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Osteosarcopenia: Bone, Muscle and Fat Interactions

Osteosarcopenia: Bone, Muscle and Fat Interactions
A Book

by Gustavo Duque

  • Publisher : Springer Nature
  • Release : 2019-11-06
  • Pages : 383
  • ISBN : 3030258904
  • Language : En, Es, Fr & De
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This edited work presents the most current evidence on osteosarcopenia from bench to bedside, which is expected to facilitate the understanding of this syndrome and to develop preventive and therapeutic strategies. With our aging population, chronic diseases such as osteoporosis and sarcopenia are becoming highly prevalent. Fortunately, our understanding of the bone and muscle interactions has increased in recent years. This has allowed to the coining of the term osteosarcopenia to describe a syndrome in which these two diseases overlap. This overlap between osteoporosis and sarcopenia has major negative effects not only on our older adults but also on health systems worldwide. Readers will find a highly translational approach that starts with a summary of recent discoveries on stem cells biology, muscle and bone interactions – including the role of local bone and muscle fat – followed by comprehensive reviews on myokines (i.e. myostatin), osteokines (i.e. osteocalcin) and adipokines (i.e. interleukins) as major players and determinants of bone and muscle loss with aging. In addition, the role of sex steroids (i.e. estrogens, androgens), and calciotropic hormones (i.e. parathyroid hormone, vitamin D) in the pathogenesis of this syndrome is also reviewed. Moreover, using practical diagnostic and therapeutic tips, this book summarizes the clinical characteristics of osteosarcopenic patients thus facilitating the diagnosis and treatment of this syndrome in clinical practice. Finally, the book presents the case for the Falls and Fractures Clinic as the optimal model of care for this syndrome, aimed to avoid fragmentation and optimize osteosarcopenia care, and simultaneously prevent falls and fractures in older persons. This book offers relevant information on the mechanisms of osteosarcopenia, and a practical guide on how to identify and treat this geriatric syndrome and its adverse outcomes, which are dramatically affecting our aging population. The work is written by leaders in the field and is especially suited not only to any researcher in the musculoskeletal arena but also to medical specialists and allied health professionals involved in the care of older persons.

Osteosarcopenia

Osteosarcopenia
A Book

by Gustavo Duque,Bruce R. Troen

  • Publisher : Elsevier
  • Release : 2021-08-15
  • Pages : 240
  • ISBN : 9780128200889
  • Language : En, Es, Fr & De
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Falls, fractures, frailty, osteoporosis and sarcopenia are highly prevalent in older persons. While the concept of osteosarcopenia is new, it is a rapidly evolving and cross-disciplinary problem. Prevention and treatment are challenging and a combined therapeutic approach is needed. Osteosarcopenia provides evidence-based information on how to prevent and treat these conditions at multiple settings, including multiple illustrations, care pathways and tips to easily understand the pathophysiology, diagnostic methods and therapeutic approach to these conditions. This work evaluates the potential for a link between osteoporosis, sarcopenia and obesity. Presents diagnostic and therapeutic tips that facilitate the design and implementation of new care pathways,?impacting the wellbeing of our older population Provides cross-disciplinary understanding by experts from the bone/osteoporosis field and the muscle/sarcopenia field Covers muscle and bone biology, mesenchymal stem cells, age-related changes and cross-talk between?muscle, fat and bone, falls and fracture risk, glucose metabolism, diagnosis, imaging, and genetics of?osteosarcopenia

