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Personalized Cancer Chemotherapy

Personalized Cancer Chemotherapy
An Effective Way of Enhancing Outcomes in Clinics

by Da Yong Lu

  • Publisher : Woodhead Publishing
  • Release : 2014-12-05
  • Pages : 84
  • ISBN : 0081003471
  • Language : En, Es, Fr & De
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Personalized Cancer Chemotherapy separately describes and addresses "individualized cancer chemotherapy" (ICC) strategies new and old, to provide readers with new insights into their characteristics and techniques, as well as key debates and future trends in this area. The book devotes chapters to drug sensitivity testing, cancer biomarkers and bioinformatics detection, pharmacogenetics, individualized antimetastatic therapy, drug combinations, assistant chemotherapy, and cost-effectiveness considerations. A major obstacle to controlling cancer growth and metastases in patients is the inappropriate use of anticancer and antimetastatic drugs. Researchers and clinicians are now beginning to focus on ICC also called "personalized cancer chemotherapy" (PCC), to improve therapeutic quality and outcomes by selecting and prescribing the most appropriate and effective drugs. Using genetic, molecular, and bioinformatics data and modern experimental techniques, known tumor genes can be detected more easily than ever before; the average speed of genetic sequencing has increased 15,000 to 50,000 times since the Human Geonme Project was completed. This book will help readers understand the pros and cons of each individualized cancer chemotherapy strategy from different angles so as to make good judgments and predictions of drug responses and clinical outcomes. Explores the central components of cancer treatment Investigates new developments in cancer treatment Discusses the many strategies of individualized cancer chemotherapy

Current Challenges in Personalized Cancer Medicine

Current Challenges in Personalized Cancer Medicine
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2012-12-31
  • Pages : 576
  • ISBN : 0123984831
  • Language : En, Es, Fr & De
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For this volume of Advances in Pharmacology we have brought together some of the foremost basic science and clinical researchers to discuss some of the new frontiers in the development of targeted cancer therapy. Although still in its formative stages, the development of targeted cancer therapies has already shown incredible promise in a limited number of cancer types. As basic cancer research and drug development continues, we expect this number to grow and more patients to benefit from these exciting advances. Through better patient selection and novel strategies to manage resistance, a future can be envisaged in which cancer can be reduced to the level of a chronic, manageable disease. Brought together some of the foremost basic science and clinical researchers Part of the renowned Advances in Pharmacology Serial Discussion of some of the new frontiers in the development of targeted cancer therapy

Principles of Molecular Diagnostics and Personalized Cancer Medicine

Principles of Molecular Diagnostics and Personalized Cancer Medicine
A Book

by Dongfeng Tan,Henry T. Lynch

  • Publisher : Lippincott Williams & Wilkins
  • Release : 2012-12-07
  • Pages : 992
  • ISBN : 1469820641
  • Language : En, Es, Fr & De
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The role of molecular genetics in the treatment of malignancy continues to grow at an astonishing rate. Today’s subspecialized multidisciplinary approach to oncology has incorporated advances in targeted molecular therapy, prognosis, risk assessment, and prevention—all based at least in part on molecular diagnostics and imaging. Inside this cutting-edge resource, readers will explore broad, comprehensive perspectives on the current trends in molecular diagnosis of cancer and personalized cancer medicine. Authoritative discussions share insights from noted experts in cancer research, clinical trials, molecular diagnostics, personalized therapy, bioinformatics, and federal regulations. From the basic mechanisms of carcinogenesis to the most advanced molecular screening, staging, and treatment technologies, readers will discover clear and straightforward discussions directly relevant to patient diagnosis and care.

Personalized Cancer Treatment

Personalized Cancer Treatment
Predicting Neoadjuvant Chemotherapy Response Using Fine Needle Aspirates

by Sheldon Lerman

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 31
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecular Diagnostics

Molecular Diagnostics
The Key in Personalized Cancer Medicine

by Jan Trost Jorgensen,Henrik Winther

  • Publisher : CRC Press
  • Release : 2019-05-08
  • Pages : 352
  • ISBN : 9814241458
  • Language : En, Es, Fr & De
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This unique book provides a thorough overview of developing molecular cancer diagnostic assays, which are the prerequisites for optimal solutions within personalized cancer medicine. The book takes the reader through definitions of the pharmacodiagnostic concept, historical perspectives of the early steps into molecular cancer diagnostics linked to therapy, the basis of different diagnostic molecular techniques, ongoing research, drug-diagnostic co-development, assay validation, clinical trial methodology, regulatory issues around pharmacodiagnostics and future aspects within personalized cancer medicine.

