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Phytochemicals as Lead Compounds for New Drug Discovery

Phytochemicals as Lead Compounds for New Drug Discovery
A Book

by Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal

  • Publisher : Elsevier
  • Release : 2019-09-07
  • Pages : 378
  • ISBN : 0128178914
  • Language : En, Es, Fr & De
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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Neglected Tropical Diseases and Phytochemicals in Drug Discovery
A Book

by Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje

  • Publisher : John Wiley & Sons
  • Release : 2021-10-25
  • Pages : 624
  • ISBN : 1119617154
  • Language : En, Es, Fr & De
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NEGLECTED TROPICAL DISEASES AND PHYTOCHEMICALS IN DRUG DISCOVERY Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Neglected Tropical Diseases and Phytochemicals in Drug Discovery

Neglected Tropical Diseases and Phytochemicals in Drug Discovery
A Book

by Chukwuebuka Egbuna,Muhammad Akram,Jonathan Chinenye Ifemeje

  • Publisher : John Wiley & Sons
  • Release : 2021-10-12
  • Pages : 592
  • ISBN : 1119616603
  • Language : En, Es, Fr & De
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Explore novel drug discovery updates from medicinal plants to help fight the devastating effects of neglected tropical diseases Neglected Tropical Diseases and Phytochemicals in Drug Discovery delivers a comprehensive exploration of the drug discovery process as it pertains to neglected tropical diseases. The book covers recent advancements in drug discovery, as well as druggable targets and new challenges facing the industry. It offers readers expansive discussions of specific diseases, including protozoan, helminth, bacterial, viral, fungal, and ectoparasitic infections. This book provides readers with insightful perspectives from leading industry voices on fifty years of trends and progress in the search for new, safe, and affordable therapeutic drugs in the fight against neglected tropical diseases. It includes information beneficial to researchers in a variety of fields of biology, chemistry, medicine, and pharmaceuticals. The distinguished authors cover topics including the effects of phytochemicals on the causative agent of leprosy and the potential applicability of phytochemicals in the management of Dengue fever. Readers will also enjoy the inclusion of: Thorough introductions to neglected tropical diseases, phytochemicals, protein targets, and mechanisms in drug discovery, as well as the epidemiology of neglected tropical diseases An exploration of novel bioactive lead compounds for drug discovery against neglected tropical diseases, leishmaniasis, lymphatic filariasis, trypanosomiasis, and schistosomiasis Discussions of protozoan infections, including herbal, nutritional, and traditional remedies for giardiasis and the anti-leishmanial potentials of phytochemicals Examinations of helminth infections, including the prospects of phytochemicals in the treatment of helminthiasis Perfect for medicinal chemists, drug developers, and research and development scientists, Neglected Tropical Diseases and Phytochemicals in Drug Discovery will also earn a place in the libraries of toxicologists and researchers in biology, chemistry, medicinal chemistry, ethnobotany, and bioinformatics seeking a one-stop resource for drug discovery for neglected tropical diseases.

Dietary Phytochemicals

Dietary Phytochemicals
A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes

by Chukwuebuka Egbuna,Sadia Hassan

  • Publisher : Springer Nature
  • Release : 2021-08-20
  • Pages : 265
  • ISBN : 3030729990
  • Language : En, Es, Fr & De
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This book presents comprehensive coverage on the importance of good nutrition in the treatment and management of obesity, cancer and diabetes. Naturally occurring bioactive compounds are ubiquitous in most dietary plants available to humans and provide opportunities for the management of diseases. The text provides information about the major causes of these diseases and their association with nutrition. The text also covers the role of dietary phytochemicals in drug development and their pathways. Later chapters emphasize novel bioactive compounds as anti-diabetic, anti-cancer and anti-obesity agents and describe their mechanisms to regulate cell metabolism. Written by global team of experts, Dietary Phytochemicals: A Source of Novel Bioactive Compounds for the Treatment of Obesity, Cancer and Diabetes describes the potentials of novel phytochemicals, their sources, and underlying mechanism of action. The chapters were drawn systematically and incorporated sequentially to facilitate proper understanding. This book is intended for nutritionists, physicians, medicinal chemists, drug developers in research and development, postgraduate students and scientists in area of nutrition and life sciences.

