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Nutritional Epigenomics

Nutritional Epigenomics
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-07-20
  • Pages : 478
  • ISBN : 0128173106
  • Language : En, Es, Fr & De
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Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease. Empowers the reader to employ nutritional epigenomics approaches in their own research Discusses the latest topics in nutritional epigenomics in the regulation of aging, circadian rhythm, inheritance and fetal development, as well as metabolism and disease Offers a full grounding in epigenetic reprogramming and nutritional intervention in the treatment and prevention of disease, as informed by population-based studies

Human Epigenomics

Human Epigenomics
A Book

by Carsten Carlberg,Ferdinand Molnár

  • Publisher : Springer
  • Release : 2018-02-01
  • Pages : 223
  • ISBN : 9811076146
  • Language : En, Es, Fr & De
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The term epigenetics describes regulatory and information storing mechanisms of specific genes that do not involve any change of their DNA sequence. Epigenetics is closely related to the extensively folded state, in which the genome is packaged, known as chromatin. New genomic tools nowadays allow the genome-wide assessment of, for example, chromatin states and DNA modifications, and led to the discovery of unexpected new epigenetic principles, such as epigenomic memory. This was the start of the field of epigenomics, the relation of which to human health and disease is discussed in this textbook. This book aims to summarize, in a condensed form, the role of epigenomics in defining chromatin states that are representative of active genes (euchromatin) and repressed genes (heterochromatin). Moreover, this book discusses the principles of gene regulation, chromatin stability, genomic imprinting and the reversibility of DNA methylation and histone modifications. This information should enable a better understanding of cell type identities and will provide new directions for studies of, for example, cellular reprograming, the response of chromatin to environmental signals and epigenetic therapies that can improve or restore human health. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of the book is based on the lecture course “Molecular Medicine and Genetics” that is given by one of us (C. Carlberg) in different forms since 2002 at the University of Eastern Finland in Kuopio. Thematically, this book is located between our textbooks “Mechanisms of Gene Regulation” (ISBN 978-94-017-7741-4) and “Nutrigenomics” (ISBN 978-3-319-30415-1), studying of which may also be interesting to our readers. The book is sub-divided into three sections and 13 chapters. Following the Introduction (section A), section B will explain the molecular basis of epigenomics, while section C will provide examples for the impact of epigenomics in human health and disease. The lecture course is primarily designed for Master level students of biomedicine, but is also frequented by PhD students as well as by students of other bioscience disciplines. Besides its value as a textbook, Human Epigenomics will be a useful reference for individuals working in biomedicine.

Nutrition Therapy and Pathophysiology

Nutrition Therapy and Pathophysiology
A Book

by Marcia Nelms,Kathryn P. Sucher

  • Publisher : Nelson Education
  • Release : 2015
  • Pages : 1008
  • ISBN : 1305446003
  • Language : En, Es, Fr & De
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NUTRITION THERAPY AND PATHOPHYSIOLOGY, 3E provides a comprehensive review of disease pathophysiology and treatment with a focus on current research into and application of evidence-based nutritional care for students, clinicians, and researchers. The third edition continues to provide an all-in-one resource for the study of nutrition therapy that closely integrates the nutrition care process through its chapter organization and pedagogy. NUTRITION THERAPY AND PATHOPHYSIOLOGY strives to prepare students for success in clinical practice and foster growth in expertise in their field. Important Notice: Media content referenced within the product description or the product text may not be available in the ebook version.

Functional Food and Human Health

Functional Food and Human Health
A Book

by Vibha Rani,Umesh C. S. Yadav

  • Publisher : Springer
  • Release : 2018-10-12
  • Pages : 694
  • ISBN : 9811311234
  • Language : En, Es, Fr & De
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Global health and the increasing incidence of various diseases are a cause for concern, and doctors and scientists reason that the diet, food habits and lifestyle are contributing factors. Processed food has reduced the nutritional value of our diet, and although supplementing foods with various additives is considered an alternative, the long-term impact of this is not known. Many laboratories around the world are working to identify various nutritional components in our daily food and their effect on human health. These have been classified as Nutraceuticals or functional food, and they may have preventive and therapeutic effects in a number of pathologies associated with modern dietary habits and lifestyles. This book addresses various aspects of this issue, revitalizing the discussion and consolidating the latest research on nutritional and functional food and their effects in in-vitro, in-vivo and human clinical studies.

