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Nucleic Acids in Chemistry and Biology

Nucleic Acids in Chemistry and Biology
A Book

by G. Michael Blackburn

  • Publisher : Royal Society of Chemistry
  • Release : 2006-01-01
  • Pages : 470
  • ISBN : 0854046542
  • Language : En, Es, Fr & De
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The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

Organic Chemistry of Nucleic Acids

Organic Chemistry of Nucleic Acids
Part B

by N. Kochetkov

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 371
  • ISBN : 1468429736
  • Language : En, Es, Fr & De
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The study of nucleic acids is one of the most rapidly developing fields in modern science. The exceptionally important role of the nucleic acids as a key to the understanding of the nature of life is reflected in the enormous number of published works on the subject, including many outstanding monographs and surveys. The pathways of syn thesis and metabolism of nucleic acid,s and the many and varied biological functions of these biopolymers are examined with the utmost detail in the literature. Nearly as much attention has been paid to the macromolecular chemistry of the nucleic acids: elucidation of the size and shape of their molecules, the study of the physicochemical properties of their solutions, and the appropriate methods to be used in such research. The surveys of the chemistry of nucleic acids which have been published so far deal almost entirely with their synthesis and, in particular, with the synthetic chemistry of monomers (nucleosides and nucleotides) ; less attention has been paid to the synthesis of poly nucleotides. There is yet another highly important aspect of the chemistry of nucleic acids which is still in the formative stage, the study of the reactivity of nucleic acid macromolecules and their components. This can make an important contribution to the deter mination of the structure of these remarkable biopolymers and to the correct understanding of their biological functions.

Nucleic Acids in Immunology

Nucleic Acids in Immunology
Proceedings of a Symposium Held at the Institute of Microbiology of Rutgers, The State University

by O. J. Plescia,W. Braun

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 724
  • ISBN : 3642876684
  • Language : En, Es, Fr & De
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Two fields have played a leading role in biomedical research in recent years, the biochemistry of nucleic acids and immunology. Yet, with the exception of those aspects which have been concerned with antibody synthesis as an example of protein synthesis, there was until recently a lack of direct association between the two fields. Until quite recently the antigenicity of nucleic acids was still in doubt and indeed represented a controversial subject. Also, the exact role of the various nucleic acids in various stages of antibody synthesis was uncertain. These skepticisms and uncertainties disappeared rapidly in the last few years. New experi mental approaches brought the realization that nucleic acids, under appropriate conditions, are indeed immunogenic, and that the resulting antibodies can furnish new tools for the exploration of the mplecular structure of the all-important family of nucleic acid molecules. ' At the same time, the recognition of the antigenicity of nucleic acids brought a new level of understanding to certain auto-immune diseases and pro vided new material for the exploration of the role of a carrier in immune responses. Side by side with this development was the almost explosive development of new experimental approaches and new ideas pertaining to the problem of antibody formation. Nucleic acids in their various forms were recognized as playing an expected major role in the activation of antibody-forming cells. Perhaps less to be expected was the role they can playas non-specific stimulators of antibody formation.

Nucleic Acids

Nucleic Acids
A Book

by John M. Walker

  • Publisher : Humana
  • Release : 1984-12-11
  • Pages : 375
  • ISBN : 9780896031074
  • Language : En, Es, Fr & De
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In recent years there has been a tremendous increase in our understanding of the functioning of the cell at the molecular level. This has been achieved in the main by the invention and development of new methodology, parti- larly in that area generally referred to as "genetic en- neering". While this revolution has been taking place in the field of nucleic acids research, the protein chemist has at the same time developed fresh methodology to keep pace with the requirements of present day molecular bi- ogy. Today's molecular biologist can no longer be content with being an expert in one particular area alone. He/she needs to be equally competent in the laboratory at h- dling DNA, RNA, and proteins, moving from one area to another as required by the problem he/she is trying to solve. Although many of the new techniques in molecular biology are relatively easy to master, it is often difficult for a researcher to obtain all the relevant information nec- sary for setting up and successfully applying a new te- nique. Information is of course available in the research l- erature, but this often lacks the depth of description that the new user requires. This requirement for in-depth pr- tical details has become apparent by the considerable - mand for places on our Molecular Biology Workshops held at Hatfield each summer.