Plant Bioactives as Natural Panacea against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development

Plant Bioactives as Natural Panacea against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development
A Book

by Kanti Bhooshan Pandey,Maitree Suttajit

  • Publisher : Elsevier
  • Release : 2022-06-15
  • Pages : 425
  • ISBN : 9780323905817
  • Language : En, Es, Fr & De
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Plant Bioactives as Natural Panacea Against Age-induced Diseases: Nutraceuticals and Functional Lead Compounds for Drug Development presents in detail the complications of aging and the bioactive phytochemicals that in specific herbal formulations including beverages can mitigate them. The book extensively describes the current information not only on the role of plant bioactive components in delaying or preventing the aging process and associated complications, but also the different strategies and scientific evidence of the possible synergistic effects of these studies, enabling the formulation of more effective natural drugs to intervene in aging and associated events. Chapters cover the broad areas of plant bioactive compounds in promoting healthy aging and longevity, including balancing glucose homeostasis, in cognitive impairments, age-related diseases, food trends and the anti-aging diet in Asia and other regions, as well as the social and economic impact of dietary patterns in aging interventions. Written by a team of global experts, Plant Bioactives as Lead Compounds for New Drug Discovery Against Aging and Related Diseases is the ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists and analytical chemists. Describes plant bioactives for specific age disorders Focuses on the discovery of new herbal origin drugs and potential druggable targets for the treatment of chronic diseases of world importance Includes cutting edge research information on cell senescence during aging and assesses the plant bioactive compounds

Machine Learning and Analytics in Healthcare Systems

Machine Learning and Analytics in Healthcare Systems
Principles and Applications

by Himani Bansal,Balamurugan Balusamy,T. Poongodi,Firoz Khan KP

  • Publisher : CRC Press
  • Release : 2021-07-01
  • Pages : 274
  • ISBN : 1000406199
  • Language : En, Es, Fr & De
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This book provides applications of machine learning in healthcare systems and seeks to close the gap between engineering and medicine. It will combine the design and problem-solving skills of engineering with health sciences, in order to advance healthcare treatment. The book will include areas such as diagnosis, monitoring, and therapy. The book will provide real-world case studies, gives a detailed exploration of applications in healthcare systems, offers multiple perspectives on a variety of disciplines, while also letting the reader know how to avoid some of the consequences of old methods with data sharing. The book can be used as a reference for practitioners, researchers and for students at basic and intermediary levels in Computer Science, Electronics and Communications.

Functional Foods and Nutraceuticals

Functional Foods and Nutraceuticals
Bioactive Components, Formulations and Innovations

by Chukwuebuka Egbuna,Genevieve Dable Tupas

  • Publisher : Springer Nature
  • Release : 2020-08-24
  • Pages : 642
  • ISBN : 3030423190
  • Language : En, Es, Fr & De
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Functional foods and nutraceuticals are food products that naturally offer or have been modified to offer additional health benefits beyond basic nutrition. As such products have surged in popularity in recent years, it is crucial that researchers and manufacturers understand the concepts underpinning functional foods and the opportunity they represent to improve human health, reduce healthcare costs, and support economic development worldwide. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations presents a guide to functional foods from experienced professionals in key institutions around the world. The text provides background information on the health benefits, bioavailability, and safety measurements of functional foods and nutraceuticals. Subsequent chapters detail the bioactive components in functional foods responsible for these health benefits, as well as the different formulations of these products and recent innovations spurred by consumer demands. Authors emphasize product development for increased marketability, taking into account safety issues associated with functional food adulteration and solutions to be found in GMP adherence. Various food preservation methods aimed at enhancing the quality and shelf life of functional food are also highlighted. Functional Foods and Nutraceuticals: Bioactive Components, Formulations and Innovations is the first of its kind, designed to be useful to students, teachers, nutritionists, food scientists, food technologists and public health regulators alike.