Systems Biology of Cancer

Systems Biology of Cancer
A Book

by Sam Thiagalingam

  • Publisher : Cambridge University Press
  • Release : 2015-04-09
  • Pages : 548
  • ISBN : 0521493390
  • Language : En, Es, Fr & De
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An overview of the current systems biology-based knowledge and the experimental approaches for deciphering the biological basis of cancer.

Nutrition and Epigenetics

Nutrition and Epigenetics
A Book

by Emily Ho,Frederick Domann

  • Publisher : CRC Press
  • Release : 2014-10-16
  • Pages : 422
  • ISBN : 1482203820
  • Language : En, Es, Fr & De
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Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.

Design of human nutrigenomics studies

Design of human nutrigenomics studies
A Book

by Siân Astley,Linda Penn

  • Publisher : Wageningen Academic Publishers
  • Release : 2009-07-28
  • Pages : 104
  • ISBN : 908686094X
  • Language : En, Es, Fr & De
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The key to exploiting links between diet and health is to have a better understanding of how our bodies respond to what we eat. In the past, many food constituents were regarded as unimportant because they lacked a specific nutritional role. More recently nutritional research has been limited to a few dietary compounds, a handful of relevant biochemical pathways and a small number of genes pertinent to specific diseases. These studies have given rise to specific examples of benefits provided by individual/ groups of food compounds including non-nutrients, and demonstrated that whilst poor diet can accelerate age-related degeneration, a diet rich in fruits and vegetables, cereals and plant oils significantly reduces our risk of chronic disease. However, the benefits of dietary and lifestyle choices are not the same for everyone.Nutrigenomics offers a more holistic approach to nutritional research. It considers not only our genes and the effect they have on our response to diet but, also how diet affects our genes and proteins to alter our metabolism and our risk of disease as we age. However, the logistics associated with human study design and interpretation of the data generated, using these technologies, is complex. The European Network of Excellence NuGO was established in 2004 with the specific aim of developing and integrating omic technologies for European nutritional research. This has meant focusing on technical problems specific to nutrition as well as training existing and new researchers to use the technology alongside existing and new approaches. The workshop, Design of human nutrigenomic studies, reviewed examples of successful human nutrition studies using post-genomics technologies (transcriptomics, metabolomics, and proteomics) and the issues discussed are described in detail in this publication.

Nutrition, Diet and Cancer

Nutrition, Diet and Cancer
A Book

by Sharmila Shankar,Rakesh K. Srivastava

  • Publisher : Springer Science & Business Media
  • Release : 2012-03-16
  • Pages : 628
  • ISBN : 9400729227
  • Language : En, Es, Fr & De
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Chemoprevention of cancer has been the focus of intensive research for more than two decades. Epidemiological evidence has shown a small, but significant association between fruit and vegetable intake and a reduction in cancer risk. Diet may account for about thirty five percent of cancer. Large claims have been made for the effectiveness of particular diets in determining one's risk of developing cancer, ranging from protection against cancer initiation, progression and metastasis. A wide array of dietary components has been demonstrated to be as effective in fighting off cancer. Towards an increased understanding of the nutrition, excercise and diet in preventing cancer or inhibiting its progression has led to the discovery and development of novel and effective drugs that regulate intracellular signaling network in the body. This information will be very useful to explore novel and highly effective chemopreventive strategies for reducing the health burden of cancer. Hippocrates, who proclaimed 25 centuries ago, 'Let food be thy medicine and medicine be thy food'. They estimated that one third of all cancer cases could be prevented by a healthier diet; statements which are widely accepted in the scientific literature. This book covers the current state-of-the art knowledge on the impact of nutrition and diet with nutrigenetics, nutritional epigenomics, nutritional transcriptomics, proteomics, and metabolomics approach in cancer prevention and therapy.

