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Organofluorine Chemistry

Organofluorine Chemistry
A Book

by Kenji Uneyama

  • Publisher : John Wiley & Sons
  • Release : 2008-04-15
  • Pages : 352
  • ISBN : 1405172932
  • Language : En, Es, Fr & De
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The replacement of hydrogen with fluorine in organic molecules canprofoundly influence their chemical and physical properties,leading to a range of compounds with highly desirable properties.These molecules are of interest across the wide spectrum ofindustrial and academic organic chemistry, so that organofluorinechemistry is economically highly important. Organofluorine Chemistry will help chemists to develop a systematicknowledge of the chemistry of fluorine with a view towards itsapplication in the design of new reactions and syntheses, and thecreation of novel fluorinated molecules and materials. With initialchapters focusing on why fluorine creates such unique properties inorganic compounds, the book then covers general reactions offluorine. Coverage is chosen from the recent research literature,concentrating on the development of novel bioactive compounds andcatalytic ligands, and explaining, in the context of the initialchapters, how and why fluorine is so effective. With a finalchapter covering the general synthetic chemistry of organofluorinecompounds, the book is a cohesive summary of the fundamentalprincipals of organofluorine chemistry.

Organofluorine Chemistry

Organofluorine Chemistry
Techniques and Synthons

by Richard D. Chambers

  • Publisher : Springer
  • Release : 2003-09-05
  • Pages : 252
  • ISBN : 3540691979
  • Language : En, Es, Fr & De
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The excitement of the chemistry of organofluorine compounds stems from the unique reactions that arise and the "special effects" that introduction of fluorine impart on a molecule. Indeed, these effects are now exploited in a remarkable array of applications the whole of the chemical, pharmaceutical, and plant-protection industries. In this two-volume set, we have gathered authors with immense experience in various aspects of their fields and each is a world-authority on the important topics which they have described. The first volume treats the chemistry of fluorinated alkenes, which are important "building-blocks" for the synthesis of a range of fluorinated systems and are used widely in industry. The second volume is directed to techniques and synthons for obtaining fluorinated compounds.

Organofluorine Chemistry

Organofluorine Chemistry
Synthesis and Applications

by V. Prakash Reddy

  • Publisher : Elsevier
  • Release : 2020-03-20
  • Pages : 358
  • ISBN : 0128132876
  • Language : En, Es, Fr & De
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Organofluorine Chemistry: Synthesis and Applications gives a comprehensive outlook on modern synthetic methodologies for organofluorine compounds. It illustrates chemical, biochemical, and materials applications of fluorine-containing compounds, including synthesis and applications of small molecule compounds in drug discovery, positron emission tomography, and fluorinated polymers in solar cells. This book is of use to scientists working in the interdisciplinary areas, such as chemical, biochemical, and biomedical engineering, as well as those involved in materials science and medicinal chemistry. It is also a useful reference for researchers and graduate students interested in organofluorine chemistry. Provides modern synthetic methods and reactions of organofluorine compounds Incorporates the synthesis and chemical, biochemical and biomedical applications of fluorine-containing compounds, nanomaterials, PET imaging agents, pharmaceuticals, and polymeric materials Features emerging "hot" topics, such as late-stage fluorinations and drug discovery

Organofluorine Chemistry

Organofluorine Chemistry
Principles and Commercial Applications

by R.E. Banks,B.E. Smart,J.C. Tatlow

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-11
  • Pages : 644
  • ISBN : 1489912029
  • Language : En, Es, Fr & De
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During the past fifteen years commercial interest in compounds containing carbon fluorine bonds has burgeoned beyond all expectations, mainly owing to business opportunities arising from work on biologically active fluoroorganics-particularly agrochemicals, the relentless search for new markets for fluoropolymers and fluoro carbon fluids, developments in the field of medical diagnostics, and the drive to find replacements for ozone-depleting CFCs and Halon fire-extinguishing agents. Judging the situation to warrant the publication of a comprehensive collection of up-to-date reviews dealing with commercial organofluorine compounds within a single volume of manageable size (and hence reasonable cost), we were delighted to be invited by Plenum Publishing Corporation to produce a suitable book. In order to provide an authentic and wide-ranging account of current commercial applications of fluoroorganic materials, it clearly was necessary to assemble a sizeable team of knowledgeable contributing authors selected almost entirely from industry. Through their efforts we have been able to produce an almost complete coverage of the modem organofluorochemicals business in a manner designed to attract a reader ship ranging from experts in the field, through chemists and technologists currently unaware of the extent of industrial involvement with fluoroorganics, to students of applied chemistry. Promised chapters dedicated to perfluoroolefin oxides and 18F labeling of radiopharmaceuticals failed to materialize. This is somewhat unfortunate in view of our aim to achieve comprehensive coverage of the subject.

