more efficient

Cancer Nanotheranostics

Cancer Nanotheranostics
A Book

by P. Gopinath,S. Uday Kumar,Ishita Matai,Bharat Bhushan,Deepika Malwal,Abhay Sachdev,Poornima Dubey

  • Publisher : Springer
  • Release : 2015-03-10
  • Pages : 119
  • ISBN : 9812874356
  • Language : En, Es, Fr & De
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This Brief provides a clear insight of the recent advances in the field of cancer theranostics with special emphasis upon nano scale carrier molecules (polymeric, protein and lipid based) and imaging agents (organic and inorganic).

NanoOncology, An Issue of Clinics in Laboratory Medicine - E-Book

NanoOncology, An Issue of Clinics in Laboratory Medicine - E-Book
A Book

by Kewal Jain

  • Publisher : Elsevier Health Sciences
  • Release : 2012-03-26
  • Pages : 120
  • ISBN : 1455742899
  • Language : En, Es, Fr & De
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This issue of Clinics in Laboratory Medicine includes the following topics: Detection of cancer biomarkers by cerium oxide nanoparticles; Quantum dot-based assays for cancer biomarkers; Monoclonal antibody conjugated fluorescent magnetic nanoparticles for in vivo diagnosis of cancer; RNA quantification with gold nanoprobes for cancer diagnostics; Nanostructured silica materials for imaging in cancer; and Nanoparticle-based cancer cell sorting.

The Nano-Micro Interface, 2 Volumes

The Nano-Micro Interface, 2 Volumes
Bridging the Micro and Nano Worlds

by Marcel Van de Voorde,Matthias Werner,Hans-Jörg Fecht

  • Publisher : John Wiley & Sons
  • Release : 2015-01-12
  • Pages : 756
  • ISBN : 3527679219
  • Language : En, Es, Fr & De
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Controlling the properties of materials by modifying their composition and by manipulating the arrangement of atoms and molecules is a dream that can be achieved by nanotechnology. As one of the fastest developing and innovative -- as well as well-funded -- fields in science, nanotechnology has already significantly changed the research landscape in chemistry, materials science, and physics, with numerous applications in consumer products, such as sunscreens and water-repellent clothes. It is also thanks to this multidisciplinary field that flat panel displays, highly efficient solar cells, and new biological imaging techniques have become reality. This second, enlarged edition has been fully updated to address the rapid progress made within this field in recent years. Internationally recognized experts provide comprehensive, first-hand information, resulting in an overview of the entire nano-micro world. In so doing, they cover aspects of funding and commercialization, the manufacture and future applications of nanomaterials, the fundamentals of nanostructures leading to macroscale objects as well as the ongoing miniaturization toward the nanoscale domain. Along the way, the authors explain the effects occurring at the nanoscale and the nanotechnological characterization techniques. An additional topic on the role of nanotechnology in energy and mobility covers the challenge of developing materials and devices, such as electrodes and membrane materials for fuel cells and catalysts for sustainable transportation. Also new to this edition are the latest figures for funding, investments, and commercialization prospects, as well as recent research programs and organizations.

Cancer Theranostics

Cancer Theranostics
A Book

by Xiaoyuan Chen,Stephen Wong

  • Publisher : Academic Press
  • Release : 2014-03-20
  • Pages : 544
  • ISBN : 0124078842
  • Language : En, Es, Fr & De
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Aiding researchers seeking to eliminate multi-step procedures, reduce delays in treatment and ease patient care, Cancer Theranostics reviews, assesses, and makes pertinent clinical recommendations on the integration of comprehensive in vitro diagnostics, in vivo molecular imaging, and individualized treatments towards the personalization of cancer treatment. Cancer Theranostics describes the identification of novel biomarkers to advance molecular diagnostics of cancer. The book encompasses new molecular imaging probes and techniques for early detection of cancer, and describes molecular imaging-guided cancer therapy. Discussion also includes nanoplatforms incorporating both cancer imaging and therapeutic components, as well as clinical translation and future perspectives. Supports elimination of multi-step approaches and reduces delays in treatments through combinatorial diagnosis and therapy Fully assesses cancer theranostics across the emergent field, with discussion of biomarkers, molecular imaging, imaging guided therapy, nanotechnology, and personalized medicine Content bridges laboratory, clinic, and biotechnology industries to advance biomedical science and improve patient management

