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The Emerging Discipline of Quantitative Systems Pharmacology

The Emerging Discipline of Quantitative Systems Pharmacology

by Tarek A. Leil,Sergey Ermakov

  • Publisher : Unknown Publisher
  • Release : 2015-09-07
  • Pages : 129
  • ISBN : 2889196429
  • Language : En, Es, Fr & De
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In 2011, the National Institutes of Health (NIH), in collaboration with leaders from the pharmaceutical industry and the academic community, published a white paper describing the emerging discipline of Quantitative Systems Pharmacology (QSP), and recommended the establishment of NIH-supported interdisciplinary research and training programs for QSP. QSP is still in its infancy, but has tremendous potential to change the way we approach biomedical research. QSP is really the integration of two disciplines that have been increasingly useful in biomedical research; “Systems Biology” and “Quantitative Pharmacology”. Systems Biology is the field of biomedical research that seeks to understand the relationships between genes and biologically active molecules to develop qualitative models of these systems; and Quantitative Pharmacology is the field of biomedical research that seeks to use computer aided modeling and simulation to increase our understanding of the pharmacokinetics (PK) and pharmacodynamics (PD) of drugs, and to aid in the design of pre-clinical and clinical experiments. The purpose of QSP modeling is to develop quantitative computer models of biological systems and disease processes, and the effects of drug PK and PD on those systems. QSP models allow testing of numerous potential experiments “in-silico” to eliminate those associated with a low probability of success, avoiding the potential costs of evaluating all of those failed experiments in the real world. At the same time, QSP models allow us to develop our understanding of the interaction between drugs and biological systems in a more systematic and rigorous manner. As the need to be more cost-efficient in the use of research funding increases, biomedical researchers will be required to gain the maximum insight from each experiment that is conducted. This need is even more acute in the pharmaceutical industry, where there is tremendous competition to develop innovative therapies in a highly regulated environment, combined with very high research and development (R&D) costs for bringing new drugs to market (~$1.3 billion/drug). Analogous modeling & simulation approaches have been successfully integrated into other disciplines to improve the fundamental understanding of the science and to improve the efficiency of R&D (e.g., physics, engineering, economics, etc.). The biomedical research community has been slow to integrate computer aided modeling & simulation for many reasons: including the perception that biology and pharmacology are “too complex” and “too variable” to be modeled with mathematical equations; a lack of adequate graduate training programs; and the lack of support from government agencies that fund biomedical research. However, there is an active community of researchers in the pharmaceutical industry, the academic community, and government agencies that develop QSP and quantitative systems biology models and apply them both to better characterize and predict drug pharmacology and disease processes; as well as to improve efficiency and productivity in pharmaceutical R&D.

Quantitative Systems Pharmacology

Quantitative Systems Pharmacology
Models and Model-Based Systems with Applications

by Davide Manca

  • Publisher : Elsevier
  • Release : 2018-07-18
  • Pages : 418
  • ISBN : 0444639675
  • Language : En, Es, Fr & De
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Quantitative Systems Pharmacology: Models and Model-Based Systems with Applications, Volume 42, provides a quantitative approach to problem-solving that is targeted to engineers. The book gathers the contributions of doctors, pharmacists, biologists, and chemists who give key information on the elements needed to model a complex machine like the human body. It presents information on diagnoses, administration and release of therapeutics, distribution metabolism and excretion of drugs, compartmental pharmacokinetics, physiologically-based pharmacokinetics, pharmacodynamics, identifiability of models, numerical methods for models identification, design of experiments, in vitro and in vivo models, and more. As the pharma community is progressively acknowledging that a quantitative and systematic approach to drug administration, release, pharmacokinetics and pharmacodynamics is highly recommended to understand the mechanisms and effects of drugs, this book is a timely resource. Outlines a model-based approach (based on Process Systems Engineering-OSE and Computer Aided Process Engineering-CAPE) in quantitative pharmacology Explains how therapeutics work in the human body and how anatomy and physiology influences drug efficacy Discusses how drugs are driven to specific targets using nanoparticles Offers insight into how in vitro and in vivo experiments help understand the drug mechanism of action and optimize their performance Includes case studies showing the positive outcome of these methods in personalized therapies, therapeutic drug monitoring, clinical trials analysis and drug formulation

Quantitative Systems Pharmacology Modeling of Biotherapeutics in Oncology

Quantitative Systems Pharmacology Modeling of Biotherapeutics in Oncology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 218
  • ISBN : 9780578891200
  • Language : En, Es, Fr & De
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The Emerging Discipline of Quantitative Systems Pharmacology

The Emerging Discipline of Quantitative Systems Pharmacology
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstracts ASCPT 2015 Annual Meeting & Quantitative Systems Pharmacology: Multiscale Model-Based Drug Development Through Integrating Systems Biology and Pharmacometrics Pre-Conference