Cancer Genetics and Genomics for Personalized Medicine

Cancer Genetics and Genomics for Personalized Medicine
A Book

by Il-Jin Kim

  • Publisher : CRC Press
  • Release : 2017-04-11
  • Pages : 286
  • ISBN : 1315341107
  • Language : En, Es, Fr & De
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This book covers almost all fields of cancer genetics and genomics for personalized medicine. Targeted therapy, or precision medicine, or personalized medicine is becoming a standard treatment for many diseases, including cancer. However, how much do we know about the personalized medicine approach? This lucid book helps undergraduate and graduate students, professional researchers, and clinicians to better understand the key concept of personalized medicine. The most up-to-date topics on personalized medicine in this book cover the recent trends in and updates on lung, gastric, liver, breast, and other types of cancers. Circulating tumor cell, cell-free circulating DNA, and microRNAs are discussed as new diagnostic and prognostic markers for cancer. The avatar mouse model is also discussed for maximizing treatment efficacy and prognosis prediction, and so is microenvironment as a drug resistance mechanism. With classical and new pathological approaches, the book provides a systemic overview of personalized immunotherapies and hyperthermic intraperitoneal chemotherapy, followed by new emerging fields of hereditary cancer, thereby equipping readers to eventually contribute in developing more advanced tools and therapies for curing cancer.

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine

Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine
A Book

by Yusuf Tutar

  • Publisher : Bentham Science Publishers
  • Release : 2020-06-08
  • Pages : 198
  • ISBN : 9811456895
  • Language : En, Es, Fr & De
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Nanotheranostics is a recent medical field which integrates diagnostic imaging protocols and therapeutic functions to monitor real time drug release in the body and distribution to the target site. The combined processes allow technicians to observe the effectiveness of a specifically designed drug candidate and predict its possible side effects. All these features help clinicians in optimizing treatment options for cancer and other diseases for the individual patient. Current research is tailored to individual therapy because each drug may display a variety of responses depending on variations in an individual’s genetics and subsequently, their clinical biochemistry. Many tumors are still challenging for therapists in terms of available treatment and nanotheranostic strategies may help them to combat cancer more efficiently. Advances in Cancer Nanotheranostics for Experimental and Personalized Medicine presents information about current theranostic technologies in use at clinics and recent research on nanotheranostic applications, with a focus on cancer treatment. Information is presented in seven organized chapters that cover the basics of cancer nanotheranostics, tumor microenvironmental factors, gene therapy and gene delivery concepts, and the combined application of diagnostic imaging with cancer chemotherapy. A chapter focusing on the role of non-coding MRNAs in breast cancer carcinogenesis is also included, giving readers a glimpse of the complexities in the molecular biology of cancer which drive the need for new theranostic technologies. The book is of interest to medical professionals (including oncologists and specialists in internal medicine), diagnostic imaging technicians, and researchers in the fields of pharmacology, molecular biology and nuclear medicine.

Pharmacogenetics of Breast Cancer

Pharmacogenetics of Breast Cancer
Towards the Individualization of Therapy

by Brian Leyland-Jones

  • Publisher : CRC Press
  • Release : 2008-05-19
  • Pages : 352
  • ISBN : 9781420052930
  • Language : En, Es, Fr & De
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Pharmacogenetics is becoming increasingly relevant in the diagnosis, treatment, and recovery of cancer patients. A major problem facing oncologists is the outstanding varied efficacy of treatment. Promising advances in pharmacogenetics have allowed the development of effective agents which will enable personalized cancer chemotherapy to become routine for the clinical practice. Written by experts in the field and combining information that is unable to be found in a single source volume, Pharmacogenetics of Breast Cancer: combines a complete overview of pharmacogenetics and how it relates to breast oncology for diagnosis, treatment, and the recovery of patients using an individualized therapy model is the first single source reference demonstrating the application of pharmacogenetics in the care of breast cancer patients enables physicians a coherent interpretation of the emerging science of pharmacogenetics, aiding them to incorporate individual therapies in their own practice gives practical guidance on various forms of specimen collection, tissue selection, and handling procedures