Sarcopenia

Sarcopenia
A Book

by Alfonso J. Cruz-Jentoft,John E. Morley

  • Publisher : John Wiley & Sons
  • Release : 2021-07-06
  • Pages : 464
  • ISBN : 1119597870
  • Language : En, Es, Fr & De
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SARCOPENIA An in-depth examination of sarcopenia’s underexplored yet widespread impact within the field of gerontology Sarcopenia is common in older men and women, and yet awareness of its clinical relevance is still relatively low. Only formally included in the International Classification of Diseases in 2016, the condition may impact societies with serious health-related and financial consequences unless consistent, effective methods of identification and management are adopted. This second edition of Sarcopenia provides geriatricians and other healthcare professionals with a revised and expanded examination of this understudied and underdiagnosed condition. Edited by two leading authorities on the subject, it covers the epidemiology and diagnosis of sarcopenia, as well as treatment options and possible prevention strategies. Eight newly written chapters build upon existing knowledge with fresh data on topics including sarcopenia’s biomarkers and its impact on the healthcare economy. This important text: Defines sarcopenia and explains its clinical relevance Covers all recent scientific evidence Outlines treatment options Considers prevention strategies Discusses sarcopenia as a public health priority Features eight new chapters covering topics such as sarcopenia’s clinical management, its biomarkers, and its financial impact Containing vital information for clinicians and other professionals working in geriatric care, nursing homes, nutrition, cancer, endocrinology, surgery, sports medicine and many other specialties, Sarcopenia, second edition, is a groundbreaking and essential new resource.

Postmenopausal Diseases and Disorders

Postmenopausal Diseases and Disorders
A Book

by Faustino R. Pérez-López

  • Publisher : Springer
  • Release : 2019-07-10
  • Pages : 484
  • ISBN : 3030139360
  • Language : En, Es, Fr & De
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Supported by the latest scientific data, this book serves as a guide to the clinical assessment of women’s health during the second half of life (post-reproductive years), including approaches to the management of the most frequent age-related diseases and disorders and the most recent advances in treatment. In addition, it discusses preventive aspects of healthcare in post-reproductive women, identifying lifestyle measures to enhance healthy aging. By highlighting research gaps, it promotes the development of quick and easy-to-use assessment tools and predictive markers of age-related co-morbidities. As such, the book is a valuable resource for researchers and clinicians alike.

Osteoporosis Treatment

Osteoporosis Treatment
A Clinical Overview

by Elaine Dennison

  • Publisher : Springer Nature
  • Release : 2021-08-16
  • Pages : 225
  • ISBN : 3030781283
  • Language : En, Es, Fr & De
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This book provides a practical overview of osteoporosis for the wide spectrum of clinicians that might encounter the osteoporotic patient. Concise and well-structured chapters examine the public health importance of the condition, the current treatment gap, how to identify individuals who would benefit from treatment, bone turnover and how this can be modified by osteoporosis therapies, adjuvant lifestyle modification, the calcium and vitamin D story, antiresorptive therapies, anabolic therapies, emerging therapies, adherence and compliance with therapy and the perception of fracture risk. Osteoporosis Treatment: A Clinical Overview meets the need for a book that improves awareness of this major public health problem and possible therapeutic approaches. Primary care physicians, endocrinologists, rheumatologists, orthopaedic surgeons and those providing specialist care for the elderly will all benefit from this highly accessible and informative guide to treating osteoporosis.

Marcus and Feldman's Osteoporosis

Marcus and Feldman's Osteoporosis
A Book

by David W. Dempster,Jane A. Cauley,Mary L. Bouxsein,Felicia Cosman

  • Publisher : Academic Press
  • Release : 2020-10-08
  • Pages : 1946
  • ISBN : 0128130741
  • Language : En, Es, Fr & De
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Marcus and Feldman's Osteoporosis, Fifth Edition, is the most comprehensive, authoritative reference on this disease. Led by a new editorial team, this fifth edition offers critical information on reproductive and hormonal risk factors, new therapeutics, ethnicity, nutrition, therapeutics, management and economics, comprising a tremendous wealth of knowledge in a single source not found elsewhere. Written by renowned experts in the field, this two-volume reference is a must-have for biomedical researchers, research clinicians, fellows, academic and medical libraries, and any company involved in osteoporosis drug research and development. Summarizes the latest research in bone biology and translational applications in a range of new therapeutic agents, including essential updates on therapeutic uses of calcium, vitamin D, SERMS, bisphosphonates, parathyroid hormone, and new therapeutic agents Recognizes the critical importance of new signaling pathways for bone health, including Wnt, OPG and RANK, of interest to both researchers who study bone biology and clinicians who treat osteoporosis Offers new insights into osteoporosis associated with menopause, pre-menopause, chronic kidney disease, diabetes, HIV and other immune disorders