Abstracts ASCPT 2015 Annual Meeting & Quantitative Systems Pharmacology: Multiscale Model-Based Drug Development Through Integrating Systems Biology and Pharmacometrics Pre-Conference
March 3 - 7, 2015, Hyatt Regency, New Orleans, LA.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 116
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics

Biochemical Thermodynamic Modelling of Cellular Bioenergetics
A Quantitative Systems Pharmacology Approach

by R. A. Kelly

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Abstracts ASCPT 2013 Annual Meeting & Quantitative Systems Pharmacology: an Integrating Framework for Translational Medicine

Abstracts ASCPT 2013 Annual Meeting & Quantitative Systems Pharmacology: an Integrating Framework for Translational Medicine
March 5 - 9, 2013, JW Marriott Hotel, Indianapolis, IN.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 137
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Systems Pharmacology and Pharmacodynamics

Systems Pharmacology and Pharmacodynamics
A Book

by Donald E. Mager,Holly H.C. Kimko

  • Publisher : Springer
  • Release : 2016-11-29
  • Pages : 511
  • ISBN : 3319445340
  • Language : En, Es, Fr & De
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While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

Translational Systems Medicine and Oral Disease

Translational Systems Medicine and Oral Disease
A Book

by Stephen Sonis,Alessandro Villa

  • Publisher : Academic Press
  • Release : 2019-09-14
  • Pages : 458
  • ISBN : 0128137630
  • Language : En, Es, Fr & De
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Translational Systems Medicine and Oral Disease bridges the gap between discovery science and clinical oral medicine, providing opportunities for both the scientific and clinical communities to understand how to apply recent findings in cell biology, genomic profiling, and systems medicine to favorably impact the diagnosis, treatment and management of oral diseases. Fully illustrated chapters from leading international contributors explore clinical applications of genomics, proteomics, metabolomics, microbiomics and epigenetics, as well as analytic methods and functional omics in oral medicine. Disease specific chapters detail systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease, and autoimmune disease, among others. In addition, the book emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology and primary care. Presents the work of leading international researchers and clinicians who speak on the clinical applications of genomics, proteomics, metabolomics, microbiomics, and epigenetics, as well as analytic methods and functional omics in oral medicine Provides full-color, richly illustrated chapters that examine systems approaches to periodontal disease, salivary gland diseases, oral cancer, bone disease and autoimmune diseases Includes clinical case studies that illustrate examples of oral disease diagnostics and management, highlighting points of key importance for the reader Emphasizes biological synergisms across disciplines and their translational impact for clinicians, researchers, and students in the fields of dentistry, dermatology, gastroenterology, otolaryngology, oncology, and primary care

Computational Systems Pharmacology and Toxicology

Computational Systems Pharmacology and Toxicology
A Book

by Rudy J Richardson,Dale E Johnson

  • Publisher : Royal Society of Chemistry
  • Release : 2017-03-01
  • Pages : 332
  • ISBN : 1782623736
  • Language : En, Es, Fr & De
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The network approaches of systems pharmacology and toxicology serve as early predictors of the most relevant screening approach to pursue both in drug discovery and development and ecotoxicological assessments. Computational approaches have the potential to improve toxicological experimental design, enable more rapid drug efficacy and safety testing and also reduce the number of animals used in experimentation. Rapid advances in availability of computing technology hold tremendous promise for advancing applied and basic science and increasing the efficiency of risk assessment. This book provides an understanding of the basic principles of computational toxicology and the current methods of predictive toxicology using chemical structures, toxicity-related databases, in silico chemical-protein docking, and biological pathway tools. The book begins with an introduction to systems pharmacology and toxicology and computational tools followed by a section exploring modelling adverse outcomes and events. The second part of the book covers the discovery of protein targets and the characterisation of toxicant-protein interactions. Final chapters include case studies and additionally discuss interactions between phytochemicals and Western therapeutics. This book will be useful for scientists involved in environmental research and risk assessment. It will be a valuable resource for postgraduate students and researchers wishing to learn about key methods used in studying biological targets both from a toxicity and pharmacological activity standpoint.

