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Protein Homeostasis Diseases

Protein Homeostasis Diseases
Mechanisms and Novel Therapies

by Angel L. Pey

  • Publisher : Academic Press
  • Release : 2020-02-13
  • Pages : 450
  • ISBN : 0128191333
  • Language : En, Es, Fr & De
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Protein Homeostasis Diseases: Mechanisms and Novel Therapies offers an interdisciplinary examination of the fundamental aspects, biochemistry and molecular biology of protein homeostasis disease, including the use of natural and pharmacological small molecules to treat common and rare protein homeostasis disorders. Contributions from international experts discuss the biochemical and genetic components of protein homeostasis disorders, the mechanisms by which genetic variants may cause loss-of-function and gain-of-toxic-function, and how natural ligands can restore protein function and homeostasis in genetic diseases. Applied chapters provide guidance on employing high throughput sequencing and screening methodologies to develop pharmacological chaperones and repurpose approved drugs to treat protein homeostasis disorders. Provides an interdisciplinary examination of protein homeostasis disorders, with an emphasis on treatment strategies employing small natural and pharmacological ligands Offers applied approaches in employing high throughput sequencing and screening to develop pharmacological chaperones to treat protein homeostasis disease Gathers expertise from a range of international chapter authors who work across various biological methods and disease specific disciplines of relevance

Protein Homeostasis

Protein Homeostasis
A Book

by Richard I. Morimoto,Dennis J. Selkoe,Jeffery W. Kelly

  • Publisher : Unknown Publisher
  • Release : 2012
  • Pages : 349
  • ISBN : 9781936113064
  • Language : En, Es, Fr & De
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Proper expression, folding, transport, and clearance of proteins is critical for cell function. Chaperones and enzymes that posttranslationally assist newly synthesized proteins help ensure that they fold correctly or are degraded. Translocation machineries, proteasomes, and autophagic activities help to localize and degrade proteins as necessary. Stress and aging can cause such mechanisms to become dysfunctional or overloaded, resulting in the accumulation and aggregation of misfolded proteins a feature of numerous neurodegenerative conditions. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology covers the entire spectrum of protein homeostasis in healthy cells and the diseases that result when control of protein production, protein folding, and protein degradation goes awry. The contributors examine the physical biochemistry of protein folding and the roles of the various cellular compartments in protein quality control, as well as approaches for ameliorating protein misfolding and aggregation diseases. Including discussions of specific disorders such as Alzheimer's disease, Huntington's disease, and prion diseases, this book is an essential reference for not only molecular and cellular biologists but also medical scientists wishing to understand the pathological consequences of and potential therapies for protein homeostasis deficiencies in common human diseases.

Proteostasis and Disease

Proteostasis and Disease
From Basic Mechanisms to Clinics

by Rosa Barrio,James D. Sutherland,Manuel S. Rodriguez

  • Publisher : Springer
  • Release : 2021-04-24
  • Pages : 348
  • ISBN : 9783030382681
  • Language : En, Es, Fr & De
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This book, written by members of the European network PROTEOSTASIS, provides an up-to-date review of the research regarding protein homeostasis in health and disease. With new discoveries contributing to the increasing complexity of this topic, the book offers a detailed overview of the pathways regulating protein homeostasis, including autophagy and the ubiquitin protein family. Following a basic introduction, it explains how defects in protein homeostasis contribute to numerous pathologies, including cancer, neurodegeneration, inflammation and a number of rare diseases. In addition, it discusses, the role of protein homeostasis in cellular development and physiology. Highlighting the latest research in the field of protein homeostasis and its implications for various clinically relevant diseases, the book appeals to researchers and clinicians, while also offering a reference guide for scholars who are new to the field.

Protein Quality Control in Neurodegenerative Diseases

Protein Quality Control in Neurodegenerative Diseases
A Book

by Richard I. Morimoto,Yves Christen

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-13
  • Pages : 136
  • ISBN : 3642279287
  • Language : En, Es, Fr & De
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The health of the proteome depends upon protein quality control to regulate the proper synthesis, folding, translocation, and clearance of proteins. The cell is challenged constantly by environmental and physiological stress, aging, and the chronic expressions of disease associated misfolded proteins. Substantial evidence supports the hypothesis that the expression of damaged proteins initiates a cascade of molecular events that leads to Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and other diseases of protein conformation.