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism

Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism
A Book

by Anonim

  • Publisher : John Wiley & Sons
  • Release : 2018-12-06
  • Pages : 1136
  • ISBN : 1119266564
  • Language : En, Es, Fr & De
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The authoritative reference to bone diseases and disorders of mineral metabolism, revised and updated Now in its ninth edition, The Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism offers an updated and comprehensive guide to bone and mineral health. Since it was first published 30 years ago, the Primer has become the leading reference on the topic. With contributions from noted experts, the text explores basic biological factors of healthy development and disease states and makes the information accessible for clinical interventions. The ninth edition provides concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. The new edition of this invaluable reference expands coverage and includes the most recent developments in the field that help to strengthen its usefulness and ensure that the Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism maintains its place as the pre-eminent reference on bone and mineral health. This vital resource: Provides the most accurate, up-to-date evidence-based information on basic and clinical bone science Includes more than 10 new chapters and contributions from 300 authors from wide-ranging international research centers Captures the very cutting edge of research covering mineral homeostasis, osteoporosis and other metabolic bone diseases, skeletal measurement technologies, and genetics Presents a new companion website with useful supplementary materials at www.asbmrprimer.com Written for advanced students, clinicians, and researchers working in the field of bone health and disease, Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism is the definitive, one-stop reference for anyone working in the field of bone health and disease.

Advances in Clinical Chemistry

Advances in Clinical Chemistry
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-01-17
  • Pages : 340
  • ISBN : 0128208023
  • Language : En, Es, Fr & De
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Advances in Clinical Chemistry, Volume 94, the latest installment in this internationally acclaimed series, contains chapters authored by world-renowned clinical laboratory scientists, physicians and research scientists. The serial discusses the latest technologies relating to the field of clinical chemistry, with specific chapters in this new release covering Hypertensive disorders of pregnancy: Strategy to develop clinical peptide biomarkers for more accurate evaluation of the pathophysiological status of this syndrome, Clotting factors - Clinical biochemistry and their roles as plasma enzymes, Myokines: The endocrine coupling of skeletal muscle and bone, Epigenetic reprogramming and potential application of epigenetic-modifying drugs in acquired chemotherapeutic resistance, and more. Provides the most up-to-date technologies in clinical chemistry and clinical laboratory science Authored by world renowned clinical laboratory scientists, physicians and research scientists Presents the international benchmark for novel analytical approaches in the clinical laboratory

Orthogeriatrics

Orthogeriatrics
A Book

by Paolo Falaschi

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 3030481263
  • Language : En, Es, Fr & De
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Assessment and Treatment of Sarcopenia and Frailty in the Setting of Personalized Internal Medicine

Assessment and Treatment of Sarcopenia and Frailty in the Setting of Personalized Internal Medicine
A Book

by Gad Segal,Amir Tirosh,Idan Goren

  • Publisher : Cambridge Scholars Publishing
  • Release : 2020-01-27
  • Pages : 150
  • ISBN : 1527546187
  • Language : En, Es, Fr & De
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The recognition and implementation of personalized internal medicine is of the utmost importance for physicians, nurses, dieticians and other healthcare professionals engaged in clinics. The assessment of sarcopenia and frailty, in middle-aged patients, as an embodiment of treatment personalization, is essential in settings of acute and chronic disease, both in the hospital and in ambulatory settings. This book describes various practical tools for the assessment of sarcopenia and frailty, reviews relevant findings from the current professional literature, and suggests treatment modifications for frail patients.