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases

Quantitative Pharmacology and Individualized Therapy Strategies in Development of Therapeutic Proteins for Immune-Mediated Inflammatory Diseases
A Book

by Honghui Zhou,Diane R. Mould

  • Publisher : Wiley
  • Release : 2019-03-19
  • Pages : 496
  • ISBN : 111928919X
  • Language : En, Es, Fr & De
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Thorough Overview Identifies and Addresses Critical Gaps in the Treatment of Several Chronic Diseases With increasing numbers of patients suffering from Immune-Mediated Inflammatory Diseases (IMIDs), and with the increasing reliance on biopharmaceuticals to treat them, it is imperative that researchers and medical practitioners have a thorough understanding of the absorption, distribution, metabolism and excretion (ADME) of therapeutic proteins as well as translational pharmacokinetic/pharmacodynamic (PK/PD) modeling for them. This comprehensive volume answers that need to be addressed. Featuring eighteen chapters from world-renowned experts and opinion leaders in pharmacology, translational medicine and immunology, editors Honghui Zhou and Diane Mould have curated a much-needed collection of research on the advanced applications of pharmacometrics and systems pharmacology to the development of biotherapeutics and individualized treatment strategies for the treatment of IMIDs. Authors discuss the pathophysiology of autoimmune diseases in addition to both theoretical and practical aspects of quantitative pharmacology for therapeutic proteins, current translational medicine research methodologies and novel thinking in treatment paradigm strategies for IMIDs. Other notable features include: • Contributions from well-known authors representing leading academic research centers, specialized contract research organizations and pharmaceutical industries whose pipelines include therapeutic proteins • Chapters on a wide range of topics (e.g., pathophysiology of autoimmune diseases, biomarkers in ulcerative colitis, model-based meta-analysis use in the development of therapeutic proteins) • Case studies of applying quantitative pharmacology approaches to guiding therapeutic protein drug development in IMIDs such as psoriasis, inflammatory bowel disease, multiple sclerosis and lupus Zhou and Mould’s timely contribution to the critical study of biopharmaceuticals is a valuable resource for any academic and industry researcher working in pharmacokinetics, pharmacology, biochemistry, or biotechnology as well as the many clinicians seeking the safest and most effective treatments for patients dealing with chronic immune disorders.

Medical Empathy, Pharmacological Systems, and Treatment Strategies in Integrative Cardiovascular Chinese Medicine

Medical Empathy, Pharmacological Systems, and Treatment Strategies in Integrative Cardiovascular Chinese Medicine
Volume 2

by Anika Niambi Al-Shura

  • Publisher : Academic Press
  • Release : 2019-10-18
  • Pages : 196
  • ISBN : 0128175753
  • Language : En, Es, Fr & De
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Medical Empathy, Pharmacological Systems, and Treatment Strategies in Integrative Cardiovascular Chinese Medicine, volume two in the Integrative Cardiovascular Chinese Medicine series, presents sections on holism and humanity in medicine, considering the patient, medical empathy in prescribing, modifying and weaning, an overview of pharmacologic systems, an overview of pharmacology sciences and the cardiovascular drug classes and types as revealed from perspectives of Chinese and Western medicine, including descriptions of pharmaceutical drugs from China and the United States, with current pictures and inpatient directions. Finally, principles and treatments according to disease stages for each cardiovascular disease within the scope of integrative medicine is outlined. This important reference will aid cardiovascular researchers in the study of integrative Chinese and Western medicine and provide a clear, structured base to guide clinical practice and encourage collaboration between Chinese and Western medicine practitioners Integrates Western and Chinese Medicine for a realistic and complete scope of cardiology treatment, establishing the basis for standardization and rationale of inclusion of Traditional Chinese Medicine in cardiology Identifies and inspires ideas where future research can develop and strengthen Contains a breakdown comparison of herb and drug formula constituents on the pharmacokinetic and dynamic level Includes personalized medicine explaining the human genetics associated with the use of medicines and the advantages/disadvantages of herbs and/or drugs within treatment

Systems Medicine

Systems Medicine
Integrative, Qualitative and Computational Approaches

by Anonim

  • Publisher : Academic Press
  • Release : 2020-08-24
  • Pages : 1589
  • ISBN : 0128160780
  • Language : En, Es, Fr & De
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Technological advances in generated molecular and cell biological data are transforming biomedical research. Sequencing, multi-omics and imaging technologies are likely to have deep impact on the future of medical practice. In parallel to technological developments, methodologies to gather, integrate, visualize and analyze heterogeneous and large-scale data sets are needed to develop new approaches for diagnosis, prognosis and therapy. Systems Medicine: Integrative, Qualitative and Computational Approaches is an innovative, interdisciplinary and integrative approach that extends the concept of systems biology and the unprecedented insights that computational methods and mathematical modeling offer of the interactions and network behavior of complex biological systems, to novel clinically relevant applications for the design of more successful prognostic, diagnostic and therapeutic approaches. This 3 volume work features 132 entries from renowned experts in the fields and covers the tools, methods, algorithms and data analysis workflows used for integrating and analyzing multi-dimensional data routinely generated in clinical settings with the aim of providing medical practitioners with robust clinical decision support systems. Importantly the work delves into the applications of systems medicine in areas such as tumor systems biology, metabolic and cardiovascular diseases as well as immunology and infectious diseases amongst others. This is a fundamental resource for biomedical students and researchers as well as medical practitioners who need to need to adopt advances in computational tools and methods into the clinical practice. Encyclopedic coverage: ‘one-stop’ resource for access to information written by world-leading scholars in the field of Systems Biology and Systems Medicine, with easy cross-referencing of related articles to promote understanding and further research Authoritative: the whole work is authored and edited by recognized experts in the field, with a range of different expertise, ensuring a high quality standard Digitally innovative: Hyperlinked references and further readings, cross-references and diagrams/images will allow readers to easily navigate a wealth of information