Organofluorine Compounds in Biology and Medicine

Organofluorine Compounds in Biology and Medicine
A Book

by V Prakash Reddy

  • Publisher : Newnes
  • Release : 2015-01-25
  • Pages : 330
  • ISBN : 044453749X
  • Language : En, Es, Fr & De
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This book covers topics on biochemically relevant organofluorine compounds and their synthesis and biochemical pathways. Organofluorine compounds have renewed interest in pharmaceutical industry, and therefore a concise book on this topic is highly relevant to the scientific community involved in this area. Covers the synthesis, biochemical, and therapeutic applications of organofluorine compounds Offers a complete text on biochemically relevant organofluorine compounds and their synthesis and mechanistic pathways Provides one of the first major reference books on the biological and medicinal applications of organofluorine chemistry

Organofluorine Chemistry

Organofluorine Chemistry
Synthesis, Modeling, and Applications

by Kalman J. Szabo,Nicklas Selander

  • Publisher : John Wiley & Sons
  • Release : 2021-03-22
  • Pages : 464
  • ISBN : 3527347119
  • Language : En, Es, Fr & De
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By presenting novel methods for the efficient preparation of fluorinated compounds and their application in pharmaceutical and agrochemical chemistry as well as medicine, this is a valuable source of information for all researchers in academia and industry!

Organofluorine Compounds

Organofluorine Compounds
Chemistry and Applications

by Tamejiro Hiyama

  • Publisher : Springer Science & Business Media
  • Release : 2013-03-09
  • Pages : 272
  • ISBN : 3662041642
  • Language : En, Es, Fr & De
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In view of increasing interest in organofluorine compounds, this book was undertaken to describe biological and physical properties of organofluorine compounds, synthetic methods of these, their roles in pharmaceutical, agrochemical and material sciences. In particular, the book will emphasize on the usefulness of fluorination reaction, availability of fluorination agents, so that even graduate students who are unfamiliar to this field can understand and participate in this fascinating heteroatom chemistry.

Modern Fluoroorganic Chemistry

Modern Fluoroorganic Chemistry
Synthesis, Reactivity, Applications

by Peer Kirsch

  • Publisher : John Wiley & Sons
  • Release : 2006-03-06
  • Pages : 320
  • ISBN : 3527604197
  • Language : En, Es, Fr & De
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In this handbook, Peer Kirsch clearly shows that this exciting field is no longer an exotic area of research. Aimed primarily at synthetic chemists wanting to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds, the main part of the book presents a wide range of synthetic methodologies and the experimental procedures selected undeniably show that this can be done with standard laboratory equipment. To round off, the author looks at fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers and more besides. This long-awaited book represents an indispensable source of high quality information for everyone working in the field.

Frontiers Of Organofluorine Chemistry

Frontiers Of Organofluorine Chemistry
A Book

by Iwao Ojima

  • Publisher : World Scientific
  • Release : 2019-12-24
  • Pages : 844
  • ISBN : 1786347342
  • Language : En, Es, Fr & De
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This book focuses on the new frontiers of organofluorine chemistry in synthetic, organometallic, bioorganic, medicinal, agricultural, and materials chemistry as well as chemical physics and their applications to biomedical and material sciences. The extraordinary potential of fluorine-containing molecules in biology, pharmaceuticals, agrochemical, materials and their wide range of applications has been recognized by researchers who are not in the traditional fluorine chemistry field, and thus the new wave of organofluorine chemistry is rapidly expanding its frontiers.Featuring major leading researchers from all over the world and their cutting-edge research projects, this title reviews the recent advances and envision the new exciting developments in the future. Frontiers of Organofluorine Chemistry is an excellent reference book for professional researchers, and graduate students, in both industry and academia to get inspirations and new ideas for their projects.