Staying Alive

Staying Alive
A Book

by Kate Gregorevic

  • Publisher : Macmillan Publishers Aus.
  • Release : 2020-06-30
  • Pages : 300
  • ISBN : 1760982091
  • Language : En, Es, Fr & De
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Discover how to thrive and live better for longer. By the time we turn 60 most of us will still have one third of our lives to live. How well we live these years will depend on our health: are we agile and disease free? Or dependent on medication and physical assistance? In Staying Alive you'll discover the science on how you can avoid or manage the major diseases that impact us as we age, including heart health, diabetes and dementia, and boost your everyday behaviours to improve your enjoyment of life. Specialist Australian geriatrician Dr Kate Gregorevic clearly outlines key lifestyle-enhancing strategies for nutrition, exercise, cognitive and emotional health, and the positive impact they will have as you age. Easy to understand and based on the latest research, this is the day-to-day lifestyle guide you need to benefit you now and into a long and healthy future.

Healthy Aging

Healthy Aging
A Complete Guide to Clinical Management

by Patrick P. Coll

  • Publisher : Springer
  • Release : 2019-03-29
  • Pages : 399
  • ISBN : 3030062007
  • Language : En, Es, Fr & De
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This book weaves all of these factors together to engage in and promote medical, biomedical and psychosocial interventions, including lifestyle changes, for healthier aging outcomes. The text begins with an introduction to age-related changes that increase in disease and disability commonly associated with old age. Written by experts in healthy aging, the text approaches the principles of disease and disability prevention via specific health issues. Each chapter highlights the challenge of not just increasing life expectancy but also deceasing disease burden and disability in old age. The text then shifts into the whole-person implications for clinicians working with older patients, including the social and cultural considerations that are necessary for improved outcomes as Baby Boomers age and healthcare systems worldwide adjust. Healthy Aging is an important resource for those working with older patients, including geriatricians, family medicine physicians, nurses, gerontologists, students, public health administrators, and all other medical professionals.

Textbook of Palliative Medicine and Supportive Care

Textbook of Palliative Medicine and Supportive Care
A Book

by Eduardo Bruera,Irene J. Higginson,Charles F. von Gunten,Tatsuya Morita

  • Publisher : CRC Press
  • Release : 2021-07-21
  • Pages : 974
  • ISBN : 1000280896
  • Language : En, Es, Fr & De
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This new edition provides the essential clinical guidance both for those embarking upon a career in palliative medicine and for those already established in the field. A team of international experts here distil what every practitioner needs to know into a practical and reliable resource.

The Biology of Senescence

The Biology of Senescence
A Translational Approach

by Bernard Swynghedauw

  • Publisher : Springer
  • Release : 2019-06-06
  • Pages : 121
  • ISBN : 3030151115
  • Language : En, Es, Fr & De
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This book describes the fundamental process of senescence, and reviews a new concept developed by a number of research groups that is based on cellular senescence and its secretome. This concept provides a basic explanation of the main physiological and pathological features of senescence, and delineates possibilities for “treating” it. Following an introduction to the emerging medical landscape, the increasing incidence of a new epidemiological group (age-related “chronic non-transmissible diseases”), and the multiple origins of aging, the book explores and characterizes the senescent cell, which is linked to benign and pathological age-related manifestations. In turn, the closing chapters discuss how to “treat” or “prevent” the aging process, underscoring the central role of physical exercise and caloric reduction as compared to new senolytic approaches. Appendices are also provided, and address circadian rhythms, telomere shortening, diabetic cardiomyopathy, and senescence in plants and bacteria. Given its scope, the book will primarily be of interest to geriatricians, but will also appeal to a wider range of clinicians.

