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Pragmatic Randomized Clinical Trials

Pragmatic Randomized Clinical Trials
Using Primary Data Collection and Electronic Health Records

by Cynthia J. Girman,Mary E. Ritchey

  • Publisher : Academic Press
  • Release : 2021-04-23
  • Pages : 498
  • ISBN : 0128176644
  • Language : En, Es, Fr & De
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Pragmatic Randomized Clinical Trials Using Primary Data Collection and Electronic Health Records addresses the practical aspects and challenges of the design, implementation, and dissemination of pragmatic randomized trials, also sometimes referred to as practical or hybrid randomized trials. While less restrictive and more generalizable than traditional randomized controlled trials, such trials have specific challenges which are addressed in this book. The book contains chapters encompassing common designs along with advantages and limitations of such designs, analytic aspects in planning trials and estimating sample size, and how to use patient partners to help design and operationalize pragmatic randomized trials. Pragmatic trials conducted using primary data collection and trials embedded in electronic health records - including electronic medical records and administrative insurance claims - are addressed. This comprehensive resource is valuable not only for pharmacoepidemiologists, biostatisticians and clinical researchers, but also across the biomedical field for those who are interested in applying pragmatic randomized clinical trials in their research. • Addresses typical designs and challenges of pragmatic randomized clinical trials (pRCTs) • Encompasses analytic aspects of such trials • Discusses real cases on operational challenges in launching and conducting pRCTs in electronic health records

Clinical Trials

Clinical Trials
A Book

by Timothy M. Pawlik,Julie A. Sosa

  • Publisher : Springer Nature
  • Release : 2020-03-10
  • Pages : 258
  • ISBN : 3030354881
  • Language : En, Es, Fr & De
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This extensively revised second edition is a unique and portable handbook focusing on clinical trials in surgery. It includes new educational materials addressing the rapid evolution of novel research methodologies in basic science, clinical and educational research. The underlying principles of clinical trials, trial design, the development of a study cohort, statistics, data safety, data monitoring, and trial publication for device and drug trials are also discussed. Clinical Trials provides a comprehensive resource on clinical trials in surgery and describes all the stages of a clinical trial from generating a hypothesis through to trial publication and is a valuable resource for all practicing and trainee academic surgeons.

Prevention Practice in Primary Care

Prevention Practice in Primary Care
A Book

by Sherri Sheinfeld Gorin

  • Publisher : Oxford University Press
  • Release : 2013-11
  • Pages : 336
  • ISBN : 0195373014
  • Language : En, Es, Fr & De
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Prevention Practice in Primary Care systematically explores state-of-the-art practical approaches to effective prevention in primary care. Guided by theory and evidence, the book reviews approaches to risk factor identification and modification for the major causes of mortality in adulthood, including cancer, stroke, and cardiovascular disease.

Pharmacoepidemiology

Pharmacoepidemiology
A Book

by Brian L. Strom,Stephen E. Kimmel,Sean Hennessy

  • Publisher : John Wiley & Sons
  • Release : 2019-10-23
  • Pages : 1208
  • ISBN : 1119413427
  • Language : En, Es, Fr & De
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This classic, field-defining textbook, now in its sixth edition, provides the most comprehensive guidance available for anyone needing up-to-date information in pharmacoepidemiology. This edition has been fully revised and updated throughout and continues to provide a rounded view on all perspectives from academia, industry and regulatory bodies, addressing data sources, applications and methodologies with great clarity.

Oxford Textbook of Primary Medical Care

Oxford Textbook of Primary Medical Care
A Book

by Roger Jones (Prof.)

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 1299
  • ISBN : 9780198567837
  • Language : En, Es, Fr & De
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BMJ

BMJ
British Medical Journal

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Issues in Healthcare Management, Economics, and Education: 2011 Edition

Issues in Healthcare Management, Economics, and Education: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 879
  • ISBN : 1464965447
  • Language : En, Es, Fr & De
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Issues in Healthcare Management, Economics, and Education: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Healthcare Management, Economics, and Education. The editors have built Issues in Healthcare Management, Economics, and Education: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Healthcare Management, Economics, and Education in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Healthcare Management, Economics, and Education: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Hospital and Health Administration Index

Hospital and Health Administration Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Reaching Underscreened Women

Reaching Underscreened Women
Correlates of Cervical Cancer Underscreening, Reactions to Mailed HPV Self-sampling Kits, and Cost-effectiveness of HPV Self-sampling Programs