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases

Combination Drug Delivery Approach as an Effective Therapy for Various Diseases
A Book

by Prashant Kesharwani

  • Publisher : Academic Press
  • Release : 2022-04-08
  • Pages : 436
  • ISBN : 0323858767
  • Language : En, Es, Fr & De
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Combination Drug Delivery Approach as an Effective Therapy for Various Diseases explores the use of bioengineering tools in combination drug delivery approaches to control various diseases at different clinical stages of synergistic action, varying mechanisms of action, and during the suppression of drug resistance. The book presents fundamental knowledge on the experiential and experimental aspects of drug combination approaches in order to equip rational applications in preventing the emergence of resistance during the treatment of various diseases. It provides a holistic understanding of the principles behind formation, characterization, applications, regulations, toxicity, challenges and future perspectives of combination drug delivery approaches. It will be of interest to researchers and advanced graduate students in pharmaceutical science, chemistry, biology and medicine, as well as pharmaceutical companies and scientific organizations. Provides an accounting of vital aspects on various combination drug delivery approaches, presenting next generation diagnostics and therapeutics Discusses the perspectives of current technologies in highly organized tables, illustrative figures and flow charts Defines major gaps in knowledge that can lead to significant scientific discoveries

Emerging Modalities in Mitigation of Antimicrobial Resistance

Emerging Modalities in Mitigation of Antimicrobial Resistance
A Book

by Nadeem Akhtar,Kumar Siddharth Singh,Prerna,Dinesh Goyal

  • Publisher : Springer Nature
  • Release : 2022
  • Pages : 129
  • ISBN : 303084126X
  • Language : En, Es, Fr & De
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This book provides an overview of cutting-edge and next-generation research and technologies for combating antimicrobial resistance. Antibiotic-resistant infections are projected to cause 10 million deaths annually by the year 2050. A sustainable, unified approach by researchers, practitioners, policymakers, and the public is urgently needed to stem this trend. This book aims to provide a comprehensive summary of current and future-facing efforts to mitigate the threat of AMR through a One-Health approach. This book is a valuable resource for students, researchers, policymakers, and the public about AMR and novel strategies to combat AMR.

Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases

Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases
A Book

by Seyed Moayed Alavian,Seyed Mohammad Nabavi,Seyed Fazel Nabavi,Ana Sanches Silva

  • Publisher : Academic Press
  • Release : 2020-11-20
  • Pages : 314
  • ISBN : 0128175230
  • Language : En, Es, Fr & De
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Influence of Nutrients, Bioactive Compounds, and Plant Extracts in Liver Diseases provides evidence-based knowledge of the mechanism of action of natural compounds, as well as the relation of structure and function of phytochemicals in hepatitis B and C, fatty liver disease, nonalcoholic fatty liver disease, liver cancer, biliary cirrhosis, and primary sclerosing cholangitis. The effect of phytochemicals in the hepatotoxicity of drugs is also addressed. Written for health professionals seeking reliable and up-to-date information on the beneficial or toxic effects of natural compounds on liver disease, this book is sure to be a welcomed resource for nutritionists, food chemists, natural product researchers, pharmacists, medical doctors, and pharmacognosists alike. Explores the benefits of phytonutrients, especially those with a wide spectrum of biological activities Addresses various liver diseases, including hepatitis B, hepatitis C, alcoholic fatty liver disease, nonalcoholic fatty liver disease, liver cancer, biliary cirrhosis, and primary sclerosing cholangitis Provides reliable, up-to-date information on the natural compounds that have protective or toxic effects on liver diseases

Medicinal Plants in the Asia Pacific for Zoonotic Pandemics, Volume 1

Medicinal Plants in the Asia Pacific for Zoonotic Pandemics, Volume 1
Family Amborellaceae to Vitaceae

by Christophe Wiart

  • Publisher : CRC Press
  • Release : 2021-06-30
  • Pages : 423
  • ISBN : 135105905X
  • Language : En, Es, Fr & De
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Medicinal Plants in the Asia Pacific for Zoonotic Pandemics provides an unprecedented, comprehensive overview of the phylogeny, botany, ethnopharmacology, and pharmacology of more than 100 plants used in the traditional medical systems of Asia and Pacific. It discusses their actions and potentials against viruses, bacteria, and fungi that represent a threat of epidemic and pandemic diseases, with an emphasis on the molecular basis and cellular pathways. This book presents scientific names, the botanical classification, traditional medicinal uses, active chemical constituents, and pharmacology. This volume is a critical reference for anyone involved in the discovery of lead molecules or phytopharmaceutical products for the prevention or treatment of pandemic viral, bacterial, or fungal infections. FEATURES Phylogenetic presentation of medicinal plants and a chemotaxonomical rationale of antiviral, antibacterial, and antifungal actions Discusses the chemical structure–activity relationship, pharmacokinetics, and oral bioavailability of antimicrobial principles Introduces the molecular mechanism of natural products on viruses, bacteria, and fungi Contains a selection of botanical plates and useful bibliographic references This book is a useful research tool for postgraduates, academics, and the pharmaceutical, herbal, and nutrition industries. Medicinal Plants in the Asia Pacific for Zoonotic Pandemics includes commentary sections that invite further research and reflection on the fascinating and timely subject of the development of drugs and herbals from Asia-Pacific medicinal plants to safeguard humanity and other life forms against the forthcoming waves of viral, bacterial, or fungal pandemics. This book is an ideal reference text for medicinal plant enthusiasts.