Encyclopedia of Biomedical Gerontology

Encyclopedia of Biomedical Gerontology
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-11-20
  • Pages : 1640
  • ISBN : 0128160764
  • Language : En, Es, Fr & De
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Encyclopedia of Biomedical Gerontology presents a wide range of topics, ranging from what happens in the body during aging, the reasons and mechanisms relating to those age-related changes, and their clinical, psychological and social modulators and determinants. The book covers the biological and medical aspects of gerontology within the general framework of the biological basis of assessing age, biological mechanisms of aging, age-related changes in biological systems, human age-related diseases, the biomedical practicality and impracticality of interventions, and finally, the ethics of intervention. Provides a ‘one-stop’ resource to information written by world-leading scholars in the field of biomedical gerontology Fills a critical gap of information in a field that has seen significant progress in the last 10 years

Hazzard's Geriatric Medicine and Gerontology, 7E

Hazzard's Geriatric Medicine and Gerontology, 7E
A Book

by Jeffrey B. Halter,Joseph G. Ouslander,Stephanie Studenski,Kevin P. High,Sanjay Asthana,Nancy Woolard,Christine S. Ritchie,Mark A. Supiano

  • Publisher : McGraw Hill Professional
  • Release : 2016-11-18
  • Pages : 2304
  • ISBN : 0071833463
  • Language : En, Es, Fr & De
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The gold-standard text on the diagnosis and treatment of disorders affecting the elderly – completely updated with a new full-color presentation A Doody's Core Title for 2017! The definitive treatise on the subject of geriatrics, this comprehensive text combines gerontology principles with clinical geriatrics, offering a uniquely holistic approach to this ever-expanding area of medicine. Written by some of the world’s most respected geriatricians, Hazzard’s Geriatric Medicine and Gerontology, Seventh Edition presents up-to-date, evidence-based information in a rich new full-color design. Unmatched as a textbook, this classic is also valuable to fellows in geriatric medicine. Hazzards’s Geriatric Medicine and Gerontology, Seventh Edition is logically divided into five parts: Principles of Gerontology, Principles of Geriatrics, Geriatric Syndromes, Principles of Palliative Medicine, and Organ Systems and Diseases. Within its pages, you will find balanced, authoritative coverage of every essential topic – from evaluation and management to nutrition and palliative medicine. Here’s why the Seventh Edition is the best edition ever: • NEW full-color design with hundreds of color photographs • NEW chapters: Quality of Care in Older Adults, Common Non-Pain Symptoms in Older Adults, Strategies of Effective Communication Around Advanced Illness, Palliative Medicine in the Continuum of Care Including Hospice, Coagulation Disorders, and Plasma Cell Disorders • MORE chapters on Palliative Medicine • NEW Learning Objectives and Key Points added to each chapter • MORE tables, drawings, and clinical algorithms • EVIDENCE-BASED through the use of the latest clinical practice guidelines , references to systemic reviews, and critically appraised topics • UPDATED to reflect the most current clinical breakthroughs and advances for managing older adults in various settings

Bone Toxicology

Bone Toxicology
A Book

by Susan Y. Smith,Aurore Varela,Rana Samadfam

  • Publisher : Springer
  • Release : 2017-09-27
  • Pages : 474
  • ISBN : 3319561928
  • Language : En, Es, Fr & De
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The content of this book is intended to provide the toxicologist in drug development in the pharmaceutical and biotechnology industries with a broad understanding of bone and its interactions with other organ systems in safety assessments. The book is divided into three parts. The first part describes our current understanding of bone biology and its primary regulatory pathways. Additional chapters address regulatory and study design considerations for incorporating bone end points in toxicology studies, with special consideration being given to juvenile toxicology studies. This is intended to address recent regulatory requirements to evaluate skeletal development for drugs in development for pediatric populations. The second part of the book describes the principal techniques and methods used in bone research; understanding how these end-points are derived is fundamental to their appropriate application. These first two parts of the book provide the background and the means to develop the concepts in part three which describes bone and its interaction with other organ systems. The unique series of chapters in part three, contributed to by key leaders in their respective fields and in bone research, provides a comprehensive collective work. Although constantly evolving, the crosstalk and interaction of the skeleton with several organ systems is now recognized and well documented, such as for the reproductive system, muscle and kidney, while our understanding of the interaction with other organ systems, such as the immune system and CNS, is in its infancy. Recent work highlights the key role of the skeleton in the regulation of energy metabolism and the impact this has on research in metabolic diseases such as obesity and diabetes. The hope is that this book will enlighten many and encourage more to explore the impact of new compounds on the skeleton in the development of effective and safe drugs.

