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Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
A Book

by Stephen Neidle

  • Publisher : Elsevier
  • Release : 2010-07-26
  • Pages : 302
  • ISBN : 9780080553528
  • Language : En, Es, Fr & De
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This unique and practical resource provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussion of x-ray crystallography, NMR, molecular modelling, and databases. Its focus is on a survey of structures especially important for biomedical research and pharmacological applications. To aid novices, Principles of Nucleic Acid Structure includes an introduction to technical lingo used to describe nucleic acid structure and conformations (roll, slide, twist, buckle, etc.). This completely updated edition features expanded coverage of the latest advances relevant to recognition of DNA and RNA by small molecules and proteins. In particular, the reader will find extensive new discussions on: RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA). This handy guide ends with a complete list of resources, including relevant online databases and software. Completely updated with expanded discussion of topics such as RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes, and short interfering RNA (siRNA) Includes a complete list of resources, including relevant online databases and software Defines technical lingo for novices

Principles of Nucleic Acid Structure

Principles of Nucleic Acid Structure
A Book

by Wolfram Saenger

  • Publisher : Springer Science & Business Media
  • Release : 2013-12-01
  • Pages : 556
  • ISBN : 1461251907
  • Language : En, Es, Fr & De
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New textbooks at all levels of chemistry appear with great regularity. Some fields like basic biochemistry, organic reaction mechanisms, and chemical ther modynamics are well represented by many excellent texts, and new or revised editions are published sufficiently often to keep up with progress in research. However, some areas of chemistry, especially many of those taught at the grad uate level, suffer from a real lack of up-to-date textbooks. The most serious needs occur in fields that are rapidly changing. Textbooks in these subjects usually have to be written by scientists actually involved in the research which is advancing the field. It is not often easy to persuade such individuals to set time aside to help spread the knowledge they have accumulated. Our goal, in this series, is to pinpoint areas of chemistry where recent progress has outpaced what is covered in any available textbooks, and then seek out and persuade experts in these fields to produce relatively concise but instructive introductions to their fields. These should serve the needs of one semester or one quarter graduate courses in chemistry and biochemistry. In some cases the availability of texts in active research areas should help stimulate the creation of new courses. CHARLES R. CANTOR New York Preface This monograph is based on a review on polynucleotide structures written for a book series in 1976.

Physical Principles in Nucleic Acid Chemistry

Physical Principles in Nucleic Acid Chemistry
A Book

by David E. Draper

  • Publisher : CRC PressI Llc
  • Release : 2014-12-15
  • Pages : 450
  • ISBN : 9781466571280
  • Language : En, Es, Fr & De
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Principles and Practice of Experiments with Nucleic Acids

Principles and Practice of Experiments with Nucleic Acids
A Book

by John Howard Parish

  • Publisher : Unknown Publisher
  • Release : 1972
  • Pages : 511
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Nucleic acid components; Isolation; Fractionation; Identification; Degradation; Synthesis; Chemical reactions; Primary structure of DNA and RNA; Secondary structure; Hybridization; Size and shape; Interaction between nucleic acids and small molecules; Tertiary structure; Interaction between nucleic acids and proteins.

Computational studies of RNA and DNA

Computational studies of RNA and DNA
A Book

by Jirí Šponer,Filip Lankaš

  • Publisher : Springer Science & Business Media
  • Release : 2006-10-05
  • Pages : 638
  • ISBN : 1402048513
  • Language : En, Es, Fr & De
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This book integrates modern computational studies of nucleic acids, ranging from advanced electronic structure quantum chemical calculations through explicit solvent molecular dynamics (MD) simulations up to mesoscopic modelling, with the main focus given to the MD field. It gives an equal emphasis to the leading methods and applications while successes as well as pitfalls of the computational techniques are discussed.

RNA Structure and Function

RNA Structure and Function
A Book

by Robert W. Simons 1945-.,Robert W. Simons,Marianne Grunberg-Manago

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 741
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The striking functional versatility of RNA is attributable to its remarkable capacity for conformational change. Current models of RNA synthesis, its maturation, translation and degradation are all based on specific structures and there is growing appreciation of the functional importance of interactions between RNA and RNA-binding proteins. This work identifies the major intellectual and technical advances in understanding the part played by structure in how RNA works. It encompasses the experimental approaches used to define RNA structure and its influence on RNA functions such as transcription termination, catalysis, recoding and translational control. Investigators with these interests and students of molecular biology should find this volume a provocative survey of a rapidly-advancing field and a valuable complement to the monograph, The RNA World.