Polymorphisms in Pharmacogenetics of Personalized Cancer Therapy

Polymorphisms in Pharmacogenetics of Personalized Cancer Therapy
A Book

by Gizem Calıbası-Kocal

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Therapy process of personalized cancer management covers surgery, chemotherapy, radiation therapy and targeted therapies. The choice of cancer chemotherapeutic agents and doses depends upon the location and stage of tumor, as well as the general state of the patient. On the chemotherapy, radiotherapy, and targeted therapy processes, pharmacogenetics offers customized solutions according to the personal genetic information. Especially for clinicians, genetic information obtained from polymorphism-based pharmacogenetic tests is highly crucial for the better prediction ability of drug response and life-threatening toxic reactions due to the narrow therapeutic index of cancer chemotherapeutic agents. Pharmacogenotyping utilizes different examination strategies, such as single nucleotide polymorphism analysis, somatic/germline mutation analysis and partial/full genome sequencing. The promising effect of pharmacogenetics on the solving of the individual variability in drug response and toxic reactions is being observed with the accumulation of the information that unravel the human genomic variations from large-scale population and multi-parameter-based pharmacogenetic studies of the post-genomic era. Polymorphisms contribute wide variations in human genome and may define how individuals respond to medications, either by changing the pharmacokinetics and pharmacodynamics of drugs or by altering the cellular response to therapeutic agents. To define the effect of polymorphisms on the targets of chemotherapeutics is necessary for the prediction of altered pharmacokinetics of therapeutic agents.

Policy Issues in the Development of Personalized Medicine in Oncology

Policy Issues in the Development of Personalized Medicine in Oncology
Workshop Summary

by Institute of Medicine,Board on Health Care Services,National Cancer Policy Forum

  • Publisher : National Academies Press
  • Release : 2010-02-04
  • Pages : 94
  • ISBN : 9780309151351
  • Language : En, Es, Fr & De
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One of the challenges in treating cancer is the disease's complexity and variation among patients. Cancer manifests differently in each patient, so treatments that are effective in one patient may not be effective in another. As cancer care becomes more personalized, subpopulations of individuals will be given preventive or therapeutic interventions based on their susceptibility to a particular disease or their predicted response to a specific treatment. However, before the use of personalized cancer care can reach its full potential, the health care system must resolve a number of technological, regulatory, and reimbursement issues. To explore these policy challenges, the National Cancer Policy Forum held the workshop Policy Issues in the Development of Personalized Medicine in Oncology in June 2009. Experts provided presentations on the current state of personalized medicine technology, as well as issues in the validation of, regulation of, and reimbursement for the predictive tests that underpin personalized medicine. Participants discussed the obstacles and possible solutions to further developing and using personalized medicine technologies. This document summarizes the workshop.

Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management

Lung Cancer and Personalized Medicine: Novel Therapies and Clinical Management
A Book

by Aamir Ahmad,Shirish M. Gadgeel

  • Publisher : Springer
  • Release : 2015-12-24
  • Pages : 231
  • ISBN : 3319249320
  • Language : En, Es, Fr & De
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This, the second of two volumes on personalized medicine in lung cancer, touches upon the recent progress in targeted drug development based on genomics; emerging biomarkers and therapeutic targets such as EMT, cancer stem cells, and the tumor microenvironment; current personalized clinical management and radiation therapy for lung cancers; and the promise of epigenetics and next-generation sequencing for the advancements towards personalized therapy of lung cancer patients. With chapters on state-of-the-art therapies and technologies written by leading experts working to develop novel companion diagnosis tools for the personalized treatment of lung cancer patients, this volume brings readers up-to-date by presenting the current knowledge on the efforts to make personalized management of lung cancer patients a reality.

Personalized Management of Gastric Cancer

Personalized Management of Gastric Cancer
Translational and Precision Medicine

by Jia Wei,Baorui Liu

  • Publisher : Springer
  • Release : 2017-05-15
  • Pages : 227
  • ISBN : 981103978X
  • Language : En, Es, Fr & De
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This book offers essential information on basic and translational research in gastric cancer, while also illustrating potential opportunities for its application in clinical practice. Gastric cancer is the fourth-most-common cancer globally and the second-leading cause of cancer deaths. It is known to be a heterogeneous disease with varied responses to “one-size-fits-all” treatments. Expanding our knowledge of cancer cell genetics may help us to explore more effective treatments in gastric cancer. The research on molecular mechanisms and its clinical applications, both presented here, will help readers gain an in-depth understanding of gastric cancer and its effective treatment. The book’s four sections cover personalized medicine, precise regional therapy, immunotherapy and nanomedicine in gastric cancer. Each part presents the state of art, recent advances and the authors’ experiences. Moreover, several interesting cases are described to demonstrate how gastric cancer patients benefit from translational research. This informative and attractively presented book on precision treatment in gastric cancer, including experimental findings and clinical treatment options, offers a valuable resource for oncologists and graduate students working in the field of gastric cancer.