Ageing and Nutrition through Lifespan

Ageing and Nutrition through Lifespan
A Book

by Stefanos Tyrovolas

  • Publisher : MDPI
  • Release : 2020-12-29
  • Pages : 188
  • ISBN : 3039289454
  • Language : En, Es, Fr & De
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Population is ageing at an unprecedented speed globally. As concept, ageing is considered a continuous process starting from birth and is accompanied by various physiological changes and a number of chronic diseases that affect health and quality of life. Ageing as a continuous process is depending on life course exposures to health risks, lifestyle and nutrition, socioeconomic background, and other factors. There is considerable interest among scientists regarding the direct and indirect effect of nutrition in optimal ageing. Nutrition has a beneficial effect in a variety of chronic disease that impact the process of ageing. Given the importance of this issue, the journal Nutrients is planning a Special Issue on “Ageing and Nutrition through Lifespan” with the aim of providing a source for accurate, up-to-date scientific information on this topic. We invite you and your co-workers to consider submission of your original research findings or a review article on the topic. Manuscripts should focus on the direct impact of specific food components, dietary patterns, energy intake, macro-, micro- nutrients, alcohol intake, food insecurity as well as malnourishment and appetite to the ageing process (healthy, active, successful ageing, frailty and other similar indices) across lifespan. In a similar way, we also welcome manuscripts that focus on the indirect effect of nutrition to the ageing process throughout the pathway of chronic disease (i.e., obesity, diabetes, depression and mental diseases).

Prevention of Chronic Diseases and Age-Related Disability

Prevention of Chronic Diseases and Age-Related Disability
A Book

by Jean-Pierre Michel

  • Publisher : Springer
  • Release : 2018-10-30
  • Pages : 199
  • ISBN : 3319965298
  • Language : En, Es, Fr & De
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This book explains how to promote and prolong “healthy ageing,” which constitutes maintaining daily functioning and well-being until the end of life. In this context, the editor of the book and the international team of authors, all of whom are experts on the various aspects of ageing, demonstrate the value of this new approach in clinical practice. The systematic integration of a functional assessment, if not a complete and comprehensive geriatric assessment, is fundamental in daily clinical practice. Identifying risk factors at midlife will help to promote health at any age. Moreover, randomized control trials are making it increasingly clear that interventions could help ageing and elderly adults enjoy their remaining years without disability. Indeed, wellbeing will also increase, allowing elderly adults to stay independent until a very advanced age. The book also shows how considerable societal benefits can be easily forecast when more lifetime is spent without benefits, followed by a dignified end of life. This book will be of interest to all medical doctors, general practitioners and organ specialists as well as geriatricians who want to have a complete overview of what healthy ageing means.

Hormones and Aging

Hormones and Aging
A Book

by Gerald Litwack

  • Publisher : Academic Press
  • Release : 2021-03-09
  • Pages : 656
  • ISBN : 0323855490
  • Language : En, Es, Fr & De
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Hormones and Aging, Volume 115 in the Vitamins and Hormones series, highlights advances in the field, with this new volume presenting timely topics, including hypothalamic aging and hormones, endocannabinoids and aging-inflammation, neuroplasticity, mood and pain, the impact of hormones and bone loss across the menopause transition, and much more. Provides the authority and expertise of leading contributors from an international board of authors Presents the latest release in the Vitamins and Hormones series Includes the latest information on Hormones and Aging