Extracellular Nucleic Acids

Extracellular Nucleic Acids
A Book

by Yo Kikuchi,Elena Y. Rykova

  • Publisher : Springer Science & Business Media
  • Release : 2010-07-23
  • Pages : 232
  • ISBN : 3642126170
  • Language : En, Es, Fr & De
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Extracellular nucleic acids have recently emerged as important players in the fields of biology and the medical sciences. In the last several years, extracellular nucleic acids have been shown to be involved in not only microbial evolution as genetic elements but also to have structural roles in bacterial communities, such as biofilms. Circulating DNA and RNA have been found in human blood and expected to be useful as non-invasive markers for the diagnosis of several diseases. In addition, extracellular nucleic acids have attracted attention as active modulators of the immune system of higher organisms, including humans. This book covers nearly all of the newly developing fields related to extracellular nucleic acids, including those of basic biology, ecology and the medical sciences, and provides readers with the latest knowledge on them.

Nucleic Acids and Molecular Biology

Nucleic Acids and Molecular Biology
A Book

by Fritz Eckstein,David M. J. Lilley

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 223
  • ISBN : 3642833845
  • Language : En, Es, Fr & De
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Molecular biology has always been a discipline of rapid development. Despite this, we are presently experiencing a period of unprecedented proliferation of information in nucleic acid studies and molecular biology. These areas are intimately interwoven, so that each influences the other to their mutual benefit. The rapid growth in information leads to ever-increasing specialization, so that it becomes increasingly difficult for a scientist to keep abreast of developments in all the various aspects of the field, although an up-to-date knowledge of the field as a whole is highly desirable. With this background in mind we present the series Nucleic Acids and Molecular Biology. It comprises focused review articles by active researchers who report on the newest developments in their areas of particular interest.

Nucleic Acids and Proteins in Soil

Nucleic Acids and Proteins in Soil
A Book

by Paolo Nannipieri,Kornelia Smalla

  • Publisher : Springer Science & Business Media
  • Release : 2006-09-22
  • Pages : 458
  • ISBN : 354029449X
  • Language : En, Es, Fr & De
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With millions of different bacterial species living in soil, the microbial community is extremely complex, varying at very small scales. Microbe-driven functions are essential for most processes in soil. Thus, a better understanding of this microbial diversity will be invaluable for the management of the various soil functions. Nucleic Acids and Proteins in Soil combines traditional approaches in soil microbiology and biochemistry with the latest techniques in molecular microbial ecology. Included are methods to analyse the presence and importance of nucleic acids and proteins both inside and outside microbial cells, the horizontal gene transfer which drives bacterial diversity, as well as soil proteomes. Further chapters describe techniques such as PCR, fingerprinting, the challenging use of gene arrays for structural and functional analysis, stable isotope probing to identify in situ metabolic functions, and the use of marker and reporter genes in soil microbial ecology.

Chemistry of Nucleic Acids

Chemistry of Nucleic Acids
A Book

by Harri Lönnberg

  • Publisher : Walter de Gruyter GmbH & Co KG
  • Release : 2020-08-10
  • Pages : 364
  • ISBN : 3110613980
  • Language : En, Es, Fr & De
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Life in all its forms is based on nucleic acids which store and transfer genetic information. The book addresses the main aspects of synthesis, hydrolytic stability, solution equilibria of nucleosides and nucleotides as well as base modifications of nucleic acids. The author further describes their structural analogues used as therapeutic drugs, such as antivirals and anticancer agents, and prodrug strategies of nucleotides.

Medicinal Chemistry of Nucleic Acids

Medicinal Chemistry of Nucleic Acids
A Book

by Li-He Zhang,Zhen Xi,Jyoti Chattopadhyaya

  • Publisher : John Wiley & Sons
  • Release : 2011-08-10
  • Pages : 448
  • ISBN : 9781118092811
  • Language : En, Es, Fr & De
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Complete, up-to-date coverage of the broad area of nucleic acid chemistry and biology Assembling contributions from a collection of authors with expertise in all areas of nucleic acids, medicinal chemistry, and therapeutic applications, Medicinal Chemistry of Nucleic Acids presents a thorough overview of nucleic acid chemistry—a rapidly evolving and highly challenging discipline directly responsible for the development of antiviral and antitumor drugs. This reliable resource delves into a multitude of subject areas involving the study of nucleic acids—such as the new advances in genome sequencing, and the processes for creating RNA interference (RNAi) based drugs—to assist pharmaceutical researchers in removing roadblocks that hinder their ability to predict drug efficacy. Offering the latest cutting-edge science in this growing field, Medicinal Chemistry of Nucleic Acids includes: In-depth coverage of the development and application of modified nucleosides and nucleotides in medicinal chemistry A close look at a large range of current topics on nucleic acid chemistry and biology Essential information on the use of nucleic acid drugs to treat diseases like cancer A thorough exploration of siRNA for RNAi and the regulation of microRNA, non-coding RNA (ncRNA), a newly developing and exciting research area Thorough in its approach and promising in its message, Medicinal Chemistry of Nucleic Acids probes the new domains of pharmaceutical research—and exposes readers to a wealth of new drug discovery opportunities emerging in the dynamic field of nucleic acid chemistry.

