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Recent Advances in iPSC Disease Modeling, Volume 1

Recent Advances in iPSC Disease Modeling, Volume 1
A Book

by ALEXANDER BIRBRAIR

  • Publisher : Academic Press
  • Release : 2020-07-16
  • Pages : 320
  • ISBN : 0128232692
  • Language : En, Es, Fr & De
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Recent Advances in iPSC Disease Modeling, Volume 1 addresses how induced pluripotent stem cells can be used to model various diseases. Somatic cells are reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. This volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. Further insights into these mechanisms will have important implications for our understanding of disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues, and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics Covers the following diseases: severe congenital neutropenia, sickle cell and Diamond-Blackfan anemias, muscular dystrophies, Bernard-Soulier syndrome, familial hypercholesterolemia type II A, Werner syndrome, lysosomal storage diseases, and more Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several human diseases

Current Progress in iPSC Disease Modeling, Volume 14

Current Progress in iPSC Disease Modeling, Volume 14
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-11-15
  • Pages : 300
  • ISBN : 9780323857659
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC Disease Modeling, Volume 14 addresses the advances in research of how induced pluripotent stem cells are used for the creation of new tissues and organs. The creation of iPSC technology allowed the development of disease-specific human pluripotent stem cells. These cells allow researchers to study questions impossible before for some human diseases. This volume addresses using iPSCs for vascular tissue engineering, bioprinting, derived lung organoids for pulmonary disorders, skeletal muscle engineering, human kidney organoids and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers the advances in research of how induced pluripotent stem cells are used to create new tissues/organs Contributed by world-renown experts in the field

Recent Advances in iPSC-Derived Cell Types, Volume 4

Recent Advances in iPSC-Derived Cell Types, Volume 4
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-02-21
  • Pages : 282
  • ISBN : 0128224541
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC-derived Cell Types, Volume 4 addresses how different cell types can be derived from induced pluripotent stem cells. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to form different cell types which can be used in cell therapy as well as to model several diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different pathologies. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cellular populations, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs to derive different cell types, such as: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, βpancreatic cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine and therapeutics. Covers the following cell types derived from iPSCs: erythroid cells, mucosal-associated invariant T cells, megakaryocytes, cerebral cortical neurons, inner ear cell types, airway epithelial cells, male germ cells, trophoblasts, cardiomyocytes, βpancreatic cells, and more. Contributions from stem cell leaders around the world

Recent Advances in iPSC Technology, Volume 5

Recent Advances in iPSC Technology, Volume 5
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-03-31
  • Pages : 334
  • ISBN : 012822326X
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSC Technology, Volume 5 addresses the progress in induced pluripotent stem cells (iPSCs) technologies. Somatic cells can be reprogrammed into iPSCs by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes different technologies and strategies to use iPSCs for biological and clinical benefit. In recent years, remarkable progress has been made in the obtention of iPSCs and their differentiation into several cell types, tissues, and organs using state-of-the-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several disorders. This volume will cover hot topics in the iPSC field, such as iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the noncoding genome, modeling of blood–brain barrier with iPSCs, mathematical modeling of iPSCs, iPSCs to study human brain evolution, selfrenewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology, regenerative medicine, and therapeutics. Covers the following topics: iPSCs for modeling the cardiovascular toxicities of anticancer therapies, iPSC differentiation through the lens of the non-coding genome, modeling of blood-brain barrier with iPSCs, mathematical modelling of iPSCs, iPSCs to study human brain evolution, self-renewal in iPSCs, differences and similarities between iPSCs and embryonic stem cells, and more. Contributed by world-renown experts in the field

Methods in iPSC Technology

Methods in iPSC Technology
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-06-15
  • Pages : 300
  • ISBN : 9780128238820
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs as Cell Therapy for Disease Treatment, Volume 8 addresses how important induced pluripotent stems cells are and how can they can help treat certain diseases. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how induced pluripotent stem cells are being used for treatment of different disorders, such as liver disease, type-1 diabetes, Parkinson's disease, macular degeneration of the retina and much more. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers spinal cord injuries, type-1 diabetes, liver disease, Parkinson's disease, graft vs. host disease, and much more Contributed by world-renown experts in the field