The Journals of Gerontology

The Journals of Gerontology
Biological sciences and medical sciences

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Annual Review of Genomics and Human Genetics

Annual Review of Genomics and Human Genetics
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Protein Folding Disorders Of The Central Nervous System

Protein Folding Disorders Of The Central Nervous System
A Book

by Ghiso Jorge A,Rostagno Agueda A

  • Publisher : World Scientific
  • Release : 2017-09-15
  • Pages : 336
  • ISBN : 9813222972
  • Language : En, Es, Fr & De
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This exciting new book explores the dark side of the molecular protein assembly bringing an updated view of how failures in the homeostatic mechanisms that efficiently regulate protein folding leads to the accumulation of structurally abnormal pathogenic assemblies, encompassing an emerging group of diseases collectively known as "Protein Folding Disorders." This complex and diverse group of chronic and progressive entities are bridged together by their relationship to structural transitions in the native state of specific proteinaceous components, which for reasons poorly understood, convert into polymeric aggregates that generate poorly soluble tissue deposits and which are considered today the culprit of the disease pathogenesis in their respective diseases. Despite the diversity in the amino acid sequence of the different proteins involved in these heterogeneous disorders, all the pathologic conformers can trigger cascades of events ultimately resulting in cell dysfunction and death with devastating clinical consequences in many of the most precious aspects of human existence including personality, cognition, memory, and skilled movements. This book, which is composed of a compilation of chapters authored by outstanding and well-published scientists in the respective fields currently performing active investigations at world renowned universities and research centers, focuses on the growing number of diseases associated with protein misfolding in the central nervous system. Individual chapters are dedicated to the most common neurodegenerative diseases associated with protein aggregation/fibrillization focusing on the nature of the pathogenic species and the cellular pathways involved in the molecular pathogenesis of Alzheimer's, Parkinson's, and Huntington's diseases as well as in Amyotrophic Lateral Sclerosis, and Prion disorders. A group of contributions is centered on the current knowledge of the intracellular pathways and subcellular organelles affected by the different disease conditions, while others are focused in the emerging pathogenic role of misfolded subunits assembled into neurotoxic soluble oligomers, and in the novel notion of the transmissibility of the protein misfolded species, an innovative concept until recently only accepted for Prion diseases. Lastly, a different set of chapters is dedicated to the evaluation of novel therapeutic strategies for these devastating diseases. Contents: Misfolding, Aggregation, and Amyloid Formation: The Dark Side of Proteins (Agueda Rostagno and Jorge A Ghiso)Oligomers at the Synapse: Synaptic Dysfunction and Neurodegeneration (Emily Vogler, Matthew Mahavongtrakul, and Jorge Busciglio)Prion-Like Protein Seeding and the Pathobiology of Alzheimer's Disease (Lary C Walker)The Tau Misfolding Pathway to Dementia (Alejandra D Alonso, Leah S Cohen, and Viktoriya Morozova)The Biology and Pathobiology of α-Synuclein (Joel C Watts, Anurag Tandon, and Paul E Fraser)Impact of Loss of Proteostasis on Central Nervous System Disorders (Sentiljana Gumeni, Eleni N Tsakiri, Christina-Maria Cheimonidi, Zoi Evangelakou, Despoina Gianniou, Kostantinos Tallas, Eleni-Dimitra Papanagnou, Aimilia D Sklirou, and Ioannis P Trougakos)Protein Misfolding and Mitochondrial Dysfunction in Amyotrophic Lateral Sclerosis (Giovanni Manfredi and Hibiki Kawamata)Impact of Mitostasis and the Role of the Anti-Oxidant Responses on Central Nervous System Disorders (Sentiljana Gumeni, Eleni N Tsakiri, Christina-Maria Cheimonidi, Zoi Evangelakou, Despoina Gianniou, Kostantinos Tallas, Eleni-Dimitra Papanagnou, Aimilia D Sklirou, and Ioannis P Trougakos)Propagation of Misfolded Proteins in Neurodegeneration: Insights and Cautions from the Study of Prion Disease Prototypes (Robert C C Mercer, Nathalie Daude,

