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Overcoming Ovarian Cancer Chemoresistance

Overcoming Ovarian Cancer Chemoresistance
A Book

by Goli Samimi,Christina Annunziata

  • Publisher : Academic Press
  • Release : 2020-11-06
  • Pages : 188
  • ISBN : 0128198419
  • Language : En, Es, Fr & De
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Overcoming Ovarian Cancer Chemoresistance presents non-overlapping review chapters that discuss the state of the field in overcoming chemoresistance of ovarian cancer and treatment options before and following recurrence, considering the genetic makeup of the ovarian cancer patient and her tumor. With the uptake of both germline and somatic gene testing, clinicians can obtain a more comprehensive understanding of ovarian tumors and this book provides information to link the genetic makeup of a tumor (or patient) with the best available treatment. The book discusses topics such as strategies to fight chemo-resistance in ovarian cancer, circulating DNA as a monitor of response, BRCA mutations, ovarian cancer stem cells, immunotherapy and vaccines. Additionally, it brings a list of promising agents at clinical and pre-clinical stage that will impact the treatment in the near future. This book is a valuable source for cancer researchers, oncologists and several members of biomedical field who need to understand how to battle chemoresistance in ovarian cancer. Provides a comprehensive view of both biological and genetic determinants of resistance, as well as technical approaches to monitor response Discusses genetic reversions as a unique alteration and a new field of study Includes a chapter on upcoming and promising agents that are in the pre-clinical and early clinical space, to set the stage for future directions in the field

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance

Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance
A Book

by Andrew Freywald,Franco Vizeacoumar

  • Publisher : Academic Press
  • Release : 2020-12-04
  • Pages : 308
  • ISBN : 0128213116
  • Language : En, Es, Fr & De
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Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies

Cancer Drug Resistance Research Perspectives

Cancer Drug Resistance Research Perspectives
A Book

by Liman S. Torres

  • Publisher : Nova Publishers
  • Release : 2007
  • Pages : 223
  • ISBN : 9781600215728
  • Language : En, Es, Fr & De
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One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100% effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common. The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anticancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information about how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs. This book presents new and important research in this field.

Therapeutic Strategies to Overcome ALK Resistance in Cancer

Therapeutic Strategies to Overcome ALK Resistance in Cancer
A Book

by Luc Friboulet

  • Publisher : Academic Press
  • Release : 2021-01-18
  • Pages : 216
  • ISBN : 0128217790
  • Language : En, Es, Fr & De
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Therapeutic Strategies to Overcome ALK Resistance in Cancer, Volume 13, presents current strategies to improve and prolong clinical benefit in ALK driven cancers. Most patients with ALK-driven cancer are sensitive to tyrosine kinase inhibitor (TKI) therapy, but resistance invariably develops. This book discusses topics such as structure and function of ALK, ALK rearranged lung cancer, resistance mechanisms to ALK TKI tumors, and novel therapeutic strategies to enhance crizotinib anti-tumor efficacy in ALCL. Additionally, it encompasses information on drug combinations to enhance ALK TKI anti-tumor efficacy in neuroblastoma and future perspectives in the field. This book is a valuable resource for cancer researchers, clinicians and several members of biomedical field who need to understand more about how to fight ALK resistance in cancer treatment. Explains the biology of ALK RTK, focusing on its tissue expression, structure and functionality Presents an overview of current treatments and the benefits of ALK TKI in lung and other cancer types, such as ALCL, neuroblastoma and inflammatory myofibroblastic tumor Encompasses information on systemic treatments other than TKI, including chemotherapy, immunotherapy and antiangiogenic agents in ALK-driven NSCLC

Functional Foods in Cancer Prevention and Therapy

Functional Foods in Cancer Prevention and Therapy
A Book

by Yearul Kabir

  • Publisher : Academic Press
  • Release : 2020-04
  • Pages : 508
  • ISBN : 0128161515
  • Language : En, Es, Fr & De
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Functional Foods in Cancer Prevention and Therapy presents the wide range of functional foods associated with the prevention and treatment of cancer. In recent decades, researchers have made progress in our understanding of the association between functional food and cancer, especially as it relates to cancer treatment and prevention. Specifically, substantial evidence from epidemiological, clinical and laboratory studies show that various food components may alter cancer risk, the prognosis after cancer onset, and the quality of life after cancer treatment. The book documents the therapeutic roles of well-known functional foods and explains their role in cancer therapy. The book presents complex cancer patterns and evidence of the effective ways to control cancers with the use of functional foods. This book will serve as informative reference for researchers focused on the role of food in cancer prevention and physicians and clinicians involved in cancer treatment.

