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Recent Advances in Applications of Name Reactions in Multicomponent Reactions

Recent Advances in Applications of Name Reactions in Multicomponent Reactions
A Book

by Majid M. Heravi,Vahideh Zadsirjan

  • Publisher : Elsevier
  • Release : 2020-05-29
  • Pages : 438
  • ISBN : 0128196955
  • Language : En, Es, Fr & De
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Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described. Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des) Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs

Recent Advances in Applications of Name Reactions in Multicomponent Reactions

Recent Advances in Applications of Name Reactions in Multicomponent Reactions
A Book

by Majid M. Heravi,Vahideh Zadsirjan

  • Publisher : Elsevier
  • Release : 2020-06-19
  • Pages : 438
  • ISBN : 0128185848
  • Language : En, Es, Fr & De
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Recent Advances in Applications of Name Reactions in Multicomponent Reactions is an ideal reference for researchers and postgraduate students studying organic chemistry, as well as synthetic organic chemists working on the development of novel methodologies for the synthesis of various heterocyclic systems, especially drug design and discovery, in both academia and industry. The book reviews recent applications of name reactions in multicomponents for the synthesis of heterocycles and examines recent advances in applications of significant name reactions, such as Ugi and Passirini, Click, Knoevenagel, Michael, Diels-Alder, Aldol, Mannich, Heck, Huisgen, and Suzuki in MCRs. These reactions can be used in the synthesis of a wide variety of novel heterocycles with different sizes and heteroatoms, as well as in the total synthesis of natural products in order to decrease the number of synthetic steps. Since chiral inductions are necessary for most of these sequential name reactions, their asymmetric catalyzed reactions are also described. Includes the synthesis of many heterocycles, which is ideal for synthetic organic chemists engaged in the synthesis of heterocyclic systems Covers the recent advances of asymmetric synthesis of a wide range of heterocycles in satisfactory enantioselectivities (ees) or distereoselectivities (des) Reviews the synthesis of a wide variety of interesting heterocycles by using a combination of different and versatile name reactions via MCRs

Strategic Applications of Named Reactions in Organic Synthesis

Strategic Applications of Named Reactions in Organic Synthesis
A Book

by Laszlo Kurti,Barbara Czako

  • Publisher : Elsevier
  • Release : 2005-04-29
  • Pages : 864
  • ISBN : 0080575412
  • Language : En, Es, Fr & De
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Kurti and Czako have produced an indispensable tool for specialists and non-specialists in organic chemistry. This innovative reference work includes 250 organic reactions and their strategic use in the synthesis of complex natural and unnatural products. Reactions are thoroughly discussed in a convenient, two-page layout--using full color. Its comprehensive coverage, superb organization, quality of presentation, and wealth of references, make this a necessity for every organic chemist. * The first reference work on named reactions to present colored schemes for easier understanding * 250 frequently used named reactions are presented in a convenient two-page layout with numerous examples * An opening list of abbreviations includes both structures and chemical names * Contains more than 10,000 references grouped by seminal papers, reviews, modifications, and theoretical works * Appendices list reactions in order of discovery, group by contemporary usage, and provide additional study tools * Extensive index quickly locates information using words found in text and drawings

Multicomponent Reactions

Multicomponent Reactions
Concepts and Applications for Design and Synthesis

by Raquel P. Herrera,Eugenia Marqués-López

  • Publisher : John Wiley & Sons
  • Release : 2015-03-30
  • Pages : 528
  • ISBN : 111886400X
  • Language : En, Es, Fr & De
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Addressing a dynamic aspect of organic chemistry, this bookdescribes synthetic strategies and applications for multicomponentreactions – including key routes for synthesizing complexmolecules. • Illustrates the crucial role and theimportant utility of multicomponent reactions (MCRs) to organicsyntheses • Compiles novel and efficient syntheticmulticomponent procedures to give readers a complete picture ofthis class of organic reactions • Helps readers to design efficient andpractical transformations using multicomponent reactionstrategies • Describes reaction background,applications to synthesize complex molecules and drugs, andreaction mechanisms