Nucleic acids and nucleotides

Nucleic acids and nucleotides
A Book

by Anonim

  • Publisher : Elsevier Health Sciences
  • Release : 2014-11-07
  • Pages : 27
  • ISBN : 8131241629
  • Language : En, Es, Fr & De
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Nucleic acids and nucleotides Nucleic acids and nucleotides

The Components of Life

The Components of Life
From Nucleic Acids to Carbohydrates

by Britannica Educational Publishing

  • Publisher : Britannica Educational Publishing
  • Release : 2010-10-01
  • Pages : 264
  • ISBN : 1615303898
  • Language : En, Es, Fr & De
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The building blocks of all life—human and otherwise—are basic chemical molecules common to all organisms that simultaneously unite all species and set them apart. Together, nucleic acids, amino acids, proteins, lipids, and carbohydrates determine our genetic makeup, power our movements, and generally enable some of the most vital and complex chemical reactions of the body. This volume examines the structure and function of each of these fascinating elements and the interrelationships between them, which nurture all existence.

Drug-Nucleic Acid Interactions

Drug-Nucleic Acid Interactions
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2001-07-31
  • Pages : 705
  • ISBN : 0080496903
  • Language : En, Es, Fr & De
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This volume consolidates the key methods for studying ligand-nucleic acid interactions into a convenient source. Techniques that are examined range from biophysical and chemical approaches to methods rooted in molecular and cell biology.

Radiation Induced Molecular Phenomena in Nucleic Acids

Radiation Induced Molecular Phenomena in Nucleic Acids
A Comprehensive Theoretical and Experimental Analysis

by Manoj Shukla,Jerzy Leszczynski

  • Publisher : Springer Science & Business Media
  • Release : 2008-05-08
  • Pages : 677
  • ISBN : 1402081847
  • Language : En, Es, Fr & De
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Comprehensive theoretical and experimental analysis of UV-radiation and low energy electron induced phenomena in nucleic acid bases (NABs) and base assemblies are presented in this book. NABs are highly photostable; the absorbed energy is dissipated in the form of ultrafast nonradiative decay. This book highlights the possible mechanisms of these phenomena which is important for all living species and discusses technical challenges in exploration of these processes.

Chemistry and Cytochemistry of Nucleic Acids and Nuclear Proteins

Chemistry and Cytochemistry of Nucleic Acids and Nuclear Proteins
A Book

by Christoph Scholtissek,B.M. Richards,R. Vendrely,C. Vendrely,D.P. Bloch

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 236
  • ISBN : 370915569X
  • Language : En, Es, Fr & De
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The field of nucleic acids has grown to such a tremendeous size that it is impossible to include all publications concerning the chemistry and biological role of nucleic acids in an article of the length presented in this "Volume. Therefore, it is necessary to select the most important contributions and those not included "in well-known reviews. In many cases reference is made only to the authors who summarized their specialized field in chapters of the three volumes of "The Nucleic Acids" (edB. E. CHARGAFF and J. N. DAVIDSON, Acad. Press, New York 1955 and 19(0) or to the "Nucleic Acid Outlines" (V. R. POTTER, Burgess Publishing Comp. Minneapolis), where further literature and more detailed discussions may be found. Facts and theories will be dealt with, but not lists of references. Therefore it is not possible to follow in all cases the historical development of an idea and to admowledge all publications which might be important and inter esting from another point of view. Very little is mentioned about methods in the field of nucleic acids.

