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Personalized Computational Hemodynamics

Personalized Computational Hemodynamics
Models, Methods, and Applications for Vascular Surgery and Antitumor Therapy

by Yuri Vassilevski,Maxim Olshanskii,Sergey Simakov,Andrey Kolobov,Alexander Danilov

  • Publisher : Academic Press
  • Release : 2020-04-19
  • Pages : 280
  • ISBN : 0128156546
  • Language : En, Es, Fr & De
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Personalized Computational Hemodynamics: Models, Methods, and Applications for Vascular Surgery and Antitumor Therapy offers practices and advances surrounding the multiscale modeling of hemodynamics and their personalization with conventional clinical data. Focusing on three physiological disciplines, readers will learn how to derive a suitable mathematical model and personalize its parameters to account for pathologies and diseases. Written by leading experts, this book mirrors the top trends in mathematical modeling with clinical applications. In addition, the book features the major results of the "Research group in simulation of blood flow and vascular pathologies" at the Institute of Numerical Mathematics of the Russian Academy of Sciences. Two important features distinguish this book from other monographs on numerical methods for biomedical applications. First, the variety of medical disciplines targeted by the mathematical modeling and computer simulations, including cardiology, vascular neurology and oncology. Second, for all mathematical models, the authors consider extensions and parameter tuning that account for vascular pathologies. Examines a variety of medical disciplines targeted by mathematical modeling and computer simulation Discusses how the results of numerical simulations are used to support clinical decision-making Covers hemodynamics relating to various subject areas, including vascular surgery and oncological tumor treatments

Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies

Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies
A Book

by Lucian Mihai Itu,Puneet Sharma,Constantin Suciu

  • Publisher : Springer
  • Release : 2017-05-31
  • Pages : 227
  • ISBN : 3319568531
  • Language : En, Es, Fr & De
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Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies

Computational Fluid Dynamics Indicators to Improve Cardiovascular Pathologies
A Book

by Eduardo Soudah Prieto

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 181
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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In recent years, the study of computational hemodynamics within anatomically complex vascular regions has generated great interest among clinicians. The progress in computational fluid dynamics, image processing and high-performance computing haveallowed us to identify the candidate vascular regions for the appearance of cardiovascular diseases and to predict how this disease may evolve. Medicine currently uses a paradigm called diagnosis. In this thesis we attempt to introduce into medicine the predictive paradigm that has been used in engineering for many years. The objective of this thesis is therefore to develop predictive models based on diagnostic indicators for cardiovascular pathologies. We try to predict the evolution of aortic abdominal aneurysm, aortic coarctation and coronary artery disease in a personalized way for each patient. To understand how the cardiovascular pathology will evolve and when it will become a health risk, it is necessary to develop new technologies by merging medical imaging and computational science. We propose diagnostic indicators that can improve the diagnosis and predict the evolution of the disease more efficiently than the methods used until now. In particular, a new methodology for computing diagnostic indicators based on computational hemodynamics and medical imaging is proposed. We have worked with data of anonymous patients to create real predictive technology that will allow us to continue advancing in personalized medicine and generate more sustainable health systems. However, our final aim is to achieve an impact at a clinical level. Several groups have tried to create predictive models for cardiovascular pathologies, but they have not yet begun to use them in clinical practice. Our objective is to go further and obtain predictive variables to be used practically in the clinical field. It is to be hoped that in the future extremely precise databases of all of our anatomy and physiology will be available to doctors. These data can be used for predictive models to improve diagnosis or to improve therapies or personalized treatments.