Wiley Encyclopedia of Molecular Medicine, Volume 3

Wiley Encyclopedia of Molecular Medicine, Volume 3
A Book

by Wiley

  • Publisher : Wiley-Interscience
  • Release : 2001-11-01
  • Pages : 3699
  • ISBN : 9780471374961
  • Language : En, Es, Fr & De
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Proteinuria

Proteinuria
An Integrated Review

by Amadeo J. Pesce,Martin Roy First

  • Publisher : Marcel Dekker Incorporated
  • Release : 1979
  • Pages : 294
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Soft Nanotechnology

Soft Nanotechnology
The Royal Society, London, UK, 15-17 June 2009

by Anonim

  • Publisher : Faraday Discussions
  • Release : 2009
  • Pages : 394
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This book will incorporate aspects of structuring soft-materials at the nanoscale and the incorporation of such materials into actual devices. Soft nanotechnology aims to build on our knowledge of biological systems, by implementing self-assembly and 'wet chemistry' into electronic devices, actuators, fluidics, etc. Understanding, predicting and utilising the rules of self-assembly (be it at solid liquid interfaces, in solution, or in block copolymers) and interface the resulting complex structures in well-defined 2D and 3D arrangements. This timely book will appeal to scientists, researchers and anyone working in this field.

Nurse's Manual of Laboratory and Diagnostic Tests

Nurse's Manual of Laboratory and Diagnostic Tests
A Book

by Bonita Morrow Cavanaugh

  • Publisher : F. A. Davis Company
  • Release : 1999
  • Pages : 1033
  • ISBN : 9780803603639
  • Language : En, Es, Fr & De
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This manual contains comprehensive information on laboratory and diagnostic tests in a quick-retrieval format with a strong focus on nursing care before, during, and after each test.

Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Intravenous Therapy

Intravenous Therapy
Clinical Principles and Practice

by Intravenous Nurses Society

  • Publisher : W.B. Saunders Company
  • Release : 1995
  • Pages : 593
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This text addresses special areas of IV therapy, including oncology and pain management, blood and blood components and parenteral nutrition. The book also offers calculations required for parenteral therapies and applies IV therapy to a variety of settings, including home health care and long-term care. in addition, it provides therapy principles for care of paediatric and geriatric patients.

Revue Canadienne de Physiologie Appliquée

Revue Canadienne de Physiologie Appliquée
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Ubiquitin and Disease

Ubiquitin and Disease
A Book

by Josep M. Argilés,Francisco J. López-Soriano,Javier Pallarés-Trujillo

  • Publisher : Landes Bioscience
  • Release : 1998
  • Pages : 174
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Protective Strategies for Neurodegenerative Diseases

Protective Strategies for Neurodegenerative Diseases
A Book

by Debomoy K. Lahiri

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 356
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The incidence of age-related neurodegenerative diseases can be expected to rise dramatically in the future owing to an aging population. Consequently, finding the means of retarding the progression of such diseases becomes increasingly important. This volume focuses on research findings involving both nutritional and pharmacological strategies for slowing normal brain aging and its pathological variants such as Alzheimer's and Parkinson's diseases. Scientists well recognized for their molecular and mechanistic work in this area have contributed chapters to this volume. New concepts concerning neurodegenerative disease and its mitigation are also included in this volume, which is designed to promote the development of fresh research perspectives and therapeutic possibilities directed toward neuroprotection.

In Vitro and in Vivo Models for the Study of Alexander Disease Pathogenesis and Therapy

In Vitro and in Vivo Models for the Study of Alexander Disease Pathogenesis and Therapy
A Book

by Woosung Cho

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 127
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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High-protein Oedemas and the Benzo-pyrones

High-protein Oedemas and the Benzo-pyrones
The Causes, Effects, Incidence and Treatment of High-protein Oedemas, Including Lymphoedema, and how These are Improved by the Benzo-pyrones, Including the Coumarins and the Flavonoids

by J. R. Casley-Smith,Judith R. Casley-Smith

  • Publisher : Harpercollins College Division
  • Release : 1986
  • Pages : 536
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Annual Reciprocal Meat Conference, Proceedings

Annual Reciprocal Meat Conference, Proceedings
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Pesticides and Proteasome Inhibition in Neurodegeneration Associated with Parkinson's Disease

Pesticides and Proteasome Inhibition in Neurodegeneration Associated with Parkinson's Disease
A Book

by Arthur Pofei Chou

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 340
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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