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Regenerative Nephrology

Regenerative Nephrology
A Book

by Michael S. Goligorsky

  • Publisher : Academic Press
  • Release : 2021-06-12
  • Pages : 528
  • ISBN : 0128233192
  • Language : En, Es, Fr & De
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Since the publication of the first edition of this book in 2010, an explosion of spectacular discoveries in the field of regeneration has compelled the current revisit of the field of Regenerative Nephrology. This second edition features subjects as diverse as age and gender influencing regenerative processes; mechanisms and pathways of premature cell senescence affecting kidney regeneration; the ways intrinsic regenerative processes can become subverted by noxious stressors eventuating in disease progression; novel mechanistic and engineering efforts to recreate functional kidney or its component parts; cell reprogramming and reconditioning as emerging tools of future regenerative efforts; and effects of various biologicals on kidney regeneration. These newer additions to the armamentarium of Regenerative Medicine and Nephrology have become an integral part of the second edition of the book. Cutting-edge investigations are summarized by the constellation of the most experienced contributing authors coming together from around the world under the umbrella of the second edition. A significant expansion of section on induced pluripotent cells and trajectories of their differentiation. This will be followed by mechanisms and modalities of cell reprogramming for therapeutic purposes A new section on tissue engineering of the kidney of interest to nephrologists and urologists An entire section dedicated to causes of regenerative failure with the emphasis on recent discoveries of senescent cells in kidney disease, pathologic effects of senescent cells, advents in senotherapies and rejuvenation therapies A vastly expanded section on pharmacotherapies promoting kidney regeneration, trials of engineered organs, manufacturing in regenerative medicine and smooth transition to the clinical trials, with an update on some ethical issues

Kidney Transplantation, Bioengineering, and Regeneration

Kidney Transplantation, Bioengineering, and Regeneration
Kidney Transplantation in the Regenerative Medicine Era

by Giuseppe Orlando,Giuseppe Remuzzi,David F. Williams

  • Publisher : Academic Press
  • Release : 2017-06-08
  • Pages : 1252
  • ISBN : 0128018364
  • Language : En, Es, Fr & De
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Kidney Transplantation, Bioengineering, and Regeneration: Kidney Transplantation in the Regenerative Medicine Era investigates how the field of regenerative medicine is changing the traditional premises of solid organ transplantation, specifically within the field of kidney transplantation. In Section 1, chapters illustrate the state of the art in kidney transplantation as well as the research behind the bioengineering and regeneration of kidney organoids for therapeutic renal replacement. In Section II, chapters catalog the technologies that are being developed and the methods that are being implemented to bioengineer or regenerate kidneys in order to restore function, while critically highlighting those technological advances which hold the most promise. The book thus encompasses clinical renal transplantation, tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, as they are all applied to the kidney. Focuses on the synergy between renal organ transplantation and regenerative medicine, highlighting the advances within transplantation, bioengineering, regeneration, and repair Educates the transplant community on important regenerative medicine research pertinent to kidney transplantation Develops a shared language for clinicians, surgeons, and basic researchers to reach across the fields of transplantation and regenerative medicine, and facilitate more productive investigation and research Catalogs the technologies being developed and methods being implemented to bioengineer or regenerate kidneys to restore function

Kidney Development, Disease, Repair and Regeneration

Kidney Development, Disease, Repair and Regeneration
A Book

by Melissa Helen Little

  • Publisher : Academic Press
  • Release : 2015-08-06
  • Pages : 614
  • ISBN : 012800438X
  • Language : En, Es, Fr & De
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Kidney Development, Disease, Repair and Regeneration focuses on the molecular and cellular basis of kidney development, exploring the origins of kidney lineages, the development of kidney tissue subcompartments, as well as the genetic and environmental regulation of kidney development. Special coverage is given to kidney stem cells and possible steps towards kidney repair and regeneration. Emphasis is placed on the fetal origins of postnatal renal disease and our current understanding of the molecular basis of damage and repair. Biomedical researchers across experimental nephrology and developmental biology will find this a key reference for learning how the underlying developmental mechanisms of the kidney will lead to greater advances in regenerative medicine within nephrology. Offers researchers a single comprehensive resource written by leaders from both the developmental biology and the experimental nephrology communities Focuses on understanding the molecular basis of organogenesis in the kidney as well as how this can be affected both genetically and environmentally Explains the underlying developmental mechanisms which influence the kidney’s inherent repair capacity Demonstrates how a deeper understanding of mechanisms will lead to greater advances in regenerative medicine