Small Molecules in Oncology

Small Molecules in Oncology
A Book

by Uwe M. Martens

  • Publisher : Springer
  • Release : 2018-08-01
  • Pages : 276
  • ISBN : 3319914421
  • Language : En, Es, Fr & De
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This book, written by respected experts, discusses in detail the latest developments in targeted oncology therapy using small molecules. It covers a wide range of small molecules, including tyrosine kinase inhibitors, mTOR, MEK, PARP, and multikinase inhibitors, as well as cell cycle and NTRK interacting agents. For each molecule, aspects such as the chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed. Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the advances being made will mean significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book is the third edition of Small Molecules in Oncology, but has now been divided into two volumes, with the other volume focusing specifically on small molecules in hematology.

Gene-Based Therapies for Cancer

Gene-Based Therapies for Cancer
A Book

by Jack A. Roth

  • Publisher : Springer Science & Business Media
  • Release : 2010-07-28
  • Pages : 278
  • ISBN : 9781441961020
  • Language : En, Es, Fr & De
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Cancer gene therapy is a novel therapy that targets the underlying genetic defects in the cancer cell. Progress in this field has been rapid and gene therapy promises to further extend personalized cancer treatment. In this volume leading experts have contributed their experience in developing gene therapies for a variety of cancers. Translational gene therapy approaches are emphasized. Chapters include discussions of specific gene delivery technologies as well as their application to various cancers with extensive discussions of ongoing clinical trials. This information should be useful to both students, fellows, and experienced scientists with an interest in this rapidly developing area.

Cancer Genomics

Cancer Genomics
From Bench to Personalized Medicine

by Graham Dellaire,Jason N Berman,Robert J. Arceci

  • Publisher : Academic Press
  • Release : 2013-11-21
  • Pages : 510
  • ISBN : 0123972744
  • Language : En, Es, Fr & De
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Cancer Genomics addresses how recent technological advances in genomics are shaping how we diagnose and treat cancer. Built on the historical context of cancer genetics over the past 30 years, the book provides a snapshot of the current issues and state-of-the-art technologies used in cancer genomics. Subsequent chapters highlight how these approaches have informed our understanding of hereditary cancer syndromes and the diagnosis, treatment and outcome in a variety of adult and pediatric solid tumors and hematologic malignancies. The dramatic increase in cancer genomics research and ever-increasing availability of genomic testing are not without significant ethical issues, which are addressed in the context of the return of research results and the legal considerations underlying the commercialization of genomic discoveries. Finally, the book concludes with "Future Directions", examining the next great challenges to face the field of cancer genomics, namely the contribution of non-coding RNAs to disease pathogenesis and the interaction of the human genome with the environment. Tools such as sidebars, key concept summaries, a glossary, and acronym and abbreviation definitions make this book highly accessible to researchers from several fields associated with cancer genomics. Contributions from thought leaders provide valuable historical perspective to relate the advances in the field to current technologies and literature.

Lung Cancer and Personalized Medicine

Lung Cancer and Personalized Medicine
Current Knowledge and Therapies

by Aamir Ahmad,Shirish Gadgeel

  • Publisher : Springer
  • Release : 2015-12-14
  • Pages : 228
  • ISBN : 3319242237
  • Language : En, Es, Fr & De
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This, the first of two volumes on personalized medicine in lung cancer, touches on the core issues related to the understanding of lung cancer—statistics and epidemiology of lung cancer—along with the incidence of lung cancer in non-smokers. A major focus of this volume is the state of current therapies against lung cancer—immune, targeted therapies against EGFR TKIs, KRAS, ALK, angiogenesis; the associated challenges, especially resistance mechanisms; and recent progress in targeted drug development based on metal chemistry. Chapters are written by some of the leading experts in the field, who provide a better understanding of lung cancer, the factors that make it lethal, and current research focused on developing personalized treatment plans. With a unique mix of topics, this volume summarizes the current state-of-knowledge on lung cancer and the available therapies.

Cancer Chemotherapy in Clinical Practice

Cancer Chemotherapy in Clinical Practice
A Book

by Terrence Priestman

  • Publisher : Springer Science & Business Media
  • Release : 2012-05-26
  • Pages : 177
  • ISBN : 0857297279
  • Language : En, Es, Fr & De
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A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment.

