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Phytochemicals as Lead Compounds for New Drug Discovery

Phytochemicals as Lead Compounds for New Drug Discovery
A Book

by Chukwuebuka Egbuna,Shashank Kumar,Jonathan C. Ifemeje,Shahira M. Ezzat,Saravanan Kaliyaperumal

  • Publisher : Elsevier
  • Release : 2019-09-07
  • Pages : 378
  • ISBN : 0128178914
  • Language : En, Es, Fr & De
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Phytochemicals as Lead Compounds for New Drug Discovery presents complete coverage of the recent advances in the discovery of phytochemicals from medicinal plants as models to the development of new drugs and chemical entities. Functional bioactive compounds of plant origin have been an invaluable source for many human therapeutic drugs and have played a major role in the treatment of diseases around the world. These compounds possess enormous structural and chemical diversity and have led to many important discoveries. This book presents fundament concepts and factors affecting the choice for plant-based products, as well as recent advances in computer-aided drug discovery and FDA drug candidacy acceptance criteria. It also details the various bioactive lead compounds and molecular targets for a range of life-threatening diseases including cancer, diabetes, and neurodegenerative diseases. Written by a global team of experts, Phytochemicals as Lead Compounds for New Drug Discovery is an ideal resource for drug developers, phytochemists, plant biochemists, food and medicinal chemists, nutritionists and toxicologists, chemical ecologists, taxonomists, analytical chemists, and other researchers in those fields. It will also be very valuable to professors, students, and researchers in this domain. Presents fundamental concepts and factors affecting choice for plant-based products Details the FDA drug candidacy acceptance criteria, including bottlenecks and way forward Highlights recent advances in computational-based drug discovery Focuses on the discovery of new drugs and potential druggable targets for the treatment of chronic diseases of world importance

Botanical Leads for Drug Discovery

Botanical Leads for Drug Discovery
A Book

by Bikarma Singh

  • Publisher : Springer Nature
  • Release : 2020-10-05
  • Pages : 468
  • ISBN : 9811559171
  • Language : En, Es, Fr & De
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Active botanical ingredients are a prime requirement for herbal formulations and discovering a drug is all about integration of science disciplines. In recent decades there has been a growing interest in treating wounds and diseases using traditional remedies based on local herbs, combined with chemical advances. Although this has led to the development of new bioactive ingredients from plants, there has been little success in terms of clinical trials and post-marketing studies to comply with FDA guidelines. Plants have been used as a source of medicine throughout history and continue to serve as the basis for many pharmaceuticals used today. However, despite the modern pharmaceutical industry being founded on botanical medicine, synthetic approaches to drug discovery have now become standard. Science-driven translational discovery and botanical development has created a new reality, leading to enormous changes in strategies, technologies and the disciplines involved, which have been embraced by the pharmaceutical and biotech industries. This book gathers scientific expertise and traditional knowledge to promote the discovery and development of new formulations and drugs based on active ingredients and to provide guidance on taking these to clinical trials. It discusses major topics, such as how the phytochemical composition of many plants has changed over time due to factors like cultivation, which can have both positive and negative effects on the levels of bioactive compounds. It also explores the importance of plants as a valuable source of therapeutic compounds as a result of their vast biosynthetic capacity, and classifies them according to their intended use, safety and regulatory status. Further, the book offers insights into the regulatory aspects of botanical products, which is an important issue when considering standardization and quality assessment, and also examines the commercial aspects of plant-derived medications and their proven role in the treatment of chronic diseases such as heart disease, high blood pressure, pain, asthma, and other associated conditions. Given its scope, this book is a valuable tool for botanists, natural product chemists, pharmacologists and microbiologists involved in the study of phytochemicals for drug discovery.

Bioactive Phytochemicals: Drug Discovery to Product Development

Bioactive Phytochemicals: Drug Discovery to Product Development
A Book

by Javed Ahmad,Javed Ahamad

  • Publisher : Bentham Science Publishers
  • Release : 2020-10-28
  • Pages : 238
  • ISBN : 9811464464
  • Language : En, Es, Fr & De
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Natural bioactive compounds from medicinal plants are inexplicably diverse in chemical structure and biological properties. The unmet therapeutic requirements for various diseases serve as a guide for researchers to study natural compounds. These studies are intended to isolate, identify the structural characterization and eventually discover the pharmacological activity of natural compounds from their plant sources with the goal of treating specific diseases. Bioactive Phytochemicals: Drug Discovery to Product Development explores the scope and approaches of drug discovery from natural products. Chapters in the book cover information about the cultivation, collection and processing of medicinal plants, the methods and high throughput techniques for isolation and characterization of bioactive phytochemicals and pharmacological screening for activity, formulation and quality control. Information about the regulations specified for natural medicinal products in different region of the world is also presented, followed by a concluding chapter devoted to the role of natural herbal products for treatment of human diseases such as cancer, cardiovascular diseases, diabetes, obesity, inflammation and neurological disorders. Each chapter concludes with a general reference section, which is a bibliographic guide to more advanced texts. The contributing authors for this volume are drawn from a rich blend of experts in various areas of herbal medicine which encompass herbal drug discovery to product development. The concise and organized layout along with a broad coverage of phytochemistry and drug discovery makes this book a suitable reference for students of medicinal chemistry, researchers and industry professionals interested in herbal product development.

