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Precision Medicine for Autoimmune Diseases

Precision Medicine for Autoimmune Diseases
A Book

by Georg Lautscham

  • Publisher : Academic Press
  • Release : 2021-06-01
  • Pages : 366
  • ISBN : 0128227656
  • Language : En, Es, Fr & De
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Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 Americans will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future. Addresses the fact that only one drug to treat autoimmune diseases was approved by FDA Shows the need to pick up and establish the need of personalized and precision medicine for autoimmune diseases Provides insight on how novel therapies, novel diagnostics and artificial intelligence work better together to advance the field of precision medicine in Autoimmune diseases Helps to establish a precision medicine approach for the benefit of patients, payers and industry

Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
The Perfect Fit for Autoimmunity

by Michael Mahler

  • Publisher : Academic Press
  • Release : 2021-04-01
  • Pages : 300
  • ISBN : 032385432X
  • Language : En, Es, Fr & De
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Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on AI, its link to PM, and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as artificial intelligence (AI) has gained significant attention in the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems has enabled the generation of large amounts of data, making autoimmunity an ideal target for AI in the field of Precision Medicine (PM). More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large data sets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to get a good overview of the field of Precision Medicine for autoimmune diseases and Artificial Intelligence Provides background, milestone and examples of precision medicine for autoimmune disease and artificial intelligence Proves the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using artificial intelligence

Chronic

Chronic
The Hidden Cause of the Autoimmune Pandemic and How to Get Healthy Again

by Steven Phillips,Dana Parish

  • Publisher : Houghton Mifflin
  • Release : 2021-02-02
  • Pages : 288
  • ISBN : 0358064716
  • Language : En, Es, Fr & De
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Autoimmune and chronic illness are a global crisis, with an estimated 50 million sufferers in the US alone. While modern medicine has drastically reduced overall mortality rates--from heart disease, stroke, HIV, and even cancer--what is fueling this twenty-first century pandemic? In this eye-opening, provocative book, Steven Phillips, MD, and his former patient, singer/songwriter Dana Parish, take on the medical establishment. Backed by a trove of published data, Chronic reveals striking evidence that a broad range of microbes, including the Lyme bacteria, cause a variety of recurrent conditions and autoimmune diseases. Chronic delves into the history and science behind common infections that are difficult to diagnose and treat, debunks widely held beliefs by doctors and patients alike, reveals how medicine got the facts patently wrong, and provides solutions that empower readers to get their lives back. Dr. Phillips was already an internationally renowned physician specializing in complex, chronic diseases when he became a patient himself. After nearly dying from his own mystery illness, he experienced firsthand the medical community's ignorance about the pathogens that underlie a range of chronic conditions--from fibromyalgia, lupus, multiple sclerosis, chronic fatigue syndrome, and rheumatoid arthritis to depression, anxiety, and neurodegenerative disorders. Parish, too, watched her health spiral after twelve top doctors missed an underlying infection that caused heart failure and other sudden, debilitating physical and psychiatric symptoms. Now, they've come together with a mission: to change the current model of simply treating symptoms, often with dangerous, lifelong drugs, and shift the focus to finding and curing root causes of chronic diseases that affect millions around the world.

Omics for Personalized Medicine

Omics for Personalized Medicine
A Book

by Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly

  • Publisher : Springer Science & Business Media
  • Release : 2013-10-14
  • Pages : 832
  • ISBN : 8132211847
  • Language : En, Es, Fr & De
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“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005

Departments of Labor, Health and Human Services, Education, and Related Agencies Appropriations for 2005
Hearings Before a Subcommittee of the Committee on Appropriations, House of Representatives, One Hundred Eighth Congress, Second Session

by United States. Congress. House. Committee on Appropriations. Subcommittee on the Departments of Labor, Health and Human Services, Education, and Related Agencies

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genomic and Personalized Medicine

Genomic and Personalized Medicine
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2012-10-30
  • Pages : 1350
  • ISBN : 0123822289
  • Language : En, Es, Fr & De
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Genomic and Personalized Medicine, Second Edition — winner of a 2013 Highly Commended BMA Medical Book Award for Medicine — is a major discussion of the structure, history, and applications of the field, as it emerges from the campus and lab into clinical action. As with the first edition, leading experts review the development of the new science, the current opportunities for genome-based analysis in healthcare, and the potential of genomic medicine in future healthcare. The inclusion of the latest information on diagnostic testing, population screening, disease susceptability, and pharmacogenomics makes this work an ideal companion for the many stakeholders of genomic and personalized medicine. With advancing knowledge of the genome across and outside protein-coding regions of DNA, new comprehension of genomic variation and frequencies across populations, the elucidation of advanced strategic approaches to genomic study, and above all in the elaboration of next-generation sequencing, genomic medicine has begun to achieve the much-vaunted transformative health outcomes of the Human Genome Project, almost a decade after its official completion in April 2003. Highly Commended 2013 BMA Medical Book Award for Medicine More than 100 chapters, from leading researchers, review the many impacts of genomic discoveries in clinical action, including 63 chapters new to this edition Discusses state-of-the-art genome technologies, including population screening, novel diagnostics, and gene-based therapeutics Wide and inclusive discussion encompasses the formidable ethical, legal, regulatory and social challenges related to the evolving practice of genomic medicine Clearly and beautifully illustrated with 280 color figures, and many thousands of references for further reading and deeper analysis

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
A Book

by Christopher Chang,Qianjin Lu

  • Publisher : Springer Nature
  • Release : 2020-05-22
  • Pages : 403
  • ISBN : 9811534497
  • Language : En, Es, Fr & De
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Personalized Treatment Options in Dermatology

Personalized Treatment Options in Dermatology
A Book

by Thomas Bieber,Frank Nestle

  • Publisher : Springer
  • Release : 2015-02-23
  • Pages : 146
  • ISBN : 3662458403
  • Language : En, Es, Fr & De
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This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.

