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Lab-on-a-Chip Fabrication and Application

Lab-on-a-Chip Fabrication and Application
A Book

by Margarita Stoytcheva,Roumen Zlatev

  • Publisher : BoD – Books on Demand
  • Release : 2016-06-29
  • Pages : 208
  • ISBN : 9535124579
  • Language : En, Es, Fr & De
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The necessity of on-site, fast, sensitive, and cheap complex laboratory analysis, associated with the advances in the microfabrication technologies and the microfluidics, made it possible for the creation of the innovative device lab-on-a-chip (LOC), by which we would be able to scale a single or multiple laboratory processes down to a chip format. The present book is dedicated to the LOC devices from two points of view: LOC fabrication and LOC application.

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
A Book

by Jeffrey T Borenstein,Vishal Tandon,Sarah L Tao,Joseph L. Charest

  • Publisher : Elsevier
  • Release : 2018-09-12
  • Pages : 396
  • ISBN : 0128136723
  • Language : En, Es, Fr & De
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Techniques for microfabricating intricate microfluidic structures that mimic the microenvironment of tissues and organs, combined with the development of biomaterials with carefully engineered surface properties, have enabled new paradigms in and cell culture-based models for human diseases. The dimensions of surface features and fluidic channels made accessible by these techniques are well-suited to the size scale of biological cells. Microfluidic Cell Culture Systems applies design and experimental techniques used in in microfluidics, and cell culture technologies to organ-on-chip systems. This book is intended to serve as a professional reference, providing a practical guide to design and fabrication of microfluidic systems and biomaterials for use in cell culture systems and human organ models. The book covers topics ranging from academic first principles of microfluidic design, to clinical translation strategies for cell culture protocols. The goal is to help professionals coming from an engineering background to adapt their expertise for use in cell culture and organ models applications, and likewise to help biologists to design and employ microfluidic technologies in their cell culture systems. This 2nd edition contains new material that strengthens the focus on in vitro models useful for drug discovery and development. One new chapter reviews liver organ models from an industry perspective, while others cover new technologies for scaling these models and for multi-organ systems. Other new chapters highlight the development of organ models and systems for specific applications in disease modeling and drug safety. Previous chapters have been revised to reflect the latest advances. Provides design and operation methodology for microfluidic and microfabricated materials and devices for organ-on-chip disease and safety models. This is a rapidly expanding field that will continue to grow along with advances in cell biology and microfluidics technologies. Comprehensively covers strategies and techniques ranging from academic first principles to industrial scale-up approaches. Readers will gain insight into cell-material interactions, microfluidic flow, and design principles. Offers three fundamental types of information: 1) design principles, 2) operation techniques, and 3) background information/perspectives. The book is carefully designed to strike a balance between these three areas, so it will be of use to a broad range of readers with different technical interests and educational levels.

Principles of Tissue Engineering

Principles of Tissue Engineering
A Book

by Robert Lanza,Robert Langer,Joseph P. Vacanti

  • Publisher : Academic Press
  • Release : 2013-10-17
  • Pages : 1936
  • ISBN : 0123983703
  • Language : En, Es, Fr & De
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Now in its fourth edition, Principles of Tissue Engineering has been the definite resource in the field of tissue engineering for more than a decade. The fourth edition provides an update on this rapidly progressing field, combining the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation by the world’s experts of what is currently known about each specific organ system. As in previous editions, this book creates a comprehensive work that strikes a balance among the diversity of subjects that are related to tissue engineering, including biology, chemistry, material science, and engineering, among others, while also emphasizing those research areas that are likely to be of clinical value in the future. This edition includes greatly expanded focus on stem cells, including induced pluripotent stem (iPS) cells, stem cell niches, and blood components from stem cells. This research has already produced applications in disease modeling, toxicity testing, drug development, and clinical therapies. This up-to-date coverage of stem cell biology and other emerging technologies –such as brain-machine interfaces for controlling bionics and neuroprostheses– is complemented by a series of new and updated chapters on recent clinical experience in applying tissue engineering, as well as a new section on the application of tissue-engineering techniques for food production. The result is a comprehensive textbook that will be useful to students and experts alike. Includes new chapters on biomaterial-protein interactions, nanocomposite and three-dimensional scaffolds, skin substitutes, spinal cord, vision enhancement, and heart valves Offers expanded coverage of adult and embryonic stem cells of the cardiovascular, hematopoietic, musculoskeletal, nervous, and other organ systems Full-color presentation throughout