The Biochemistry of the Nucleic Acids

The Biochemistry of the Nucleic Acids
A Book

by R.L.P. Adams,J.T. Knowler,D.P. Leader

  • Publisher : Springer Science & Business Media
  • Release : 2013-04-18
  • Pages : 675
  • ISBN : 9401122903
  • Language : En, Es, Fr & De
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When the first edition of this book was published in 1950, it predated the publication of the double-helical structure of DNA by three years. It is not, therefore, surprizing that nothing of the original book remains in the current edition. Indeed, such is the pace of change in the field of nucleic acids that less than 50% of material incorporated into the 1986 edition has been retained. The book aims at the advanced undergraduate and at graduates that are undertaking course work or requiring an in-depth background for their research. It also aims to provide the established scientist with a single text that permits updating across the whole field from DNA structure, replication and repair, through gene expression and its control to protein synthesis. Every chapter is accompanied by thorough referencing that enables the reader to evaluate personally the data and methodology that cannot be included in the text. In an attempt to keep this list within bounds, references are limited to about ten per page and, to accommodate the more recent literature, many of the older references have been left out in this latest edition.

Triple-Helical Nucleic Acids

Triple-Helical Nucleic Acids
A Book

by Valery N. Soyfer,Vladimir N. Potaman

  • Publisher : Springer Science & Business Media
  • Release : 1996
  • Pages : 360
  • ISBN : 9780387944951
  • Language : En, Es, Fr & De
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The ability of DNA to exist in configurations other than its classical double-stranded form has been known for many years. There has been a spectacular recent surge of interest in these forms, notably in the three-stranded or triple-helical form. Triplex-like nucleic acids are now known to exist in vivo, and may well participate in significant biological processes. Interest in triple-helical nucleic acids has been greatly stimulated by their potential exploitation to control gene expression, serve as tools in genome mapping strategies, etc. The authors have written an encyclopedic introduction to nucleic acid triplexes based on many years of familiarity with the topic. The book includes information on chemistry, conformation, physical properties, applications, and hypotheses about the biological role of triplexes. It pays particular attention to the different methods for investigating these molecules, a feature which will be welcomed by those new to the field.

Biological Sequence Analysis

Biological Sequence Analysis
Probabilistic Models of Proteins and Nucleic Acids

by Richard Durbin,Sean R. Eddy,Anders Krogh,Graeme Mitchison

  • Publisher : Cambridge University Press
  • Release : 1998-04-23
  • Pages : 129
  • ISBN : 113945739X
  • Language : En, Es, Fr & De
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Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.

The Chemistry of Nucleic Acids

The Chemistry of Nucleic Acids
A Book

by Denis Oswald Jordan

  • Publisher : Unknown Publisher
  • Release : 1960
  • Pages : 358
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Progress in Nucleic Acid Research and Molecular Biology

Progress in Nucleic Acid Research and Molecular Biology
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2000-02-28
  • Pages : 380
  • ISBN : 9780080544427
  • Language : En, Es, Fr & De
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Nucleic acids are the fundamental building blocks of DNA and RNA and are found in virtually every living cell. Molecular biology is a branch of science that studies the physicochemical properties of molecules in a cell, including nucleic acids, proteins, and enzymes. Increased understanding of nucleic acids and their role in molecular biology will further many of the biological sciences including genetics, biochemistry, and cell biology. Progress in Nucleic Acid Research and Molecular Biology provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology. It contains contributions from leaders in their fields and abundant references. Provides a forum for discussion of new discoveries, approaches, and ideas in molecular biology Includes contributions from leaders in the field Contains abundant references

Photoinduced Phenomena in Nucleic Acids II

Photoinduced Phenomena in Nucleic Acids II
DNA Fragments and Phenomenological Aspects

by Mario Barbatti,Antonio Carlos Borin,Susanne Ullrich

  • Publisher : Springer
  • Release : 2014-12-26
  • Pages : 280
  • ISBN : 3319132725
  • Language : En, Es, Fr & De
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The series Topics in Current Chemistry presents critical reviews of the present and future trends in modern chemical research. The scope of coverage is all areas of chemical science including the interfaces with related disciplines such as biology, medicine and materials science. The goal of each thematic volume is to give the non-specialist reader, whether in academia or industry, a comprehensive insight into an area where new research is emerging which is of interest to a larger scientific audience. Each review within the volume critically surveys one aspect of that topic and places it within the context of the volume as a whole. The most significant developments of the last 5 to 10 years are presented using selected examples to illustrate the principles discussed. The coverage is not intended to be an exhaustive summary of the field or include large quantities of data, but should rather be conceptual, concentrating on the methodological thinking that will allow the non-specialist reader to understand the information presented. Contributions also offer an outlook on potential future developments in the field. Review articles for the individual volumes are invited by the volume editors. Readership: research chemists at universities or in industry, graduate students.