Personalized Treatment of Breast Cancer

Personalized Treatment of Breast Cancer
A Book

by Masakazu Toi,Eric Winer,John Benson,Suzanne Klimberg

  • Publisher : Springer
  • Release : 2016-05-24
  • Pages : 388
  • ISBN : 4431555528
  • Language : En, Es, Fr & De
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This book deals with the essential factors in the personalization of treatment for primary breast cancer. These include host issues, lymph node surgery, radiation therapy, and preoperative systemic treatment requiring specialized knowledge, multidisciplinary care experience, techniques, and research. Locoregional treatment in conjunction with systemic treatments is another important factor, with options for local therapy significantly affected by genetic BRCA mutation. Axillary treatment issues have become top priorities in recent primary breast cancer care, and these are highlighted in the book’s presentation of technological advances in lymph node mapping and diagnosis, axillary clearance in patients with nodal metastasis, and the role of axillary surgery. Attention is also given to locoregional treatment after preoperative systemic therapy. Because therapeutic impact differs depending upon biological characteristics such as tumor subtype, local therapy should be based both on tumor biology and on therapeutic response in parallel. Associated translational research and mathematical prediction tools such as nomograms also are introduced. This book provides the essence of primary breast cancer care, particularly its individualization with novel therapeutic concepts and strategies, and will greatly benefit physicians and clinical investigators in breast cancer institutions.

Towards Personalized Cancer Therapy

Towards Personalized Cancer Therapy
Microfluidic Approaches for Drug Screening

by Chi-Ting Chang

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 134
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The ability to predict a patient's response to chemotherapy is a major challenge in oncology. Despite the years of research and development with countless investments, clinical trials in oncology still experience high failure rates, resulting in patients suffering from severe side effects with little benefits. Therefore, there is a critical need to tailor chemotherapies to individual patients. Personalized approaches could lower treatment toxicity, improve patients' quality of life, and ultimately reduce mortality. In order to pursue personalized chemotherapy, advanced technologies and tools are urgently needed. One of the major challenges in oncology is tumor heterogeneity from individual patients. To demonstrate the potential for quantifying tumor heterogeneity, we developed a simple approach by using a user-friendly microwell array device to allow for tracking key cell behaviors from large numbers of single cells. We demonstrated the utility of these arrays by quantifying the proliferation and senescence of isogenic cells which expressed or had been depleted of the human Werner syndrome protein. Our results allowed us to reveal and quantify cell-to-cell heterogeneity in proliferation and senescence during clonal growth. Current drug testing assays are either based on cell lines, which enable high-throughput screening but lack the physiological relevance of the tumor microenvironment, or xenograft models which are time- and resource-intensive and may lack important tumor components. As a result, drug candidates that emerge from drug screening cannot accurately predict how drugs act in patients to select the best possible treatment. Therefore, we propose to use intact tissue slices and biopsies which preserve the tumor microenvironment for drug screening. To allow for testing large numbers of compounds on intact tissues, we developed a microfluidic device that integrates live tissue slice cultures with an intuitive multi-well platform that allows for exposing the slices to multiple compounds at once or in sequence. In order to demonstrate our microfluidic platform, we performed the response of live mouse brain slices to a range of drug doses in parallel. Drug response was measured by imaging of markers for cell apoptosis and for cell death and was quantified by the fluorescence intensity and cell counts from epifluorescence and confocal microscopy images, respectively. We further extended the application by producing tumor slices and biopsies from mouse xenografts to demonstrate selevtive drug testing on mouse xenograft slices. Our drug testing results demonstrated the feasibility to allow for identifying the subset of therapies of greatest potential value to individual patients, on a timescale rapid enough to guide therapeutic decision-making.

Biomarkers in Cancer Screening and Early Detection

Biomarkers in Cancer Screening and Early Detection
A Book

by Sudhir Srivastava

  • Publisher : John Wiley & Sons
  • Release : 2017-06-07
  • Pages : 320
  • ISBN : 1118468821
  • Language : En, Es, Fr & De
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Prepared by world leaders on this topic, Biomarkers in Cancer Screening and Early Detection offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers, from their discovery and development to their validation, clinical utility, and use in developing personalized cancer treatment. Offers a comprehensive, state-of-the-art perspective on the various research and clinical aspects of cancer biomarkers Provides immediately actionable information – and hopefully also inspiration – to move discovery and clinical application forward Offers vital knowledge to help develop personalized cancer treatment for individual patients with specific cancers