Total Synthesis and Structural Modification of Plant Natural Products Ardisiphenol D and Napabucasin as Anticancer Lead Compounds

Total Synthesis and Structural Modification of Plant Natural Products Ardisiphenol D and Napabucasin as Anticancer Lead Compounds
A Book

by Wai I Chik

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 372
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nature is a vast treasure for humans. Numerous cytotoxic phytochemicals have been derived as lead compounds for the discovery of novel chemotherapeutics over the years. However, chemotherapy resistance is common, particularly in cancer stem cells (CSCs) due to their self-renewal nature, and thus the search for novel anticancer agents must be continued. In our continuing drug discovery programme, napabucasin has been isolated from the roots of Radermachera boniana Dop. (Bignoniaceae). Napabucasin was found to bypass the resistance problem against ordinary chemo- and radio-cancer therapies by selectively targeting cancer stem cells and metastasis, and therefore considered a new generation lead compound for preventing cancer relapse and metastasis. Structural modifications of napabucasin have been attempted but the study on its N-heterocyclic analogues is limited despite the fact that nitrogen-based heterocyclic compounds comprise the largest proportion among all the other heterocycles in the U.S. Food and Drug Administration (FDA) approved anticancer small molecules. More potent candidates have been suggested in several studies, but their research have not been extended to cancer stem cells. In the present study, total synthetic routes for obtaining napabucasin (Scheme 1) and a series of nitrogen-based analogues (Scheme 2) mimicking the chemical structure of napabucasin have been established. The synthesized compounds have been subjected to tumorsphere formation assays in HCT116 human colon cancer derived CSCs. Napabucasin significantly inhibited sphere formation at 0.5 μM and even induced cell death of HCT116 cancer stem cells at higher dosage i.e. 1 μM. Interestingly, the nitrogen counterpart demonstrated no obvious effect in the assay even at high concentration of 5 μM. However, the inhibitory effect on cancer stem cell's sphere formation ability has been rescued in the synthesized analogue A120, which has a simpler structure and improved solubility. Sphere formation of cancer stem cells has been retarded upon treatment of 0.6 μM of A120, while 1.2 μM of the compound could induce cell death. The differential inhibitory effects of the chemically diversified compounds on cancer stem cells in our studies revealed that the oxygen atom in the heterocyclic ring system may act as a hydrogen bond acceptor in the interaction with its binding target (Figure 7 - 8). On the other hand, bioactivity-guided fractionation and isolation of the active extracts of the roots of Ardisia lindleynana also led to the identification of ardisiphenol D in our drug discovery programme. The research on this type of compounds has been limited. Synthetic studies have barely been touched and the functional and structural requirements of the compound have not been reported so far. Extensive studies on structural modification, structure-activity relationship elucidation, target binding and lead optimization are crucial for the development of this type of compounds into clinically potent drug candidates. In the present study, the first total synthesis of ardisiphenol D has been accomplished for a more economical and environmentally friendly approach of obtaining the natural compound (Scheme 8). The total synthesis route has also been optimized with fewer steps and can be applied in obtaining some of its analogues (Scheme 13). By several synthetic approaches as well as functional group interconversions (Figure 17), a total of 135 derivatives with rich chemical and structural diversity have been synthesized. Structure-activity relationship analysis of the derivatives (Figure 18), categorized into different classes according to the characteristic functional group constituents, has been conducted following in vitro SRB antiproliferation assay against a human colorectal cancer cell line. The acetyl group at C-4 or C-1 is determined to be crucial to the anticancer potency of this type of phenolic compounds, while the formation of an additional acyl group could enhance the activity. Compound ad4 has demonstrated improved in vitro and in vivo antineoplastic effects, with reduced toxicity. Upon treatment of HCT116 human colorectal cancer cell induced tumour in nude mice by intraperitoneal administration of ad4 at 10 mg/kg, the tumour suppression rate reached 56 %, which outperformed the mainstay colorectal cancer remedy 5-FU at 25 mg/kg. More synthetic and mechanistic studies of napaubasin and ardisiphenol D, and their related derivatives have to be done in the future to transform the compounds into drug candidates to overcome chemotherapy resistance and metastasis.