An Introduction to Computational Systems Biology

An Introduction to Computational Systems Biology
Systems-Level Modelling of Cellular Networks

by Karthik Raman

  • Publisher : CRC Press
  • Release : 2021-05-30
  • Pages : 358
  • ISBN : 0429944527
  • Language : En, Es, Fr & De
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This book delivers a comprehensive and insightful account of applying mathematical modelling approaches to very large biological systems and networks—a fundamental aspect of computational systems biology. The book covers key modelling paradigms in detail, while at the same time retaining a simplicity that will appeal to those from less quantitative fields. Key Features: A hands-on approach to modelling Covers a broad spectrum of modelling, from static networks to dynamic models and constraint-based models Thoughtful exercises to test and enable understanding of concepts State-of-the-art chapters on exciting new developments, like community modelling and biological circuit design Emphasis on coding and software tools for systems biology Companion website featuring lecture videos, figure slides, codes, supplementary exercises, further reading, and appendices: https://ramanlab.github.io/SysBioBook/ An Introduction to Computational Systems Biology: Systems-Level Modelling of Cellular Networks is highly multi-disciplinary and will appeal to biologists, engineers, computer scientists, mathematicians and others.

Artificial Intelligence for Translational Pharmacology

Artificial Intelligence for Translational Pharmacology
A Book

by Zhi-Liang Ji,Lixia Yao,Kartick Chandra Pramanik,Zhaohui John Cai

  • Publisher : Frontiers Media SA
  • Release : 2020-07-28
  • Pages : 129
  • ISBN : 288963888X
  • Language : En, Es, Fr & De
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Antibody-Drug Conjugates

Antibody-Drug Conjugates
Fundamentals, Drug Development, and Clinical Outcomes to Target Cancer

by Kenneth J. Olivier, Jr.,Sara A. Hurvitz

  • Publisher : John Wiley & Sons
  • Release : 2016-11-14
  • Pages : 560
  • ISBN : 1119060842
  • Language : En, Es, Fr & De
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Providing practical and proven solutions for antibody-drug conjugate (ADC) drug discovery success in oncology, this book helps readers improve the drug safety and therapeutic efficacy of ADCs to kill targeted tumor cells. • Discusses the basics, drug delivery strategies, pharmacology and toxicology, and regulatory approval strategies • Covers the conduct and design of oncology clinical trials and the use of ADCs for tumor imaging • Includes case studies of ADCs in oncology drug development • Features contributions from highly-regarded experts on the frontlines of ADC research and development

Concepts and Principles of Pharmacology

Concepts and Principles of Pharmacology
100 Years of the Handbook of Experimental Pharmacology

by James E. Barrett,Clive P. Page,Martin C. Michel

  • Publisher : Springer Nature
  • Release : 2019-12-24
  • Pages : 466
  • ISBN : 3030353621
  • Language : En, Es, Fr & De
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Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.

Quantitative Methods in System-Based Drug Discovery

Quantitative Methods in System-Based Drug Discovery
A Book

by Yuzhen Luo

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Modern pharmaceutical industries have faced significant challenges to deliver safe and effective medicines because of significant toxicity and severe side effects of discovered drugs. On the other hand, recent developments and advances in system-based pharmacology aim to address these challenges. In this chapter, we provide an overview of quantitative methods for system-based drug discovery. System-based drug discovery integrates chemical, molecular, and systematic information and applies this knowledge to the designing of small molecules with controlled toxicity and minimized side effects. First, we discuss current approaches for drug discovery and outline their advantages and disadvantages. Next, we introduce basic concepts of systems pharmacology with an emphasis on ligand-based drug discovery and target identification. This is followed by a discussion on structure-based drug design and statistical tools for pharmaceutical research. Finally, we provide an overview of future directions in systems pharmacology that will guide further developments.

Case Studies in Systems Biology

Case Studies in Systems Biology
A Book

by Pavel Kraikivski

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 3030677427
  • Language : En, Es, Fr & De
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Biological Control Systems and Disease Modelling

Biological Control Systems and Disease Modelling
A Book

by Babatunde Ogunnaike,David Bogle,Robert Parker,Julio R. Banga

  • Publisher : Frontiers Media SA
  • Release : 2021-06-04
  • Pages : 129
  • ISBN : 2889668517
  • Language : En, Es, Fr & De
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