Recent Advances in iPSCs for Therapy, Volume 3

Recent Advances in iPSCs for Therapy, Volume 3
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-02-15
  • Pages : 368
  • ISBN : 0128222298
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson's disease, Huntington's disease, ischemic stroke, Alzheimer's disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. . Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics . Covers the possible use of iPSCs for hair loss disorders, Parkinson's disease, Huntington's disease, ischemic stroke, Alzheimer's disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more . Contributions from stem cell leaders around the world

Medical Applications of iPS Cells

Medical Applications of iPS Cells
Innovation in Medical Sciences

by Haruhisa Inoue,Yukio Nakamura

  • Publisher : Springer
  • Release : 2019-04-01
  • Pages : 190
  • ISBN : 9811336725
  • Language : En, Es, Fr & De
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This volume highlights recent advances using iPS cells in disease modeling and medical applications along with new technologies that enhance the power of iPS cells. While the discovery of iPS cells has provided excellent opportunities for developing models of human diseases, platforms for drug discovery and cell therapies, iPS cell technology still faces many challenges. Presenting the latest advances in this rapidly evolving research area, this book is intended to widen the community of researchers and clinicians interested in the exciting field of iPS cells.

Lung Stem Cells in the Epithelium and Vasculature

Lung Stem Cells in the Epithelium and Vasculature
A Book

by Amy Firth,Jason X.-J. Yuan

  • Publisher : Springer
  • Release : 2015-05-23
  • Pages : 345
  • ISBN : 3319162322
  • Language : En, Es, Fr & De
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This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.

Programmed Cells from Basic Neuroscience to Therapy

Programmed Cells from Basic Neuroscience to Therapy
A Book

by Fred H. Gage,Yves Christen

  • Publisher : Springer Science & Business Media
  • Release : 2013-05-13
  • Pages : 130
  • ISBN : 3642366481
  • Language : En, Es, Fr & De
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The recent advances in Programming Somatic Cell (PSC) including induced Pluripotent Stem Cells (iPS) and Induced Neuronal phenotypes (iN), has changed our experimental landscape and opened new possibilities. The advances in PSC have provided an important tool for the study of human neuronal function as well as neurodegenerative and neurodevelopmental diseases in live human neurons in a controlled environment. For example, reprogramming cells from patients with neurological diseases allows the study of molecular pathways particular to specific subtypes of neurons such as dopaminergic neurons in Parkinson’s Disease, Motor neurons for Amyolateral Sclerosis or myelin for Multiple Sclerosis. Detecting disease-specific molecular signatures in live human brain cells, opens possibilities for early intervention therapies and new diagnostic tools. Importantly, once the neurological neural phenotype is detected in vitro, the so-called “disease-in-a-dish” approach allows for the screening of drugs that can ameliorate the disease-specific phenotype. New therapeutic drugs could either act on generalized pathways in all patients or be patient-specific and used in a personalized medicine approach. However, there are a number of pressing issues that need to be addressed and resolved before PSC technology can be extensively used for clinically relevant modeling of neurological diseases. Among these issues are the variability in PSC generation methods, variability between individuals, epigenetic/genetic instability and the ability to obtain disease-relevant subtypes of neurons . Current protocols for differentiating PSC into specific subtypes of neurons are under development, but more and better protocols are needed. Understanding the molecular pathways involved in human neural differentiation will facilitate the development of methods and tools to enrich and monitor the generation of specific subtypes of neurons that would be more relevant in modeling different neurological diseases.