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)

Advanced Textbook On Gene Transfer, Gene Therapy And Genetic Pharmacology: Principles, Delivery And Pharmacological And Biomedical Applications Of Nucleotide-based Therapies (Second Edition)
A Book

by Scherman Daniel

  • Publisher : World Scientific
  • Release : 2019-07-16
  • Pages : 636
  • ISBN : 1786346893
  • Language : En, Es, Fr & De
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This unique advanced textbook provides a clear and comprehensive overview of gene delivery, gene therapy and genetic pharmacology, with descriptions of the main gene transfer vectors and a set of selected therapeutic applications, along with safety considerations. The second edition features new groundbreaking material on genome editing using the recently discovered CRISPR/Cas9 system and on cancer immunotherapy by CAR-T cells. It also presents the historical milestone of gene therapy application in the field of severe combined immunodeficiency, and other fields of gene therapy and molecular medicine.The use of gene transfer is exponentially growing in the scientific and medical communities for day-to-day cell biology experiments and swift development of gene therapy, which is already revolutionizing medicine. In this advanced textbook, more than 30 leading scientists come together to explore these topics.This educational introduction provides the background material needed to further explore the subject as well as relevant research literature. It is an invaluable resource to Master, PhD or MD students, post-doctoral scientists or medical doctors, as well as any scientist wishing to deliver a gene or synthetic nucleotide or develop a gene therapy strategy. The second edition's simple and synthetic content will be of value to any reader interested in the biological and medical revolution derived from the elucidation of the human genome.

Protein Interactions: Computational Methods, Analysis And Applications

Protein Interactions: Computational Methods, Analysis And Applications
A Book

by Gromiha M Michael

  • Publisher : World Scientific
  • Release : 2020-03-05
  • Pages : 424
  • ISBN : 9811211884
  • Language : En, Es, Fr & De
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Polymeric Nanomedicines

Polymeric Nanomedicines
A Book

by Marcel Popa,Constantin V. Uglea

  • Publisher : Bentham Science Publishers
  • Release : 2013-05-29
  • Pages : 821
  • ISBN : 1608054845
  • Language : En, Es, Fr & De
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Over the last few decades, numerous nanoparticle platforms have been studied for their use in therapeutic applications. This book deals with the description of the construction of technical systems that combines different functionalities which bring liposomes, polymer-drug conjugates, polymer-protein conjugates, dendrimers, polymeric micelles, polymerosomes and other nanoparticles into the realm of nanotechnology proper, as opposed to traditional pharmacology or supramolecular chemistry. The volume additionally covers topics such as passive and active targeting, the strategies used for drug targeting, and the synthesis and characterization of polymeric nanoparticle platforms. Targeted polymeric nanomedicines have shown exciting results in preclinical studies, demonstrating their potential as therapeutic carriers. Therefore, the development of polymeric nanomedicines as therapeutic agents has generated great enthusiasm both in academia and industry. The book is systematically divided into chapters devoted to a class of polymeric nanomedicines. Each chapter also describes relevant aspects relating to drug design and targeting of polymeric nanomedicines wherever possible. In addition, a series of chapters concerning the contribution of polymeric nanomedicines in the treatment of several categories of diseases including cancer, inflammatory, renal, immunological diseases, and brain disorders is also presented. Key features of this book include: - A comprehensive and cutting-edge overview of polymeric nanomedicines available in a single dedicated volume - Discussions on advances in drug delivery systems for a variety of diseases - more than 2000 references, tables, equations, and drawings Readers, whether beginners or experts, will find in this book, contemporary and relevant information regarding the synthesis, evaluation and applications of polymeric nanomedicines. Supplemented with extensive bibliographic references, tables and figures, this book is an essential and incomparable reference for medicinal chemists, biologists, and medical (oncologic) researchers, as well as for scientists, undergraduate and graduate students in the field of medical bioengineering and polymer nanoscience.