Organofluorine Chemistry: Principles and Commercial Applications

Organofluorine Chemistry: Principles and Commercial Applications
A Book

by B.E. Smart,J.C. Tatlow

  • Publisher : Springer Science & Business Media
  • Release : 1994-09-30
  • Pages : 644
  • ISBN : 9780306446108
  • Language : En, Es, Fr & De
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Highly fluorinated compounds; Fluorocarbon code numbers; HF problem; Synthesis of C-F bonds; Aliphatic fluorides go commercial; Perfluorocarbons; Wartime advances - the Manhatten project; Synthesis of organofluorine compounds; Characterictics of C-F systems; Perfluorocarbon fluids; Electrochemical fluorination; Chlorofluorocarbons (CFCs) and alternatives; Perfluoalkyl bromides and Iodides; Ring-fluorinated aromatic compounds; Side-chain fluorinated aromatic compounds routes to Benzotrifluorides; Recent developements in Fluorine-containing agrochemicals; Fluorinated liquid crystals; Fluorine-containing dyes; Textile finishes and fluorosurfactants; Fluorplastics; Fluoroelastomers; Fluoropolymer coatings; Fluorinated membranes; Monomers and polymers from Hexafluoroacetone; Perfluoropolethers (PFPEs); Surface fluorination of polymers; Fluorinated carbon; Fluorine in chemotherapy; Fluorinated inhalation anesthetics; Biomedical applications of Perfluorocarbons; Fluorochemical industry; CFCs and the environment.

Organofluorine Chemistry

Organofluorine Chemistry
Fluorinated Alkenes and Reactive Intermediates

by B. Ameduri,V.V. Bardin

  • Publisher : Springer Science & Business Media
  • Release : 1997-09-18
  • Pages : 244
  • ISBN : 9783540631712
  • Language : En, Es, Fr & De
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The excitement of the chemistry of organofluorine compounds stems from the unique reactions that arise and the "special effects" that introduction of fluorine impart on a molecule. Indeed, these effects are now exploited in a remarkable array of applications the whole of the chemical, pharmaceutical, and plant-protection industries. In this two-volume set, we have gathered authors with immense experience in various aspects of their fields and each is a world-authority on the important topics which they have described. The first volume treats the chemistry of fluorinated alkenes, which are important "building-blocks" for the synthesis of a range of fluorinated systems and are used widely in industry. The second volume is directed to techniques and synthons for obtaining fluorinated compounds.

Fluorine in Organic Chemistry

Fluorine in Organic Chemistry
A Book

by Richard D. Chambers

  • Publisher : CRC Press
  • Release : 2004
  • Pages : 406
  • ISBN : 9780849317903
  • Language : En, Es, Fr & De
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Replacing hydrogen with fluorine in organic molecules can profoundly influence their chemical and physical properties, leading to a range of chemical compounds, from Prozac to Teflon, which rely on organic fluorine chemistry for their useful and highly desirable properties. Fluorine in Organic Chemistry introduces its subject by discussing the chemical properties and electronic effects of fluorocarbon systems. Subsequent chapters detail the most efficient methods for the preparation and synthesis of partially, selectively, and highly fluorinated systems, from electrochemical flourination, to the addition of fluorine to olefins and aceytylenes. Other topics include: the characteristics of fluorocarbon groups in terms of ions, acids, and bases; substitution effects of fluorocarbon groups on nucleophilic displacement; elimination reactions; flouroalkane, functional, and polyfluoroaromatic compounds; fluorine in biochemistry; and organometallic reagents. With applications that extend from pharmaceuticals to fine and specialty chemicals to polymers, Fluorine in Organic Chemistry is an excellent reference for all organic chemists.

Handbook of Fluorous Chemistry

Handbook of Fluorous Chemistry
A Book

by John A. Gladysz,Dennis P. Curran,István T. Horváth

  • Publisher : John Wiley & Sons
  • Release : 2006-03-06
  • Pages : 624
  • ISBN : 3527604499
  • Language : En, Es, Fr & De
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Edited by the leading experts John Gladysz, Dennis Curran, and István Horváth, this handbook is the first to summarize all the essential aspects of this emerging field of chemistry. Whether the reader is seeking an introduction to the concept of fluorous biphase catalysis, summaries of partition coefficients involving fluorous and organic solvents, or information on the latest fluorous mixture separation techniques, this authoritative compilation of contributions, written by the world's top authors, provides key information needed for successfully working with the diverse and fascinating families of fluorous molecules. The large number of reliable experimental procedures in particular makes this the ideal guide for newcomers wanting to use this elegant method in the laboratory. In addition, experts will also find a wealth of important information concisely contained in one ready reference. The result is an indispensable resource for everyone currently working or intending to work in this field.