Nanopharmaceuticals: Principles and Applications Vol. 1

Nanopharmaceuticals: Principles and Applications Vol. 1
A Book

by Vinod Kumar Yata,Shivendu Ranjan,Nandita Dasgupta,Eric Lichtfouse

  • Publisher : Springer Nature
  • Release : 2020-07-14
  • Pages : 381
  • ISBN : 3030449254
  • Language : En, Es, Fr & De
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This book discusses the biological, technical and study-design challenges of Nanopharmaceuticals. Chapters of this book are dedicated to supermagentic iron oxide nanoparticles for the diagnosis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It also includes a brief introduction to magnetic resonance imaging and ends with the future prospective of iron oxide nanoparticles in cancer detection. The book also provides a critical discussion on ‘Computational sequence design for DNA nanostructures’ and gives a brief introduction about the skin delivery. A detailed discussion has been included about the different types of nanocarriers such as micells, microemulsions, nanoemulsions, polymeric and lipid based nanoparticles. Focussing on the safety concerns of nanomedicine it also covers the safety issues, clinical benefits, ecotoxicity and regulatory frame work of nanopharmaceuticals.

Designing Nanostructures at the Interface between Biomedical and Physical Systems

Designing Nanostructures at the Interface between Biomedical and Physical Systems
Conference Focus Group Summaries

by The National Academies,The National Academies Keck Futures Initiative Nanoscience and Nanotechnology Planning Committee,The National Academies Keck Futures Initiative Nanoscience and Nanotechnology Steering Committee

  • Publisher : National Academies Press
  • Release : 2005-07-01
  • Pages : 120
  • ISBN : 0309096685
  • Language : En, Es, Fr & De
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Last November, the National Academies Keck Futures Initiative held the Designing Nanostructures at the Interface Between Biomedical and Physical Systems conference at which researchers from science, engineering and medicine discussed recent developments in nanotechnology, directions for future research, and possible biomedical applications. The centerpiece of the conference was breakout sessions in which ten focus groups of researchers from different fields spent eight hours developing research plans to solve various problems in the field of nanotechnology. Among the challenges were: Building a nanosystem that can isolate, sequence and identify RNA or DNA Developing a system to detect disease in vivo Sequencing a single molecule of protein Creating a biological system that will create a local hydrogen fuel source, and Growing a biological in vivo power source. Representatives from public and private funding organizations, government, industry, and the science media also participated in the focus groups. This book provides a summary of the conference focus groups. For more information about the conference, visit Keck Futures Initiative. The National Academies Keck Futures Initiative was launched in 2003 to stimulate new modes of scientific inquiry and break down the conceptual and institutional barriers to interdisciplinary research. The National Academies and the W.M. Keck Foundation believe considerable scientific progress and social benefit will be achieved by providing a counterbalance to the tendency to isolate research within academic fields. The Futures Initiative is designed to enable researchers from different disciplines to focus on new questions upon which they can base entirely new research, and to encourage better communication between scientists as well as between the scientific community and the public. Funded by a $40 million grant from the W.M. Keck Foundation, the National Academies Keck Futures Initiative is a 15-year effort to catalyze interdisciplinary inquiry and to enhance communication among researchers, funding agencies, universities, and the general public â€" with the object of stimulating interdisciplinary research at the most exciting frontiers. The Futures Initiative builds on three pillars of vital and sustained research: interdisciplinary encounters that counterbalance specialization and isolation; the identification and exploration of new research topics; and communication that bridges languages, cultures, habits of thought, and institutions. Toward these goals, the National Academies Keck Futures Initiative incorporates three core activities each year: Futures conferences, Futures grants, and National Academies Communication Awards.

Characterization and Development of Biosystems and Biomaterials

Characterization and Development of Biosystems and Biomaterials
A Book

by Andreas Öchsner,Lucas F. M. da Silva,Holm Altenbach

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-16
  • Pages : 254
  • ISBN : 3642314708
  • Language : En, Es, Fr & De
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This collection of recent activities provides researchers and scientists with the latest trends in characterization and developments of biosystems and biomaterials. Well known experts present their research in materials for drug delivery, dental implants and filling materials, biocompatible membranes, bioactive surface coatings and bio-compatible and eco-sustainable building materials. In The book covers also topics like microorganisms, the human eye, the musculoskeletal system and human body parts.

