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Osteosarcopenia: Bone, Muscle and Fat Interactions

Osteosarcopenia: Bone, Muscle and Fat Interactions
A Book

by Gustavo Duque

  • Publisher : Unknown Publisher
  • Release : 2019
  • Pages : 383
  • ISBN : 9783030258924
  • Language : En, Es, Fr & De
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This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions - including the role of local bone and muscle fat - followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Osteosarcopenia

Osteosarcopenia
A Book

by Gustavo Duque,Bruce R. Troen

  • Publisher : Elsevier
  • Release : 2021-08-15
  • Pages : 240
  • ISBN : 9780128200889
  • Language : En, Es, Fr & De
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Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways,?impacting the wellbeing of our older population Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between?muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of?osteosarcopenia

Postmenopausal Diseases and Disorders

Postmenopausal Diseases and Disorders
A Book

by Faustino R. Pérez-López

  • Publisher : Springer
  • Release : 2019-07-10
  • Pages : 484
  • ISBN : 3030139360
  • Language : En, Es, Fr & De
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Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes the development of quick and easy-to-use assessment tools and predictive markers of age-related co-morbidities. As such, the book is a valuable resource for researchers and clinicians alike.

Osteosarcopenia: Bone, Muscle and Fat Interactions

Osteosarcopenia: Bone, Muscle and Fat Interactions
A Book

by Gustavo Duque

  • Publisher : Springer Nature
  • Release : 2019-11-06
  • Pages : 383
  • ISBN : 3030258904
  • Language : En, Es, Fr & De
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This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Marcus and Feldman's Osteoporosis

Marcus and Feldman's Osteoporosis
A Book

by David W. Dempster,Jane A. Cauley,Mary L. Bouxsein,Felicia Cosman

  • Publisher : Academic Press
  • Release : 2020-10-08
  • Pages : 1946
  • ISBN : 0128130741
  • Language : En, Es, Fr & De
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Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
A Book

by Anonim

  • Publisher : John Wiley & Sons
  • Release : 2018-12-06
  • Pages : 1136
  • ISBN : 1119266564
  • Language : En, Es, Fr & De
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The authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. This vital resource: Provides the most accurate, up-to-date evidence-based information on basic and clinical bone science Includes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers Captures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics Presents a new companion website with useful supplementary materials at www.asbmrprimer.com Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Encyclopedia of Biomedical Gerontology

Encyclopedia of Biomedical Gerontology
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-11-20
  • Pages : 1640
  • ISBN : 0128160764
  • Language : En, Es, Fr & De
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Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Hazzard's Geriatric Medicine and Gerontology, 7E

Hazzard's Geriatric Medicine and Gerontology, 7E
A Book

by Jeffrey B. Halter,Joseph G. Ouslander,Stephanie Studenski,Kevin P. High,Sanjay Asthana,Nancy Woolard,Christine S. Ritchie,Mark A. Supiano

  • Publisher : McGraw Hill Professional
  • Release : 2016-11-18
  • Pages : 2304
  • ISBN : 0071833463
  • Language : En, Es, Fr & De
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The gold-standard text on the diagnosis and treatment of disorders affecting the elderly – completely updated with a new full-color presentation A Doody's Core Title for 2017! The definitive treatise on the subject of geriatrics, this comprehensive text combines gerontology principles with clinical geriatrics, offering a uniquely holistic approach to this ever-expanding area of medicine. Written by some of the world’s most respected geriatricians, Hazzard’s Geriatric Medicine and Gerontology, Seventh Edition presents up-to-date, evidence-based information in a rich new full-color design. Unmatched as a textbook, this classic is also valuable to fellows in geriatric medicine. Hazzards’s Geriatric Medicine and Gerontology, Seventh Edition is logically divided into five parts: Principles of Gerontology, Principles of Geriatrics, Geriatric Syndromes, Principles of Palliative Medicine, and Organ Systems and Diseases. Within its pages, you will find balanced, authoritative coverage of every essential topic – from evaluation and management to nutrition and palliative medicine. Here’s why the Seventh Edition is the best edition ever: • NEW full-color design with hundreds of color photographs • NEW chapters: Quality of Care in Older Adults, Common Non-Pain Symptoms in Older Adults, Strategies of Effective Communication Around Advanced Illness, Palliative Medicine in the Continuum of Care Including Hospice, Coagulation Disorders, and Plasma Cell Disorders • MORE chapters on Palliative Medicine • NEW Learning Objectives and Key Points added to each chapter • MORE tables, drawings, and clinical algorithms • EVIDENCE-BASED through the use of the latest clinical practice guidelines , references to systemic reviews, and critically appraised topics • UPDATED to reflect the most current clinical breakthroughs and advances for managing older adults in various settings