Fluorine Chemistry at the Millennium

Fluorine Chemistry at the Millennium
Fascinated by Fluorine

by R.E. Banks

  • Publisher : Elsevier
  • Release : 2000-12-04
  • Pages : 660
  • ISBN : 9780080531793
  • Language : En, Es, Fr & De
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This volume brings together contributions by leading researchers covering a wide scope so characteristic of fluorine chemistry. It is a monograph of historical character comprising personalized accounts of progress and events in areas of particular interest. There is also much to interest and instruct chemists from other disciplines as a good proportion of the chapters contain a considerable amount of 'hard' referenced information relating to modern organic, organoelemental and inorganic chemistry. Historians of chemistry and technology will no doubt be tempted to dip into this book, and surely whoever addresses the task of commemorating Moissan's achievement at the 150-years stage will bless us all in some measure for its existence.

Modern Synthesis Processes and Reactivity of Fluorinated Compounds

Modern Synthesis Processes and Reactivity of Fluorinated Compounds
Progress in Fluorine Science

by Henri Groult,Frederic Leroux,Alain Tressaud

  • Publisher : Elsevier
  • Release : 2016-11-04
  • Pages : 760
  • ISBN : 0128037903
  • Language : En, Es, Fr & De
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Modern Synthesis Processes and Reactivity of Fluorinated Compounds focuses on the exceptional character of fluorine and fluorinated compounds. This comprehensive work explores examples taken from all classes of fluorine chemistry and illustrates the extreme reactivity of fluorinating media and the peculiar synthesis routes to fluorinated materials. The book provides advanced and updated information on the latest synthesis routes to fluorocompounds and the involved reaction mechanisms. Special attention is given to the unique reactivity of fluorine and fluorinated media, along with the correlation of those properties to valuable applications of fluorinated compounds. Contains quality content edited, and contributed, by leading scholars in the field Presents applied guidance on the preparation of original fluorinated compounds, potentially transferable from the lab scale to industrial applications Provides practical synthesis information for a wide audience interested in fluorine compounds in many branches of chemistry, materials science, and physics

Fluorine and Health

Fluorine and Health
Molecular Imaging, Biomedical Materials and Pharmaceuticals

by Alain Tressaud,Gunter Haufe

  • Publisher : Elsevier
  • Release : 2008-06-06
  • Pages : 816
  • ISBN : 9780080558110
  • Language : En, Es, Fr & De
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Fluorine and Health presents a critical multidisciplinary overview on the contribution of fluorinated compounds to resolve the important global issue of medicinal monitoring and health care. The involved subjects are organized in three thematic parts devoted to Molecular Imaging, Biomedical Materials and Pharmaceuticals. Initially the key-position of partially fluorinated low molecular weight compounds labelled either with the natural 19F-isotope for Magnetic Resonance Imaging (MRI) or labelled with the radioactive [18F]-isotope for Positron Emission Tomography (PET) is highlighted. Both non-invasive methods belong to the most challenging in vivo imaging techniques in oncology, neurology and in cardiology for the diagnosis of diseases having the highest mortality in the industrialized countries. The manifold facets of fluorinated biomaterials range from inorganic ceramics to perfluorinated organic molecules. Liquid perfluorocarbons are suitable for oxygen transport and as potential respiratory gas carriers, while fluorinated polymers are connected to the pathology of blood vessels. Another important issue concerns the application of highly fluorinated liquids in ophthalmology. Moreover, fluorine is an essential trace element in bone mineral, dentine and tooth enamel and is applied for the prophylaxis and treatment of dental caries. The various origins of human exposure to fluoride species is detailed to promote a better understanding of the effect of fluoride species on living organisms. Medicinally relevant fluorinated molecules and their interactions with native proteins are the main focus of the third part. New molecules fluorinated in strategic position are crucial for the development of pharmaceuticals with desired action and optimal pharmacological profile. Among the hundreds of marketed active drug components there are more than 150 fluorinated compounds. The chapters will illustrate how the presence of fluorine atoms alters properties of bioactive compounds at various biochemical steps, and possibly facilitate its emergence as pharmaceuticals. Finally the synthetic potential of a fluorinase, the first C-F bond forming enzyme, is summarized. - New approach of topics involving chemistry, biology and medicinal techniques - Transdisciplinar papers on fluoride products - Importance of fluoride products in health - Updated data on specific topics

