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Polymer-Protein Conjugates

Polymer-Protein Conjugates
From Pegylation and Beyond

by Gianfranco Pasut,Samuel Zalipsky

  • Publisher : Elsevier
  • Release : 2019-10-30
  • Pages : 512
  • ISBN : 0444640827
  • Language : En, Es, Fr & De
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Polymer–Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

Polymer-Protein Conjugates

Polymer-Protein Conjugates
From Pegylation and Beyond

by Gianfranco Pasut,Samuel Zalipsky

  • Publisher : Unknown Publisher
  • Release : 2019-11
  • Pages : 312
  • ISBN : 9780444640819
  • Language : En, Es, Fr & De
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Polymer-Protein Conjugates: From Pegylation and Beyond helps researchers by offering a unique reference and guide into this fascinating area. Sections cover the challenges surrounding the homogeneity of conjugates, their purity and polymer toxicity on long-term use, and how to deal with the risk of immunogenicity. These discussions help researchers design new projects by taking into account the latest innovations for safe and site selective polymer conjugation to proteins. PEG has been the gold standard and likely will play this role for many years, but alternatives are coming into the market, some of which have already been launched. After five decades of improvements, the ideas in this book are entering into a new era of innovation because of the advances in genetic engineering, biochemistry and a better understanding of the results from clinical use of PEG conjugates in humans. Provides an overview on the state-of-the-art of protein polymer conjugation Presents both the pros and cons of polymer-protein conjugates from the point-of-view of their clinical outcomes Outlines advantages and potential risks of present technology based on PEG Offers new alternatives for PEG and new approaches for on site-selective protein modification Identifies future direction of research in this field

PEGylated Protein Drugs: Basic Science and Clinical Applications

PEGylated Protein Drugs: Basic Science and Clinical Applications
A Book

by Francesco M. Veronese

  • Publisher : Springer Science & Business Media
  • Release : 2009-12-30
  • Pages : 290
  • ISBN : 3764386797
  • Language : En, Es, Fr & De
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PEGylation technology and key applications are introduced by this topical volume. Basic physical and chemical properties of PEG as basis for altering/improving in vivo behaviour of PEG-conjugates such as increased stability, improved PK/PD, and decreased immunogenicity, are discussed. Furthermore, chemical and enzymatic strategies for the coupling and the conjugate characterization are reported. Following chapters describe approved and marketed PEG-proteins and PEG-oligonucleotides as well as conjugates in various stages of clinical development.

Bioconjugate Techniques

Bioconjugate Techniques
A Book

by Greg T. Hermanson

  • Publisher : Academic Press
  • Release : 2013-07-25
  • Pages : 1200
  • ISBN : 0123822408
  • Language : En, Es, Fr & De
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Bioconjugate Techniques, 3rd Edition, is the essential guide to the modification and cross linking of biomolecules for use in research, diagnostics, and therapeutics. It provides highly detailed information on the chemistry, reagent systems, and practical applications for creating labeled or conjugate molecules. It also describes dozens of reactions, with details on hundreds of commercially available reagents and the use of these reagents for modifying or crosslinking peptides and proteins, sugars and polysaccharides, nucleic acids and oligonucleotides, lipids, and synthetic polymers. Offers a one-stop source for proven methods and protocols for synthesizing bioconjugates in the lab Provides step-by-step presentation makes the book an ideal source for researchers who are less familiar with the synthesis of bioconjugates Features full color illustrations Includes a more extensive introduction into the vast field of bioconjugation and one of the most thorough overviews of immobilization chemistry ever presented

Polymer Therapeutics II

Polymer Therapeutics II
Polymers as Drugs, Conjugates and Gene Delivery Sytems

by Ronit Satchi-Fainaro,Ruth Duncan

  • Publisher : Springer Science & Business Media
  • Release : 2006-01-12
  • Pages : 230
  • ISBN : 9783540292111
  • Language : En, Es, Fr & De
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With contributions by numerous experts