The influence of maternal, fetal and child nutrition on the development of chronic disease in later life

The influence of maternal, fetal and child nutrition on the development of chronic disease in later life
A Book

by Scientific Advisory Committee on Nutrition

  • Publisher : The Stationery Office
  • Release : 2011-06-23
  • Pages : 194
  • ISBN : 9780108510649
  • Language : En, Es, Fr & De
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In this final report on the 'The influence of maternal, fetal and child nutrition on the development of chronic disease in later life', the Subgroup on Maternal and Child Nutrition (SMCN) reviews the evidence that early life nutrition exerts long-term effects and influences the risk of chronic disease in adulthood, bringing together findings from both observational and experimental studies, and considering implications for maternal and child nutrition in the UK. SACN concludes that there is cause for concern about the later health consequences of compromised or excessive nutrient supply during early fetal and infant life. It notes that in the context of reproduction, the impact of current dietary patterns on women and girls is of particular concern, and considers that improving the nutritional status of women of childbearing age, infants and young children has the potential to improve the health of future generations. The Committee also offers recommendations for future research in this area, particularly emphasising the need for data which better characterise dietary patterns and patterns of pre and postnatal growth.

Molecular and Quantitative Animal Genetics

Molecular and Quantitative Animal Genetics
A Book

by Hasan Khatib

  • Publisher : John Wiley & Sons
  • Release : 2015-03-02
  • Pages : 336
  • ISBN : 1118677404
  • Language : En, Es, Fr & De
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"Animal genetics is a central topic in upper-level animal science programs. Filling a void in existing literature on animal science, Animal Genetics introduces genetic principles and presents their application in production and companion animals. The book details population and quantitative genetics, epigenetics, biotechnology, and breeding among other topics. Useful in upper-level studies, Animal Genetics is an irreplaceable educational resource"--Provided by publisher.

Epigenetics and Human Health

Epigenetics and Human Health
Linking Hereditary, Environmental and Nutritional Aspects

by Alexander Haslberger,Sabine Greßler

  • Publisher : John Wiley & Sons
  • Release : 2011-08-24
  • Pages : 316
  • ISBN : 352764475X
  • Language : En, Es, Fr & De
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After first introducing the concept of epigenetics, this handbook and ready reference provides an overview of the main research on epigenetics. It adopts a multidisciplinary approach, involving molecular biology, molecular epidemiology and nutritional science, with a special focus of the book is on disease prevention and treatment. Of interest to all healthcare-related professionals as well as nutritionists, and the medical community focusing on disease prevention.

Selenium

Selenium
Its Molecular Biology and Role in Human Health

by Dolph L. Hatfield,Marla J. Berry,Vadim N. Gladyshev

  • Publisher : Springer Science & Business Media
  • Release : 2007-01-11
  • Pages : 420
  • ISBN : 0387338276
  • Language : En, Es, Fr & De
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This book examines the molecular biology of selenium and how this element makes its way into protein. The role of this element in preventing certain forms of cancer, heart disease and other cardiovascular and muscle disorders is explored in the text. The Second Edition outlines discoveries since the book was first introduced in 2001. Chapter updates have been written by investigators who have made important contributions to the field.

Epigenetics in Biology and Medicine

Epigenetics in Biology and Medicine
A Book

by Manel Esteller

  • Publisher : CRC Press
  • Release : 2008-09-17
  • Pages : 312
  • ISBN : 9781420007077
  • Language : En, Es, Fr & De
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Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

Personalized Epigenetics

Personalized Epigenetics
A Book

by Trygve Tollefsbol

  • Publisher : Academic Press
  • Release : 2015-04-28
  • Pages : 610
  • ISBN : 0128004363
  • Language : En, Es, Fr & De
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Personalized Epigenetics discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. The book details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field, it also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management. Discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures Details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, and noncoding RNA, and the consequent diagnostic, prognostic and therapeutic potential of the field Reviews the impact of the environment on epigenetic variations among individuals and the roles of pharmacology and drug development Devotes several chapters to the advances made in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management

