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Precision Medicine and Artificial Intelligence

Precision Medicine and Artificial Intelligence
The Perfect Fit for Autoimmunity

by Michael Mahler

  • Publisher : Academic Press
  • Release : 2021-04-01
  • Pages : 300
  • ISBN : 032385432X
  • Language : En, Es, Fr & De
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Precision Medicine and Artificial Intelligence: The Perfect Fit for Autoimmunity covers background on AI, its link to PM, and examples of AI in healthcare, especially autoimmunity. The book highlights future perspectives and potential directions as artificial intelligence (AI) has gained significant attention in the past decade. Autoimmune diseases are complex and heterogeneous conditions, but exciting new developments and implementation tactics surrounding automated systems has enabled the generation of large amounts of data, making autoimmunity an ideal target for AI in the field of Precision Medicine (PM). More and more diagnostic products utilize AI, which is also starting to be supported by regulatory agencies such as the Food and Drug Administration (FDA). Knowledge generation by leveraging large data sets including demographic, environmental, clinical and biomarker data has the potential to not only impact the diagnosis of patients, but also disease prediction, prognosis and treatment options. Allows the readers to get a good overview of the field of Precision Medicine for autoimmune diseases and Artificial Intelligence Provides background, milestone and examples of precision medicine for autoimmune disease and artificial intelligence Proves the paradigm shift towards precision medicine driven by value-based systems Discusses future applications of precision medicine research using artificial intelligence

Precision Medicine for Autoimmune Diseases

Precision Medicine for Autoimmune Diseases
A Book

by Georg Lautscham

  • Publisher : Academic Press
  • Release : 2021-06-01
  • Pages : 366
  • ISBN : 0128227656
  • Language : En, Es, Fr & De
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Autoimmune diseases have significant economic and social impacts and represent the second-most important market for pharmaceutical companies, which is unsurprising when you consider that, while 1 in 33 Americans will suffer from cancer, 1 in 22 Americans will suffer from an autoimmune disease, costing the US over $100 billion a year. However, the uptake of precision medicine in this area has been slow at best, even though it can be extremely difficult to accurately diagnose and treat patients effectively using the tools that are currently available. If the adoption of precision medicine is to truly gather pace among diseases outside of cancer, there are still several regulatory, technological, and funding-related hurdles to be overcome. Taking lessons learned from within the field of oncology and systematically applying them to areas such as autoimmune disease will enable the development of more effective drugs across a wider range of illnesses. Most importantly, this will lead to a better outcome for patients. Precision Medicine for Autoimmune Diseases summarizes the status, the ongoing activities and provides an outlook to the future. Addresses the fact that only one drug to treat autoimmune diseases was approved by FDA Shows the need to pick up and establish the need of personalized and precision medicine for autoimmune diseases Provides insight on how novel therapies, novel diagnostics and artificial intelligence work better together to advance the field of precision medicine in Autoimmune diseases Helps to establish a precision medicine approach for the benefit of patients, payers and industry

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
A Book

by Christopher Chang,Qianjin Lu

  • Publisher : Springer
  • Release : 2021-05-23
  • Pages : 403
  • ISBN : 9789811534515
  • Language : En, Es, Fr & De
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

Epigenetics in Allergy and Autoimmunity

Epigenetics in Allergy and Autoimmunity
A Book

by Christopher Chang,Qianjin Lu

  • Publisher : Springer Nature
  • Release : 2020-05-22
  • Pages : 403
  • ISBN : 9811534497
  • Language : En, Es, Fr & De
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This book will address the growing roles of epigenetics in disease pathogenesis, and review the contribution of epigenetic modifications to disease onset and progression. The roles that epigenetics plays in facilitating effects of the environment on allergy and immunologic diseases will be reviewed. The book is divided into three parts – the first is an introduction to epigenetics and the methods that have been developed to study epigenetics, the second addresses epigenetics in allergic diseases and the third part will cover epigenetics in autoimmune diseases. With the rapid expansion of knowledge of how genes are regulated and how this regulation affects disease phenotypes, this book will be attractive to experienced researchers as well as those just launching an epigenetics research program. It will also be of interest to allergist, immunologists, rheumatologists and dermatologist who are engaged in clinical practice as a resource for understanding the basis for personalized and precision medicine. For example, the role that epigenetics plays in the pathogenesis in various allergic and autoimmune disorders and how this determines disease phenotypes will be covered extensively in this book. This book will thus help fill the gap in available resources on epigenetics in allergy and autoimmune diseases.