Bio-inspired Polymers

Bio-inspired Polymers
A Book

by Nico Bruns,Andreas F M Kilbinger

  • Publisher : Royal Society of Chemistry
  • Release : 2016-10-14
  • Pages : 612
  • ISBN : 1782626662
  • Language : En, Es, Fr & De
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Many key aspects of life are based on naturally occurring polymers, such as polysaccharides, proteins and DNA. Unsurprisingly, their molecular functionalities, macromolecular structures and material properties are providing inspiration for designing new polymeric materials with specific functions, for example, responsive, adaptive and self-healing materials. Bio-inspired Polymers covers all aspects of the subject, ranging from the synthesis of novel polymers, to structure-property relationships, materials with advanced properties and applications of bio-inspired polymers in such diverse fields as drug delivery, tissue engineering, optical materials and lightweight structural materials. Written and edited by leading experts on the topic, the book provides a comprehensive review and essential graduate level text on bio-inspired polymers for biochemists, materials scientists and chemists working in both industry and academia.

Protein-based Engineered Nanostructures

Protein-based Engineered Nanostructures
A Book

by Aitziber L. Cortajarena,Tijana Z. Grove

  • Publisher : Springer
  • Release : 2016-09-27
  • Pages : 286
  • ISBN : 3319391968
  • Language : En, Es, Fr & De
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This book is devoted to the engineering of protein-based nanostructures and nanomaterials. One key challenge in nanobiotechnology is to be able to exploit the natural repertoire of protein structures and functions to build materials with defined properties at the nanoscale using “bottom-up” strategies. This book addresses in an integrated manner all the critical aspects that need to be understood and considered to design the next generation of nano-bio assemblies. The book covers first the fundamentals of the design and features of the protein building blocks and their self-assembly illustrating some of the most relevant examples of nanostructural design. Finally, the book contains a section dedicated to demonstrated applications of these novel bioinspired nanostructures in different fields from hybrid nanomaterials to regenerative medicine. This book provides a comprehensive updated review of this rapidly evolving field.

Renewable Resources for Functional Polymers and Biomaterials

Renewable Resources for Functional Polymers and Biomaterials
Polysaccharides, Proteins and Polyesters

by Peter A. Williams

  • Publisher : Royal Society of Chemistry
  • Release : 2011
  • Pages : 440
  • ISBN : 1849732450
  • Language : En, Es, Fr & De
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Covers polysaccharides and other important biomacromolecules, detailing their source, production, structures, properties, and current and potential application in biotechnology and medicine.

Self-Assembly

Self-Assembly
From Surfactants to Nanoparticles

by Ramanathan Nagarajan

  • Publisher : John Wiley & Sons
  • Release : 2019-01-07
  • Pages : 368
  • ISBN : 1119001366
  • Language : En, Es, Fr & De
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An introduction to the state-of-the-art of the diverse self-assembly systems Self-Assembly: From Surfactants to Nanoparticles provides an effective entry for new researchers into this exciting field while also giving the state of the art assessment of the diverse self-assembling systems for those already engaged in this research. Over the last twenty years, self-assembly has emerged as a distinct science/technology field, going well beyond the classical surfactant and block copolymer molecules, and encompassing much larger and complex molecular, biomolecular and nanoparticle systems. Within its ten chapters, each contributed by pioneers of the respective research topics, the book: Discusses the fundamental physical chemical principles that govern the formation and properties of self-assembled systems Describes important experimental techniques to characterize the properties of self-assembled systems, particularly the nature of molecular organization and structure at the nano, meso or micro scales. Provides the first exhaustive accounting of self-assembly derived from various kinds of biomolecules including peptides, DNA and proteins. Outlines methods of synthesis and functionalization of self-assembled nanoparticles and the further self-assembly of the nanoparticles into one, two or three dimensional materials. Explores numerous potential applications of self-assembled structures including nanomedicine applications of drug delivery, imaging, molecular diagnostics and theranostics, and design of materials to specification such as smart responsive materials and self-healing materials. Highlights the unifying as well as contrasting features of self-assembly, as we move from surfactant molecules to nanoparticles. Written for students and academic and industrial scientists and engineers, by pioneers of the research field, Self-Assembly: From Surfactants to Nanoparticles is a comprehensive resource on diverse self-assembly systems, that is simultaneously introductory as well as the state of the art.

