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Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations

Physiologically-Based Pharmacokinetic (PBPK) Modeling and Simulations
Principles, Methods, and Applications in the Pharmaceutical Industry

by Sheila Annie Peters

  • Publisher : John Wiley & Sons
  • Release : 2012-02-17
  • Pages : 450
  • ISBN : 1118140303
  • Language : En, Es, Fr & De
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The only book dedicated to physiologically-based pharmacokineticmodeling in pharmaceutical science Physiologically-based pharmacokinetic (PBPK) modeling has becomeincreasingly widespread within the pharmaceutical industry over thelast decade, but without one dedicated book that provides theinformation researchers need to learn these new techniques, itsapplications are severely limited. Describing the principles,methods, and applications of PBPK modeling as used inpharmaceutics, Physiologically-Based Pharmacokinetic (PBPK)Modeling and Simulations fills this void. Connecting theory with practice, the book explores theincredible potential of PBPK modeling for improving drug discoveryand development. Comprised of two parts, the book first provides adetailed and systematic treatment of the principles behindphysiological modeling of pharmacokinetic processes,inter-individual variability, and drug interactions for smallmolecule drugs and biologics. The second part looks in greaterdetail at the powerful applications of PBPK to drug research. Designed for a wide audience encompassing readers looking for abrief overview of the field as well as those who need more detail,the book includes a range of important learning aids. Featuringend-of-chapter keywords for easy reference—a valuable assetfor general or novice readers without a PBPK background—alongwith an extensive bibliography for those looking for furtherinformation, Physiologically- Based Pharmacokinetic (PBPK) Modelingand Simulations is the essential single-volume text on one of thehottest topics in the pharmaceutical sciences today.

Physiologically Based Pharmacokinetic Modeling

Physiologically Based Pharmacokinetic Modeling
Science and Applications

by Micaela Reddy,R. S. Yang,Melvin E. Andersen,Harvey J. Clewell III

  • Publisher : John Wiley & Sons
  • Release : 2005-06-14
  • Pages : 420
  • ISBN : 0471478776
  • Language : En, Es, Fr & De
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A definitive, single source of information on PBPK modeling Physiologically-based pharmacokinetic (PBPK) modeling is becomingincreasingly important in human health risk assessments and insupporting pharmacodynamic modeling for toxic responses. Organizedby classes of compounds and modeling purposes so users can quicklyaccess information, this is the first comprehensive reference ofits kind. This book presents an overview of the underlying principles of PBPKmodel development. Then it provides a compendium of PBPK modelinginformation, including historical development, specific modelingchallenges, and current practices for: * Halogenated Alkanes * Halogenated Alkenes * Alkene and Aromatic Compounds * Reactive Vapors in the Nasal Cavity * Alkanes, Oxyhydrocarbons, and Related Compounds * Pesticides and Persistent Organic Pollutants * Dioxin and Related Compounds * Metals and Inorganic Compounds * Drugs * Antineoplastic Agents * Perinatal Transfer * Mixtures * Dermal Exposure Models In addition to pinpointing specific information, readers canexplore diverse modeling techniques and applications. Anauthoritative reference for toxicologists, ecotoxicologists, riskassessors, regulators, pharmacologists, pharmacists, and graduatestudents in pharmacokinetics and toxicology, Physiologically-BasedPharmacokinetic Modeling compiles information from leaders in thefield and discusses future directions for PBPK modeling.

Physiologically Based Pharmacokinetic (PBPK) Modeling

Physiologically Based Pharmacokinetic (PBPK) Modeling
Methods and Applications in Toxicology and Risk Assessment

by Jeffrey W. Fisher,Jeffery M. Gearhart,Zhoumeng Lin

  • Publisher : Academic Press
  • Release : 2020-05-20
  • Pages : 346
  • ISBN : 0128196823
  • Language : En, Es, Fr & De
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Physiologically Based Pharmacokinetic (PBPK) Modeling: Methods and Applications in Toxicology and Risk Assessment presents foundational principles, advanced techniques and applications of PBPK modeling. Contributions from experts in PBPK modeling cover topics such as pharmacokinetic principles, classical physiological models, the application of physiological models for dose-response and risk assessment, the use of in vitro information, and in silico methods. With end-of-chapter exercises that allow readers to practice and learn the skills associated with PBPK modeling, dose-response, and its applications to safety and risk assessments, this book is a foundational resource that provides practical coverage of PBPK modeling for graduate students, academics, researchers, and more. Provides end-of-chapter exercises to teach hands-on computational tools used in toxicology Supplies computer code and explanations and includes examples of applied models used in regulatory toxicology and research Authored by expert editors and contributors who are among the best PBPK modelers in the world