Phytochemicals for Pest Control

Phytochemicals for Pest Control
A Book

by American Chemical Society,Paul Arthur Hedin,American Chemical Society. Division of Agrochemicals,International Chemical Congress of Pacific Basin Studies,American Chemical Society Staff

  • Publisher : Amer Chemical Society
  • Release : 1997
  • Pages : 372
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This volume identifies and describes biologically active natural products which can be used to manage a wide variety of pests, including insects, weeds, and fungi. The book presents structure-activity studies of the pest control agents and evaluates active proteins and peptides affecting insects. It also covers the identification of new plant products with unique biological properties.

Phytochemical analysis and cholesterol lowering efficiency of Averrhoa carambola Linn (star fruit).

Phytochemical analysis and cholesterol lowering efficiency of Averrhoa carambola Linn (star fruit).
An overview

by Prem Jose Vazhacharickal,Jiby John Mathew,Sajeshkumar N. K.,Ratheesh Mohanan,Ellamplackill Surya Santhosh

  • Publisher : GRIN Verlag
  • Release : 2017-07-10
  • Pages : 27
  • ISBN : 3668479445
  • Language : En, Es, Fr & De
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Scientific Study from the year 2017 in the subject Agrarian Studies, grade: 1.5, Mar Augusthinose College, course: Biochemistry, language: English, abstract: Aqueous extract of the fruit pulp of Averrhoa carambola (star fruit) were evaluated for cholesterol lowering effect, in vitro, against various fatty food materials. Peoples are consuming food items made out of chicken, beef, mutton, egg and fish which contains large amount of fat. This study aims to analyze the effect of Averrhoa carambola in reducing the cholesterol level in this fat compound using water extract of the pulp. For this fatty food samples like egg yolk, pork fat, chicken fat , ghee and cod liver oil were treated with the extract and cholesterol level was estimated by Zak’s method for a period of time. Phytochemical constituents present in water extract of Averrhoa carambola Linn. pulp includes alkaloids, saponins, steroids, phlobatannins, carbohydrate, terpenoids, phenols, coumarins, flavonoids and leucoanthocyanins. The in vitro cholesterol lowering effect of Averrhoa carambola pulp extract shows a positive result on reducing chicken fat, ghee and egg yolk. But in case of cod liver oil no beneficial change was observed.

Science & Culture

Science & Culture
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Phytochemical and pharmacological evaluation of different fractions of Lannea grandis Engl (Family: Anacardiaceae)

Phytochemical and pharmacological evaluation of different fractions of Lannea grandis Engl (Family: Anacardiaceae)
A Book

by Sharmin Akhter

  • Publisher : GRIN Verlag
  • Release : 2014-07-14
  • Pages : 129
  • ISBN : 3656696713
  • Language : En, Es, Fr & De
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Master's Thesis from the year 2012 in the subject Pharmicology, , course: Pharmacy, language: English, abstract: The present research work was conducted to investigate the phytochemical and pharmacological activities of the different fractions of Lannea grandis Engl. (Family-Anacardiaceae). In phytochemical screenings with the crude extractives demonstrated the presence of alkaloids, steroids, tannins, saponins and gum. The antibacterial and antifungal activities of the crude extracts were evaluated by the disc diffusion method against 4 Gram positive and 7 Gram negative pathogenic bacteria and 7 fungi using Ciprofloxacin and Fluconazole as standards, respectively. In the screening, ethanol extract of L. grandis showed varying degrees of antibacterial activities than other two fractions with % zone of inhibition ranging from 46.09-48.42%, with strong activity against B. subtilis and S. aureus. On the other hand, the ethanol extract of plant also revealed mild to moderate antifungal activity with highest zone of inhibition of 20.5mm against B. dermatitidis. The MICs of the extracts were found to be 15.625-250μg/ml for both bacteria and fungal species used in the screening. During screening for antidiarrhoeal and antidepressant properties at dose 400mg/kg, significant (p

Sustainable Utilisation of Non-timber Forest Products

Sustainable Utilisation of Non-timber Forest Products
Issues and Prospects

by Mohd. Yaakub Hj. Johari,Maryati Mohamed,Mary Sintoh

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 148
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Intellectual Property Rights, Naturally Derived Bioactive Compounds and Resource Conservation