Nutrition and Oral Medicine

Nutrition and Oral Medicine
A Book

by Riva Touger-Decker,Connie Mobley,Joel B. Epstein

  • Publisher : Springer Science & Business Media
  • Release : 2014-03-28
  • Pages : 420
  • ISBN : 1607614901
  • Language : En, Es, Fr & De
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This second edition addresses the complex, multifaceted relationships between nutrition and oral health, explores proposed relationships between oral, systemic and nutritional well-being and provides insights into interprofessional, comprehensive care for individuals. Chapters focus on diet, nutrition and oral health promotion and disease prevention across the lifespan, oral and dental diseases and disorders, oral manifestations of systemic diseases, and discussions of the synergy between oral tissues and nutrients. Cutting edge research issues regarding the relationship of individual antioxidants, trace elements, polyphenols and other nutrient substrates and oral health/disease, nutrigenomics, screening for nutrition and oral risk and other areas are covered in detail. Editors and authors include experts in nutrition and oral health from around the world. This second edition is a invaluable resource for health professionals in the fields of nutrition and dentistry as well as other disciplines whose research, practice and education includes nutrition and oral medicine. It is an excellent resource for graduate level nutrition and dental students, dental and nutrition practitioners, educators and researchers as well as other health professionals.

Handbook of Nutrition, Diet, and Epigenetics

Handbook of Nutrition, Diet, and Epigenetics
A Book

by Vinood Patel,Victor Preedy

  • Publisher : Springer
  • Release : 2018-12-24
  • Pages : 2290
  • ISBN : 9783319555294
  • Language : En, Es, Fr & De
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This multivolume reference work addresses the fact that the well being of humankind is predicated not only on individuals receiving adequate nutrition but also on their genetic makeup. The work includes more than 100 chapters organized in the following major sections: Introduction and Overview; Epigenetics of Organs and Diseases in Relation to Diet and Nutrition; Detailed Processes in Epigenetics of Diet and Nutrition; Modulating Epigenetics with Diet and Nutrition; and Practical Techniques. While it is well known that genes may encode proteins responsible for structural and dynamic components, there is an increasing body of evidence to suggest that nutrition itself may alter the way in which genes are expressed via the process of epigenetics. This is where chemically imposed alteration in the DNA sequence occurs or where the functional expression of DNA is modulated. This may include changes in DNA methylation, non-coding RNA, chromatin, histone acetylation or methylation, and genomic imprinting. Knowledge regarding the number of dietary components that impact on epigenetic processes is increasing almost daily. Marshalling all the information on the complex relationships between diet, nutrition, and epigenetic processes is somewhat difficult due to the wide myriad of material. It is for this reason that the present work has been compiled.

Nutrition and Epigenetics

Nutrition and Epigenetics
A Book

by Emily Ho,Frederick Domann

  • Publisher : CRC Press
  • Release : 2014-10-16
  • Pages : 422
  • ISBN : 1482203820
  • Language : En, Es, Fr & De
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Nutrition and Epigenetics presents new information on the action of diet and nutritional determinants in regulating the epigenetic control of gene expression in health and disease. Each chapter gives a unique perspective on a different nutritional or dietary component or group of components, and reveals novel mechanisms by which dietary factors modulate the epigenome and affect development processes, chronic disease, and the aging process. This pivotal text: Documents the epigenetic effect of antioxidants and their health benefits Adds to the understanding of mechanisms leading to disease susceptibility and healthy aging Illustrates that the epigenetic origins of disease occur in early (fetal) development Synthesizes the data regarding nutrient and epigenomic interactions Nutrition and Epigenetics highlights the interactions among nutrients, epigenetics, and health, providing an essential resource for scientists and clinical researchers interested in nutrition, aging, and metabolic diseases.