Genomics, Proteomics, and Metabolomics

Genomics, Proteomics, and Metabolomics
Stem Cells Monitoring in Regenerative Medicine

by Babak Arjmand

  • Publisher : Springer Nature
  • Release : 2019-11-14
  • Pages : 199
  • ISBN : 3030277275
  • Language : En, Es, Fr & De
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This book provides thorough coverage of high-throughput OMICs technologies for the monitoring of stem cells and regenerative medicine. Specific topics covered include the genomics, proteomics, and metabolomics aspects of regenerative medicine, metabolic profiling of mesenchymal stem cells, genome profiling of mesenchymal stem cells, OMICs monitoring of stem cell-derived exosomes, stem cell proteomics, lipidomics, OMICs profiling of cancer (stem) cells, and finally ethical considerations of OMICs-based investigations. Chapters are authored by world-renowned scientists who have valuable expertise in the field of OMICs and regenerative medicine. Genomics, Proteomics, and Metabolomics: Stem Cells Monitoring in Regenerative Medicine, part of Springer’s Stem Cell Biology and Regenerative Medicine series, is essential reading for researchers, clinicians, biologists, biochemists, and pharmaceutical experts conducting research in the fields of stem cell biology, molecular aspects of stem cell research, tissue engineering, regenerative medicine, cellular therapy, OMICs, bioinformatics, and ethics.

Multidisciplinary Approach to Osteoporosis

Multidisciplinary Approach to Osteoporosis
From Assessment to Treatment

by Andrea Lenzi,Silvia Migliaccio

  • Publisher : Springer
  • Release : 2018-09-04
  • Pages : 330
  • ISBN : 3319751107
  • Language : En, Es, Fr & De
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This book describes in detail the multidisciplinary management of osteoporosis, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical activity, nutritional strategies, and pharmacological treatment. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of osteoporosis, the incidence of which is increasing rapidly as populations age.

Nutritional Influences on Bone Health

Nutritional Influences on Bone Health
9th International Symposium

by Connie M. Weaver,Robin M. Daly,Heike A. Bischoff-Ferrari

  • Publisher : Springer
  • Release : 2016-08-01
  • Pages : 335
  • ISBN : 3319324179
  • Language : En, Es, Fr & De
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The 9th International Symposium is the only regular meeting in the bone field to be exclusively devoted to nutrition, bone and muscle, and it allows the authors of this book to review the new scientific data, discuss new concepts, and update the knowledge on several nutrients. The Symposium provides a unique opportunity to connect health professionals, researchers and industry across many disciplines, including nutrition and dietetics, exercise science, gerontology, nursing, general practice, academia and the food and fitness industry. Most causes for osteoporosis, like genetics, age, menopause, and associated diseases with their treatments, are not modifiable. The investigation of the influence of nutrition on bone health is important as a key modifiable factor of the development of bone and the prevention of osteoporosis. It is the privilege of this symposium to gather every three years with scientists from all over the world working in this field.

A Practical Manual for Musculoskeletal Research

A Practical Manual for Musculoskeletal Research
A Book

by Kwok-Sui Leung,Wing-Hoi Cheung

  • Publisher : World Scientific
  • Release : 2008
  • Pages : 940
  • ISBN : 9812794093
  • Language : En, Es, Fr & De
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This manual provides technical protocols for musculoskeletal research on a translational basis, i.e. a disease-orientated approach. It offers guidance on various laboratory techniques, including cell culture and molecular biology, histology and histomorphometry, microscopy and bioimaging, laboratory animal models, CT- and MRI-based densitometry and microarchitectural analysis, biomechanics and functional analysis of orthopedic kinesiology, etc. The content is simple and straightforward, with illustrations and step-by-step procedures as an easy experimental reference for personnel in basic and clinical musculoskeletal research and education. This book will provide a unique multidisciplinary platform for various professions OCo not only orthopedics, but also biomedical engineering and biomaterial sciences OCo involving both basic and clinical medicine."

