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Overflow Metabolism

Overflow Metabolism
From Yeast to Marathon Runners

by Alexei Vazquez

  • Publisher : Academic Press
  • Release : 2017-10-27
  • Pages : 84
  • ISBN : 0128123354
  • Language : En, Es, Fr & De
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Overflow Metabolism: From Yeast to Marathon Runners provides an overview of overflow metabolism, reviewing the major phenomenological aspects as observed in different organisms, followed by a critical analysis of proposed theories to explain overflow metabolism. In our ideal view of metabolism, we think of catabolism and anabolism. In catabolism nutrients break down to carbon dioxide and water to generate biochemical energy. In anabolism nutrients break down to generate building blocks for cell biosynthesis. Yet, when cells are pushed to high metabolic rates they exhibit incomplete catabolism of nutrients, with a lower energy yield and excretion of metabolic byproducts. This phenomenon, characterized by the excretion of metabolic byproducts that could otherwise be used for catabolism or anabolism, is generally known as overflow metabolism. Overflow metabolism is a ubiquitous phenotype that has been conserved during evolution. Examples are the acetate switch in the bacterium E. coli, Crabtree effect in unicellular eukaryote yeasts, the lactate switch in sports medicine, and the Warburg effect in cancer. Several theories have been proposed to explain this seemingly wasteful phenotype. Yet, there is no consensus about what determines overflow metabolism and whether it offers any selective advantage. Includes examples of overflow metabolism and major phenomenological features Features a critical view of proposed theories to explain overflow metabolism Provides a summary of our preview work, proposing molecular crowding as the cause of overflow metabolism, together with new unpublished results

The significance of overflow metabolism in the physiology and g...

The significance of overflow metabolism in the physiology and g...
A Book

by Oense Martinus Neijssel

  • Publisher : Unknown Publisher
  • Release : 1976
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New and Future Developments in Microbial Biotechnology and Bioengineering

New and Future Developments in Microbial Biotechnology and Bioengineering
Microbial Secondary Metabolites Biochemistry and Applications

by Vijai G. Gupta,Anita Pandey

  • Publisher : Elsevier
  • Release : 2019-06-15
  • Pages : 462
  • ISBN : 0444635041
  • Language : En, Es, Fr & De
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New and Future Developments in Microbial Biotechnology and Bioengineering: Microbial Secondary Metabolites Biochemistry and Applications examines the areas of biotechnology and chemical engineering, covering aspects of plants, bacteria and machines, and using microbes as factories. The book is aimed at undergraduates, post-graduates and researchers studying microbial secondary metabolites, and is an invaluable reference source for biochemical engineers working in biotechnology, manipulating microbes, and developing new uses for bacteria and fungi. The applications of secondary metabolites in biotechnology, pharmaceuticals, diagnostics and medical device development are also extensively covered. The book integrates the aforementioned frontline branches into an interdisciplinary research work to satisfy those working in biotechnology, chemical engineering, alternative fuel development, diagnostics and pharmaceuticals. Chapters related to important research work on applications of microbial secondary metabolites are written by specialists in the various disciplines from the international community. Compiles the latest developments in the area of microbial secondary metabolites Authored by the top international researchers in this area Includes information related to nearly all areas of a microbial secondary metabolites system

Insulin Resistance As a Risk Factor in Visceral and Neurological Disorders

Insulin Resistance As a Risk Factor in Visceral and Neurological Disorders
A Book

by Akhlaq A. Farooqui

  • Publisher : Academic Press
  • Release : 2020-03
  • Pages : 300
  • ISBN : 0128196033
  • Language : En, Es, Fr & De
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Insulin Resistance as a Risk Factor in Visceral and Neurological Disorders provides an overview on the risk factors for insulin resistance in visceral and neurological disorders. The book focuses on molecular mechanisms and signal transduction processes associated with the links. The comprehensive information in this monograph will not only help in the early detection of insulin resistance related visceral and neurological disorders, but also promote the discovery of new drugs which may block or delay onset in elderly patients. Understanding these processes is important not only for patients, caregivers and health professionals, but also for health policymakers who must plan for national resources.

The Journal of General Physiology

The Journal of General Physiology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1948
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Metabolites and Metabolism

Metabolites and Metabolism
A Commentary on Secondary Metabolism

by Edwin Haslam

  • Publisher : Oxford University Press, USA
  • Release : 1985
  • Pages : 161
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Bioactive Microbial Products

Bioactive Microbial Products
Search and Discovery

by John Desmond Bu'Lock,L. J. Nisbet,D. J. Winstanley,Society for General Microbiology

  • Publisher : Academic Press
  • Release : 1982
  • Pages : 148
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Insect-Plant Interactions

Insect-Plant Interactions
A Book

by Elizabeth A. Bernays

  • Publisher : CRC Press
  • Release : 2019-10-01
  • Pages : 176
  • ISBN : 100069755X
  • Language : En, Es, Fr & De
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First Published in 1989, this book explores the relationship between plants and insects and the ways in which they interact with each other. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for students of oncology, and other practitioners in their respective fields.