Oxford Textbook of Clinical Nephrology

Oxford Textbook of Clinical Nephrology
A Book

by Neil Turner,David Goldsmith,Christopher Winearls,Nobert Lamiere,Jonathan Himmelfarb,Giuseppe Remuzzi

  • Publisher : Oxford University Press
  • Release : 2015-10-22
  • Pages : 3000
  • ISBN : 0199592543
  • Language : En, Es, Fr & De
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This fourth edition of the Oxford Textbook of Clinical Nephrology builds on the success and international reputation of the publication as an important resource for the practising clinician in the field. It provides practical, scholarly, and evidence-based coverage of the full spectrum of clinical nephrology, written by a global faculty of experts. The most relevant and important reference to clinical nephrology, this is an authoritative and comprehensive textbook combining the clinical aspects of renal disease essential to daily clinical practice with extensive information about the underlying basic science and current evidence available. Each section of the textbook has been critically and comprehensively edited under the auspices of a leading expert in the field. This new edition has been significantly expanded and reapportioned to reflect developments and new approaches to topics, and includes treatment algorithms to aid and enhance patient care where possible. The fourth edition offers increased focus on the medical aspects of transplantation, HIV-associated renal disease, and infection and renal disease, alongside entirely new sections on genetic topics and clinical and physiological aspects of fluid/electrolyte and tubular disorders. The emphasis throughout is on marrying advances in scientific research with clinical management. Richly illustrated throughout in full colour, this is a truly modern and attractive edition which reinforces the Oxford Textbook of Clinical Nephrology's position as an indispensable reference work of consistent quality and reliability. Enriched and refined by careful revision, this new edition continues the tradition of excellence.

Kidney Regeneration

Kidney Regeneration
Special Topic Issue: Nephron Experimental Nephrology 2014, Vol. 126

by A. Benigni,P. Romagnani,G. Remuzzi

  • Publisher : Unknown Publisher
  • Release : 2014-05-16
  • Pages : 92
  • ISBN : 9783318026771
  • Language : En, Es, Fr & De
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Adult stem cells and progenitor cells can respond dynamically to injury and fuel substantial regeneration of damaged tissues. In this publication, the roles of renal progenitors and other stem cell types involved in the response to injury, cell therapy, reprogramming, and tissue engineering are explored.

Acute Kidney Injury and Regenerative Medicine

Acute Kidney Injury and Regenerative Medicine
A Book

by Yoshio Terada,Takashi Wada,Kent Doi

  • Publisher : Springer Nature
  • Release : 2020-05-14
  • Pages : 396
  • ISBN : 981151108X
  • Language : En, Es, Fr & De
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This book presents up-to-date information on the clinical-pathophysiological features of acute renal injury and discusses the KDIGO diagnostic criteria, as well as novel experimental findings, including in the area of regenerative medicine. It also highlights the clinical-pathophysiological importance of AKI in clinical settings, including differential diagnoses and management of AKI. In the past, the pathology associated with sudden renal impairment was characterized as acute renal failure (ARF). However, in the 2000s, the joint efforts of specialists in fields including nephrology, intensive care medicine, and cardiovascular medicine led to the introduction of a novel concept known as acute kidney injury (AKI). As medical care progressed, patients such as high-risk elderly subjects who were not deemed to be candidates for invasive therapy came to be treated in intensive care units (ICUs). As a result, kidney injury as a subset of multiple organ failure was re-considered as AKI, especially in intensive care medicine. AKI was then proposed as a novel disease concept to emphasize the importance of early diagnosis and early intervention to improve prognosis.Presenting novel features, such as the definition of AKI, risk factors and management; biomarkers, such as neutrophil gelatinase-associated lipocalin (NGAL) and L-type fatty acid-binding protein (L-FABP); long-term outcomes of AKI; as well as renal regeneration using iPS cell, manipulation of embryonic genes, and Xenotransplanted embryonic kidney, this book is of interest to all physicians and researchers in this field around the globe.