The Autoimmune Diseases

The Autoimmune Diseases
A Book

by Noel R. Rose,Ian R. Mackay

  • Publisher : Academic Press
  • Release : 2019-10-15
  • Pages : 1532
  • ISBN : 0128122420
  • Language : En, Es, Fr & De
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The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P’s" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunologic diagnostic methods and treatments. The book also covers several cross-cutting issues related to the recognition and treatment of autoimmune diseases, including chapters on the measurement of autoantibodies and T cells, the use of biomarkers as early predictors of disease, and new methods of treatment. Gives a thorough and important overview on the entire field, framing individual disease chapters with information that compares and contrasts each disorder and its therapy Provides thorough, up-to-date information on specific diseases, along with clinical applications in an easily found reference for clinicians and researchers interested in certain diseases Keeps readers abreast of current trends and emerging areas in the field Ensures that content is not only up-to-date, but applicable and relevant Includes new, updated chapters that emphasize hot topics in the field, e.g., research on auto inflammatory diseases and autoimmune responses following cancer immunotherapy

Clinical Applications of Immunogenetics

Clinical Applications of Immunogenetics
Immunogenetics: A Molecular and Clinical Overview, Volume II

by Muneeb U. Rehman,Shafat Ali

  • Publisher : Academic Press
  • Release : 2021-11-15
  • Pages : 466
  • ISBN : 9780323902502
  • Language : En, Es, Fr & De
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Immunogenetic approaches to understand diseases provides the readers with an exclusive updated overview of scientific knowledge, achievements and findings in the field of immunogenetics. Immunogenetic approaches to understand diseases gives information from origin and development to immunogenetic approaches of several autoimmune and viral diseases. In thirteen chapters Immunogenetic approaches to understand diseases gives insight in advancements and approaches in the immunogenetics of viral and autoimmune diseases. Three chapters are dedicated to the immunogenetic mechanisms in the treatment of immune disorders, cancer, neurological and neurodegenerative disorders. Immunogenetic approaches to understand diseases also provides chapters on the immunogenomics of precision medicine, clinical medicine and transplantation. A special chapter is allocated to COVID 19: A novel challenge to human immune-genetic machinery. Immunogenetic approaches to understand diseases provides readily available updated information on the immunogenetic approaches of the most common viral and autoimmune diseases, that no doubt help the readers, researchers, scientists, teachers as well as clinicians in this field. Contains exclusive information about global research on immunogenetics Provides a solid foundation to researchers wanting to work on immunogenetics and their application to understand different autoimmune, virus and infectious diseases Delivers the information in a meticulous, attractive manner to make it more attractive to readers by being fully equipped with the pictures, illustrations and tables Gives insight to immunogenetics and its utility in therapeutics

Personalized Treatment Options in Dermatology

Personalized Treatment Options in Dermatology
A Book

by Thomas Bieber,Frank Nestle

  • Publisher : Springer
  • Release : 2015-02-23
  • Pages : 146
  • ISBN : 3662458403
  • Language : En, Es, Fr & De
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This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.

Towards Precision Medicine in Vasculitis

Towards Precision Medicine in Vasculitis
A Book

by Federico Alberici,Andreas Kronbichler,Giacomo Emmi

  • Publisher : Frontiers Media SA
  • Release : 2021-01-05
  • Pages : 329
  • ISBN : 2889663493
  • Language : En, Es, Fr & De
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Genome-Wide Association Studies

Genome-Wide Association Studies
A Book

by Tatsuhiko Tsunoda,Toshihiro Tanaka,Yusuke Nakamura

  • Publisher : Springer Nature
  • Release : 2019-10-31
  • Pages : 209
  • ISBN : 9811381771
  • Language : En, Es, Fr & De
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This book examines the utility of genome-wide association studies (GWAS) in the era of next-generation sequencing and big data, identifies limitations and potential means of overcoming them, and looks to the future of GWAS and what may lay beyond. GWAS are among the most powerful tools for elucidating the genetic aspects of human and disease diversity. In Genome-Wide Association Studies, experts in the field explore in depth the impacts of GWAS on genomic research into a variety of common diseases, including cardiovascular, autoimmune, diabetic, cancer, and infectious diseases. The book will equip readers with a sound understanding both of the types of disease and phenotypes that are suited for GWAS and of the ways in which a road map resulting from GWAS can lead to the realization of personalized/precision medicine: functional analysis, drug seeds, pathway analysis, disease mechanism, risk prediction, and diagnosis.