Carbon Substrates in Biotechnology

Carbon Substrates in Biotechnology
A Book

by J. D. Stowell

  • Publisher : Oxford University Press, USA
  • Release : 1987
  • Pages : 206
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Basic Biotechnology

Basic Biotechnology
A Book

by Colin Ratledge,Bjorn Kristiansen

  • Publisher : Cambridge University Press
  • Release : 2006-05-25
  • Pages : 666
  • ISBN : 0521840317
  • Language : En, Es, Fr & De
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Biotechnology is one of the major technologies of the twenty-first century. Its wide-ranging, multi-disciplinary activities include recombinant DNA techniques, cloning and the application of microbiology to the production of goods from bread to antibiotics. In this new edition of the textbook Basic Biotechnology, biology and bioprocessing topics are uniquely combined to provide a complete overview of biotechnology. The fundamental principles that underpin all biotechnology are explained and a full range of examples are discussed to show how these principles are applied; from starting substrate to final product. A distinctive feature of this text are the discussions of the public perception of biotechnology and the business of biotechnology, which set the science in a broader context. This comprehensive textbook is essential reading for all students of biotechnology and applied microbiology, and for researchers in biotechnology industries.

Flux Balance Analysis of Escherichia Coli Metabolism

Flux Balance Analysis of Escherichia Coli Metabolism
A Book

by Amit Varma

  • Publisher : Unknown Publisher
  • Release : 1994
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production

Metabolic Regulation and Metabolic Engineering for Biofuel and Biochemical Production
A Book

by Kazuyuki Shimizu

  • Publisher : CRC Press
  • Release : 2017-07-12
  • Pages : 325
  • ISBN : 1351650106
  • Language : En, Es, Fr & De
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The global warming problem is becoming critical year by year, causing climate disaster all over the world, where it has been believed that the CO2 gas emitted from the factories and the burning of fossil fuels may be one of the reasons of global warming. Moreover, the global stock of fossil fuels is limited, and may run out soon within several tens of years. Although wind, geo-thermal, and tide energies have been considered as clean energy sources, those depend on the land or sea locations and subject to the climate change. Biofuel and biochemical production from renewable bio-resources has thus been paid recent attention from environmental protection and energy production points of view, where the current chemical and energy producing plants can be also utilized with slight modification. The so-called 1st generation biofuels have been produced from corn starch and sugarcane in particular in USA and Brazil. However, this causes the problem of the so-called "food and energy issues" as the production scale increases. The 2nd generation biofuel production from lingo-cellulosic biomass or wastes has thus been paid recent attention. However, it requires energy intensive pretreatment for the degradation of lingo-cellulosic biomass, and the fermentation is slow due to low growth rate, and thus the productivity of biofuels and bio-chemicals is low. The 3rd generation biofuel production from photosynthetic organisms such as cyanobacteria and algae has been also paid attention, because such organisms can grow with only sun light and CO2 in the air, but the cell growth rate and thus the productivity of the fuels is significantly low. The main part or core of such production processes is the fermentation by micro-organisms. In particular, it is critical to properly understand the cell metabolism followed by the efficient metabolic engineering. The book gives comprehensive explanation of the cell metabolism and the metabolic regulation mechanisms of a variety of micro-organisms. Then the efficient metabolic engineering approaches are explained to properly design the microbial cell factories for the efficient cell growth and biofuel and biochemical production.

Glucose Metabolism in Gluconobacter Oxydans

Glucose Metabolism in Gluconobacter Oxydans
A Book

by Wiebe Olijve

  • Publisher : Unknown Publisher
  • Release : 1978
  • Pages : 88
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biotechnology, Products of Primary Metabolism

Biotechnology, Products of Primary Metabolism
A Book

by Hans-Jürgen Rehm,Max Roehr,Gerald Reed,Alfred Pühler

  • Publisher : Wiley-Blackwell
  • Release : 1996-12-16
  • Pages : 753
  • ISBN : 9783527283163
  • Language : En, Es, Fr & De
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Fermentation products of primary metabolism such as ethanol, acetic acid, and lactic acid were the first commercial products of the fermentation industry, followed by citric acid and related products of fungal origin. As high-volume/low-price products they still occupy top positions in the respective markets. Several of these, especially alcohols, have attracted additional attention as possible sources of alternative energy carriers and chemicals. This volume describes theory and practice of production of these commodities - from classical processes to most recent developments - and also provides data on the relevant raw materials. Futhermore, products related to primary metabolism are treated in this volume. Topics included are: Sugar-Based/Starch-Based Raw Materials - Ethanol - Glycerol and Other Polyols - Acetone, Butanol, Isopropanol - 2,3-Butanediol - Lactic Acid - Citric Acid - Gluconic Acid - Further Organic Acids - Acetic Acid - PHB and Other Polyhydroxyalkanoic Acids - Amino Acids - Nucleotides - Extracellular Polysaccharides - Biosurfactants

The Effect of Cations on Microbial Metabolism and Growth Energetics

The Effect of Cations on Microbial Metabolism and Growth Energetics
A Book

by Ed T. Buurman

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 109
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstracts of Papers

Abstracts of Papers
A Book

by Hanswerner Dellweg

  • Publisher : Unknown Publisher
  • Release : 1976
  • Pages : 531
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Ion-selective Electrode Reviews

Ion-selective Electrode Reviews
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1982
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Special Issue on a Sea of Microbes

Special Issue on a Sea of Microbes
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 212
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biotechnology: Microbial products II

Biotechnology: Microbial products II
A Book

by Hans-Jürgen Rehm,Gerald Reed

  • Publisher : Unknown Publisher
  • Release : 1981
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Microbial Products II

Microbial Products II
A Book

by H. Pape,Hans-Jürgen Rehm

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 673
  • ISBN : 9783527257645
  • Language : En, Es, Fr & De
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