Intellectual Property Rights, Naturally Derived Bioactive Compounds and Resource Conservation
A Book

by C. Gyllenhaal,N.R. Farnsworth,American Society of Pharmacognosy. Interim Meeting

  • Publisher : Elsevier Science Limited
  • Release : 1997-07-02
  • Pages : 336
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The tropical rain forests have become an important focus in the search for new drugs from natural sources, especially from plants. This volume aims to promote a better understanding between scientists and institutions located in the developed and developing countries, in their efforts to search for new medicinal agents from the plants of these forests. The papers have been contributed by scientists and researchers from both developed and developing countries worldwide, and cover issues relevant to biodiversity prospecting activities. Such issues include rules and regulations on the collection of genetic materials for biological testing; logistical and technical challenges to be faced; sharing the benefits of discovery; patent protection for the discovery of potentially useful drug candidates; intellectual property rights; and indigenous property rights. The volume will be invaluable in achieving more fruitful collaborative efforts between scientists from different countries and different institutional affiliations, in their search for new drugs from tropical forest plants.

Phytochemical Diversity

Phytochemical Diversity
A Source of New Industrial Products

by E. Chrystal

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 254
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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While the study of the chemicals produced by plants is arguably one of the oldest of the natural product sciences, current global concerns regarding the disappearance of biodiversity, along with the availability of methodology for systematic genetic manipulation and plant tissue culture, have rekindled industrial interest in phytochemical screening. Phytochemical Diversity gives a comprehensive overview of recent discoveries and developments of new products from plants that have potential utility in the pharmaceutical, agrochemical and cosmetic industries. It covers such areas as high throughput screening approaches for the discovery of novel phytochemicals, ethnobotanical drug discovery, comparisons of the chemical diversity available from plants and other natural sources, and adding value to phytochemicals through microbial biotransformations and synthetic approaches. It is particularly timely in its look at the ramifications of the recent UN Convention on Biological Diversity and its impact on the search for new industrial products from plants. This book provides a single source on developments in phytochemical research, with contributions from both academia to industry, and developing to developed countries, which will prove invaluable to bio-organic chemists, biotechnologists and those involved in medicinal and pharmaceutical chemistry.

Bioassay Methods in Natural Product Research and Drug Development

Bioassay Methods in Natural Product Research and Drug Development
A Book

by Lars Bohlin,Jan G. Bruhn

  • Publisher : Springer Science & Business Media
  • Release : 1999-01-31
  • Pages : 201
  • ISBN : 9780792354802
  • Language : En, Es, Fr & De
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Bioassay Methods in Natural Product Research and Drug Development contains the proceedings from the Phytochemical Society of Europe's very successful symposium on this topic, held August 24-27, 1997 in Uppsala, Sweden. In this volume, leading academic and industrial scientists discuss novel methods for assaying natural products to find new structure-activity relationships. Of key importance in this process is the availability and reliability of specific bioassay methods, but chapters also discuss chemical and biological diversity and how to dereplicate natural product extracts to increase efficiency in lead discovery. Anti-tumor, HIV-inhibitory, antiprotozoal, anti-infective and immunomodulatory natural products are discussed. Various industrial projects are presented for the first time. This volume bridges the gap between academic and industrial research and scientists, and should be required reading in drug companies and faculties of pharmacy, as well as serving scientists in pharmacognosy, pharmacology, phytochemistry, natural products and drug discovery.

Current Organic Chemistry

Current Organic Chemistry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Provides in depth reviews on current progress in the fields of asymmetric synthesis, organometallic chemistry, bioorganic chemistry, heterocyclic chemistry, natural product chemistry, and analytical methods in organic chemistry. Each issue is edited by an appointed Executive Guest Editor

Trease and Evans' Pharmacognosy

Trease and Evans' Pharmacognosy
A Book

by William Charles Evans,George Edward Trease

  • Publisher : W B Saunders Company
  • Release : 1996
  • Pages : 612
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This reference covers the medicinal properties of plant and animal products. It seeks to maintain a balance between topical and classic aspects of the subject, and this edition includes an expanded section on complementary and traditional systems of medicine, taking in aromatherapy and Chinese and African medicine. This edition also covers application of gene transfer techniques to the production of medicinal plants, and there are new chapters on: antiprotozoals, oral hypoglycaemic and anti-mepatotoxic drugs, and on vitamins and hormones.