Patient-Specific Modeling of the Cardiovascular System

Patient-Specific Modeling of the Cardiovascular System
Technology-Driven Personalized Medicine

by Roy C.P. Kerckhoffs

  • Publisher : Springer Science & Business Media
  • Release : 2010-09-03
  • Pages : 240
  • ISBN : 9781441966919
  • Language : En, Es, Fr & De
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Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI

Towards Personalized Models of the Cardiovascular System Using 4D Flow MRI
A Book

by Belén Casas Garcia

  • Publisher : Linköping University Electronic Press
  • Release : 2019-02-15
  • Pages : 71
  • ISBN : 9176852172
  • Language : En, Es, Fr & De
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Current diagnostic tools for assessing cardiovascular disease mostly focus on measuring a given biomarker at a specific spatial location where an abnormality is suspected. However, as a result of the dynamic and complex nature of the cardiovascular system, the analysis of isolated biomarkers is generally not sufficient to characterize the pathological mechanisms behind a disease. Model-based approaches that integrate the mechanisms through which different components interact, and present possibilities for system-level analyses, give us a better picture of a patient’s overall health status. One of the main goals of cardiovascular modelling is the development of personalized models based on clinical measurements. Recent years have seen remarkable advances in medical imaging and the use of personalized models is slowly becoming a reality. Modern imaging techniques can provide an unprecedented amount of anatomical and functional information about the heart and vessels. In this context, three-dimensional, three-directional, cine phase-contrast (PC) magnetic resonance imaging (MRI), commonly referred to as 4D Flow MRI, arises as a powerful tool for creating personalized models. 4D Flow MRI enables the measurement of time-resolved velocity information with volumetric coverage. Besides providing a rich dataset within a single acquisition, the technique permits retrospective analysis of the data at any location within the acquired volume. This thesis focuses on improving subject-specific assessment of cardiovascular function through model-based analysis of 4D Flow MRI data. By using computational models, we aimed to provide mechanistic explanations of the underlying physiological processes, derive novel or improved hemodynamic markers, and estimate quantities that typically require invasive measurements. Paper I presents an evaluation of current markers of stenosis severity using advanced models to simulate flow through a stenosis. Paper II presents a framework to personalize a reduced-order, mechanistic model of the cardiovascular system using exclusively non-invasive measurements, including 4D Flow MRI data. The modelling approach can unravel a number of clinically relevant parameters from the input data, including those representing the contraction and relaxation patterns of the left ventricle, and provide estimations of the pressure-volume loop. In Paper III, this framework is applied to study cardiovascular function at rest and during stress conditions, and the capability of the model to infer load-independent measures of heart function based on the imaging data is demonstrated. Paper IV focuses on evaluating the reliability of the model parameters as a step towards translation of the model to the clinic.

Bioinformatics and Biomedical Engineering

Bioinformatics and Biomedical Engineering
8th International Work-Conference, IWBBIO 2020, Granada, Spain, May 6-8, 2020, Proceedings

by Ignacio Rojas,Olga Valenzuela,Fernando Rojas,Luis Javier Herrera,Francisco Manuel Ortuño

  • Publisher : Springer Nature
  • Release : 2020
  • Pages : 837
  • ISBN : 3030453855
  • Language : En, Es, Fr & De
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This volume constitutes the proceedings of the 8th International Work-Conference on IWBBIO 2020, held in Granada, Spain, in May 2020. The total of 73papers presented in the proceedings, was carefully reviewed and selected from 241 submissions. The papers are organized in topical sections as follows: Biomarker Identification; Biomedical Engineering; Biomedical Signal Analysis; Bio-Nanotechnology; Computational Approaches for Drug Design and Personalized Medicine; Computational Proteomics and Protein-Protein Interactions; Data Mining from UV/VIS/NIR Imaging and Spectrophotometry; E-Health Technology, Services and Applications; Evolving Towards Digital Twins in Healthcare (EDITH); High Performance in Bioinformatics; High-Throughput Genomics: Bioinformatic Tools and Medical Applications; Machine Learning in Bioinformatics; Medical Image Processing; Simulation and Visualization of Biological Systems. --

Quality Assurance in Healthcare Service Delivery, Nursing and Personalized Medicine: Technologies and Processes