Advances in Heterocyclic Chemistry

Advances in Heterocyclic Chemistry
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2020-04-24
  • Pages : 492
  • ISBN : 0128211725
  • Language : En, Es, Fr & De
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Advances in Heterocyclic Chemistry is the definitive series in the field - one of great importance to organic chemists, polymer chemists, and many biological scientists. Because biology and organic chemistry increasingly intersect, the associated nomenclature also is being used more frequently in explanations. Written by established authorities in the field from around the world, this comprehensive review combines descriptive synthetic chemistry and mechanistic insight to yield an understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds. Considered the definitive serial in the field of heterocyclic chemistry Serves as the go-to reference for organic chemists, polymer chemists and many biological scientists Provides the latest comprehensive reviews written by established authorities in the field Combines descriptive synthetic chemistry and mechanistic insight to enhance understanding of how chemistry drives the preparation and useful properties of heterocyclic compounds

Current Topics in Chirality

Current Topics in Chirality
From Chemistry to Biology

by Takashiro Akitsu

  • Publisher : BoD – Books on Demand
  • Release : 2021-09-01
  • Pages : 196
  • ISBN : 1839689536
  • Language : En, Es, Fr & De
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Chirality is a concept related not only to organic chemistry but also to each field of natural science. Awareness of hierarchy is important for universal and comprehensive understanding. As such, this book examines myriad subjects related to chirality in chemistry and interdisciplinary applications. In contrast to the previous book, this new book about chirality includes contributions from authors in many fields of natural science, providing a wider overview. The book’s focus is chirality and organic chemistry, including synthesis and reactions.

Handbook of Reagents for Organic Synthesis

Handbook of Reagents for Organic Synthesis
Reagents for Heteroarene Synthesis

by André B. Charette

  • Publisher : John Wiley & Sons
  • Release : 2017-06-26
  • Pages : 728
  • ISBN : 1119952298
  • Language : En, Es, Fr & De
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The Handbook is a compilation of 99 articles on diverse reagents and catalysts that describe the synthesis of heteroarenes, the building blocks of a wide range of chemicals used in pharma and chemical industries. Articles are selected from theï¿1⁄2e-EROS databaseï¿1⁄2and edited to make sure that it includes only the material relevant to the topic of the book and focus on the synthetic aspects. This makes the articles very focused on the needs of readers wanting information on specific syntheses of specific heteroarenes. In addition, the chemistry of each ï¿1⁄2parent heteroareneï¿1⁄2 is also included to ensure that the reader rapidly finds important information. The Handbook is a part of the Handbook of Reagents for Organic Chemistry series, aiming at collecting articles on a particular theme that individual researchers in academia or industry can use on a daily basis.

Advances in Organometallic Chemistry

Advances in Organometallic Chemistry
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2016-10-21
  • Pages : 298
  • ISBN : 0128050756
  • Language : En, Es, Fr & De
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Advances in Organometallic Chemistry contains authoritative review articles of worldwide known researchers on the field of organometallic chemistry, covering topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more. The book will benefit a wide range of researchers involved in organometallic chemistry, including synthetic protocols, mechanistic studies, and practical applications. Contains contributions from leading authorities in the field of organometallic chemistry Covers topics in organometallic synthesis, reactions, mechanisms, homogeneous catalysis, and more Informs and updates readers on all the latest developments in the field Carefully edited to provide easy-to-read material

