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Oral Delivery of Insulin

Oral Delivery of Insulin
A Book

by T.A. Sonia,Chandra P. Sharma

  • Publisher : Elsevier
  • Release : 2014-12-11
  • Pages : 290
  • ISBN : 1908818689
  • Language : En, Es, Fr & De
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Diabetes Mellitus, a syndrome of disordered metabolism, characterised by abnormal elevation in blood glucose level, has become a life-threatening condition for many people. Current means of therapy for Diabetes Mellitus do not mimic the normal physiological pattern of insulin release. Oral delivery is the preferred route of administration due to its non-invasive nature. Oral delivery of insulin presents an overview of Diabetes Mellitus, and discusses the strategies and techniques adopted for oral delivery of insulin. This title begins with an introductory chapter on symptoms, complications and therapy for Diabetes Mellitus. Subsequent chapters cover the various routes for administering insulin; the challenges and strategies of oral delivery; experimental techniques in the development of an oral insulin carrier; lipids; inorganic nanoparticles and polymers in oral insulin delivery; and a summary and presentation of future perspectives on oral delivery of insulin. Presents an overview of Diabetes Mellitus Includes a discussion of various strategies and techniques adopted for oral delivery of insulin Presents an update of research in the field

Development of Nanoparticles for Oral Delivery of Insulin

Development of Nanoparticles for Oral Delivery of Insulin
A Book

by Sunandini Chopra

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 177
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Parenteral administration remains the mainstay of drug administration for protein therapeutics. However, for diseases that require frequent drug dose over long periods of time, injections can result in patient incompliance and poor treatment outcomes. For such diseases, oral drug delivery is the most non-invasive and patient-compliant method of drug administration. Although oral delivery of many small molecule drugs is routine, oral delivery of protein drugs - e.g. insulin presents several challenges including oral bioavailability of the protein therapeutic because of degradation in the stomach, inactivation and digestion of the therapeutics by the proteolytic enzymes in the luminal cavity, and poor permeability of drugs across the intestinal epithelium. Polymeric nanoparticle (NP) carriers provide new opportunities for controlled delivery of drugs, and have the potential to address challenges associated with effective oral delivery of insulin. NPs can protect the protein therapeutic from degradation in the GI tract as well as allow targeted transport across the epithelial lining. An efficient NP based oral insulin delivery solution that can enable targeted transport of insulin across the GI tract must have (1) high insulin loading, (2) sub-100 nm size, (3) ability to release insulin before opsonization by macrophages and (4) the ability to be surface-functionalized with ligands that facilitate transport across the epithelium. This work presents a detailed study on mechanistic understanding of polymeric insulin NP formation with a focus on the effect of synthesis parameters on insulin loading and NP size. We report how buffer conditions, ionic chelation, and NP preparation methods influence insulin loading in poly (lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-PEG) NPs. We report a 10-fold increase in insulin loading with the use of chelating zinc ions and by the optimization of the pH during nanoprecipitation. Next, we report the development of novel insulin Eudragit-PLGA-PEG blended NPs (Ins-Eud-NPs) with high insulin loading (13.1%) and sub-100 nm size. These NPs enable rapid release of insulin when triggered by a change in pH that occurs when the NPs cross the duodenal epithelium and go from acidic to neutral pH. The NPs are formed by successfully blending Eudragit S100, a commercially available polymer which dissolves at pH greater than 7 with a non-pH responsive polymer, PLGA-PEG. To enable effective transport of these NPs across the epithelial lining, NPs were designed to use the FcRn transport pathway that mediates IgG antibody transport across epithelial barriers. We report the successful chemical conjugation of the Fc fragment on the surface of Ins-Eud- NPs by overcoming the presence of non-ideal conjugation parameters owing to the pH restrictions of the system. This dissertation provides mechanistic insights and helps to understand fundamental concepts about polymeric NP formation and protein encapsulation. The modular NP system developed in this work can be extended to other protein drug delivery systems that are subject to limited drug loading and restricted transport across epithelial barriers.

Subcutaneous and Oral Delivery of Insulin

Subcutaneous and Oral Delivery of Insulin
A Book

by Zakieh Al Kurdi

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nanoparticle Mediated Oral Delivery of Insulin

Nanoparticle Mediated Oral Delivery of Insulin
A Book

by Etienne Cabane

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 324
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Oral Delivery of Insulin for Diabetes Therapy

Oral Delivery of Insulin for Diabetes Therapy
The Design, Fabrication and Characterisation of a Modified-chitosan Based Nanoparticle System

by Revanth Rayasam

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Design, Development and Evaluation of an Oral Delivery System for Insulin

Design, Development and Evaluation of an Oral Delivery System for Insulin
A Book

by Mukur Gupta

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 358
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug Delivery