Microfluidic Cell Culture Systems

Microfluidic Cell Culture Systems
A Book

by Christopher Bettinger,Jeffrey T Borenstein,Sarah L Tao

  • Publisher : William Andrew
  • Release : 2012-12-31
  • Pages : 452
  • ISBN : 143773460X
  • Language : En, Es, Fr & De
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The fields of microfluidics and BioMEMS are significantly impacting cell biology research and applications through the application of engineering solutions to human disease and health problems. The dimensions of microfluidic channels are well suited to the physical scale of biological cells, and the many advantages of microfluidics make it an attractive platform for new techniques in biology. This new professional reference applies the techniques of microsystems to cell culture applications. The authors provide a thoroughly practical guide to the principles of microfluidic device design and operation and their application to cell culture techniques. The resulting book is crammed with strategies and techniques that can be immediately deployed in the lab. Equally, the insights into cell culture applications will provide those involved in traditional microfluidics and BioMEMS with an understanding of the specific demands and opportunities presented by biological applications. The goal is to guide new and interested researchers and technology developers to the important areas and state-of-the-practice strategies that will enhance the efficiency and value of their technologies, devices and biomedical products. Provides insights into the design and development of microfluidic systems with a specific focus on cell culture applications Focuses on strategies and techniques for the design and fabrication of microfluidic systems and devices for cell culture Provides balanced coverage of microsystems engineering and bioengineering

"Poem to my Litter" by Max Ritvo. An Analysis about Laboratory Mice and their Misuse

'Poem to my Litter' by Max Ritvo. An Analysis about Laboratory Mice and their Misuse
A Book

by Rashida Thielhorn

  • Publisher : GRIN Verlag
  • Release : 2019-03-26
  • Pages : 5
  • ISBN : 3668907536
  • Language : En, Es, Fr & De
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Essay from the year 2018 in the subject American Studies - Literature, grade: 2,3, University of Frankfurt (Main), language: English, abstract: Nowadays experimenting with and especially on animals seems to be the norm not everyone likes to discuss about: Animals like mice, dogs, cats, monkeys, fish, guinea pigs and rats are used in laboratories to develop general biological and anatomical knowledge, verify chemical substances, test make up products (outside Germany), or even test new medicines and drugs to calculate the consequences for human beings, who have a similar DNA structure. The used animals differ from their free relatives as laboratory rodents are bred to have the characteristics they need to serve society and fulfill their morally questionable purpose. Three million laboratory animals have to die yearly as a consequence of experiments in Germany. The number is far less then the number of slaughtered animals, who die for the meat production. In 2015 1.2 million people demonstrated in front of the EU Parliament; not to intensify the Prevention of Cruelty to Animals Act but to finally stop experimenting on animals. In other countries of the world, for example the USA, well-known organizations like PETA fight to stop animal-testing.

Stem Cells

Stem Cells
Scientific Facts and Fiction

by Christine Mummery,Anja van de Stolpe,Bernard Roelen,Hans Clevers

  • Publisher : Academic Press
  • Release : 2014-05-23
  • Pages : 448
  • ISBN : 0124115675
  • Language : En, Es, Fr & De
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The second edition of Stem Cells: Scientific Facts and Fiction provides the non-stem cell expert with an understandable review of the history, current state of affairs, and facts and fiction of the promises of stem cells. Building on success of its award-winning preceding edition, the second edition features new chapters on embryonic and iPS cells and stem cells in veterinary science and medicine. It contains major revisions on cancer stem cells to include new culture models, additional interviews with leaders in progenitor cells, engineered eye tissue, and xeno organs from stem cells, as well as new information on "organs on chips" and adult progenitor cells. In the past decades our understanding of stem cell biology has increased tremendously. Many types of stem cells have been discovered in tissues that everyone presumed were unable to regenerate in adults, the heart and the brain in particular. There is vast interest in stem cells from biologists and clinicians who see the potential for regenerative medicine and future treatments for chronic diseases like Parkinson's, diabetes, and spinal cord lesions, based on the use of stem cells; and from entrepreneurs in biotechnology who expect new commercial applications ranging from drug discovery to transplantation therapies. Explains in straightforward, non-specialist language the basic biology of stem cells and their applications in modern medicine and future therapy Includes extensive coverage of adult and embryonic stem cells both historically and in contemporary practice Richly illustrated to assist in understanding how research is done and the current hurdles to clinical practice