Thiol-X Chemistries in Polymer and Materials Science

Thiol-X Chemistries in Polymer and Materials Science
A Book

by Andrew B Lowe,Christopher N Bowman

  • Publisher : Royal Society of Chemistry
  • Release : 2013-08-13
  • Pages : 336
  • ISBN : 1849736960
  • Language : En, Es, Fr & De
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Thiol-X chemistries are already well established techniques, but it is only recently that they have been exploited for the functionalization and synthesis of polymers and other materials. As such, information on these techniques is scattered across the literature and Thiol-X Chemistries in Polymer and Materials Science is the first book to compile work specifically focussing on the application of thiol-based chemistries in materials design and synthesis. The book introduces the various thiol-X chemistries currently available and applications where they have been successfully used, including examples of 'click' processes, in polymerizations, polymer synthesis, and polymer modification. Short 'how to' sections within the chapters also provide general experimental techniques to employ the various chemistries described. Written by leading experts in the field, this book is a comprehensive resource for postgraduates, academics and industrial practitioners interested in polymer and materials applications.

Polymer Therapeutics I

Polymer Therapeutics I
Polymers as Drugs, Conjugates and Gene Delivery Systems

by Ronit Satchi-Fainaro,Ruth Duncan

  • Publisher : Springer Science & Business Media
  • Release : 2006-02-10
  • Pages : 204
  • ISBN : 9783540292104
  • Language : En, Es, Fr & De
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Silicon Versus Carbon

Silicon Versus Carbon
Fundamental Nanoprocesses, Nanobiotechnology and Risks Assessment

by Yuri Magarshak,Sergey Kozyrev,Ashok K. Vaseashta

  • Publisher : Springer Science & Business Media
  • Release : 2009-05-21
  • Pages : 416
  • ISBN : 9048125235
  • Language : En, Es, Fr & De
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Even though there is no generally accepted definition of nanotechnologies to be defined as distinct discipline there is an emerging consensus that their advent and development is a growing in importance factor of the contemporary and future technological civilization. One of these most fundamental issues we are confronted with is the compatibility with life itself. From single cell organisms to humans, carbon is a key building block of all molecular structures of life. In contrast the man created electronic industry to build on other elements, of which silicon is the most common. Both carbon and silicon create molecular chains, although different in their internal structure. All life is built from carbon-based chains. As long as the man built technological products do not directly interfere with the physiology of life the associated risks from them are relatively easy to identify. They are primarily in the environmental pollution and the possibility of upsetting the natural balance of biocoenosis, on a planetary scale. The basic life functions are still not directly subverted. We can use TV, computers, drive cars and use other technological utilities without fear of direct interference with our cellular functions. This is in particular because all these technological utilities are many orders of magnitude larger than typical scales of biological activity. Most of biological activity, from fermentative catalysis to DNA replication takes place on nanoscale. The situation is radically different when the technological goals are building nanoscale size products. All biological processes take place on nanoscale.

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials

Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials
A Book

by Munmaya Mishra

  • Publisher : CRC Press
  • Release : 2017-08-16
  • Pages : 1800
  • ISBN : 1351653032
  • Language : En, Es, Fr & De
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The Concise Encyclopedia of Biomedical Polymers and Polymeric Biomaterials presents new and selected content from the 11-volume Biomedical Polymers and Polymeric Biomaterials Encyclopedia. The carefully culled content includes groundbreaking work from the earlier published work as well as exclusive online material added since its publication in print. A diverse and global team of renowned scientists provide cutting edge information concerning polymers and polymeric biomaterials. Acknowledging the evolving nature of the field, the encyclopedia also features newly added content in areas such as tissue engineering, tissue repair and reconstruction, and biomimetic materials.