Nutrigenomics

Nutrigenomics
A Book

by Carsten Carlberg,Stine Marie Ulven,Ferdinand Molnár

  • Publisher : Springer
  • Release : 2016-06-11
  • Pages : 222
  • ISBN : 3319304151
  • Language : En, Es, Fr & De
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The fascinating area of Nutrigenomics describes this daily communication between diet, food and nutrients, their metabolites and our genome. This book describes how nutrition shapes human evolution and demonstrates its consequences for our susceptibility to diseases, such as diabetes and atherosclerosis. Inappropriate diet can yield stress for our cells, tissues and organs and then it is often associated with low-grade chronic inflammation. Overnutrition paired with physical inactivity leads to overweight and obesity and results in increased burden for a body that originally was adapted for a life in the savannas of East Africa. Therefore, this textbook does not discuss a theoretical topic in science, but it talks about real life, and our life-long “chat” with diet. We are all food consumers, thus each of us is concerned by the topic of this book and should be aware of its mechanisms. The purpose of this book is to provide an overview on the principles of nutrigenomics and their relation to health or disease. We are not aiming to compete with more comprehensive textbooks on molecular nutrition, evolutionary biology, genomics, gene regulation or metabolic diseases, but rather will focus on the essentials and will combine, in a compact form, elements from different disciplines. In order to facilitate the latter, we favor a high figure-to-text ratio following the rule “a picture tells more than thousand words”. The content of this book is based on the lecture course “Nutrigenomics”, which is held since 2003 once per year by Prof. Carlberg at the University of Eastern Finland in Kuopio. The book is subdivided into three sections and twelve chapters. Following the "Introduction" there are sections on the "Molecular genetic basis" and the "Links to disease", which take a view on nutrigenomics from the perspective of molecular mechanisms or from the causes of metabolic diseases, respectively. Besides its value as a textbook, Nutrigenomics will be a usefull reference for individuals working in biomedicine.

Nutrition in Epigenetics

Nutrition in Epigenetics
A Book

by Mihai D. Niculescu,Paul Haggarty

  • Publisher : John Wiley & Sons
  • Release : 2011-03-25
  • Pages : 332
  • ISBN : 9780470959800
  • Language : En, Es, Fr & De
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The study of epigenetics, or how heritable changes in gene expression are regulated without modifying the coding DNA sequence, has become an increasingly important field of study in recent years. Rapid developments in our understanding of the way in which gene function is modulated by the environment has revolutionized the way we think about human development and health. Nutrition in Epigenetics reviews the latest research looking at the interaction between genes and nutrients and the role they play together in maintaining human health. Nutrition in Epigenetics is divided into two primary parts. The first part provides key principles such as epigenetic mechanisms, developmental epigenetics, and the role of epigenetics in disease. The second part looks specifically at the application of epigenetics to the field of human nutrition. Chapters review the role of specific nutrients in modulating epigenetic status and the effect on health and disease. Nutrition in Epigenetics is an indispensable resource for researchers, professionals and advanced students with an interest in human nutrition, epigenetics, and biomedical research.

Genomic Imprinting

Genomic Imprinting
A Book

by Hiroyuki Sasaki,Fumitoshi Ishino

  • Publisher : S Karger Ag
  • Release : 2006
  • Pages : 349
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genomic imprinting, a parent-of-origin-specific epigenetic modification of the genome, is observed in placental mammals and some plants (angiosperms). Since its discovery in the early 1980s, this intriguing phenomenon has been intensively investigated and has spawned an exciting new research area. Imprinting is relevant to a variety of biological events such as embryogenesis, growth and behavior, and its disruption can lead to congenital malformation syndromes and cancers. Furthermore, imprinting has been serving as an excellent model system to study epigenetic mechanisms of gene regulation and helping us to understand how gene clusters and genome domains are regulated. This special issue provides an overview of the current knowledge of genomic imprinting. Including both excellent reviews and original research articles by outstanding researchers in the field, many of which were participants of the genomic imprinting workshops in Montpellier (September 2004) and Oxford (April 2005), it represents the forefront of imprinting research.