The Autoimmune Diseases

The Autoimmune Diseases
A Book

by Noel R. Rose,Ian R. Mackay

  • Publisher : Academic Press
  • Release : 2019-10-15
  • Pages : 1532
  • ISBN : 0128122420
  • Language : En, Es, Fr & De
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The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Textbook of Hyperbaric Medicine

Textbook of Hyperbaric Medicine
A Book

by Kewal K. Jain

  • Publisher : Hogrefe & Huber Pub
  • Release : 2004
  • Pages : 536
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This textbook covers hyperbaric medicine and the applications of hyperbaric oxygen (HBO) techniques. It explains the basic principles of HBO therapy, and its application in carbon monoxide poisoning and decompression sickness, as well as its use in numerous other areas.

Experimental Biology and Medicine

Experimental Biology and Medicine
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Comprehensive Medicinal Chemistry II, Vol 8

Comprehensive Medicinal Chemistry II, Vol 8
CASE HISTORIES AND CUMULATIVE SUBJECT INDEX

by John B Taylor,David J Triggle

  • Publisher : Elsevier Science Limited
  • Release : 2007
  • Pages : 644
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Presents a different view of medicinal chemistry through personal accounts by eminent scientists describing their lifetime experiences in the field. Also illustrates 14 case studies of successful drug discovery and development. * valuable content available May 2009 as an individual volume * separate volumes will appeal to a wider chemistry, biochemistry and medicinal audience * priced for individual researcher as well as library purchase

BioScan

BioScan
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Genome-Wide Association Studies

Genome-Wide Association Studies
A Book

by Tatsuhiko Tsunoda,Toshihiro Tanaka,Yusuke Nakamura

  • Publisher : Springer Nature
  • Release : 2019-10-31
  • Pages : 209
  • ISBN : 9811381771
  • Language : En, Es, Fr & De
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This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.

Clinical Applications of Immunogenetics

Clinical Applications of Immunogenetics
Immunogenetics: A Molecular and Clinical Overview, Volume II

by Muneeb U. Rehman,Shafat Ali

  • Publisher : Academic Press
  • Release : 2021-11-15
  • Pages : 466
  • ISBN : 9780323902502
  • Language : En, Es, Fr & De
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Immunogenetic approaches to understand diseases provides the readers with an exclusive updated overview of scientific knowledge, achievements and findings in the field of immunogenetics. Immunogenetic approaches to understand diseases gives information from origin and development to immunogenetic approaches of several autoimmune and viral diseases. In thirteen chapters Immunogenetic approaches to understand diseases gives insight in advancements and approaches in the immunogenetics of viral and autoimmune diseases. Three chapters are dedicated to the immunogenetic mechanisms in the treatment of immune disorders, cancer, neurological and neurodegenerative disorders. Immunogenetic approaches to understand diseases also provides chapters on the immunogenomics of precision medicine, clinical medicine and transplantation. A special chapter is allocated to COVID 19: A novel challenge to human immune-genetic machinery. Immunogenetic approaches to understand diseases provides readily available updated information on the immunogenetic approaches of the most common viral and autoimmune diseases, that no doubt help the readers, researchers, scientists, teachers as well as clinicians in this field. Contains exclusive information about global research on immunogenetics Provides a solid foundation to researchers wanting to work on immunogenetics and their application to understand different autoimmune, virus and infectious diseases Delivers the information in a meticulous, attractive manner to make it more attractive to readers by being fully equipped with the pictures, illustrations and tables Gives insight to immunogenetics and its utility in therapeutics

Science

Science
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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PAREXEL's Pharmaceutical Research and Development Statistical Sourcebook

PAREXEL's Pharmaceutical Research and Development Statistical Sourcebook
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases

Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases

by Azzam A. Maghazachi

  • Publisher : Frontiers Media SA
  • Release : 2017-09-18
  • Pages : 329
  • ISBN : 2889452883
  • Language : En, Es, Fr & De
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More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.

Precision Medicine: A Guide to Genomics in Clinical Practice

Precision Medicine: A Guide to Genomics in Clinical Practice
A Book

by Jeanette J. McCarthy,Bryce A. Mendelsohn

  • Publisher : McGraw Hill Professional
  • Release : 2017-01-05
  • Pages : 304
  • ISBN : 1259644146
  • Language : En, Es, Fr & De
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Incorporate genomics into every applicable area of your clinical practice with this complete how-to guide Precision Medicine: A Guide to Genomics in Clinical Practice is a comprehensive, yet succinct overview of the practice of genomic medicine. It is written for general healthcare practitioners, specialists, and trainees with the goal of providing detailed guidance on how to incorporate genomic medicine into daily practice. Features that make this book valuable to every practice: •Intentionally avoids excessive technical content and consistently emphasizes real-life patient care and decision support •Follows the course of a human life, beginning before conception through pregnancy, childhood, and adulthood, discussing the current and future applications of genomics and precision medicine at each stage •Organization allows healthcare providers to quickly and easily find the information relevant to their practice. •The authors highlight common pitfalls – technical and ethical – that might complicate the delivery of quality genomic healthcare •Enhanced by eleven valuable appendices that cover important topics ranging from the basics of genetics to ethical issues to regulation and reimbursement If you are searching for a clinically relevant, non-technical resource that will teach you how genomic medicine can and should be practiced in your specific field of interest, Precision Medicine: A Guide to Genomics in Clinical Practicebelongs on your desk.

The Value Line Investment Survey

The Value Line Investment Survey
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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