Development of New Radical Cascades and Multi-Component Reactions

Development of New Radical Cascades and Multi-Component Reactions
Application to the Synthesis of Nitrogen-Containing Heterocycles

by Marie-Helene Larraufie

  • Publisher : Springer Science & Business Media
  • Release : 2013-12-16
  • Pages : 326
  • ISBN : 3319013246
  • Language : En, Es, Fr & De
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In this dissertation, Marie-Hélène Larraufie develops original radical and pallado-catalyzed methodologies to enable the synthesis of several classes of bioactive nitrogen-containing heterocycles. New radical cascades employing the N-acylcyanamide moiety offer straightforward routes to quinazolinones and guanidines, as well as new insights into the mechanism of homolytic aromatic substitutions. In parallel, Larraufie expands the scope of visible light photoredox catalysis to the ring opening of epoxides and aziridines, thus providing new sustainable alternatives for the generation of radicals. Furthermore, in a collaborative effort with the Catellani group, the author investigates dual palladium/norbornene catalysis. First, she develops a C-amination coupling variant of the Catellani reaction with unprotected amines which provides an expeditious route to phenanthridines. Then, she examines the influence of the chelating effect on Pd(IV) intermediates reactivity with the help of experimental studies and DFT calculations. The work in this thesis has resulted in numerous publications in high impact journals.The clarity and depth of the experimental section will be useful for students and researchers working in this field.

Multi-component Reactions in Molecular Diversity

Multi-component Reactions in Molecular Diversity
A Book

by Jean-Philippe Goddard,Max Malacria,Cyril Ollivier

  • Publisher : John Wiley & Sons
  • Release : 2020-01-09
  • Pages : 198
  • ISBN : 1786305119
  • Language : En, Es, Fr & De
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While very useful for studying syntheses of molecular diversity, multi-component reactions also offer rapid access to a variety of complex molecules that are relevant for biological applications. Multi-component Reactions in Molecular Diversity analyzes these reactions, whether they are realized by organometallic, ionic or even radical processes. It highlights popular methods based on monotype reactions (cascade, tandem, domino) and their efficiency and academic industrial domain are illustrated. This book also investigates the most efficient ways to prepare complex molecules. Multi-component reactions are in tune with the concepts of atom and steps economy, which are of prior importance in all the reported processes ? from the laboratory to the pilot scale. The essential criteria for green chemistry are also examined in the book in detail.

Applied Organic Chemistry

Applied Organic Chemistry
Reaction Mechanisms and Experimental Procedures in Medicinal Chemistry

by Surya K. De

  • Publisher : John Wiley & Sons
  • Release : 2021-01-26
  • Pages : 856
  • ISBN : 3527347852
  • Language : En, Es, Fr & De
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An indispensable guide for all synthetic chemists who want to learn about the most relevant reactions and reagents employed to synthesize important heterocycles and drugs! The synthesis of natural products, bioactive compounds, pharmaceuticals, and drugs is of fundamental interest in modern organic chemistry. New reagents and reaction methods towards these molecules are being constantly developed. By understanding the mechanisms involved and scope and limitations of each reaction applied, organic chemists can further improve existing reaction protocols and develop novel efficient synthetic routes towards frequently used drugs, such as Aspirin or Penicillin. Applied Organic Chemistry provides a summary of important (name) reactions and reagents applied in modern organic chemistry and drug synthesis. It covers rearrangement, condensation, olefination, metathesis, aromatic electrophilic substitutions, Pd-catalyzed C-C bond forming reactions, multi-component reactions, as well as oxidations and reductions. Each chapter is clearly structured, providing valuable information on reaction details, step-by-step mechanism, experimental procedures, applications, and (patent) references. By providing mechanistic information and representative experimental procedures, this book is an indispensable guide for researchers and professionals in organic chemistry, natural product synthesis, pharmaceutical, and medicinal chemistry, as well as post-graduates preparing themselves for a job in the pharmaceutical industry. Hot Topic: Reviews important classes of organic reactions (incl. name reactions) and reagents in medicinal chemistry. Useful: Provides information on reaction details, common reagents, and functional group transformations used to synthesize natural products, bioactive compounds, drugs, and pharmaceuticals, e.g. Aspirin, Penicillin. Unique: For every reaction the mechanism is explained step by step, and representative experimental procedures are given, unlike most books in this area. User-friendly: Chapters are clearly structured making it easy for the reader to compare different reactions. Applied Organic Chemistry is an indispensable guide for researchers and professionals in organic chemistry, natural product synthesis, pharmaceutical, and medicinal chemistry, as well as post-graduates preparing themselves for a job in the pharmaceutical industry.