Phytochemistry, the Military and Health

Phytochemistry, the Military and Health
Phytotoxins and Natural Defenses

by Andrew G. Mtewa,Chukwuebuka Egbuna

  • Publisher : Elsevier
  • Release : 2021-03-02
  • Pages : 606
  • ISBN : 0128232307
  • Language : En, Es, Fr & De
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Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses comes as a response to the gap that there has for so long existed between phytochemistry and survival of both service personnel and civilian communities during and after conflicts. Armed conflicts cause a lot of devastation to communities and should be avoided as much as it can be possible. The devastation is usually evident in service provisions such as Health, Education, Water, and Food among many others. Both service personnel and civilians are affected to various degrees. Facilities usually end up being physically destroyed, with no essential supplies and/or having dysfunctional systems. Going with untreated wounds, communicable and non-communicable diseases for weeks with no medical interventions due to the conflicts, disease burdens heavily weigh down on communities as well as security personnel. To make the situation even more complicated, masses of people are forced to migrate for safety and security reasons, likely going with diseases along wherever they go. In such instances, phytochemicals become handy in providing solutions from first aid, basic analgesia, antimicrobials, and the general improvement of health. Phytochemicals are known to play a major role in the day to day management of diseases and health. There has been much research into their effectiveness as community medicines and as alternatives to conventional drugs. However, the role that phytochemicals play in the military, counterterrorism, and security has been overlooked. Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses discusses the roles that phytochemicals play as friends and foes in the military, including insights aimed to help develop antidotes against phytochemicals and other chemical agents used maliciously as weapons. Filling a gap between drug discovery, security, and emergency medicine, this book describes which plants can be categorized for protection and controls, which can be helpful in times of conflicts and soon after conflicts, in military operations, and those that can be used as deterrents and as emergency medicines. Carefully designed to show the contribution that phytochemicals play in safety and security, this book is useful for researchers, regulators and anyone interested in plant chemistry. Covers the contribution that phytochemicals play in safety and security Contains insights that will help in the development of antidotes against phytochemical and other chemical weapons Categorizes plants in terms of their usefulness as well as the potential security risks they possess

Nutrition, Food and Diet in Ageing and Longevity

Nutrition, Food and Diet in Ageing and Longevity
A Book

by Suresh I. S. Rattan,Gurcharan Kaur

  • Publisher : Springer Nature
  • Release : 2021-11-04
  • Pages : 642
  • ISBN : 3030830179
  • Language : En, Es, Fr & De
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This edited volume is a compilation of 30 articles discussing what constitutes food for health and longevity. The aim is to provide up-to-date information, insights, and future tendencies in the ongoing scientific research about nutritional components, food habits and dietary patterns in different cultures. The health-sustaining and health-promoting effects of food are certainly founded in its overall composition of macronutrients and micronutrients. However, the consumption of these nutrients is normally in the form of raw or prepared food from the animal and plant sources. The book is divided into four parts and a conclusion, and successfully convenes the well-established information and knowledge, along with the personal views of a diversified group of researchers and academicians on the multifaceted aspects of nutrition, food and diet. The first part reviews the scientific information about proteins, carbohydrates, fats and oils, micronutrients, pro- and pre-biotics, and hormetins, along with a discussion of the evolutionary principles and constraints about what is optimal food, if any. The second part discusses various kinds of foods and food supplements with respect to their claimed benefits for general health and prevention of some diseases. The third part brings in the cultural aspects, such as what are the principles of healthy eating according to the traditional Chinese and Indian systems, what is the importance of mealing times and daily rhythms, and how different cultures have developed different folk wisdoms for eating for health, longevity and immortality. In the part four, various approaches which are either already in practice or are still in the testing and research phases are discussed and evaluated critically, for example intermittent fasting and calorie restriction, food-based short peptides, senolytics, Ayurvedic compounds, optimal food for old people, and food for the prevention of obesity and other metabolic disorders. The overreaching aim of this book is to inform, inspire and encourage students, researchers, educators and medical health professionals thinking about food and food habits in a holistic context of our habits, cultures and patterns. Food cannot be reduced to a pill of nutritional components. Eating food is a complex human behavior culturally evolved over thousands of years. Perhaps the old adage “we are what we eat” needs to be modified to “we eat what we are”.