Drug Delivery
An Integrated Clinical and Engineering Approach

by Yitzhak Rosen,Pablo Gurman,Noel Elman

  • Publisher : CRC Press
  • Release : 2017-09-19
  • Pages : 602
  • ISBN : 1351643851
  • Language : En, Es, Fr & De
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Integrating the clinical and engineering aspects of drug delivery, this book offers a much needed comprehensive overview and patient-oriented approach for enhanced drug delivery optimization and advancement. Starting with an introduction to the subject and pharmacokinetics, it explores advances for such topics as oral, gastroretentive, intravitreal, and intrathecal drug delivery, as well as insulin delivery, gene delivery, and biomaterials-based delivery systems. It also describes drug delivery in cancer, cardiac, infectious diseases, airway diseases, and obstetrics and gynecology applications. Examining special clinical states requiring innovative drug delivery modifications, such as hypercoagulability often seen in pregnancy, cancer, and autoimmune diseases, the book also discusses methods for improved drug delivery in clinical settings using clinical end points, clinical trials, simulations, and other venues. It also describes the latest drug delivery advances involving nanomaterials, NEMS and MEMS devices, hydrogels, microencapsulation, lipids, stem cells, patches, and ultrasound. The book is rounded out by a chapter on the FDA regulatory and bioethical challenges involved in advancing drug delivery.

The Potential of Polymeric Nanoparticles for Oral Delivery of Insulin

The Potential of Polymeric Nanoparticles for Oral Delivery of Insulin
A Book

by Gaurav Sharma

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 526
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chitosan Nanoparticles for the Oral Delivery of Insulin

Chitosan Nanoparticles for the Oral Delivery of Insulin
A Book

by Zengshuan Ma

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 442
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Oral Delivery of Insulin by Polymer-coated Liposomes

Oral Delivery of Insulin by Polymer-coated Liposomes
A Book

by Majid Tabbakhian,University of Alberta. Faculty of Pharmacy and Pharmaceutical Sciences

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 328
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Modification of Insulin to Enhance Oral Delivery Systems

The Modification of Insulin to Enhance Oral Delivery Systems
A Book

by Melissa Ann Kanzelberger

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 366
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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While a number of PEGylated proteins have been studied for injectable applications and reviewers have used this data to speculate possible oral delivery improvements, a detailed investigation of PEGylated insulin for oral delivery and the development of an optimized pH-sensitive carrier for PEGylated insulin conjugates had yet to be accomplished. In order to proceed with oral delivery study, improvements in yield, with respect to previous PEGylation methods were necessary to enable the completion of high throughput drug delivery studies. Subsequently, a reaction scheme for the covalent attachment of PEG to insulin using nitrophenyl carbonate-PEG was developed. It was demonstrated that this reaction occurred at a 1:1 ratio and was site specific at the B29Lys position. A P(MAA-g-EG) hydrogel carrier was developed to optimize loading and release behavior for PEGylated insulin. It was demonstrated that the density and length of polymer grafts affected both loading and release behavior of PEGylated insulin. The best performing grafted polymers had a 3:1 methacrylic acid: ethylene glycol (MAA:EG) ratio and achieved loading efficiencies from 96% to nearly 100%. With respect to release, polymer particles containing fewer, but longer grafts shown to release faster than polymers with shorter grafts with the same MAA:EG ratio. Finally, the effects of PEGylation on intestinal absorption was investigated using an intestinal epithelial model as well as a rat model. It was demonstrated that PEGylated insulin in the presence of P(MAA-g-EG) microparticles did not significantly alter the tight junctions over unmodified insulin. However, the conjugate permeabilities across the membrane were reduced. The pharmacological availability (PA) was then verified by injecting the insulin conjugates subcutaneously in fasted Sprague-Dawley rats. It was determined that PEG 1000 insulin (1KPI) had a PA roughly equivalent to insulin, while it was reduced by 59% for 2KPI and by 81% for 5KPI. The effectiveness of utilizing PEGylated insulin as an oral drug delivery candidate was evaluated with a closed loop intestinal study, in which PEGylated insulin or insulin in solution was delivered directly to the jejunum. It was shown that 1KPI and insulin performed identically; with a pharmacological availability of 0.56%. 2KPI, however improved the pharmacological availability of insulin by 2.8 times. These results demonstrate that PEGylation holds promise for improving the oral delivery of proteins.

Oral Controlled Release Formulation Design and Drug Delivery

Oral Controlled Release Formulation Design and Drug Delivery
Theory to Practice

by Hong Wen,Kinam Park

  • Publisher : John Wiley & Sons
  • Release : 2011-01-14
  • Pages : 376
  • ISBN : 9781118060322
  • Language : En, Es, Fr & De
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This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Diabetes Treatment by Oral Delivery of Novel Fibrillar-insulin Formulations

Diabetes Treatment by Oral Delivery of Novel Fibrillar-insulin Formulations
A Book

by Yaron Yakov Dekel

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 182
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Recent Advances in Novel Drug Carrier Systems

Recent Advances in Novel Drug Carrier Systems
A Book

by Ali Demir Sezer

  • Publisher : IntechOpen
  • Release : 2012-10-31
  • Pages : 514
  • ISBN : 9789535108108
  • Language : En, Es, Fr & De
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This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.