Name Reactions in Heterocyclic Chemistry

Name Reactions in Heterocyclic Chemistry
A Book

by Jie Jack Li

  • Publisher : John Wiley & Sons
  • Release : 2004-12-27
  • Pages : 592
  • ISBN : 0471704148
  • Language : En, Es, Fr & De
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Covers important name reactions relevant to heterocyclic chemistry The field of heterocyclic chemistry has long presented a specialchallenge for chemists. Because of the enormous amount and varietyof information, it is often a difficult topic to cover forundergraduate and graduate chemistry students, even in simplifiedform. Yet the chemistry of heterocyclic compounds and methods fortheir synthesis form the bedrock of modern medicinal chemical andpharmaceutical research. Thus there is a great need for highquality, up-to-date, and authoritative books on heterocyclicsynthesis helpful to both the professional research chemist as wellas the advanced student. Name Reactions in Heterocyclic Chemistry provides aone-stop repository for this important field of organic chemistry.The primary topics include three- and four-membered heterocycles,five-membered heterocycles including indoles, furans, thiophenes,and oxazoles, six-membered heterocycles including quinolines,isoquinolines, and pyrimidines, and other heterocycles. Each name reaction is summarized in seven sections: Description Historical perspective Mechanism Variations and improvements Synthetic utility Experimental References Authored by a team of world-renowned contributors - some of whomhave discovered the very reactions they describe - NameReactions in Heterocyclic Chemistry represents astate-of-the-art resource for students and researchers alike.

Multicomponent Reactions

Multicomponent Reactions
A Book

by Jieping Zhu,Hugues Bienaymé

  • Publisher : John Wiley & Sons
  • Release : 2006-03-06
  • Pages : 484
  • ISBN : 3527604243
  • Language : En, Es, Fr & De
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In the very first book on this hot topic, the expert editors andauthors present a comprehensive overview of these elegantreactions. From the contents: Organoboron compounds Free-radical mediated multicomponent coupling reactions Applications in drug discovery Metal catalyzed reactions Total synthesis of natural products Asymmetric isocyanide-based reactions The Biginelli reaction Asymmetric isocyanide-based reactions The Domino-Knoevenagel-Hetero-Diels-Alder Reaction and relatedtransformations Catalytic asymmetric reactions Algorithm based methods for discovering novel reactions Post-condensation modifications of the Passerini and Ugireactions An essential reference for organic and catalytic chemists, andthose working in organometallics both in academia and industry.

Isocyanide Chemistry

Isocyanide Chemistry
Applications in Synthesis and Material Science

by V. Nenajdenko

  • Publisher : John Wiley & Sons
  • Release : 2012-06-04
  • Pages : 624
  • ISBN : 3527652558
  • Language : En, Es, Fr & De
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The efficacy of isocyanide reactions in the synthesis of natural or naturallike products has resulted in a renaissance of isocyanide chemistry. Now isocyanides are widely used in different branches of organic, inorganic, coordination, combinatorial and medicinal chemistry. This invaluable reference is the only book to cover the topic in such depth, presenting all aspects of synthetic isonitrile chemistry. The highly experienced and internationally renowned editor has brought together an equally distinguished team of authors who cover multicomponent reactions, isonitriles in total synthesis, isonitriles in polymer chemistry and much more.