Antioxidants

Antioxidants
Benefits, Sources, Mechanisms of Action

by Viduranga Waisundara

  • Publisher : BoD – Books on Demand
  • Release : 2021-09-08
  • Pages : 646
  • ISBN : 1839688645
  • Language : En, Es, Fr & De
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Antioxidants are one of the most sought-after biological compounds of interest to both scientific and nonscientific communities. The term gained popularity with the advent of identifying these compounds as having the ability to maintain health and wellness by combating against pathways leading to non-communicable diseases. This book covers several aspects of antioxidants—mechanisms of action, assays of measuring potency, sources, and even methods of isolation and identification. While it may seem these aspects have been covered in depth in several publications before this, this book intends to be positioned as an update, especially since the area of antioxidant research is as dynamic as ever. There are several chapters that might be of interest to health buffs, specifically those who are quite keen on maintaining health and wellness.

Computational Intelligence in Healthcare

Computational Intelligence in Healthcare
A Book

by Amit Kumar Manocha,Shruti Jain,Mandeep Singh,Sudip Paul

  • Publisher : Springer Nature
  • Release : 2021-05-11
  • Pages : 412
  • ISBN : 3030687236
  • Language : En, Es, Fr & De
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Artificial intelligent systems, which offer great improvement in healthcare sector assisted by machine learning, wireless communications, data analytics, cognitive computing, and mobile computing provide more intelligent and convenient solutions and services. With the help of the advanced techniques, now a days it is possible to understand human body and to handle & process the health data anytime and anywhere. It is a smart healthcare system which includes patient, hospital management, doctors, monitoring, diagnosis, decision making modules, disease prevention to meet the challenges and problems arises in healthcare industry. Furthermore, the advanced healthcare systems need to upgrade with new capabilities to provide human with more intelligent and professional healthcare services to further improve the quality of service and user experience. To explore recent advances and disseminate state-of-the-art techniques related to intelligent healthcare services and applications. This edited book involved in designing systems that will permit the societal acceptance of ambient intelligence including signal processing, imaging, computing, instrumentation, artificial intelligence, internet of health things, data analytics, disease detection, telemedicine, and their applications. As the book includes recent trends in research issues and applications, the contents will be beneficial to Professors, researchers, and engineers. This book will provide support and aid to the researchers involved in designing latest advancements in communication and intelligent systems that will permit the societal acceptance of ambient intelligence. This book presents the latest research being conducted on diverse topics in intelligence technologies with the goal of advancing knowledge and applications healthcare sector and to present the latest snapshot of the ongoing research as well as to shed further light on future directions in this space. The aim of publishing the book is to serve for educators, researchers, and developers working in recent advances and upcoming technologies utilizing computational sciences.

Natural Bio-active Compounds

Natural Bio-active Compounds
Volume 2: Chemistry, Pharmacology and Health Care Practices

by Mallappa Kumara Swamy,Mohd Sayeed Akhtar

  • Publisher : Springer Nature
  • Release : 2019-09-19
  • Pages : 492
  • ISBN : 9811372055
  • Language : En, Es, Fr & De
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Nature has consistently provided human beings with bioactive compounds that can be used directly as drugs or indirectly as drug leads. Some of the major classes of natural bioactive compounds include phenolics, alkaloids, tannins, saponins, lignin, glycosides, terpenoids, and many more. They possess a broad range of biological activities and are primarily useful in the treatment of various health issues. At the same time, the search for new and novel drugs is never-ending and, despite major advances in synthetic chemistry, nature remains an essential resource for drug discovery. Therefore, more and more researchers are interested in understanding the chemistry, clinical pharmacology, and beneficial effects of bioactive compounds in connection with solving human health problems. This book presents a wealth of information on natural metabolites that have been or are currently being used as drugs or leads for the discovery of new drugs. In addition, it highlights the importance of natural products against various human diseases, and their applications in the drug, nutraceuticals, cosmetics and herbal industries. Accordingly, the book offers a valuable resource for all students, educators, and healthcare experts involved in natural product research, phytochemistry, and pharmacological research.