Oral Colon-Specific Drug Delivery

Oral Colon-Specific Drug Delivery
A Book

by David R. Friend

  • Publisher : CRC Press
  • Release : 1992-07-27
  • Pages : 288
  • ISBN : 9780849366888
  • Language : En, Es, Fr & De
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Oral Colon-Specific Drug Delivery covers approaches used to deliver a variety of drugs to the colon. Anatomy and physiology of the gastrointestinal tract as it affects colonic drug delivery and pharmacokinetics are reviewed, as well as drug absorption from the colon. The book presents valuable information on a variety of topics, including oral peptide/protein delivery, dextran-based delivery systems, glycoside/glycosidase-based delivery, azo-bond prodrugs, hydroxypropyl methacrylamide copolymers for colonic delivery, and matrices for colonic drug delivery. Special emphasis is placed on delivery systems, especially biochemical approaches to delivery, such as the use of degradable polymers and both low and high molecular weight prodrugs. Oral Colon-Specific Drug Delivery will provide a valuable reference resource for gastroenterologists, pharmaceutical scientists, and other researchers working with drug delivery to the colon.

Oral Insulin Delivery Using Bovine Mucin

Oral Insulin Delivery Using Bovine Mucin
A Book

by Momoh Mumuni,Prof. Michael Umale Adikwu

  • Publisher : LAP Lambert Academic Publishing
  • Release : 2010-08
  • Pages : 112
  • ISBN : 9783838383774
  • Language : En, Es, Fr & De
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The purpose of this research was to investigate whether bovine mucin has the potential to serve as an oral delivery agent peptide drugs like insulin. mucin was proceessed from the small intestine of freshly slaughter cow via precipitation with acetone, air-drying and pulvirized. The mucin so extracted was used for further study.The physiochemical viscosity and bioadhessiveness property was assessed. Several ratio of mucin: insulin was formulated into catchet and was used for the glucose lowering potential in an alloxan made hyperghlycaemia rats, insulin alone was used as a control. The mechanism of insulin release from the catchet was study. The results of the physiochemical property revealed carbohydrate, protein, fat and oil. The viscosity and the bioadhessivness was mucin concentration dependent. All the animal show a glucose lowering potential and it is best in the formulation with high mucin content. Based on our finding, we proposed that the biological activity of insulin in preserved in the preparation: and mucin protected the degradation f insulin inthe GIT.

Drug Delivery Nanoparticles Formulation and Characterization

Drug Delivery Nanoparticles Formulation and Characterization
A Book

by Yashwant Pathak,Deepak Thassu

  • Publisher : CRC Press
  • Release : 2016-04-19
  • Pages : 416
  • ISBN : 1420078054
  • Language : En, Es, Fr & De
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Exploring fundamental concepts, Drug Delivery Nanoparticles Formulation and Characterization presents key aspects of nanoparticulate system development for various therapeutic applications and provides advanced methods used to file for regulatory approval.This comprehensive guide features:Process Analytical Techniques (PAT) used in manufacturing Na

Drug Delivery Systems

Drug Delivery Systems
A Book

by Vasant V. Ranade,Mannfred A. Hollinger,John B. Cannon

  • Publisher : CRC Press
  • Release : 2003-08-26
  • Pages : 464
  • ISBN : 1420040146
  • Language : En, Es, Fr & De
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Drug delivery technologies represent a vast and vital area of Research and Development. The demand for innovative drug delivery systems continues to grow, and this growth continues to drive new developments. Building on the foundation provided by the first edition, Drug Delivery Systems, Second Edition covers the latest developments in both

Oral Delivery of Insulin Bioconjugates Using Complexation Hydrogels

Oral Delivery of Insulin Bioconjugates Using Complexation Hydrogels
A Book

by Nikhil J. Kavimandan

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Polysaccharide based Nano-Biocarrier in Drug Delivery

Polysaccharide based Nano-Biocarrier in Drug Delivery
A Book

by Tapan Kumar Giri,Bijaya Ghosh

  • Publisher : CRC Press
  • Release : 2018-09-03
  • Pages : 368
  • ISBN : 0429830661
  • Language : En, Es, Fr & De
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This book discusses various fundamental aspects of polysaccharide based nano-biocarrier drug delivery systems and its application in the delivery of small molecules, proteins, peptides, oligonucleotides and genes. It also discusses advances in drug delivery systems in treatment of cancer, cardiovascular, pulmonary, and infectious diseases.