Protein-Nucleic Acid Interactions

Protein-Nucleic Acid Interactions
Structural Biology

by Phoebe A. Rice,Carl C. Correll

  • Publisher : Royal Society of Chemistry
  • Release : 2008-05-22
  • Pages : 397
  • ISBN : 0854042725
  • Language : En, Es, Fr & De
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The structural biology of protein-nucleic acid interactions is in some ways a mature field and in others in its infancy. High-resolution structures of protein-DNA complexes have been studied since the mid 1980s and a vast array of such structures has now been determined, but surprising and novel structures still appear quite frequently. High-resolution structures of protein-RNA complexes were relatively rare until the last decade. Propelled by advances in technology as well as the realization of RNA's importance to biology, the number of example structures has ballooned in recent years. New insights are now being gained from comparative studies only recently made possible due to the size of the database, as well as from careful biochemical and biophysical studies. As a result of the explosion of research in this area, it is no longer possible to write a comprehensive review. Instead, current review articles tend to focus on particular subtopics of interest. This makes it difficult for newcomers to the field to attain a solid understanding of the basics. One goal of this book is therefore to provide in-depth discussions of the fundamental principles of protein-nucleic acid interactions as well as to illustrate those fundamentals with up-to-date and fascinating examples for those who already possess some familiarity with the field. The book also aims to bridge the gap between the DNA- and the RNA- views of nucleic acid - protein recognition, which are often treated as separate fields. However, this is a false dichotomy because protein - DNA and protein - RNA interactions share many general principles. This book therefore includes relevant examples from both sides, and frames discussions of the fundamentals in terms that are relevant to both. The monograph approaches the study of protein-nucleic acid interactions in two distinctive ways. First, DNA-protein and RNA-protein interactions are presented together. Second, the first half of the book develops the principles of protein-nucleic acid recognition, whereas the second half applies these to more specialized topics. Both halves are illustrated with important real life examples. The first half of the book develops fundamental principles necessary to understand function. An introductory chapter by the editors reviews the basics of nucleic acid structure. Jen-Jacobsen and Jacobsen discuss how solvent interactions play an important role in recognition, illustrated with extensive thermodynamic data on restriction enzymes. Marmorstein and Hong introduce the zoology of the DNA binding domains found in transcription factors, and describe the combinational recognition strategies used by many multiprotein eukaryotic complexes. Two chapters discuss indirect readout of DNA sequence in detail: Berman and Lawson explain the basic principles and illustrate them with in-depth studies of CAP, while in their chapter on DNA bending and compaction Johnson, Stella and Heiss highlight the intrinsic connections between DNA bending and indirect readout. Horvath lays out the fundamentals of protein recognition of single stranded DNA and single stranded RNA, and describes how they apply in a detailed analysis of telomere end binding proteins. Nucleic acids adopt more complex structures - Lilley describes the conformational properties of helical junctions, and how proteins recognize and cleave them. Because RNA readily folds due to the stabilizing role of its 2'-hydroxyl groups, Li discusses how proteins recognize different RNA folds, which include duplex RNA. With the fundamentals laid out, discussion turns to more specialized examples taken from important aspects of nucleic acid metabolism. Schroeder discusses how proteins chaperone RNA by rearranging its structure into a functional form. Berger and Dong discuss how topoisomerases alter the topology of DNA and relieve the superhelical tension introduced by other processes such as replication and transcription. Dyda and Hickman show how DNA transposes mediate genetic mobility and Van Duyne discusses how site-specific recombinases "cut" and "paste" DNA. Horton presents a comprehensive review of the structural families and chemical mechanisms of DNA nucleases, whereas Li in her discussion of RNA-protein recognition also covers RNA nucleases. Lastly, FerrÚ-D'AmarÚ shows how proteins recognize and modify RNA transcripts at specific sites. The book also emphasises the impact of structural biology on understanding how proteins interact with nucleic acids and it is intended for advanced students and established scientists wishing to broaden their horizons.

Thermodynamics of RNA Structural Changes

Thermodynamics of RNA Structural Changes
A Book

by Peter J. Mikulecky

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 520
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Quasispecies and RNA Virus Evolution

Quasispecies and RNA Virus Evolution
Principles and Consequences

by Esteban Domingo

  • Publisher : CRC Press
  • Release : 2001
  • Pages : 173
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This book focuses on a new aspect of RNA virology: the highly dynamic, heterogeneous and plastic nature of RNA viruses which comprise more than 75% of the viruses that have been recognized as disease agents. It is the first attempt to bridge the gap from the basic, theoretical formulations underlying error-prone replications and generation of quasispecies, to their impact on how RNA viruses adapt and cause disease.

DNA Structure and Recognition

DNA Structure and Recognition
A Book

by Stephen Neidle

  • Publisher : Oxford University Press, USA
  • Release : 1994
  • Pages : 108
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This book is a concise, comprehensive survey of DNA structure, from first principles to the ways in which drugs and proteins interact with DNA. Such an understanding of DNA structure is essential for more detailed study in areas such as gene regulation and DNA-targeted drug action.