Perspectives in Regenerative Medicine

Perspectives in Regenerative Medicine
A Book

by Ena Ray Banerjee

  • Publisher : Springer
  • Release : 2014-10-20
  • Pages : 152
  • ISBN : 8132220536
  • Language : En, Es, Fr & De
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The information given in this book tries to capture the essence of the sheer dynamicity of the cell along with useful tips on how to address critical rate limiting steps in the process of exploration and investigation of its capacity to regenerate, rebuild and replenish from within. The definitions of stem cells, stemness, and the niche concept continue to undergo revisions. In adult vertebrates, hematopoietic and some non-hematopoietic progenitors are synthesized within specialized niches of bone marrow. They migrate to designated tissues, and are either trans-differentiated or become quiescent and settle down. These form the stem cell niche reservoir in all tissues. Not only the primary hematopoietic tissue but all organs and tissues are also capable of generating progenitors which are either synthesized from these migrants or are direct recruits from other tissues. In the niches, the cells settle down and await their turn to either make more clones like themselves or differentiate and mobilize in an exigency. Thus progenitors are important reserves, to be multiplied and deployed or travel as important message bearing molecules via blood as circulating progenitors which can home to their allocated destinations. Upon reaching, specific integrins and selectins help them “dock” and “port” and they may be reprogrammed to induce further differentiation and help repopulate the denuded tissue. In pulmonary fibrosis and asthma, progenitors from both systemic circulation and local stem cell niches have been found to participate in the myriad ramifications of repair, replacement and regeneration of lost or diseased tissue. Whether they are lung specific or global in origin and role remain to be explored. Research tools, fundamental concepts, techniques, methodologies and standard operating protocols and animal models and human extrapolations, have been discussed in a concise way along with detailed description and discussion on the appropriate rationale to introduce the subject to the casual reader and provide valuable tactical information to the specialist in Regenerative Medicine. I sincerely hope you enjoy the work and appreciate the hard work that has gone into designing and executing elegant experiments by many researchers in the field. The branch is multi-disciplinary and I hope that the readers will not be limited to biologists alone.

Regenerative Medicine Applications in Organ Transplantation

Regenerative Medicine Applications in Organ Transplantation
A Book

by Giuseppe Orlando

  • Publisher : Academic Press
  • Release : 2013-10-11
  • Pages : 1050
  • ISBN : 012398520X
  • Language : En, Es, Fr & De
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Regenerative Medicine Applications in Organ Transplantation illustrates exactly how these two fields are coming together and can benefit one another. It discusses technologies being developed, methods being implemented, and which of these are the most promising. The text encompasses tissue engineering, biomaterial sciences, stem cell biology, and developmental biology, all from a transplant perspective. Organ systems considered include liver, renal, intestinal, pancreatic, and more. Leaders from both fields have contributed chapters, clearly illustrating that regenerative medicine and solid organ transplantation speak the same language and that both aim for similar medical outcomes. The overall theme of the book is to provide insight into the synergy between organ transplantation and regenerative medicine. Recent groundbreaking achievements in regenerative medicine have received unprecedented coverage by the media, fueling interest and enthusiasm in transplant clinicians and researchers. Regenerative medicine is changing the premise of solid organ transplantation, requiring transplantation investigators to become familiar with regenerative medicine investigations that can be extremely relevant to their work. Similarly, regenerative medicine investigators need to be aware of the needs of the transplant field to bring these two fields together for greater results. Bridges the gap between regenerative medicine and solid organ transplantation and highlights reasons for collaboration Explains the importance and future potential of regenerative medicine to the transplant community Illustrates to regenerative medicine investigators the needs of the transplant discipline to drive and guide investigations in the most promising directions

Kidney Regeneration

Kidney Regeneration
Special Topic Issue: Nephron Experimental Nephrology 2014, Vol. 126

by A. Benigni

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 92
  • ISBN : 9783318026788
  • Language : En, Es, Fr & De
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Adult stem cells and progenitor cells can respond dynamically to injury and fuel substantial regeneration of damaged tissues. For these reasons, they are thought to have important roles in the etiology of disease, malignancy, and aging. In humans, there exists a renal progenitor system consisting of bipotent progenitors, tubular progenitors, and podocyte progenitors. Growing evidence indicates that some renal disorders can be related to renal progenitor dysfunction, suggesting that renal progenitor function may be modulated for therapeutic purposes. In this publication, the roles of renal progenitors and other stem cell types involved in the response to injury, cell therapy, reprogramming, and tissue engineering are explored, presenting the current foundation of tissue engineering/regenerative medicine strategies for future therapies of untreatable kidney disorders.