Overcoming Drug Resistance in Gynecologic Cancers

Overcoming Drug Resistance in Gynecologic Cancers
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2021-05-15
  • Pages : 300
  • ISBN : 9780128242995
  • Language : En, Es, Fr & De
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Overcoming Drug Resistance in Gynecologic Cancers provides up-to-date information related to important gynecologic cancers and focuses on mechanisms of drug resistance, genetics, signaling, immunology, health disparities, nanotechnology, economic considerations and financial impacts. The book covers not only drug resistance but also important means to reverse resistance both in the laboratory and clinic. The book discusses topics such as lifestyle, nutrition and risk of gynecologic cancers, the financial impact of drug resistance, chemosensitizing agents and targeted therapies in cervical, endometrial and ovarian cancer, immunotherapy to overcome drug resistance, and genetic polymorphisms in gynecologic cancers. Additionally, it discusses ethnic and racial health disparity perspectives and future developments in chemosensitizing activities to reverse drug resistance in gynecologic cancers. It is a valuable resource for cancer researchers, oncologists, clinicians and other biomedical field members who are interested in new approaches to improve chemotherapy outcome in patients with gynecologic cancers. Provides a comprehensive resource with all the details needed for readers to understand and follow information Encompasses schematics, diagrams and flow charts in all chapters to help readers easily follow critical information Presents tables and figures especially developed to summarize the information with appropriate statistical rigor and to show details of clinical specimens such as pathological, radiological characteristics, and/or laboratory biomarkers

Cancer Drug Resistance

Cancer Drug Resistance
Proceedings of a Workshop Held at the XIV International Congress of Chemotherapy in Kyoto, Japan, June 23-28, 1985

by Thomas C. Hall

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 235
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cancer Research

Cancer Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Anticancer Research

Anticancer Research
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Progress in Cancer Drug Resistance Research

Progress in Cancer Drug Resistance Research
A Book

by Robert A. Parsons

  • Publisher : Nova Publishers
  • Release : 2007
  • Pages : 223
  • ISBN : 9781600218224
  • Language : En, Es, Fr & De
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One of the main causes of failure in the treatment of cancer is the development of drug resistance by the cancer cells. The design of cancer chemotherapy has become increasingly sophisticated, yet there is no cancer treatment that is 100 percent effective against disseminated cancer. Resistance to treatment with anticancer drugs results from a variety of factors including individual variations in patients and somatic cell genetic differences in tumours, even those from the same tissue of origin. Frequently resistance is intrinsic to the cancer, but as therapy becomes more and more effective, acquired resistance has also become common.The most common reason for acquisition of resistance to a broad range of anticancer drugs is expression of one or more energy-dependent transporters that detect and eject anti-cancer drugs from cells, but other mechanisms of resistance including insensitivity to drug-induced apoptosis and induction of drug-detoxifying mechanisms probably play an important role in acquired anticancer drug resistance. Studies on mechanisms of cancer drug resistance have yielded important information on how to circumvent this resistance to improve cancer chemotherapy and have implications for pharmacokinetics of many commonly used drugs.

Drug Resistance in Epilepsy

Drug Resistance in Epilepsy
Lessons from Oncology

by Novartis Foundation

  • Publisher : Wiley-Blackwell
  • Release : 2002-04-26
  • Pages : 246
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Drug resistance in epilepsy is an important clinical problem. About 20% of patients diagnosed as having epilepsy fail to respond to prescribed antiepileptic drugs and continue to have seizures. But despite the size of the problem, remarkably little attention has been paid to the biological basis of refractory epilepsy. Recent work has shown that brain tissue from some patients with epilepsy shows increased expression of a protein that mediates drug resistance in cancer, P glycoprotein. But while resistance in cancer has been extensively studied, and trials of reversal of resistance have been undertaken with some success, resistance in epilepsy has only just begun to be addressed. This novel book brings together, for the first time, epilepsy researchers and oncologists, with a view to stimulating further work on drug resistance in epilepsy. Successfully bridging the two fields, the stimulating discussions contained in this book should be of great interest to those working on cancer resistance and refractory epilepsy alike.