Hot Topics in Endocrine and Endocrine-Related Diseases

Hot Topics in Endocrine and Endocrine-Related Diseases
A Book

by Monica Fedele

  • Publisher : BoD – Books on Demand
  • Release : 2013-05-08
  • Pages : 276
  • ISBN : 9535110802
  • Language : En, Es, Fr & De
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This book covers a selected number of hot topics in endocrine and hormone-related pathologies, discussed by eminent scientists and clinicians coming from different countries of the world. It deals with advanced recent trends in the field, including neuroendocrine and pituitary tumors, thyroid dysfunctions, diabetes and a series of endocrine-related diseases, such as those related to the anabolic effects of testosterone, obesity, cancer, the liver complications of diabetes and the pediatric nonalcoholic fatty liver disease. The readers should be able to have a basic, as well as critic and advanced, overview of these selected hot pathologies of the endocrine system.

Human Body Composition

Human Body Composition
A Book

by Timothy Lohman,ZiMian Wang,Scott B. Going

  • Publisher : Human Kinetics
  • Release : 2005
  • Pages : 523
  • ISBN : 9780736046558
  • Language : En, Es, Fr & De
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The 2nd edition of Human Body Composition includes updated information and new chapters. The editors and 35 contributors are well respected researchers in the field of body composition science. This is one of few texts that provides comprehensive coverage of body composition research. The primary intent is to present current information on research methods. This book can serve as a textbook for those who are students or new researchers. Descriptions of various methods and background information are imparted in great detail with numerous references. New chapters address energy expenditure, animal body composition, molecular genetics and body composition as it relates to disease states of cancer, HIV, obesity and certain inflammatory diseases like rheumatoid arthritis, inflammatory bowel disease, congestive heart failure and chronic obstructive pulmonary disease. This book is recommended for students and new researchers in the field of body composition research who need to learn various methods, histories and practical applications--Publisher's description.

Health, Illness, and Optimal Aging

Health, Illness, and Optimal Aging
Biological and Psychosocial Perspectives

by Carolyn M. Aldwin,Dr Diane F Gilmer,Diane F. Gilmer

  • Publisher : SAGE
  • Release : 2004
  • Pages : 418
  • ISBN : 9780761922599
  • Language : En, Es, Fr & De
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In Health, Illness, and Optimal Aging: Biological and Psychosocial Perspectives, Carolyn M. Aldwin and Diane F. Gilmer undertake the challenging task of assembling an objective and holistic picture of human aging. The authors provide comprehensive, multidisciplinary coverage of the physical aspects of aging, including age-related changes and disease-related processes, the demography of the aging population, theories of aging, and the promotion of optimal aging. In addition, the book covers the psychosocial aspects of aging, including mental health, stress and coping, spirituality, and care giving in later years. Health, Illness and Optimal Aging is recommended for researchers seeking an overview of health psychology and aging, as well as undergraduate and graduate students taking classes in the social, behavioral, and health sciences. This text is also valuable for practitioners working with the elderly in fields such as nursing, social work, occupational and physical therapy, day-care and nursing home administration, psychology, and rehabilitation.

Muscle Biophysics

Muscle Biophysics
From Molecules to Cells

by Rassier Dilson J.E

  • Publisher : Springer Science & Business Media
  • Release : 2010-09-08
  • Pages : 354
  • ISBN : 9781441963666
  • Language : En, Es, Fr & De
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Muscle contraction has been the focus of scientific investigation for more than two centuries, and major discoveries have changed the field over the years. Early in the twentieth century, Fenn (1924, 1923) showed that the total energy liberated during a contraction (heat + work) was increased when the muscle was allowed to shorten and perform work. The result implied that chemical reactions during contractions were load-dependent. The observation underlying the “Fenn effect” was taken to a greater extent when Hill (1938) published a pivotal study showing in details the relation between heat production and the amount of muscle shortening, providing investigators with the force-velocity relation for skeletal muscles. Subsequently, two papers paved the way for the current paradigm in the field of muscle contraction. Huxley and Niedergerke (1954), and Huxley and Hanson (1954) showed that the width of the A-bands did not change during muscle stretch or activation. Contraction, previously believed to be caused by shortening of muscle filaments, was associated with sliding of the thick and thin filaments. These studies were followed by the classic paper by Huxley (1957), in which he conceptualized for the first time the cross-bridge theory; filament sliding was driven by the cyclical interactions of myosin heads (cross-bridges) with actin. The original cross-bridge theory has been revised over the years but the basic features have remained mostly intact. It now influences studies performed with molecular motors responsible for tasks as diverse as muscle contraction, cell division and vesicle transport.