Handbook of Biochemistry and Molecular Biology

Handbook of Biochemistry and Molecular Biology
A Book

by Roger L. Lundblad,Fiona Macdonald

  • Publisher : CRC Press
  • Release : 2018-06-14
  • Pages : 1001
  • ISBN : 1315314436
  • Language : En, Es, Fr & De
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Edited by renowned protein scientist and bestselling author Roger L. Lundblad, with the assistance of Fiona M. Macdonald of CRC Press, this fifth edition of the Handbook of Biochemistry and Molecular Biology gathers a wealth of information not easily obtained, including information not found on the web. Presented in an organized, concise, and simple-to-use format, this popular reference allows quick access to the most frequently used data. Covering a wide range of topics, from classical biochemistry to proteomics and genomics, it also details the properties of commonly used biochemicals, laboratory solvents, and reagents. An entirely new section on Chemical Biology and Drug Design gathers data on amino acid antagonists, click chemistry, plus glossaries for computational drug design and medicinal chemistry. Each table is exhaustively referenced, giving the user a quick entry point into the primary literature. New tables for this edition: Chromatographic methods and solvents Protein spectroscopy Partial volumes of amino acids Matrix Metalloproteinases Gene Editing Click Chemistry

Biochemistry and Molecular Biology Compendium

Biochemistry and Molecular Biology Compendium
A Book

by Roger L. Lundblad

  • Publisher : CRC Press
  • Release : 2007-06-08
  • Pages : 424
  • ISBN : 9781420043488
  • Language : En, Es, Fr & De
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While biomedical investigation has greatly advanced, investigators have lost touch with and inadvertently corrupted significant nomenclature at the foundation of their science. Nowadays, one has to be an insider to even understand the titles of journals, as modern biochemists have a tendency to invent new terms to describe old phenomena and apply a

Science of Synthesis: Multicomponent Reactions Vol. 1

Science of Synthesis: Multicomponent Reactions Vol. 1
General Discussion and Reactions Involving a Carbonyl Compound as Electrophilic Component

by Anonim

  • Publisher : Georg Thieme Verlag
  • Release : 2014-05-14
  • Pages : 652
  • ISBN : 313176581X
  • Language : En, Es, Fr & De
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The two volumes "Science of Synthesis: Multicomponent Reactions" critically review the state of the art of domino, sequential, and consecutive multicomponent reactions in what is a highly dynamic field. They serve as the basis for practical application to reach the goals of diversity-oriented synthesis, reaction design, and novel synthetic concepts. As is typical for the Science of Synthesis series, the reference work on multicomponent reactions presents the best synthetic methods as judged by experts in the field and includes typical and general experimental procedures. The volume "Reactions Involving a Carbonyl Compound as Electrophilic Component" covers the following topics: - Biginelli Reaction - Strecker Reaction - Hantzsch Pyridine Synthesis - Mannich Reaction - Petasis Reaction - Willgerodt-Kindler Reaction - Kabachnik-Fields Reaction - Passerini Reaction - Ugi Reaction - Gewald Reaction

Multicomponent Reactions

Multicomponent Reactions
Synthesis of Bioactive Heterocycles

by K.L. Ameta, Ph.D.,Anshu Dandia

  • Publisher : CRC Press
  • Release : 2017-09-20
  • Pages : 394
  • ISBN : 1498734197
  • Language : En, Es, Fr & De
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This timely book provides a succinct summary of methods for the synthesis of bioactive heterocycles using a multicomponent reaction (MCR) approach. The majority of pharmaceuticals and biologically active agrochemicals are heterocycles while countless additives and modifiers used in industrial applications are heterocyclic in nature. With the recent introduction of high-throughput biological evaluation, the importance of MCRs for drug discovery has been recognized and considerable efforts have been focused especially on the design and development of multi-component procedures for the generation of various bioactive heterocycles due to their significant therapeutic potential.