Anticancer Plants: Mechanisms and Molecular Interactions

Anticancer Plants: Mechanisms and Molecular Interactions
A Book

by Mohd Sayeed Akhtar,Mallappa Kumara Swamy

  • Publisher : Springer
  • Release : 2018-07-03
  • Pages : 360
  • ISBN : 9811084173
  • Language : En, Es, Fr & De
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This book summarizes the application of plant derived anticancer compounds as chemopreventives to treat several cancer types, focusing on the molecular mechanisms of action of phytocompounds and providing an overview of the basic processes at the cellular and molecular level that are involved in the progression of the cancer and can be employed in targeted preventive therapies. In addition, it highlights the development of novel anticancer drugs from plant sources using bioinformatics approaches. The compiled chapter data aids readers understanding of issues related to bioavailability, toxic effects and mechanisms of action of phytocompounds, and helps them identify the leads and utilize them against various cancer types effectively. Furthermore, it promotes the use of bioinformatics tools in medicinal plants to expedite their use in plant breeding programs to develop molecular markers to distinguish disease subtypes and predicting mutation, which in turn improves cancer diagnosis and prognosis, and to develop new lead compounds computationally. The book provides scientific verifications of plant compounds mechanisms of action against various cancers and offers useful information for students, teachers, and healthcare professionals involved in drug discovery, and clinical and therapeutic research.

Journal of the Indian Institute of Science

Journal of the Indian Institute of Science
A Book

by Indian Institute of Science, Bangalore

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Phytochemistry, the Military and Health

Phytochemistry, the Military and Health
Phytotoxins and Natural Defenses

by Andrew G. Mtewa,Chukwuebuka Egbuna

  • Publisher : Elsevier
  • Release : 2021-03-15
  • Pages : 606
  • ISBN : 0128232307
  • Language : En, Es, Fr & De
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Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses comes as a response to the gap that there has for so long existed between phytochemistry and survival of both service personnel and civilian communities during and after conflicts. Armed conflicts cause a lot of devastation to communities and should be avoided as much as it can be possible. The devastation is usually evident in service provisions such as Health, Education, Water, and Food among many others. Both service personnel and civilians are affected to various degrees. Facilities usually end up being physically destroyed, with no essential supplies and/or having dysfunctional systems. Going with untreated wounds, communicable and non-communicable diseases for weeks with no medical interventions due to the conflicts, disease burdens heavily weigh down on communities as well as security personnel. To make the situation even more complicated, masses of people are forced to migrate for safety and security reasons, likely going with diseases along wherever they go. In such instances, phytochemicals become handy in providing solutions from first aid, basic analgesia, antimicrobials, and the general improvement of health. Phytochemicals are known to play a major role in the day to day management of diseases and health. There has been much research into their effectiveness as community medicines and as alternatives to conventional drugs. However, the role that phytochemicals play in the military, counterterrorism, and security has been overlooked. Phytochemistry, the Military and Health: Phytotoxins and Natural Defenses discusses the roles that phytochemicals play as friends and foes in the military, including insights aimed to help develop antidotes against phytochemicals and other chemical agents used maliciously as weapons. Filling a gap between drug discovery, security, and emergency medicine, this book describes which plants can be categorized for protection and controls, which can be helpful in times of conflicts and soon after conflicts, in military operations, and those that can be used as deterrents and as emergency medicines. Carefully designed to show the contribution that phytochemicals play in safety and security, this book is useful for researchers, regulators and anyone interested in plant chemistry. Covers the contribution that phytochemicals play in safety and security Contains insights that will help in the development of antidotes against phytochemical and other chemical weapons Categorizes plants in terms of their usefulness as well as the potential security risks they possess

Medicinal & Aromatic Plants Abstracts

Medicinal & Aromatic Plants Abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Phytochemistry of Plants Used in Traditional Medicine

Phytochemistry of Plants Used in Traditional Medicine
A Book

by Phytochemical Society of Europe

  • Publisher : Oxford University Press on Demand
  • Release : 1995
  • Pages : 408
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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There is an increasing interest in natural plant products as a source of new pharmaceuticals and other biologically-active compounds. This is a timely review of the latest advances and trends in a field which is becoming a commercially significant area of investigation for the pharmaceuticalindustry. The pharmacological and phytochemical aspects of different preparations from vegetable sources is a truly interdisciplinary field and this book includes information on ethnopharmacology, selection, isolation and structure determination of plant-derived natural products. Many examples ofdifferent bioassays (in vitro and in vivo test systems) and pharmacological tests are given, providing the reader with an insight of what is presently possible in the study of bioactive plant material.

A Textbook of Pharmaceutical Medicine

A Textbook of Pharmaceutical Medicine
Current Practice

by Ronald David Mann,Michael David Rawlins,Richard Maitland Auty

  • Publisher : Parthenon Publishing
  • Release : 1993
  • Pages : 461
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This textbook comprises a collection of over 50 articles on aspects of pharmaceutical medicine, ranging over new drug development, pre-clinical research and post-marketing surveillance. Controversies over suspicious data and medicines for the Third World are also covered.

Indian Science Abstracts

Indian Science Abstracts
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009-11
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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