Quality Assurance in Healthcare Service Delivery, Nursing and Personalized Medicine: Technologies and Processes
Technologies and Processes

by Lazakidou, Athina

  • Publisher : IGI Global
  • Release : 2011-09-30
  • Pages : 302
  • ISBN : 1613501218
  • Language : En, Es, Fr & De
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Quality of life is difficult to define and even more difficult to measure; as such, outcomes from nursing in continuing care are not easily articulated. Quality Assurance in Healthcare Service Delivery, Nursing and Personalized Medicine: Technologies and Processes offers a framework for measuring quality of service in the healthcare industry as it pertains to nursing, with insight into how new technologies and the design of personalized medicine have improved quality of care and quality of life. Assessment and feedback are a vital part of developing and designing personalized medicine, and this book details case studies and the latest research in the field of healthcare service delivery assessment. In addition to describing assessment methodology, the book is also a compendium of the latest research into new medical technologies.

Biomedical Technology

Biomedical Technology
Modeling, Experiments and Simulation

by Peter Wriggers,Thomas Lenarz

  • Publisher : Springer
  • Release : 2017-08-29
  • Pages : 362
  • ISBN : 3319595482
  • Language : En, Es, Fr & De
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This book provides an overview of new mathematical models, computational simulations and experimental tests in the field of biomedical technology, and covers a wide range of current research and challenges. The first part focuses on the virtual environment used to study biological systems at different scales and under multiphysics conditions. In turn, the second part is devoted to modeling and computational approaches in the field of cardiovascular medicine, e.g. simulation of turbulence in cardiovascular flow, modeling of artificial textile-reinforced heart valves, and new strategies for reducing the computational cost in the fluid-structure interaction modeling of hemodynamics. The book’s last three parts address experimental observations, numerical tests, computational simulations, and multiscale modeling approaches to dentistry, orthopedics and otology. Written by leading experts, the book reflects the remarkable advances that have been made in the field of medicine, the life sciences, engineering and computational mechanics over the past decade, and summarizes essential tools and methods (such as virtual prototyping of medical devices, advances in medical imaging, high-performance computing and new experimental test devices) to enhance medical decision-making processes and refine implant design. The contents build upon the International Conference on Biomedical Technology 2015 (ICTB 2015), the second ECCOMAS thematic conference on Biomedical Engineering, held in Hannover, Germany in October 2015.

Parallel Finite Volume Computation on General Meshes

Parallel Finite Volume Computation on General Meshes
A Book

by Yuri Vassilevski,Ivan Kapyrin,Kirill Nikitin,Kirill Terekhov

  • Publisher : Springer
  • Release : 2020-08-05
  • Pages : 184
  • ISBN : 9783030472313
  • Language : En, Es, Fr & De
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This book presents a systematic methodology for the development of parallel multi-physics models and its implementation in geophysical and biomedical applications. The methodology includes conservative discretization methods for partial differential equations on general meshes, as well as data structures and algorithms for organizing parallel simulations on general meshes. The structures and algorithms form the core of the INMOST (Integrated Numerical Modelling Object-oriented Supercomputing Technologies) platform for the development of parallel models on general meshes. The authors consider applications for addressing specific geophysical and biomedical challenges, including radioactive contaminant propagation with subsurface waters, reservoir simulation, and clot formation in blood flows. The book gathers all the components of this methodology, from algorithms and numerical methods to the open-source software, as well as examples of practical applications, in a single source, making it a valuable asset for applied mathematicians, computer scientists, and engineers alike.

Modeling the Heart and the Circulatory System

Modeling the Heart and the Circulatory System
A Book

by Alfio Quarteroni

  • Publisher : Springer
  • Release : 2015-04-24
  • Pages : 238
  • ISBN : 3319052306
  • Language : En, Es, Fr & De
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The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the preprocessing of clinical data to the development of mathematical equations, their numerical solution, and both in-vivo and in-vitro validation. They discuss the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are presented. This book is addressed to all scientists interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system.