iPSCs for Modeling Central Nervous System Disorders, Volume 6

iPSCs for Modeling Central Nervous System Disorders, Volume 6
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-05-12
  • Pages : 352
  • ISBN : 032385642X
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. iPSCs for Modeling Central Nervous System Disorders, Volume 6 addresses how induced pluripotent stem cells can be used to model various CNS disorders. Somatic cells can be reprogrammed into Induced pluripotent stem cells by the expression of specific transcription factors. These cells are transforming biomedical research in the last 15 years. The volume teaches readers about current advances in the field. This book describes the use of induced pluripotent stem cells to model several CNS diseases in vitro, enabling us to study the cellular and molecular mechanisms involved in different CNS pathologies. Further insights into these mechanisms will have important implications for our understanding of CNS disease appearance, development, and progression. In recent years, remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. These advantages facilitated identification of key targets and definition of the molecular basis of several CNS disorders. This volume will cover what we know so far about the use of iPSCs to model different CNS disorders, such as: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. The volume is written for researchers and scientists interested in stem cell therapy, cell biology, regenerative medicine, and neuroscience; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of induced pluripotent stem cell technology and its application in neurobiology. Covers the following CNS diseases: Alzheimer’s disease, Autism, Amyotrophic Lateral Sclerosis, Schizophrenia, Fragile X Syndrome, Spinal Muscular Atrophy, Rett Syndrome, Angelman syndrome, Parkinson`s Disease, Leber Hereditary Optic Neuropathy, Anorexia Nervosa, and more. Contains description of cutting-edge research on the development of disease-specific human pluripotent stem cells. These cells allow us to study cellular and molecular processes involved in several CNS human diseases.

Recent Advances in Parkinson's Disease

Recent Advances in Parkinson's Disease
A Book

by Angela Cenci-Nilsson

  • Publisher : Academic Press
  • Release : 2020-03
  • Pages : 358
  • ISBN : 0444642609
  • Language : En, Es, Fr & De
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Recent Advances in Parkinson ́s Disease Research, Volume 252, represents a follow-up on two previous volumes presented in the Progress in Brain Research series, Volumes 193 and 193, both published in 2010. It contains a collection of overview articles written by leading researchers in Parkinson's, discussing the most important advances made in basic, translational and clinical research. Topics of note in this new release include What can we learn from iPS cell models of PD, What can we learn from animal models of PD?, Molecular basis of selective neuronal vulnerability in PD, Role of innate and adaptive immunity in Parkinson ́s disease, and much more.

Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases

Nontargeted Metabolite Profiling of Induced Pluripotent Stem Cells (iPSCs) Derived Neural Cells: Insights Into Mechanisms of Brain Diseases
A Book

by Šárka Lehtonen

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Since the discovery that introduction of four specific genes encoding transcription factors convert mature human somatic cells into induced pluripotent stem cells (iPSCs), there has been an enormous increase in the applications of iPSC technologies to medical sciences, especially in modeling human diseases. In this review, we summarize recent advances in applying human iPSC reprogramming to generate patient-specific neural subtypes in order to reveal molecular pathways affected in various neurodegenerative diseases. Metabolites provide a functional readout of various cellular states enabling identification of biomarker candidates for early diagnosis, segregation of patient cohorts, and to follow-up disease progression or disease responses to novel therapies. With emerging technologies, that is, mass spectrometry and nuclear magnetic resonance applications to metabolomics and various software solutions of bioinformatics, it has become possible to measure thousands of metabolites simultaneously. These fascinating new techniques provide a powerful tool for setting scientific hypotheses and linking cellular pathways to biological mechanism. This review focuses on mass spectrometry-based metabolomics as a tool for iPSC research.

Stem Cell Genetics for Biomedical Research

Stem Cell Genetics for Biomedical Research
Past, Present, and Future

by Raul Delgado-Morales

  • Publisher : Springer
  • Release : 2018-06-27
  • Pages : 426
  • ISBN : 331990695X
  • Language : En, Es, Fr & De
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This book looks at where stem cell technology is presently and how it is instrumental in advancing the field of disease modeling and cell transplantation. By focusing on major human disorders such as Alzheimer’s disease, cancer, and heart disorders, the book summarizes the major findings in the field of human stem cells and dissect the current limitations on our understanding of stem cells biology. The chapters focus on the genetics, genomics, epigenetics and physiology of stem cells models, together with technological advances on molecular biology such as CRISPR/Cas9 or epigenetic editing, that will be instrumental in the future of human disease modeling and treatment. In base of the limitations of current disease models and in front of the unmet necessity of finding therapeutical interventions for human disorders, the availability of stem cell technology has opened new doors for several fields. The unlimited self-renewal capacity and more extensive differentiation potential of stem cells offers a theoretically inexhaustible and replenishable source of any cell subtype. Since Professor Shinya Yamanaka described it, 10 years ago in his seminal paper, that somatic cells could be reprogrammed to inducible stem cells (iPSC) just by expressing four transcription factors, the field of has exploded, especially its applications in biomedical research.