Principles of Tissue Engineering

Principles of Tissue Engineering
A Book

by Robert Lanza,Robert Langer,Joseph P. Vacanti

  • Publisher : Elsevier
  • Release : 2000-05-16
  • Pages : 995
  • ISBN : 008053967X
  • Language : En, Es, Fr & De
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The opportunity that tissue engineering provides for medicine is extraordinary. In the United States alone, over half-a-trillion dollars are spent each year to care for patients who suffer from tissue loss or dysfunction. Although numerous books and reviews have been written on tissue engineering, none has been as comprehensive in its defining of the field. Principles of Tissue Engineering combines in one volume the prerequisites for a general understanding of tissue growth and development, the tools and theoretical information needed to design tissues and organs, as well as a presentation of applications of tissue engineering to diseases affecting specific organ systems. The first edition of the book, published in 1997, is the definite reference in the field. Since that time, however, the discipline has grown tremendously, and few experts would have been able to predict the explosion in our knowledge of gene expression, cell growth and differentiation, the variety of stem cells, new polymers and materials that are now available, or even the successful introduction of the first tissue-engineered products into the marketplace. There was a need for a new edition, and this need has been met with a product that defines and captures the sense of excitement, understanding and anticipation that has followed from the evolution of this fascinating and important field. Key Features * Provides vast, detailed analysis of research on all of the major systems of the human body, e.g., skin, muscle, cardiovascular, hematopoietic, and nerves * Essential to anyone working in the field * Educates and directs both the novice and advanced researcher * Provides vast, detailed analysis of research with all of the major systems of the human body, e.g. skin, muscle, cardiovascular, hematopoietic, and nerves * Has new chapters written by leaders in the latest areas of research, such as fetal tissue engineering and the universal cell * Considered the definitive reference in the field * List of contributors reads like a "who's who" of tissue engineering, and includes Robert Langer, Joseph Vacanti, Charles Vacanti, Robert Nerem, A. Hari Reddi, Gail Naughton, George Whitesides, Doug Lauffenburger, and Eugene Bell, among others

Biomimetic Microengineering

Biomimetic Microengineering
A Book

by Hyun Jung Kim

  • Publisher : CRC Press
  • Release : 2020-02-05
  • Pages : 380
  • ISBN : 1000725804
  • Language : En, Es, Fr & De
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This book will examine the relevant biological subjects involved in biomimetic microengineering as well as the design and implementation methods of such engineered microdevices. Physiological topics covered include regeneration of complex responses of our body on a cellular, tissue, organ, and inter-organ level. Technological concepts in cell and tissue engineering, stem cell biology, microbiology, biomechanics, materials science, micro- and nanotechnology, and synthetic biology are highlighted to increase understanding of the transdisciplinary methods used to create the more complex, robust biomimetic engineered models. The effectiveness of the new bioinspired microphysiological systems as replacements for existing in vitro or in vivo models is explained through sections that include the protocols to reconstitute three-dimensional (3D) structures, recapitulate physiological functions, and emulate the pathophysiology of human diseases. This book will also discuss how researchers can discover bridge technologies for disease modeling and personalized precision medicine. Features Focuses on cutting edge technologies that enable manipulation of living systems in a spatiotemporal manner. Incorporates research on reverse engineering of comples microenvironmental factors in human diseases. Highlights technologies related to patient-specific personalized medicine and their potential uses. Written by chapter authors who are highly respected researchers in science and engineering. Includes extensive references at the end of each chapter to enhance further study. Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving hois Ph.D. degree at Yonsei University in the Republic of Korea, he did extensive postdctoral research at both the University of Chicago and the Wyss Institute at Harvard University. These efforts resulted in cutting-edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microsystem. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new therapeutics in inflammatory bowel disease and colorectal cancers at UT Austin. In collaboration with clinicians, his lab is currently developing disease-oriented, patient-specific models for the advancement in pharmaceutical and clinical fields. • Focuses on cutting edge technologies that enable manipulation of living systems in a spatiotemporal manner. • Incorporates research on reverse engineering of complex microenvironmental factors in human diseases. • Highlights technologies related to patient-specific personalized medicine and their potential uses. • Written by chapter authors who are highly respected researchers in science and engineering. • Includes extensive references at the end of each chapter to enhance further study. Hyun Jung Kim is an Assistant Professor in the Department of Biomedical Engineering at The University of Texas at Austin. After receiving his Ph.D. degree at Yonsei University in the Republic of Korea, he did extensive postdoctoral research at both the University of Chicago and the Wyss Institute at Harvard University. These efforts resulted in cutting-edge breakthroughs in synthetic microbial community research and organomimetic human Gut-on-a-Chip microsystem. His research on Gut-on-a-Chip technology leads to the creation of a microfluidic device that mimics the physiology and pathology of the living human intestine. Since 2015, he has explored novel human host-microbiome ecosystems to discover the disease mechanism and new therapeutics in inflammatory bowel disease and colorectal cancer at UT Austin. In collaboration with clinicians, his lab is currently developing disease-oriented, patient-specific models for the advancement in pharmaceutical and clinical fields.