Computer Assisted Learning

Computer Assisted Learning
Selected Proceedings from the CAL 81 Symposium Held on 8-10 April 1981 at the University of Leeds

by Peter R. Smith

  • Publisher : Pergamon
  • Release : 1981
  • Pages : 182
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Provides an important international forum for those interested in the theory and practice of computer-assisted learning in education and training. The papers are grouped under 4 main themes: hardware interaction with CAL; fundamental aspects of CAL; experimental studies in CAL; and developments and future directions.

Modern Mechanobiology

Modern Mechanobiology
Convergence of Biomechanics, Development, and Genomics

by Juhyun Lee,Sharon Gerecht,Hanjoong Jo,Tzung Hsiai

  • Publisher : CRC Press
  • Release : 2021-02-25
  • Pages : 250
  • ISBN : 1000021262
  • Language : En, Es, Fr & De
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Modern mechanobiology converges both engineering and medicine to address personalized medicine. This book is built on the previously well-received edition, Hemodynamics and Mechanobiology of Endothelium. The central theme is "omic" approaches to mechanosignal transduction underlying tissue development, injury, and repair. A cadre of investigators has contributed to the chapters, enriching the interface between mechanobiology and precision medicine for personalized diagnosis and intervention. The book begins with the fundamental basis of vascular disease in response to hemodynamic shear stress and then details cardiovascular development and regeneration, valvular and cardiac morphogenesis, mechanosensitive microRNA and histone unfolding, computational fluid dynamics, and light-sheet imaging. This edition represents a paradigm shift from traditional biomechanics and signal transduction to transgenic models, including novel zebrafish and chick embryos, and targets a wider readership from academia to industry and government agencies in the field of mechanobiology.

Dissertation Abstracts International

Dissertation Abstracts International
The sciences and engineering. B

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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World Congress on Medical Physics and Biomedical Engineering May 26-31, 2012, Beijing, China

World Congress on Medical Physics and Biomedical Engineering May 26-31, 2012, Beijing, China
A Book

by Mian Long

  • Publisher : Springer Science & Business Media
  • Release : 2013-02-11
  • Pages : 2345
  • ISBN : 3642293050
  • Language : En, Es, Fr & De
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The congress’s unique structure represents the two dimensions of technology and medicine: 13 themes on science and medical technologies intersect with five challenging main topics of medicine to create a maximum of synergy and integration of aspects on research, development and application. Each of the congress themes was chaired by two leading experts. The themes address specific topics of medicine and technology that provide multiple and excellent opportunities for exchanges.

Aerospace Medicine and Biology

Aerospace Medicine and Biology
A Continuing Bibliography with Indexes

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1989
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Modeling and Optimization for Pediatric Cardiovascular Surgeries