Current Progress in iPSC-derived Cell Types

Current Progress in iPSC-derived Cell Types
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-06-30
  • Pages : 336
  • ISBN : 0128238852
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Current Progress in iPSC-derived Cell Types, Volume 10 addresses how induced pluripotent stem cells can be differentiated into different cell types. Somatic cells can be reprogrammed into induced pluripotent stem cells by the expression of specific transcription factors. These cells have been transforming biomedical research over the last 15 years. This volume will address the advances in research of how research of induced pluripotent stem cells can be reprogrammed to develop new treatment technologies in regenerative medicine. The volume is written for researchers and scientists in stem cell therapy, cell biology, regenerative medicine and organ transplantation; and is contributed by world-renowned authors in the field. Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine and therapeutics Covers iPSCs derived cardiomyocytes, skeletal muscles, brown adipocytes, airway epithelial cells, and much more Contributed by world-renown experts in the field

Recent Advances in iPSCs for Therapy, Volume 3

Recent Advances in iPSCs for Therapy, Volume 3
A Book

by Alexander Birbrair

  • Publisher : Academic Press
  • Release : 2021-01-30
  • Pages : 368
  • ISBN : 032385186X
  • Language : En, Es, Fr & De
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The series Advances in Stem Cell Biology is a timely and expansive collection of comprehensive information and new discoveries in the field of stem cell biology. Recent Advances in iPSCs for Therapy, Volume 3 addresses the use of induced pluripotent stem cells for therapy of several disorders. The volume teaches the reader about the biology of induced pluripotent stem cells and their possible use as cell therapy. Remarkable progress has been made in the obtention of induced pluripotent stem cells and their differentiation into several cell types, tissues and organs using state-of-art techniques. This volume will cover what we know so far about the use of iPSCs for therapy of multiple diseases, such as: hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more. The volume is written for researchers and scientists interested in cell therapy, stem cell biology, regenerative medicine, and organ transplantation and is contributed by world-renowned authors in the field. • Provides overview of the fast-moving field of stem cell biology and function, regenerative medicine, and therapeutics • Covers the possible use of iPSCs for hair loss disorders, Parkinson’s disease, Huntington’s disease, ischemic stroke, Alzheimer’s disease, Glaucoma, Optic Neuropathy, Age-Related Macular Degeneration, Type 1 Diabetes, Heart Failure, liver diseases, infertility, Autoimmune Diseases, and more • Contributions from stem cell leaders around the world

Brain Organoids: Modeling in Neuroscience

Brain Organoids: Modeling in Neuroscience
A Book

by Cristina Cereda,Alysson Renato Muotri,Anna Maria Di Giulio

  • Publisher : Frontiers Media SA
  • Release : 2020-12-18
  • Pages : 329
  • ISBN : 2889662640
  • Language : En, Es, Fr & De
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Genome-wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells

Genome-wide Approaches for Understanding Disease Mechanisms in Human IPS Derived Cells
A Book