Phytochemical Diversity

Phytochemical Diversity
A Source of New Industrial Products

by E. Chrystal

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 254
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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While the study of the chemicals produced by plants is arguably one of the oldest of the natural product sciences, current global concerns regarding the disappearance of biodiversity, along with the availability of methodology for systematic genetic manipulation and plant tissue culture, have rekindled industrial interest in phytochemical screening. Phytochemical Diversity gives a comprehensive overview of recent discoveries and developments of new products from plants that have potential utility in the pharmaceutical, agrochemical and cosmetic industries. It covers such areas as high throughput screening approaches for the discovery of novel phytochemicals, ethnobotanical drug discovery, comparisons of the chemical diversity available from plants and other natural sources, and adding value to phytochemicals through microbial biotransformations and synthetic approaches. It is particularly timely in its look at the ramifications of the recent UN Convention on Biological Diversity and its impact on the search for new industrial products from plants. This book provides a single source on developments in phytochemical research, with contributions from both academia to industry, and developing to developed countries, which will prove invaluable to bio-organic chemists, biotechnologists and those involved in medicinal and pharmaceutical chemistry.

Natural Products and Drug Discovery

Natural Products and Drug Discovery
A Book

by Pinarosa Avato

  • Publisher : MDPI
  • Release : 2020-04-22
  • Pages : 392
  • ISBN : 303928746X
  • Language : En, Es, Fr & De
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Natural products hold a prominent position in the current discovery and development of drugs and have diverse indications for both human and animal health. Plants, in particular, play a leading role as a source of specialized metabolites with medical effects. Other organisms, such as marine and terrestrial animals and microorganisms, produce very important drug candidate molecules. Specialized metabolites from these varied natural sources can be used directly as bioactive compounds or drug precursors. In addition, due to their broad chemical diversity, they can act as drug prototypes and/or be used as pharmacological tools for different targets. Some examples of natural metabolites that have been developed into useful medical drug are cardiotonic digoxin from Digitalis sp., antimalarial artemisinin from Artemisia annua, anti-cancer taxol from Taxus sp., or podophyllotoxin from Podophyllum peltatum, which served as a synthetic model for the anti-cancer etoposide. The study of natural products is still attracting great scientific attention and their current importance, as a valuable lead for drug discovery, is undebatable. I cordially invite authors to contribute original articles, as well as survey articles, that give the readers of Molecules **MOLECULES NEEDS TO BE ITALICIZED** updated and new perspectives on natural products in drug discovery, including but not limited to natural sources, identification and separation of bioactive phytochemicals, standardization, new biological targets, pre-clinical and clinical trials, pharmacological effects/side effects, and bioassays.

Poisonous Plants and Phytochemicals in Drug Discovery

Poisonous Plants and Phytochemicals in Drug Discovery
A Book

by Andrew G. Mtewa,Chukwuebuka Egbuna,G. M. Narasimha Rao

  • Publisher : John Wiley & Sons
  • Release : 2020-12-04
  • Pages : 432
  • ISBN : 1119650275
  • Language : En, Es, Fr & De
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Focusing on phytochemicals and their potential for drug discovery, this book offers a comprehensive resource on poisonous plants and their applications in chemistry and in pharmacology. Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery - Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery - Written and edited by leading researchers in phytochemistry, medicinal chemistry, analytical chemistry, toxicology, and more - Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career Provides a comprehensive resource on phytotoxins, covering historical perspectives, modern applications, and their potential in drug discovery Covers the mechanisms, benefits, risks and management protocols of phytotoxins in a scientific laboratory and the usefulness in drug discovery Presents chapters in a carefully designed, clear order, making it an ideal resource for the academic researcher or the industry professional at any stage in their career