Tissue Engineering

Tissue Engineering
A Book

by Clemens Van Blitterswijk,Jan De Boer

  • Publisher : Academic Press
  • Release : 2014-12-10
  • Pages : 896
  • ISBN : 0124202101
  • Language : En, Es, Fr & De
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Tissue Engineering is a comprehensive introduction to the engineering and biological aspects of this critical subject. With contributions from internationally renowned authors, it provides a broad perspective on tissue engineering for students coming to the subject for the first time. In addition to the key topics covered in the previous edition, this update also includes new material on the regulatory authorities, commercial considerations as well as new chapters on microfabrication, materiomics and cell/biomaterial interface. Effectively reviews major foundational topics in tissue engineering in a clear and accessible fashion Includes state of the art experiments presented in break-out boxes, chapter objectives, chapter summaries, and multiple choice questions to aid learning New edition contains material on regulatory authorities and commercial considerations in tissue engineering

Biomaterials for Organ and Tissue Regeneration

Biomaterials for Organ and Tissue Regeneration
New Technologies and Future Prospects

by Nihal Vrana,Helena Knopf-Marques,Julien Barthes

  • Publisher : Woodhead Publishing
  • Release : 2020-03-20
  • Pages : 846
  • ISBN : 0081029071
  • Language : En, Es, Fr & De
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Biomaterials for Organ and Tissue Regeneration: New Technologies and Future Prospects examines the use of biomaterials in applications related to artificial tissues and organs. With a strong focus on fundamental and traditional tissue engineering strategies, the book also examines how emerging and enabling technologies are being developed and applied. Sections provide essential information on biomaterial, cell properties and cell types used in organ generation. A section on state-of-the-art in organ regeneration for clinical purposes is followed by a discussion on enabling technologies, such as bioprinting, on chip organ systems and in silico simulations. Provides a systematic overview of the field, from fundamentals, to current challenges and opportunities Encompasses the classic paradigm of tissue engineering for creation of new functional tissue Discusses enabling technologies such as bioprinting, organ-on-chip systems and in silico simulations

Animal Experimentation

Animal Experimentation
Working Towards a Paradigm Change

by Kathrin Herrmann,Kimberley Jayne

  • Publisher : Human-Animal Studies
  • Release : 2019
  • Pages : 714
  • ISBN : 9789004356184
  • Language : En, Es, Fr & De
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Animal Experimentation: Working Towards a Paradigm Change critically appraises current animal use in science and discusses ways in which we can contribute to a paradigm change towards human-biology based approaches.

Microfluidics in Cell BiologyPart A: Microfluidics for multicellular systems

Microfluidics in Cell BiologyPart A: Microfluidics for multicellular systems
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2018-07-20
  • Pages : 273
  • ISBN : 0128142812
  • Language : En, Es, Fr & De
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Microfluidics in Cell Biology Part A: Volume 146, the latest release in the Methods in Cell Biology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. Unique to this updated volume are sections on Cell monolayers/spheroids, Collective migration in microtubes, Leukocyte adhesion dynamics on endothelial monolayers under flow, Constrained spheroid for perfusion culture, Cells in droplet arrays, Heart on chips, Kidney on chips, Liver on chips and hepatic immune responses, Gut on chips, 3D microvascular model-based lymphoma model, Blood brain barrier on chips, Multi-organ-on-a-chip for pharmacokinetic analysis, Cancer immunotherapy on chips, and more. Contains contributions from experts in the field from across the globe Covers a wide array of topics on both mitosis and meiosis Includes relevant, analysis based topics