by Valerie Sapp

  • Publisher : Unknown Publisher
  • Release : 2020
  • Pages : 130
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Human iPSCs derived cells provide the context to uncover novel mechanisms of development and disease in patient specific primary cells. The establishment of genome-scale functional genomics based approaches in iPSC derived cells complements recent advances in disease modeling in these cells and is well poised to highlight novel human specific, cell-autonomous mechanisms of disease. In the decade since their discovery, iPSC derived cardiomyocyte models have been developed for a range of conditions from hereditary cardiomyopathies and channelopathies to drug induced cardiotoxicity. The ability to leverage iPSC derived cells to understand disease mechanisms at genome-scale had been limited by a lack of pooled-format functional genomics screening approaches in these cells. In Chapter 2 of this dissertation I outline the optimized methods we developed for CRISPR screening in human iPS derived cells which optimize for infection with a genome-scale CRISPR library and allow screening in functional iPS derived cardiomyocytes with preserved library representation. In Chapter 3 we apply this to uncover novel mechanisms of drug induced cardiotoxicity, which is both a major impediment to new drug approval and a limiting factor in the utilization of approved drugs. We discover the transporter SLCO1A2 as a novel mediator of doxorubicin induced cardiotoxicity in cardiomyocytes, but not breast cancer cells. Through this discovery we highlight the utility of genome-scale functional genomics screening in specifically human differentiated cells of interest. In addition to their utility for modeling human disease, iPS cells have also provided a context to identify novel factors governing pluripotency maintenance and cell fate specification and have provided critical insights into the contribution of transcriptional and signaling pathways in cell fate decisions. Experiments to identify the role of signaling metabolites in cell fate specification have been limited by insufficient techniques to measure and characterize the vast majority of signaling metabolites. Recent advances in untargeted mass-spectrometry afford us the opportunity for to profile thousands of novel signaling lipids in cardiomyocyte specification. We identify a saturated dihydroxy fatty acids as a new family of pluripotency associated metabolites, which have the potential to govern stemness.

Recent Advances in Stem Cells

Recent Advances in Stem Cells
From Basic Research to Clinical Applications

by Essam M. Abdelalim

  • Publisher : Springer
  • Release : 2016-09-14
  • Pages : 269
  • ISBN : 3319332708
  • Language : En, Es, Fr & De
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This volume explores recent advances in the use of pluripotent stem cells (PSCs) and adult stem cells (ASCs) in basic and clinical applications. The chapters discuss use of PSCs for drug screening, genome editing, modeling of kidney, motor neuron diseases, and diabetes as well as their application in cancer; ASCs are discussed in the contexts of banking of umbilical cord stem cells, use of multipotential stromal cells (MSCs) for bone repair, cellular interactions during fracture repair stages, and therapeutic applications of neural crest stem cells and lung stem cells. The text is organized by sections dealing with PSCs and ASCs specifically, presenting the reader with a comprehensive examination of both these forms of stem cells. Expertly authored and drawing from a wealth of international perspectives, Recent Advances in Stem Cells: From Basic Research to Clinical Applications presents a succinct yet detailed review of cutting-edge research in this rapidly expanding field. This installment of Springer’s Stem Cell Biology and Regenerative Medicine series is essential reading for academics, researchers, and clinicians in the fields of cell biology, genetics, nephrology, osteology, oncology, and pulmonology.

Recent Advances in Neurodegeneration

Recent Advances in Neurodegeneration
A Book

by Antonella Borreca

  • Publisher : BoD – Books on Demand
  • Release : 2019-10-09
  • Pages : 100
  • ISBN : 1838812334
  • Language : En, Es, Fr & De
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This Edited Volume Recent Advances in Neurodegeneration is a is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of neurodegeneration. The book comprises single chapters authored by various researchers and edited by an expert active in the neurodegeneration research area. All chapters are complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on neurodegeneration, and open new possible research paths for further novel developments.

Lung Stem Cells in the Epithelium and Vasculature

Lung Stem Cells in the Epithelium and Vasculature
A Book

by Amy Firth,Jason X.-J. Yuan

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 329
  • ISBN : 9783319162331
  • Language : En, Es, Fr & De
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This book covers the identification and role of endogenous lung stem cells in health and disease, particularly the most recent advances. In addition, it discusses the rapidly growing field of stem cells and cell therapy as it relates to lung biology and disease as well as ex vivo lung bioengineering. Such approaches may provide novel therapeutic approaches for lung diseases. Human pluripotent stem cell differentiation to model the pulmonary epithelium and vasculature is also discussed. World-recognized scientists who specialize in studying both the lung epithelium and pulmonary vasculature contribute the chapters. Topics covered include: stem cell niches in the lung, the role of progenitor cells in fibrosis and asthma, iPSC in modeling lung disease, vascular repair by endothelial progenitor cells and circulating fibrocytes in pulmonary vascular remodeling. This volume of the Stem Cell Biology and Regenerative Medicine series is essential reading for researchers and clinicians interested in stem cells, lung biology and regenerative medicine. It is also an invaluable resource for advanced students studying cell biology, regenerative medicine and lung physiology.