Physiologically-Based Pharmacokinetic (PBPK) Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3-Glucuronide (M3G) in Man and Rat

Physiologically-Based Pharmacokinetic (PBPK) Models for the Description of Sequential Metabolism of Codeine to Morphine and Morphine 3-Glucuronide (M3G) in Man and Rat
A Book

by Shu Chen

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 250
  • ISBN : 9780494725412
  • Language : En, Es, Fr & De
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Whole-body PBPK models were developed based on both the intestinal traditional model (TM) and segregated-flow model (SFM) to describe codeine sequential metabolism in man/rat. Model parameters were optimized with ScientistRTM and SimcypRTM simulator to predict literature data after oral (p.o.) and intravenous (i.v.) codeine administration in man/rat. In vivo codeine PK studies on rats were performed to provide more data for simulation. The role of fm' (fractional formation clearance of morphine from codeine) in model discrimination between the TM and SFM was investigated. A greater difference between the [AUC M3G/AUCMorphine]p.o. and [ AUCM3G/AUCMorphine]i.v. ratio existed for the SFM, especially when the fm' was low. It was found that our tailor-made PBPK models using ScientistRTM were superior to those from SimcypRTM in describing codeine sequential metabolism. Residual sum of squares and AUC's were calculated for each model, which demonstrated superiority of the SFM over TM in predicting codeine sequential metabolism in man/rat.

Translational Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation to Support Drug Development and Pharmacotherapy

Translational Physiologically-based Pharmacokinetic (PBPK) Modeling and Simulation to Support Drug Development and Pharmacotherapy
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Environmental Health Perspectives

Environmental Health Perspectives
Supplements

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Microcomputer Programs for Physiologically-based Pharmacokinetic (PB-PK) Modeling

Microcomputer Programs for Physiologically-based Pharmacokinetic (PB-PK) Modeling
A Book

by Michael H. Dong

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 28
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Selenium

Selenium
A Book

by Department of Health & Human Resources

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Draft Toxicological Profile for Carbon Monoxide

Draft Toxicological Profile for Carbon Monoxide
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 328
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicological Profile for Chromium

Toxicological Profile for Chromium
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 419
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicological Profile for Methylene Chloride

Toxicological Profile for Methylene Chloride
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 271
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II
A Book

by John B. Taylor,D. J. Triggle

  • Publisher : Elsevier Science Ltd
  • Release : 2007
  • Pages : 7200
  • ISBN : 9780080445137
  • Language : En, Es, Fr & De
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The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Government Reports Announcements & Index

Government Reports Announcements & Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Quantitative Cancer Modeling and Risk Assessment

Quantitative Cancer Modeling and Risk Assessment
A Book

by Charles Donald Holland,Robert L. Sielken

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 386
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicological Profile for Sulfur Trioxide and Sulfuric Acid

Toxicological Profile for Sulfur Trioxide and Sulfuric Acid
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 189
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Modelling and Control in Biomedical Systems 1997 (including Biological Systems)

Modelling and Control in Biomedical Systems 1997 (including Biological Systems)
A Proceedings Volume from the IFAC Symposium, Warwick, UK, 23-26 March 1997

by D. A. Linkens,Ewart R. Carson

  • Publisher : Pergamon
  • Release : 1997
  • Pages : 367
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Paperback. This volume contains the 90 papers presented at the 3rd IFAC Symposium on Modelling and Control in Biomedical Systems held in Warwick, UK from 23-26 March 1997. Significant work in the field of biomedical systems analysis and design is taking place throughout the world and the opportunities for technological interchanges offered by symposia like this one are extremely valuable for the progress and stability of effort and vision in this important human-centred field.The symposium was multi- and inter-disciplinary in nature with the choice of topics solicited covering the major systems' components and functions of complex physiology. The remit was also extended, on this occasion, beyond mammalian physiology to that of biological systems. Therefore, a special session was devoted to the modelling and control of botanical systems with the aim of providing an exchange of ideas with biomathematicians.

Draft Toxicological Profile for Wood Creosote, Coal Tar Creosote, Coal Tar, Coal Tar Pitch, and Coal Tar Pitch Volatiles

Draft Toxicological Profile for Wood Creosote, Coal Tar Creosote, Coal Tar, Coal Tar Pitch, and Coal Tar Pitch Volatiles
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 342
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicological Profile for Chlorophenols

Toxicological Profile for Chlorophenols
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 238
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Toxicological Profile for Benzene

Toxicological Profile for Benzene
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 442
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Draft Toxicological Profile for Phosphate Ester Flame Retardants

Draft Toxicological Profile for Phosphate Ester Flame Retardants
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 278
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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