Smart Polymer Catalysts and Tunable Catalysis

Smart Polymer Catalysts and Tunable Catalysis
A Book

by Songjun Li,Peter A. Lieberzeit,Sergey A. Piletsky,Anthony P.F. Turner

  • Publisher : Elsevier
  • Release : 2019-09-10
  • Pages : 300
  • ISBN : 0128118725
  • Language : En, Es, Fr & De
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Smart Polymer Catalysts and Tunable Catalysis describes the latest advances in smart polymer catalysts and tunable catalysis. This book will serve as an ideal reference for scientists, students and researchers working in the fields of catalysis, chemical engineering, chemistry, materials science, biotechnology and nanotechnology. Users will find this to be a distinct, systematic and comprehensive body of knowledge on the field with its compilation of essential knowledge and discussions of extensive potential in both social and commercial impacts. Provides a single-source summary of the emerging frontiers in scientific research in smart polymer catalysts and tunable catalysis Includes very well-organized chapters that are illustrated with over 130 illustrations and figures Written by scientists from prestigious universities and industries across the world Edited by veteran researchers in the field of smart polymers and catalysis

Polymeric Nanomedicines

Polymeric Nanomedicines
A Book

by Marcel Popa,Constantin V. Uglea

  • Publisher : Bentham Science Publishers
  • Release : 2013-05-29
  • Pages : 821
  • ISBN : 1608054845
  • Language : En, Es, Fr & De
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Over the last few decades, numerous nanoparticle platforms have been studied for their use in therapeutic applications. This book deals with the description of the construction of technical systems that combines different functionalities which bring liposomes, polymer-drug conjugates, polymer-protein conjugates, dendrimers, polymeric micelles, polymerosomes and other nanoparticles into the realm of nanotechnology proper, as opposed to traditional pharmacology or supramolecular chemistry. The volume additionally covers topics such as passive and active targeting, the strategies used for drug targeting, and the synthesis and characterization of polymeric nanoparticle platforms. Targeted polymeric nanomedicines have shown exciting results in preclinical studies, demonstrating their potential as therapeutic carriers. Therefore, the development of polymeric nanomedicines as therapeutic agents has generated great enthusiasm both in academia and industry. The book is systematically divided into chapters devoted to a class of polymeric nanomedicines. Each chapter also describes relevant aspects relating to drug design and targeting of polymeric nanomedicines wherever possible. In addition, a series of chapters concerning the contribution of polymeric nanomedicines in the treatment of several categories of diseases including cancer, inflammatory, renal, immunological diseases, and brain disorders is also presented. Key features of this book include: - A comprehensive and cutting-edge overview of polymeric nanomedicines available in a single dedicated volume - Discussions on advances in drug delivery systems for a variety of diseases - more than 2000 references, tables, equations, and drawings Readers, whether beginners or experts, will find in this book, contemporary and relevant information regarding the synthesis, evaluation and applications of polymeric nanomedicines. Supplemented with extensive bibliographic references, tables and figures, this book is an essential and incomparable reference for medicinal chemists, biologists, and medical (oncologic) researchers, as well as for scientists, undergraduate and graduate students in the field of medical bioengineering and polymer nanoscience.

Bioconjugation Protocols

Bioconjugation Protocols
Strategies and Methods

by Sonny S. Mark

  • Publisher : Humana Press
  • Release : 2016-08-23
  • Pages : 605
  • ISBN : 9781493960965
  • Language : En, Es, Fr & De
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Contemporary approaches to the synthesis of chemically modified biomacromolecules (proteins, nucleic acids, lipids, and carbohydrates) not only require efficient means to control conjugation and the specific site of attachment of the conjugated moiety but also the effective use of recent developments in the fields of pharmaceutical chemistry, biomolecular/polymer engineering, and nanobiotechnology. In this second edition of Bioconjugation Protocols: Strategies and Methods, expert researchers update the classic methods and introduce valuable new approaches that go beyond basic conjugation techniques to include elements from advanced organic synthesis, molecular biology, surface biotechnology, materials science, and nanobioscience/engineering. These readily reproducible methods cover the preparation of biomolecular conjugates using a variety of labeling techniques and semisynthetic approaches. Additional chapters address the biofunctionalization of surface structures, including organic/inorganic thin films, as well as various types of nanostructures (magnetic nanoparticles, quantum dots, carbon nanotubes, and silicon nanowire devices). All the protocols follow the successful Methods in Molecular BiologyTM series format, each one offering step-by-step laboratory instructions, an introduction outlining the principle behind the technique, lists of the necessary equipment and reagents, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and highly practical, Bioconjugation Protocols: Strategies and Methods, Second Edition offers both novice and experienced researchers access to the broad array of techniques needed to carry out the semisynthesis of functional biomolecular reagents and/or the biofunctionalization of surfaces and structures of unique interest for a wide variety of applications, ranging from novel biomedical diagnostics to powerful new therapeutics to advanced biomaterials.