Principles of Regenerative Medicine

Principles of Regenerative Medicine
A Book

by Anthony Atala,Robert Lanza,James A. Thomson,Robert Nerem

  • Publisher : Academic Press
  • Release : 2010-12-16
  • Pages : 1202
  • ISBN : 9780123814234
  • Language : En, Es, Fr & De
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Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs

3D Printing Technology in Nanomedicine

3D Printing Technology in Nanomedicine
A Book

by Nabeel Ahmad,P. Gopinath,Rajiv Dutta

  • Publisher : Elsevier
  • Release : 2019-03-30
  • Pages : 202
  • ISBN : 0128158913
  • Language : En, Es, Fr & De
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3D Printing Technology in Nanomedicine provides an integrated and introductory look into the rapidly evolving field of nanobiotechnology. It demystifies the processes of commercialization and discusses legal and regulatory considerations. With a focus on nanoscale processes and biomedical applications, users will find this to be a comprehensive resource on how 3D printing can be utilized in a range of areas, including the diagnosis and treatment of a variety of human diseases. Examines the emerging market of 3D-printed biomaterials and their clinical applications, with a particular focus on both commercial and premarket tools Examines the promising market of 3D-printed nanoparticles, nanomaterial, biomaterials, composite nanomaterial and their clinical applications in the cardiovascular and chemotherapy realms Develops the concept of integrating different technologies along the hierarchical structure of biological systems

Open-Space Microfluidics

Open-Space Microfluidics
Concepts, Implementations, Applications

by Emmanuel Delamarche,Govind V. Kaigala

  • Publisher : John Wiley & Sons
  • Release : 2018-01-18
  • Pages : 450
  • ISBN : 3527696792
  • Language : En, Es, Fr & De
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Summarizing the latest trends and the current state of this research field, this up-to-date book discusses in detail techniques to perform localized alterations on surfaces with great flexibility, including microfluidic probes, multifunctional nanopipettes and various surface patterning techniques, such as dip pen nanolithography. These techniques are also put in perspective in terms of applications and how they can be transformative of numerous (bio)chemical processes involving surfaces. The editors are from IBM Zurich, the pioneers and pacesetters in the field at the forefront of research in this new and rapidly expanding area.

Clinical and Translational Science

Clinical and Translational Science
Principles of Human Research

by David Robertson,Gordon H. Williams

  • Publisher : Academic Press
  • Release : 2016-11-25
  • Pages : 808
  • ISBN : 012802111X
  • Language : En, Es, Fr & De
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Clinical and Translational Science: Principles of Human Research, Second Edition, is the most authoritative and timely resource for the broad range of investigators taking on the challenge of clinical and translational science, a field that is devoted to investigating human health and disease, interventions, and outcomes for the purposes of developing new treatment approaches, devices, and modalities to improve health. This updated second edition has been prepared with an international perspective, beginning with fundamental principles, experimental design, epidemiology, traditional and new biostatistical approaches, and investigative tools. It presents complete instruction and guidance from fundamental principles, approaches, and infrastructure, especially for human genetics and genomics, human pharmacology, research in special populations, the societal context of human research, and the future of human research. The book moves on to discuss legal, social, and ethical issues, and concludes with a discussion of future prospects, providing readers with a comprehensive view of this rapidly developing area of science. Introduces novel physiological and therapeutic strategies for engaging the fastest growing scientific field in both the private sector and academic medicine Brings insights from international leaders into the discipline of clinical and translational science Addresses drug discovery, drug repurposing and development, innovative and improved approaches to go/no-go decisions in drug development, and traditional and innovative clinical trial designs

The House of the Scorpion

The House of the Scorpion
A Book

by Nancy Farmer

  • Publisher : Simon and Schuster
  • Release : 2013-08-01
  • Pages : 400
  • ISBN : 1471120384
  • Language : En, Es, Fr & De
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Matt is six years old when he discovers that he is different from other children and other people. To most, Matt isn't considered a boy at all, but a beast, dirty and disgusting. But to El Patron, lord of a country called Opium, Matt is the guarantee of eternal life. El Patron loves Matt as he loves himself - for Matt is himself. They share the exact same DNA. As Matt struggles to understand his existence and what that existence truly means, he is threatened by a host of sinister and manipulating characters, from El Patron's power-hungry family to the brain-deadened eejits and mindless slaves that toil Opium's poppy fields. Surrounded by a dangerous army of bodyguards, escape is the only chance Matt has to survive. But even escape is no guarantee of freedom… because Matt is marked by his difference in ways that he doesn't even suspect.