Modeling and Optimization for Pediatric Cardiovascular Surgeries
A Book

by Aekaansh Verma

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Historically, guidelines and practices in cardiovascular surgery have been developed through trial-and-error in human and animal studies. Improvements in these practices concerning overall hemodynamics in the patient require extensive experience, often gained through large clinical trials. The development of realistic patient-specific simulation capabilities offers a safe and inexpensive sand-box for rapidly testing new surgical techniques and medical devices. Recent developments in image acquisition, anatomical modeling, and predictive hemodynamics simulations have given rise to the paradigm of virtual surgical planning for cardiovascular surgeries, building on personalized treatments found in other areas of medicine. Despite these developments, clinical translation of virtual surgical planning tools have been limited by computational cost of patient-specific simulations, intractable run-times for parametric studies, and complexity of modeling cardiovascular surgery. In this thesis, I address the last two limitations, that is, reduction of run-time for design discovery, through a simulation-based optimization framework, and expansion of the current set of cardiovascular surgical modeling tools. We select the Surrogate Management Framework (SMF) is selected as the optimization framework of choice, owing to its' flexibility, ability to handle general constraints, non-smooth convergence theory, and popularity as a black-box optimizer. To reduce the SMF run-time in a high-performance computing environment, two fully concurrent variants of the SMF are developed. The trade-off between total computational expense and time-efficiency for these variants are shown for a set of analytical functions. Substantial savings in time is also obtained on a model simulation-based optimization problem. The concurrent methods also showed more robustness to choice of initialization set. The developed concurrent SMF is then applied to a problem of clinical interest: the design of a systemic-to-pulmonary shunt for the assisted bidirectional Glenn (ABG), a recently proposed alternative for stage-1 single ventricle palliation. With the goal of maximizing pulmonary flow subject to physiological Vena Caval pressure constraint, optimal pulmonary flow-SVC pressure behavior is found to depend strongly on pulmonary vascular resistance. Pulmonary vascular resistance values in neonates, assessed from literature and from a retrospective study, show theoretical viability of optimal ABG designs, as well as raise fundamental questions on existing notions of oxygen delivery in single ventricle neonates. These questions are discussed in detail with the help of lumped parameter models. Prior efforts to model complex vascular interventions in-silico have been limited to either placement of medical devices, such as stents, or to the addition or removal of whole vessels or grafts. A new direction for extending analysis-based virtual surgery modeling is presented through the example of an end-to-end resection surgery for aortic coarctation patients. A mesh generated from an anatomical model is altered directly using computational geometric operations, instead of analytical features of the model. This allows for a more physical parametrization of the surgical method used for coarctation repair. The developed pipeline is demonstrated on an animal model of aortic coarctation. Future directions for extending computational geometric tools for analysis-driven virtual surgery are also motivated.

International Aerospace Abstracts

International Aerospace Abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1976
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Medical Imaging

Medical Imaging
Physiology, function, and structure from medical images

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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VIII Latin American Conference on Biomedical Engineering and XLII National Conference on Biomedical Engineering

VIII Latin American Conference on Biomedical Engineering and XLII National Conference on Biomedical Engineering
Proceedings of CLAIB-CNIB 2019, October 2-5, 2019, Cancún, México

by César A. González Díaz,Christian Chapa González,Eric Laciar Leber,Hugo A. Vélez,Norma P. Puente,Dora-Luz Flores,Adriano O. Andrade,Héctor A. Galván,Fabiola Martínez,Renato García,Citlalli J. Trujillo,Aldo R. Mejía

  • Publisher : Springer Nature
  • Release : 2019-09-30
  • Pages : 1518
  • ISBN : 3030306488
  • Language : En, Es, Fr & De
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This book gathers the joint proceedings of the VIII Latin American Conference on Biomedical Engineering (CLAIB 2019) and the XLII National Conference on Biomedical Engineering (CNIB 2019). It reports on the latest findings and technological outcomes in the biomedical engineering field. Topics include: biomedical signal and image processing; biosensors, bioinstrumentation and micro-nanotechnologies; biomaterials and tissue engineering. Advances in biomechanics, biorobotics, neurorehabilitation, medical physics and clinical engineering are also discussed. A special emphasis is given to practice-oriented research and to the implementation of new technologies in clinical settings. The book provides academics and professionals with extensive knowledge on and a timely snapshot of cutting-edge research and developments in the field of biomedical engineering.

5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary

5th European Conference of the International Federation for Medical and Biological Engineering 14 - 18 September 2011, Budapest, Hungary
A Book

by Ákos Jobbágy

  • Publisher : Springer Science & Business Media
  • Release : 2012-02-02
  • Pages : 1446
  • ISBN : 3642235085
  • Language : En, Es, Fr & De
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This volume presents the 5th European Conference of the International Federation for Medical and Biological Engineering (EMBEC), held in Budapest, 14-18 September, 2011. The scientific discussion on the conference and in this conference proceedings include the following issues: - Signal & Image Processing - ICT - Clinical Engineering and Applications - Biomechanics and Fluid Biomechanics - Biomaterials and Tissue Repair - Innovations and Nanotechnology - Modeling and Simulation - Education and Professional