Ovarian Cancer

Ovarian Cancer
A Book

by Ian J. Jacobs,John Shepherd,Chris Hudson,David Oram

  • Publisher : Oxford University Press, USA
  • Release : 2002
  • Pages : 427
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Ovarian cancer provides an up-to-date and comprehensive synthesis of clinical management and research progress in the field of epithelial ovarian cancer. The book has its origins in two separate but complementary initiatives. One initiative was a series of reviews commissioned to cover thespectrum of clinical management of ovarian cancer from prevention, screening and diagnosis to surgery, chemotherapy and palliative care. The reviews were invited from an international panel of clinicians with expertise in the management of ovarian cancer. The second initiative was co-ordinated bythe Helene Harris Memorial Trust (HHMT) which has organised key biennial meetings on ovarian cancer for the last 12 years. Attendance at the meetings is by invitation to a small group of international authorities on research aspects of ovarian cancer. Setting the clinically focused reviewsalongside the HHMT research focused chapters has created a unique book. First, the book is unusually up-to-date and presents recent advances not included in other books in this field. Second, the contents are comprehensive and cover aetiology, pathology, screening, prevention, diagnosis,prognostic techniques, surgery, adjuvant therapy and palliative care. Third, the review chapters are set alongside more detailed coverage of recent clinical and basis science developments. Examples of this are the coverage of familial cancer, prevention, screening, and current therapy which areconsequently much more topical and exciting. Fourth, there are sections on 'tumour biology' and 'novel therapies' which have not been covered in comparable books about ovarian cancer. Finally, the contributions are from a representative spectrum of experts from both research and clinicalbackgrounds and with a truly international perspective.

Reversal of Drug Resistance in Non-Hodgkin's Lymphoma by Immunotherapy

Reversal of Drug Resistance in Non-Hodgkin's Lymphoma by Immunotherapy
Rituximab as a Sensitizing Antibody for the Induction of Apoptosis in Chemi-resistant B-NHL by Therapeutic Drugs

by Steve Anthony Alas

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 344
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A Woman's Guide to Overcoming Sexual Fear & Pain

A Woman's Guide to Overcoming Sexual Fear & Pain
A Book

by Aurelie Jones Goodwin,Marc E. Agronin

  • Publisher : New Harbinger Publications Incorporated
  • Release : 1997
  • Pages : 280
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Explores the reasons for sexual disorders and advises when professional help is necessary

American Book Publishing Record

American Book Publishing Record
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Mechanism and New Approach on Drug Resistance of Cancer Cells

The Mechanism and New Approach on Drug Resistance of Cancer Cells
Proceedings of the International Symposium on the Mechanism and New Approach on Drug Resistance of Cancer Cells, Sapporo, 15-17 October 1992

by Tamotsu Miyazaki,Fumimaro Takaku,Keisuke Sakurada

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 335
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Therapeutic approaches targetting drug resistance mechanisms have been studied in the clinical field of cancer chemotherapy, and this text contributes to the progress in clinical research on the circumvention of drug resistance.

Parliamentary Papers

Parliamentary Papers
A Book

by Queensland. Parliament. Legislative Assembly

  • Publisher : Unknown Publisher
  • Release : 1988
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Ovarian Cancer

Ovarian Cancer
Proceedings of the International Symposium on Ovarian Cancer, Birmingham, 24-25 September 1979

by Chris E. Newman,C. H. J. Ford,Joseph A. Jordan

  • Publisher : Pergamon
  • Release : 1980
  • Pages : 249
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Hardbound. Internationally recognised experts have contributed individual chapters on a variety of topics ranging from histopathology through surgical, radiotherapeutic and chemotherapeutic treatment modalities to in vitro sensitivity testing and epidemiology. The book, therefore, presents a broad based review of current achievements and will be of interest to all those with an interest in ovarian cancer, including clinicians, epidemiologists and research workers. Topic orientated panel discussions and questions raised after delivery of individual papers have been included

Cancer of the Ovary

Cancer of the Ovary
A Book

by Maurie Markman,William J. Hoskins

  • Publisher : Lippincott Williams & Wilkins
  • Release : 1993
  • Pages : 442
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Provides the in-depth theoretical and practical information required by physicians in the treatment of women with ovarian cancer. Coverage progresses from research on the basic biology, epidemiology and genetics of ovarian cancer to practical guidelines on diagnosis and management of the disease.

European Journal of Gynaecological Oncology

European Journal of Gynaecological Oncology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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