Drug Delivery

Drug Delivery
A Book

by Monika Schäfer-Korting

  • Publisher : Springer Science & Business Media
  • Release : 2010-03-10
  • Pages : 501
  • ISBN : 9783642004773
  • Language : En, Es, Fr & De
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In the view of most experts pharmacology is on drugs, targets, and actions. In the context the drug as a rule is seen as an active pharmaceutical ingredient and not as a complex mixture of chemical entities of a well defined structure. Today, we are becoming more and more aware of the fact that delivery of the active compound to the target site is a key. The present volume gives a topical overview on various modern approaches to drug targeting covering today’s options for specific carrier systems allowing successful drug treatment at various sites of the body difficult to address and allowing to increase the benefit-risk-ratio to the optimum possible.

Drug Delivery Nanosystems

Drug Delivery Nanosystems
From Bioinspiration and Biomimetics to Clinical Applications

by Natassa Pippa,Costas Demetzos,Stergios Pispas

  • Publisher : CRC Press
  • Release : 2019-01-15
  • Pages : 418
  • ISBN : 0429955227
  • Language : En, Es, Fr & De
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Nanotechnology seeks to exploit distinct technological advances controlling the structure of nanoscale biomaterials at a nanodimensional scale approaching individual molecules and their aggregates or supramolecular structures. The term "nanomedicine" is used to describe those technologies under the umbrella of nanotechnology that have therapeutic applications in human health. This book presents recent trends and research achievements in the field of pharmaceutical nanotechnology and advanced drug delivery nanosystems, especially for theranostic purposes. The applications of drug delivery nanosystems considered carriers of active pharmaceutical ingredients (APIs) (e.g., proteins, peptides, and nucleic acids) are analyzed on the basis of technology, preparation protocols, and biomedical applications. The book also extensively reports on the principles, design protocols, and applications of nanosystems in drug delivery, imaging, and targeting of active molecules of pharmaceutical interest.

Enzyme Immunoassays

Enzyme Immunoassays
From Concept to Product Development

by S.S. Deshpande

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-06
  • Pages : 464
  • ISBN : 1461311691
  • Language : En, Es, Fr & De
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This unique reference provides a pragmatic approach to the development of successful commercial immunodiagnostic products based on enzyme immunoessay technology. Presenting both the basic and applied principles, Enzyme Immunoassays gathers information on all aspects of this process, from the initial conceptualization to the introduction of the product to the market.

Natural Polymers for Drug Delivery

Natural Polymers for Drug Delivery
A Book

by Harsha Kharkwal,Srinivas Janaswamy

  • Publisher : CABI
  • Release : 2016-12-07
  • Pages : 216
  • ISBN : 1780644477
  • Language : En, Es, Fr & De
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Natural polymers have been utilized extensively in food, pharmaceuticals, cosmetics, textiles, oil drilling and paint industries. Their non-toxic and inexpensive attributes readily enhance their commercial acceptability and make them potent agents in lieu of synthetic polymers. This book explores the opportunistic utility of natural polymers in developing effective drug delivery systems and provides a comprehensive and up-to-date analysis of their source, chemical structure and mechanism of action. Covering novel polymers for drug delivery - in particular extracts from plants, microorganisms and proteins, as well as water soluble and water insoluble biodegradable polymers - it presents an encyclopaedic overview of natural polymers'. Natural Polymers for Drug Delivery is an invaluable resource for researchers, students and industrial scientists in the fields of biochemistry, chemistry, pharmacology and food science.