by Colin Michael Cox Malone

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 120
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Underscreening is a major risk factor for the development of cervical cancer. This dissertation examines factors associated with clinic-based Pap screening and human papillomavirus (HPV) self-sampling in a U.S. healthcare system and summarizes the existing evidence on the cost-effectiveness of HPV self-screening in order to support health system implementation of new strategies to increase cervical cancer screening. The first chapter is an analysis of electronic health record data from Kaiser Permanente Washington (KPWA) to identify correlates of underscreening among 48,711 women aged 30-64 years, with different levels of interaction with the health care system, namely primary care visits and/or use of an online health portal. Recent healthcare interactions were associated with lower odds of underscreening. Compared to screening-adherent women, underscreening was associated with older age, higher body mass index (BMI), current smoking, and non-adherence to breast and colorectal cancer screening guidelines. These screening disparities persisted even among women who interacted with the healthcare system. The second chapter identifies attitudes, experiences, and reactions to mailed HPV self-sampling kits among women who were enrolled in a pragmatic randomized trial at KPWA. Using a web-based survey, women who did and did not use and return a kit were queried about potential psychosocial correlates of HPV self-sampling (including knowledge, barriers to Pap screening, trust in physicians, and perceived risk), their experiences with using a kit (or reasons for non-return), and their reactions to the kit (trust in HPV self-sampling, screening preferences, and future intentions). Most kit returners had positive reactions to using a kit and would use them again, and many non-returners reported openness to using a kit in the future. Many kit returners and non-returners, however, lacked trust in HPV self-sampling as a cervical cancer prevention method. The third chapter is a systematic literature review on the cost-effectiveness of HPV self-sampling to prevent cervical cancer. Sixteen eligible studies were identified, eleven conducted in high-income countries and five set in low/middle-income countries. Fourteen of sixteen studies reported that HPV self-sampling was cost-effective under certain conditions. Overall, studies found that the most important factor for cost-effective HPV self-sampling implementation was the observed increase in screening uptake, with HPV self-sampling kit cost, sensitivity for detecting cervical precancers, and the screening status of self-sampling users also having an impact. There are gaps in the literature on the effects of vaccination and new HPV self-sampling triage strategies on cost-effectiveness in high-income settings, as well as a need for additional studies based on real-world implementation of HPV self-sampling, especially in low/middle-income countries. New technologies such as HPV-self-sampling offer health systems opportunities to increase screening uptake among underscreened women. The results of this study suggest that existing health care interactions (such as those between patient and provider) may be an important avenue for building women's trust and confidence in HPV self-sampling. Many women are open to using HPV self-sampling; to optimize the effectiveness and cost-effectiveness of HPV self-sampling programs, health systems should focus on leveraging existing points of patient interaction and continuing to research ways to reach those women who persistently do not engage with the health care system.

Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition

Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 2915
  • ISBN : 1464963665
  • Language : En, Es, Fr & De
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Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Clinical Psychology, Psychiatry, and Counseling. The editors have built Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Clinical Psychology, Psychiatry, and Counseling in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Clinical Psychology, Psychiatry, and Counseling: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition

Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 1345
  • ISBN : 1464964602
  • Language : En, Es, Fr & De
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Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about National, Regional, and Environmental Health and Medicine. The editors have built Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about National, Regional, and Environmental Health and Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in National, Regional, and Environmental Health and Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU.

An Electronic Tool for the Evaluation and Treatment of Sepsis in the ICU.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstract : Objectives: To determine whether addition of an electronic sepsis evaluation and management tool to electronic sepsis alerting improves compliance with treatment guidelines and clinical outcomes in septic ICU patients. Design: A pragmatic randomized trial. Setting: Medical and surgical ICUs of an academic, tertiary care medical center. Patients: Four hundred and seven patients admitted during a 4-month period to the medical or surgical ICU with a diagnosis of sepsis established at the time of admission or in response to an electronic sepsis alert. Interventions: Patients were randomized to usual care or the availability of an electronic tool capable of importing, synthesizing, and displaying sepsis-related data from the medical record, using logic rules to offer individualized evaluations of sepsis severity and response to therapy, informing users about evidence-based guidelines, and facilitating rapid order entry. Measurements and Main Results: There was no difference between the electronic tool (218 patients) and usual care (189 patients) with regard to the primary outcome of time to completion of all indicated Surviving Sepsis Campaign 6-hour Sepsis Resuscitation Bundle elements (hazard ratio, 1.98; 95% CI, 0.75–5.20; p = 0.159) or time to completion of each element individually. ICU mortality, ICU-free days, and ventilator-free days did not differ between intervention and control. Providers used the tool to enter orders in only 28% of available cases. Conclusions: A comprehensive electronic sepsis evaluation and management tool is feasible and safe but did not influence guideline compliance or clinical outcomes, perhaps due to low utilization. Abstract : Supplemental Digital Content is available in the text.

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards

Index to Theses with Abstracts Accepted for Higher Degrees by the Universities of Great Britain and Ireland and the Council for National Academic Awards
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Health Informatics in Africa

Health Informatics in Africa
HELINA 93 : First International Conference on Health Informatics in Africa, Ile-Ife, Nigeria, 19-23 April, 1993

by Salah H. Mandil

  • Publisher : Unknown Publisher
  • Release : 1993
  • Pages : 222
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This volume contains the proceedings of a conference on health informatics. As informatics is essentially human expertise, it is a technology that developing countries can contribute to. Participants emanated from 26 African countries and 10 other countries around the globe.

Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition

Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 4090
  • ISBN : 1464963401
  • Language : En, Es, Fr & De
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Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pediatric and Adolescent Medicine Research and Practice. The editors have built Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pediatric and Adolescent Medicine Research and Practice in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pediatric and Adolescent Medicine Research and Practice: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Current Index to Journals in Education

Current Index to Journals in Education
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition

Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 4229
  • ISBN : 1464963444
  • Language : En, Es, Fr & De
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Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation. The editors have built Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pharmacology, Pharmacy, Drug Research, and Drug Innovation in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pharmacology, Pharmacy, Drug Research, and Drug Innovation: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Orthopedics and Occupational and Sports Medicine: 2011 Edition

Issues in Orthopedics and Occupational and Sports Medicine: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 3196
  • ISBN : 1464963584
  • Language : En, Es, Fr & De
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Issues in Orthopedics and Occupational and Sports Medicine: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Orthopedics and Occupational and Sports Medicine. The editors have built Issues in Orthopedics and Occupational and Sports Medicine: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Orthopedics and Occupational and Sports Medicine in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Orthopedics and Occupational and Sports Medicine: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.