Precision Medicine and the Reinvention of Human Disease

Precision Medicine and the Reinvention of Human Disease
A Book

by Jules J. Berman

  • Publisher : Academic Press
  • Release : 2018-01-26
  • Pages : 398
  • ISBN : 0128143940
  • Language : En, Es, Fr & De
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Despite what you may have read in the popular press and in social media, Precision Medicine is not devoted to finding unique treatments for individuals, based on analyzing their DNA. To the contrary, the goal of Precision Medicine is to find general treatments that are highly effective for large numbers of individuals who fall into precisely diagnosed groups. We now know that every disease develops over time, through a sequence of defined biological steps, and that these steps may differ among individuals, based on genetic and environmental conditions. We are currently developing rational therapies and preventive measures, based on our precise understanding of the steps leading to the clinical expression of diseases. Precision Medicine and the Reinvention of Human Disease explains the scientific breakthroughs that have changed the way that we understand diseases, and reveals how medical scientists are using this new knowledge to launch a medical revolution. Clarifies the foundational concepts of Precision Medicine, distinguishing this field from its predecessors such as genomics, pharmacogenetics, and personalized medicine. Gathers the chief conceptual advances in the fields of genetics, pathology, and bioinformatics, and synthesizes a coherent narrative for the field of Precision Medicine. Delivers its message in plain language, and in a relaxed, conversational writing style, making it easy to understand the complex subject matter. Guides the reader through a coherent and logical narrative, gradually providing expertise and skills along the way. Covers the importance of data sharing in Precision Medicine, and the many data-related challenges that confront this fragile new field.

A Toolbox for Personalized Medicine of Methotrexate Therapy in Arthritis

A Toolbox for Personalized Medicine of Methotrexate Therapy in Arthritis
Handvatten Voor Medicatie Op Maat Van Methotrexaat Therapie Voor Artritis

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 218
  • ISBN : 9789053359136
  • Language : En, Es, Fr & De
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Handbook of Biomarkers and Precision Medicine

Handbook of Biomarkers and Precision Medicine
A Book

by Claudio Carini,Mark Fidock,Alain van Gool

  • Publisher : CRC Press
  • Release : 2019-04-16
  • Pages : 631
  • ISBN : 0429576730
  • Language : En, Es, Fr & De
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"The field of Biomarkers and Precision Medicine in drug development is rapidly evolving and this book presents a snapshot of exciting new approaches. By presenting a wide range of biomarker applications, discussed by knowledgeable and experienced scientists, readers will develop an appreciation of the scope and breadth of biomarker knowledge and find examples that will help them in their own work." -Maria Freire, Foundation for the National Institutes of Health Handbook of Biomarkers and Precision Medicine provides comprehensive insights into biomarker discovery and development which has driven the new era of Precision Medicine. A wide variety of renowned experts from government, academia, teaching hospitals, biotechnology and pharmaceutical companies share best practices, examples and exciting new developments. The handbook aims to provide in-depth knowledge to research scientists, students and decision makers engaged in Biomarker and Precision Medicine-centric drug development. Features: Detailed insights into biomarker discovery, validation and diagnostic development with implementation strategies Lessons-learned from successful Precision Medicine case studies A variety of exciting and emerging biomarker technologies The next frontiers and future challenges of biomarkers in Precision Medicine Claudio Carini, Mark Fidock and Alain van Gool are internationally recognized as scientific leaders in Biomarkers and Precision Medicine. They have worked for decades in academia and pharmaceutical industry in EU, USA and Asia. Currently, Dr. Carini is Honorary Faculty at Kings’s College School of Medicine, London, UK. Dr. Fidock is Vice President of Precision Medicine Laboratories at AstraZeneca, Cambridge, UK. Prof.dr. van Gool is Head Translational Metabolic Laboratory at Radboud university medical school, Nijmegen, NL.