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals

Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics, and Agrochemicals
Progress in Fluorine Science Series

by Gunter Haufe,Frederic Leroux

  • Publisher : Academic Press
  • Release : 2018-09-19
  • Pages : 686
  • ISBN : 0128127341
  • Language : En, Es, Fr & De
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Fluorine in Life Sciences: Pharmaceuticals, Medicinal Diagnostics and Agrochemicals, volume four in Alain Tressaud’s Progress in Fluorine Science series, presents a critical, multidisciplinary overview of the contributions of fluorinated products to solve important global issues in various life science fields, particularly in medicinal chemistry, molecular imaging techniques and agriculture. Edited by recognized experts, this book provides unique coverage of the wide-ranging uses and implications of fluorine and fluorinated compounds. Topics include medicinal monitoring and diagnosis, 19F MRI in medicine and in vivo cell tracking, 18F-labeled radiopharmaceuticals, brain imaging and neurology, risk assessment of reactive metabolites in drug discovery, and more. Edited by Alain Tressaud, past Chair and founder of the CNRS French Fluorine Network, each book in the collection also includes the work of highly-respected volume editors and contributors from both academia and industry who bring valuable and varied content to this active field. Covers a wide range of topics - from organic and physical chemistry, to pharmaceuticals, agrochemicals and medical diagnostics Describes major modern syntheses and unique reaction mechanisms yielding fluorine compounds in these diverse life science settings Features contributions from a wealth of global experts Acts as the fourth volume in Alain Tressaud’s Progress in Fluorine Science

Fluorine in Heterocyclic Chemistry Volume 1

Fluorine in Heterocyclic Chemistry Volume 1
5-Membered Heterocycles and Macrocycles

by Valentine Nenajdenko

  • Publisher : Springer
  • Release : 2014-06-30
  • Pages : 681
  • ISBN : 3319043463
  • Language : En, Es, Fr & De
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This two-volume work combines comprehensive information on the chemistry of the fluorinated heterocycles. The material has been divided such that the first volume is dedicated to 5-membered fluorinated heterocycles and macrocycles, while the second volume combines data connected with the chemistry of fluorine containing 6-membered heterocycles. Both volumes will be of interest to synthetic organic chemists in general, and particularly for those colleagues working in the fields of heterocyclic-compound chemistry, materials chemistry, medicinal chemistry, and fluorine chemistry. All information is presented and classified clearly to be effective source for broad auditory of chemists. It will be interesting for scientists working in the field of inorganic and coordination chemistry. Fluorinated heterocycles are becoming increasingly important in many areas including the pharmaceutical industry, materials science and agriculture. The presence of fluorine can result in substantial functional changes in the biological as well as physicochemical properties of organic compounds. Incorporation of fluorine into drug molecules can greatly affect their physicochemical properties, such as bond strength, lipophilicity, bioavailability, conformation, electrostatic potential, dipole moment, pKa etc. as well as pharmacokinetic properties, such as tissue distribution, rate of metabolism and pharmacological properties, such as pharmacodynamics and toxicology.

Organofluorine Chemistry

Organofluorine Chemistry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Emerging Fluorinated Motifs, 2 Volume Set

Emerging Fluorinated Motifs, 2 Volume Set
Synthesis, Properties and Applications

by Dominique Cahard,Jun-An Ma

  • Publisher : John Wiley & Sons
  • Release : 2020-05-26
  • Pages : 760
  • ISBN : 3527346813
  • Language : En, Es, Fr & De
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A must-have resource for all the researchers working in the organofluorine and related fields This timely two-volume set uniquely focuses on emerging fluorinated motifs beyond R-CF3 and R-F, like R-CF2H, R-OCF3, R-SCF3 and R-SF5. It also offers descriptions of the properties, synthesis, and applications of these emerging fluorinated motifs in order to help readers design new chemical entities, while providing new interest for researchers in organofluorine chemistry and new tools for those in other areas. Emerging Fluorinated Motifs: Synthesis, Properties and Applications begins with a description of carbon-linked fluorine-containing groups that include monofluoromethyl and difluoromethyl groups. It then details combinations of heteroatoms, Oxygen, Sulfur, Selenium, Nitrogen, and Phosphorus with fluorine-containing groups, outlining subsections of the most popular current motifs. Fluoroalkyl ethers, thioethers, and the recent blossoming of the SF5 unit is covered. Other chapters look at: selenium-linked fluorine-containing motifs; construction of N?CF2H, N?CF3, N?CH2CF3 motifs; and the synthesis and applications of P¿Rf-containing molecules. -Focuses on the synthesis, properties, and applications of emerging fluorinated motifs -Covers carbon-linked fluorine-containing motifs, oxygen-linked fluorine-containing motifs, sulfur-linked fluorine-containing motifs, and more -Appeals to academic and industrial researchers working in organic chemistry, medicinal chemistry, food chemistry, and materials science -Edited by world-renowned experts in organofluorine chemistry Emerging Fluorinated Motifs is intended for academic research institutes, university libraries, researchers, graduate students, postdoctors, and researchers in the chemical industry.