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience

Domino and Intramolecular Rearrangement Reactions as Advanced Synthetic Methods in Glycoscience
A Book

by Zbigniew J. Witczak,Roman Bielski

  • Publisher : John Wiley & Sons
  • Release : 2016-02-23
  • Pages : 368
  • ISBN : 1119044200
  • Language : En, Es, Fr & De
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The book consists of a brief introduction, a foreward provided by professor Danishefsky of Columbia University, and about 14 – 16 chapters, each written by one or two eminent scholars/authors describing their recent research in the area of either domino reactions or intramolecular rearrangements in carbohydrate chemistry. Three or four chapters will be reviews. The domino (cascade, tandem) reactions are always intramolecular. They are usually very fast, clean and offer highly complex structures in a one pot process. Intramolecular rearrangements offer very similar advantages and often lead to highly complex products as well. Although many recently isolated carbohydrates fulfill various sophisticated functions, their structures are often very complex. The editors cover the broadest scope of novel methodologies possible. All the synthetic and application aspects of domino/cascade reactions are explored in this book. A second theme that will be covered is intramolecular rearrangement, which is also fast, stereoselective, and often constitutes one or more steps of domino /cascade process. Selected examples of intramolecular rearrangements are presented. Together, both processes offer an elegant and convenient approach to the synthesis of many complex molecules, which are normally difficult to synthesize via alternative routes. It appears that domino and intramolecular rearrangements are ideally suited to synthesize certain specific modified monosaccharides. What is particularly important is that both processes are intermolecular and almost always yield products with very well-defined stereochemistry. This high definition is absolutely crucial when synthesizing advanced, modified mono and oligosaccharides. The choice of contributors reflects an emphasis on both therapeutic and pharmacological aspects of carbohydrate chemistry.

The Complete Book on Biodegradable Plastics and Polymers (Recent Developments, Properties, Analysis, Materials & Processes)

The Complete Book on Biodegradable Plastics and Polymers (Recent Developments, Properties, Analysis, Materials & Processes)
A Book

by NIIR Board of Consultants & Engineers

  • Publisher : ASIA PACIFIC BUSINESS PRESS Inc.
  • Release : 2006-10-01
  • Pages : 672
  • ISBN : 8178330350
  • Language : En, Es, Fr & De
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Biodegradable plastics made with plant based materials have been available for many years. The term biodegradable means that a substance is able to be broken down into simpler substances by the activities of living organisms, and therefore is unlikely to persist in the environment. There are many different standards used to measure biodegradability, with each country having its own. The requirements range from 90 per cent to 60 per cent decomposition of the product within 60 to 180 days of being placed in a standard composting environment. They may be composed of either bio plastics, which are plastics whose components are derived from renewable raw materials, or petroleum based plastics which contain additives. Biodegradability of plastics is dependent on the chemical structure of the material and on constitution of the final product, not just on the raw materials used for its production. Polyesters play a predominant role as biodegradable plastics due to their potentially hydrolysable ester bonds. Bio based polymers are divided into three categories based on their origin and production; polymer directly extracted from biomass, polymers produced by classical chemical synthesis using renewable biomass monomer and polymers produces by microorganisms or genetically modified bacteria. In response to public concern about the effects of plastics on the environment and in particular the damaging effects of sea litter on animals and birds, legislation is being enacted or is pending in many countries to ban non degradable packing, finishing nets etc. This book basically deals with biodegradable plastics developments and environmental impacts, hydro biodegradable and photo biodegradable, starch synthetic aliphatic polyester blends, difference between standards for biodegradation, polybutylene succinate (pbs) and polybutylene, recent developments in the biopolymer industry, recent advances in synthesis of biopolymers by traditional methodologies, polymers, environmentally degradable synthetic biodegradable polymers as medical devices, polymers produced from classical chemical synthesis from bio based monomers, potential bio based packaging materials, conventional packaging materials, environmental impact of bio based materials: biodegradability and compostability, etc. Environmentally acceptable degradable polymers have been defined as polymers that degrade in the environment by several mechanisms and culminate in complete biodegradation so that no residue remains in the environment. The present book gives thorough information to biodegradable plastic and polymers. This is an excellent book for scientists engineers, students and industrial researchers in the field of bio based materials.