Protein-nucleic Acid Interaction

Protein-nucleic Acid Interaction
A Book

by Wolfram Saenger,Udo Heinemann

  • Publisher : CRC PressI Llc
  • Release : 1989
  • Pages : 209
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Realistic Simulation of Nucleic Acids in Solution

Realistic Simulation of Nucleic Acids in Solution
A Book

by Thomas Edward Cheatham

  • Publisher : Unknown Publisher
  • Release : 1997
  • Pages : 524
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Fourteenth Symposium on Nucleic Acids Chemistry

Fourteenth Symposium on Nucleic Acids Chemistry
Held in Tokushima, Japan, October 30th-November 1st, 1986

by Mikio Honjo

  • Publisher : Irl Press
  • Release : 1986
  • Pages : 232
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Revue roumaine de biochimie

Revue roumaine de biochimie
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1984
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Understanding DNA

Understanding DNA
The Molecule and How It Works

by Chris R. Calladine,Horace Drew

  • Publisher : Academic Press
  • Release : 1997-03-14
  • Pages : 283
  • ISBN : 9780080572529
  • Language : En, Es, Fr & De
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The Second Edition of Understanding DNA has been entirely revised and updated, and expanded by more than 50% to cover new advances. The book explains step-by-step how DNA forms specific structures, the nature of these structures, and how they fundamentally affect the biological processes of transcription and replication. The functional properties of any molecule are directly related to and affected by its structure; this is especially true for DNA, the molecule that carries the code for all life on earth. Written in a clear, concise, and at times lively fashion, Understanding DNA is essential reading for all molecular biology, biochemistry, and genetics students, for newcomers to the field from such areas as physics or chemistry, and for even the most seasoned researchers who really want to understand DNA. Key Features * New edition, expanded by more than 50% * Completely revised and updated * Includes many additional and updated references * Summarizes the recent studies of DNA in disease and medicine * Contains more than 110 illustrations, some in full color * Describes the basic units of DNA and how these form the double helix * Characterizes the various types of DNA double helix that have been found * Explains how and why DNA twists and curves * Discusses the mechanisms of DNA supercoiling * Summarizes the assembly of DNA and proteins into chromosomes * Outlines the methods used to study DNA structure Describes the latest work on protein-DNA complexes * Contains simple exercises and further reading at the end of each chapter

Biochemistry, Biomolecules

Biochemistry, Biomolecules
A Book

by Donald Voet,Judith G. Voet

  • Publisher : Wiley
  • Release : 2003-05-20
  • Pages : 1200
  • ISBN : 9780471250906
  • Language : En, Es, Fr & De
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Biochemistry is a modern classic that had been thoroughly revised. Explains biochemical concepts while offering a unified presentation of life and its variation through evolution. Incorporates both classical and current research to illustrate the historical source of much of our biochemical knowledge. This edition has been updated to reflect the enormous advances in molecular and protein structure. Features a new chapter on nucleic acids, gene expression, and recombinant DNA technology, as well as a new chapter on nucleotide metabolism. Integrated Biochemical Interactions CD.

The World of the Cell

The World of the Cell
A Book

by Wayne M. Becker,D. W. Deamer

  • Publisher : Addison Wesley Publishing Company
  • Release : 1991
  • Pages : 886
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Spectroscopic and Kinetic Data. Physical Data I / Spektroskopische und kinetische Daten. Physikalische Daten I

Spectroscopic and Kinetic Data. Physical Data I / Spektroskopische und kinetische Daten. Physikalische Daten I
A Book

by C. Altona,J.J. Butzow,G.L. Eichhorn,H. Eisenberg,M.D. Frank-Kamenetskii,S.M. Freier,W. Guschlbauer,C.W. Hilbers,W.C. Johnson,H.H. Klump,W.L. Peticolas,Y.A. Shin,N. Sugimoto,D.H. Turner,J.A.L.I. Walters

  • Publisher : Springer
  • Release : 1990-10-30
  • Pages : 445
  • ISBN : 9783540194286
  • Language : En, Es, Fr & De
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Group VII of the Landolt-Börnstein New Series is devoted to the physical properties of biological systems. It begins with volume VII/1 covering the nucleic acids which are of central importance in all processes in- volving gene expression. This field has become of practical consequence during the last decade through the development of genetic engineering. Because of the amount of the data available, volume VII/1 had to be divided into several subvolumes. The first two subvolumes, VII/1a and VII/1b, which appeared in 1988, deal with crystallographic and structural data which give a comprehensive information on the three-dimensional structure of the nucleic acids, their folding properties, their hydrogen bonding schemes, their metal binding capabilities, their hydration and their drug complexation. The present subvolume VII/1c covers the first part of spectroscopic, kinetic and physical data; the following subvolume VII/1d concludes this chapter and also deals with theoretical investigations.

Anti DNA Antibodies in SLE

Anti DNA Antibodies in SLE
A Book

by Edward W. Voss

  • Publisher : CRC PressI Llc
  • Release : 1988
  • Pages : 180
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Fluorescent Nucleosides as Probes for DNA Structure and Recognition

Fluorescent Nucleosides as Probes for DNA Structure and Recognition
A Book

by Susan Seaman

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 270
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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