Detection Methods in Precision Medicine

Detection Methods in Precision Medicine
A Book

by Mengsu (Michael) Yang,Michael Thompson

  • Publisher : Royal Society of Chemistry
  • Release : 2020-12-10
  • Pages : 370
  • ISBN : 1788019962
  • Language : En, Es, Fr & De
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Precision medicine is a topical subject that attracts tremendous attention from scientific and medical communities, being set to transform health care in the future. This book will be among the first to cover the detection methods for precision medicine. The first section provides an overview of the biomarkers used for precision medicine, such as proteins, nucleic acids, and metabolites. The coverage then turns to sequencing techniques and their applications, and other bioanalytical techniques, including mass spectrometry for proteome and phosphoproteome analysis, immunological methods and droplet technologies. The final sections include biosensors applied to precision medicine and clinical applications. This book provides a reference for researchers and students interested and working in the development of bioanalytical techniques for clinical applications. It provides a useful introduction for physicians and medical laboratory technologists to the recent advances in detection methods for precision medicine.

Realizing the Promise of Precision Medicine

Realizing the Promise of Precision Medicine
The Role of Patient Data, Mobile Technology, and Consumer Engagement

by Paul Cerrato,John Halamka

  • Publisher : Academic Press
  • Release : 2017-08-24
  • Pages : 218
  • ISBN : 0128116366
  • Language : En, Es, Fr & De
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Realizing the Promise of Precision Medicine: The Role of Patient Data, Mobile Technology, and Consumer Engagement explains the potential of personalized medicine and the value of those approaches in making that potential a reality. The book helps transform one-size-fits-all healthcare into a system that focuses on individual needs and the unique needs of each family member, discussing topics such as U.S. sponsored precision medicine initiative, genomics, the role of electronic health records and mobile medicine, patient engagement and empowerment, health information exchange and patient data protection. In addition, the book discusses the barriers and limitations of precision medicine and how to overcome them. Readers will find valuable insights into how big data, patient engagement, mobile technology, and genomics help individualize medical care and offer a pathway to help detect many undiscovered causes of diseases. Provides drawings and flow charts to help readers visualize the breadth and depth of precision medicine Includes sidebars with more details on specific topics for a complementary, deeper understanding of the main text Uses case studies to turn abstract concepts into flesh and blood examples of how personalized medicine benefits patients

Omics for Personalized Medicine

Omics for Personalized Medicine
A Book

by Debmalya Barh,Dipali Dhawan,Nirmal Kumar Ganguly

  • Publisher : Springer Science & Business Media
  • Release : 2013-10-14
  • Pages : 832
  • ISBN : 8132211847
  • Language : En, Es, Fr & De
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“Omics for Personalized Medicine” will give to its prospective readers the insight of both the current developments and the future potential of personalized medicine. The book brings into light how the pharmacogenomics and omics technologies are bringing a revolution in transforming the medicine and the health care sector for the better. Students of biomedical research and medicine along with medical professionals will benefit tremendously from the book by gaining from the diverse fields of knowledge of new age personalized medicine presented in the highly detailed chapters of the book. The book chapters are divided into two sections for convenient reading with the first section covering the general aspects of pharmaocogenomic technology that includes latest research and development in omics technologies. The first section also highlights the role of omics in modern clinical trials and even discusses the ethical consideration in pharmocogenomics. The second section is focusing on the development of personalized medicine in several areas of human health. The topics covered range from metabolic and neurological disorders to non-communicable as well as infectious diseases, and even explores the role of pharmacogenomics in cell therapy and transplantation technology. Thirty-four chapters of the book cover several aspects of pharmacogenomics and personalized medicine and have taken into consideration the varied interest of the readers from different fields of biomedical research and medicine. Advent of pharmacogenomics is the future of modern medicine, which has resulted from culmination of decades of research and now is showing the way forward. The book is an honest endeavour of researchers from all over the world to disseminate the latest knowledge and knowhow in personalized medicine to the community health researchers in particular and the educated public in general.

Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases

Immunomodulatory Effects of Drugs for Treatment of Immune-Related Diseases

by Azzam A. Maghazachi

  • Publisher : Frontiers Media SA
  • Release : 2017-09-18
  • Pages : 329
  • ISBN : 2889452883
  • Language : En, Es, Fr & De
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More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.

Progress and Challenges in Precision Medicine

Progress and Challenges in Precision Medicine
A Book

by Mukesh Verma,Debmalya Barh

  • Publisher : Academic Press
  • Release : 2016-12-22
  • Pages : 344
  • ISBN : 0128095024
  • Language : En, Es, Fr & De
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Progress and Challenges in Precision Medicine presents an insightful overview to the myriad factors of personalized and precision medicine. The availability of the human genome, large amounts of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the age of personalized and precision medicine. Bringing together a global range of experts on precision medicine, this book collects previously scattered information into one concise volume which covers the most important developments so far in precision medicine and also suggests the most likely avenues for future development. The book includes clinical information, informatics, public policy implications, and information on case studies. It is a useful reference and background work for students, researchers, and clinicians working in the biomedical and medical fields, as well as policymakers in the health sciences. Provides an overview of the growing field of precision medicine Contains chapters from geographically diverse experts in their field Explores important aspects of precision medicine, including applications, ethics, and development

Immunology and Allergy Clinics, An Issue of Immunology and Allergy Clinics of North America , E-Book

Immunology and Allergy Clinics, An Issue of Immunology and Allergy Clinics of North America , E-Book
A Book

by Mark Ballow,Elena Ronda Pérez

  • Publisher : Elsevier Health Sciences
  • Release : 2020-08-04
  • Pages : 240
  • ISBN : 032376004X
  • Language : En, Es, Fr & De
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This issue of Immunology and Allergy Clinics, guest edited by Dr. Mark Ballow and Dr. Elena Perez, will provide up-to-date clinical concepts regarding Immunodeficiencies. Articles in this outstanding issue include: Precision Medicine for Patients with Primary Immune Dysregulation, Immune Disorders Associated with Abnormalities in Treg Cells, Defining Common Variable Immunodeficiency, The Importance of Primary Immune Deficiency Registries, Chronic Lung Disease in Primary Antibody Deficiency: Diagnosis and Management, Immune Deficiencies Associated with Th17 Immunity, Truths and Myths of Vaccines in Patients with Primary Immune Deficiency, The Nuts and Bolts of Subcutaneous Immunoglobulin Replacement Therapy, Newly Discovered Primary Immune Deficiencies, and Specific Antibody Deficiency.

Machine Learning Advanced Dynamic Omics Data Analysis for Precision Medicine

Machine Learning Advanced Dynamic Omics Data Analysis for Precision Medicine
A Book

by Tao Zeng,Tao Huang,Chuan Lu

  • Publisher : Frontiers Media SA
  • Release : 2020-03-30
  • Pages : 329
  • ISBN : 2889635546
  • Language : En, Es, Fr & De
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Precision Medicine in Cancers and Non-Communicable Diseases

Precision Medicine in Cancers and Non-Communicable Diseases
Prediction, Prevention with Personalization

by Debmalya Barh

  • Publisher : CRC Press
  • Release : 2018-09-03
  • Pages : 326
  • ISBN : 1498775624
  • Language : En, Es, Fr & De
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The availability of human genome, large amount of data on individual genetic variations, environmental interactions, influence of lifestyle, and cutting-edge tools and technologies for big-data analysis have led to the era of clinical practice of "Precision Medicine". This book aims to provide a readily available resource on all the important developments achieved so far in the field of oncology. All recent developments have been explained along with epidemiology, technologies and approaches to manage the included diseases. Therefore, readers will get the up to date information on the next-generation approach in tackling all kinds of cancer. Key Features • Presents the latest trend of cancer management based on precision/predictive medicine approach • Reviews the latest and up to date literature in the field of Precision Medicine • Highlights the next generation approach in tackling malignant diseases • Discusses how a life-threatening disease like cancer can be managed with the help of Precision Medicine • Encapsulates a global prospective