Osteoporosis in Older Persons

Osteoporosis in Older Persons
Advances in Pathophysiology and Therapeutic Approaches

by Gustavo Duque,Douglas P. Kiel

  • Publisher : Springer
  • Release : 2016-07-11
  • Pages : 282
  • ISBN : 3319259768
  • Language : En, Es, Fr & De
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This new edition includes the most up-to-date information about the pathophysiology and new therapeutic alternatives for osteoporosis of advanced age. It is written by investigators (clinicians and basic scientists) in the field of aging bone research. It was just recently that a new syndrome, osteoporosis of advanced age, was recognized as a new entity with its own pathophysiology and potential treatments. Unfortunately, and despite the fact that hip fractures are mostly a consequence of this process, and apart from the first edition of this book, there are few publications about this subject. The first edition of this book demonstrated that there is a need to understand the particular features of osteoporosis in older persons, which is the main aim of this book. The institutions where the authors are affiliated are highly recognized as the main centers in aging bone research. As an innovation, the second edition includes some aspects of muscle and bone interaction focusing of the impact of age-related muscle loss (sarcopenia) on the pathogenesis of falls and fractures in older persons. As in the previous edition, this book is expected to be the reference guide for geriatricians, gerontologists, and bone biologists as well as medical trainees in order to understand the mechanisms of senile osteoporosis with a practical approach to the treatment of its consequences.

Rehabilitation Medicine for Elderly Patients

Rehabilitation Medicine for Elderly Patients
A Book

by Stefano Masiero,Ugo Carraro

  • Publisher : Springer
  • Release : 2017-09-04
  • Pages : 545
  • ISBN : 331957406X
  • Language : En, Es, Fr & De
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This book clearly explains when and how different rehabilitation techniques should be applied in the aging patient, thereby enabling readers to identify and apply those rehabilitation strategies that will maximize quality of life and functional independence in individual cases. It is specifically designed for ease of consultation and rapid retrieval of the information most relevant to clinical practice. Prominence is given to the benefits of a multidisciplinary approach to rehabilitation, with discussion of a very wide range of aspects of rehabilitation in different disease settings. The breadth of coverage is illustrated by the attention paid to less commonly addressed topics such as visual and hearing rehabilitation, the role of robotics and 3D imaging techniques, variations in approach among health care systems, and rehabilitation in end-of-life care. The authors are international academic experts in their fields, guaranteeing a high scientific standard throughout. This manual will be an invaluable tool and source of knowledge for geriatricians and physiatrists but will also appeal to a wider range of clinicians, practitioners, and students.

Palliative Care for Older People

Palliative Care for Older People
A Public Health Perspective

by Lieve Van Den Block,Gwenda Albers,Bregje Onwuteaka-Philipsen,Sandra Martins Pereira,Roeline Pasman,Luc Deliens

  • Publisher : Oxford University Press, USA
  • Release : 2015-05-07
  • Pages : 336
  • ISBN : 019871761X
  • Language : En, Es, Fr & De
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Palliative care for older people: A public health perspective offers not only insights into the current state of policy work around the world; it also offers examples of good practice and recommendations for the future. Recommendations that can inspire, support, and direct healthcare policy and decision-making at organisational, regional, national and international levels. Aimed at policy and decision-makers on a worldwide level,this book is essential reading for managers in healthcare as well as healthcare professionals and practitioners working in public health, palliative care, and geriatric medicine.

Addressing Food and Nutrition Security in Developed Countries

Addressing Food and Nutrition Security in Developed Countries
A Book

by Christina M. Pollard,Sue Booth

  • Publisher : MDPI
  • Release : 2019-07-31
  • Pages : 428
  • ISBN : 3039212818
  • Language : En, Es, Fr & De
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This book is a printed edition of the Special Issue Addressing Food and Nutrition Security in Developed Countries that was published in IJERPH