Nanoscience in Dermatology

Nanoscience in Dermatology
A Book

by Michael R. Hamblin,Pinar Avci,Tarl Prow

  • Publisher : Academic Press
  • Release : 2016-08-13
  • Pages : 402
  • ISBN : 0128029455
  • Language : En, Es, Fr & De
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Nanoscience in Dermatology covers one of the two fastest growing areas within dermatological science, nanoscience and nanotechnology in dermatology. Recently, great progress has been made in the research and development of nanotechnologies and nanomaterials related to various applications in medicine and, in general, the life sciences. There is increasing enthusiasm for nanotechnology applications in dermatology (drug delivery, diagnostics, therapeutics, imaging, sensors, etc.) for understanding skin biology, improving early detection and treatment of skin diseases, and in the design and optimization of cosmetics. Light sensitive nanoparticles have recently been explored, opening a new era for the combined applications of light with nanotechnology, also called photonanodermatology. However, concerns have been raised regarding the adverse effects of intentional and unintentional nanoparticle exposure and their toxicity. Written by experts working in these exciting fields, this book extensively covers nanotechnology applications, together with the fundamentals and toxicity aspects. It not only addresses current applications of nanotechnology, but also discusses future trends of these ever-growing and rapidly changing fields, providing scientists and dermatologists with a clear understanding of the advantages and challenges of nanotechnology in skin medicine. Provides knowledge of current and future applications of nanoscience and nanotechnology in dermatology Outlines the fundamentals, methods, toxicity aspects, and other relevant aspects for nanotechnology based applications in dermatology Coherently structured book written by experts working in the fields covered

Structural Aspects of Protein Synthesis

Structural Aspects of Protein Synthesis
A Book

by Anders Liljas

  • Publisher : World Scientific
  • Release : 2004
  • Pages : 290
  • ISBN : 9789812388674
  • Language : En, Es, Fr & De
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This comprehensive and highly illustrated book provides a basic and up-to-date summary of translation on bacterial ribosomes, with emphasis on the structural insights. It is an attempt to present the ribosome and its functional activities in a coherent manner. Two types of illustrations are used to describe the translation field: simplified black-and-white illustrations to depict aspects of translation and color plates to give correct structural representations.The book presents essentially all aspects of the translation system, focusing on the relation between structure and function. Upper level undergraduates and graduate students with an interest in protein synthesis will find this lecture notes volume invaluable. The book is also an essential source of information for researchers who want to get an overview of translation.

Polymers and Nanomaterials for Gene Therapy

Polymers and Nanomaterials for Gene Therapy
A Book

by Ravin Narain

  • Publisher : Woodhead Publishing
  • Release : 2016-01-09
  • Pages : 302
  • ISBN : 0081005210
  • Language : En, Es, Fr & De
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Polymers and Nanomaterials for Gene Therapy provides the latest information on gene therapy, a topic that has attracted significant attention over the past two decades for the treatment of inherited and acquired genetic diseases. Major research efforts are currently focused on designing suitable carrier vectors that compact and protect oligonucleotides for gene therapy. The book explores the most recent developments in the field of polymer science and nanotechnology, and how these advancements have helped in the design of advanced materials. Non-viral vector systems, including cationic lipids, polymers, dendrimers, peptides and nanoparticles, are potential routes for compacting DNA for systemic delivery. However, unlike viral analogues that have no difficulty in overcoming cellular barriers and immune defense mechanisms, non-viral gene carriers consistently exhibit significant reduced transfection efficiency due to numerous extra- and intracellular obstacles. Therefore, biocompatibility and potential for large-scale production make these compounds increasingly attractive for gene therapy. This book contains chapters on the engineering of polymers and nanomaterials for gene therapy, and how they can form complexes with DNA and avoid both in vitro and in vivo barriers. Other chapters describe in vitro, ex vivo, in vivo gene therapy studies, and the current issues affecting non-viral gene therapy. Explores current challenges in the research of genetic diseases Discusses polymers for gene therapy and their function in designing advanced materials Provides examples of organic and inorganic nanomaterials for gene therapy Includes labeling, targeting, and assays Looks at characterization, physico-(bio)chemical properties, and applications