Critical Care Nephrology E-Book

Critical Care Nephrology E-Book
A Book

by Claudio Ronco,Rinaldo Bellomo,John A. Kellum,Zaccaria Ricci

  • Publisher : Elsevier Health Sciences
  • Release : 2017-12-14
  • Pages : 1840
  • ISBN : 0323511996
  • Language : En, Es, Fr & De
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Comprehensive and clinically relevant, the 3rd Edition of Critical Care Nephrology provides authoritative coverage of the latest advances in critical care procedures for patients with renal diseases or disorders. Using common guidelines and standardized approaches to critically ill patients, this multidisciplinary reference facilitates better communication among all physicians who care for critically ill patients suffering from kidney disease, electrolyte and metabolic imbalances, poisoning, severe sepsis, major organ dysfunction, and other pathological events. Offers detailed discussions of different forms of organ support, artificial organs, infections, acute illness occurring in chronic hemodialysis patients, and much more. Places a special emphasis on therapeutic interventions and treatment procedures for a hands on clinical reference tool. Presents information clearly, in a format designed for easy reference – from basic sciences to clinical syndromes to diagnostic tools. Covers special populations such as children, diabetic patients, and the elderly. An exceptional resource for nephrologists, intensivists, surgeons, or critical care physicians – anyone who treats critically ill renal patients. Shares a combined commitment to excellence lead by Drs. Claudio Ronco, Rinaldo Bellomo, John Kellum, and Zaccaria Ricci – unparalleled leaders in this field. Addresses key topics with expanded coverage of acute kidney injury, stress biomarkers, and sepsis, including the latest developments on mechanisms and management. Provides up-to-date information on extracorporeal therapies from new editor Dr. Zaccaria Ricci.

Pancreas, Kidney and Skin Regeneration

Pancreas, Kidney and Skin Regeneration
A Book

by Phuc Van Pham

  • Publisher : Springer
  • Release : 2017-06-07
  • Pages : 326
  • ISBN : 3319556878
  • Language : En, Es, Fr & De
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This invaluable resource discusses clinical applications with effects and side-effects of applications of stem cells in diabetes, kidney and wound treatment. All chapters are contributed by pre-eminent scientists in the field and covers such topics as stem cells and cell therapy in the treatment of diabetes mellitus, kidney failure, wound and other skin aging diseases, characteristics of some kinds of stem/progenitor cells for therapy, future directions of the discussed therapies and much more. Pancreas, Kidney and Skin Regeneration and the other books in the Stem Cells in Clinical Applications series will be invaluable to scientists, researchers, advanced students and clinicians working in stem cells, regenerative medicine or tissue engineering.

Stem Cell and Gene-Based Therapy

Stem Cell and Gene-Based Therapy
Frontiers in Regenerative Medicine

by Alexander Battler,Jonathan Leor

  • Publisher : Springer Science & Business Media
  • Release : 2007-06-26
  • Pages : 422
  • ISBN : 9781846286766
  • Language : En, Es, Fr & De
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Regenerative medicine – stem cell and gene-based therapy – offers a new approach for restoring function of damaged organs and tissues. This is the first book to cover the major new aspects and field of regenerative medicine. This title is therefore a timely addition to the literature. It brings together the major approaches to regenerative medicine in one text, which ensures that techniques learnt in one discipline are disseminated across other areas of medicine.

Advances in Biomedical Engineering Research and Application: 2013 Edition

Advances in Biomedical Engineering Research and Application: 2013 Edition
ScholarlyBrief

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-06-21
  • Pages : 544
  • ISBN : 1481669591
  • Language : En, Es, Fr & De
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Advances in Biomedical Engineering Research and Application: 2013 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about ZZZAdditional Research in a concise format. The editors have built Advances in Biomedical Engineering Research and Application: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about ZZZAdditional Research in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Biomedical Engineering Research and Application: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Present and Future Therapies for End-Stage Renal Disease

Present and Future Therapies for End-Stage Renal Disease
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 129
  • ISBN : 9814467375
  • Language : En, Es, Fr & De
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Regulatory Networks in Stem Cells

Regulatory Networks in Stem Cells
A Book

by Vinagolu K. Rajasekhar

  • Publisher : Springer Science & Business Media
  • Release : 2009-03-04
  • Pages : 601
  • ISBN : 9781603272278
  • Language : En, Es, Fr & De
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Stem cells appear to be fundamental cellular units associated with the origin of multicellular organisms and have evolved to function in safeguarding the cellular homeostasis in organ t- sues. The characteristics of stem cells that distinguish them from other cells have been the fascinating subjects of stem cell research. The important properties of stem cells, such as ma- tenance of quiescence, self-renewal capacity, and differentiation potential, have propelled this exciting ?eld and presently form a common theme of research in developmental biology and medicine. The derivation of pluripotent embryonic stem cells, the prospective identi?cation of multipotent adult stem cells, and, more recently, the induced pluripotent stem cells (popularly called iPS) are important milestones in the arena of stem cell biology. Complex networks of transcription factors, different signaling molecules, and the interaction of genetic and epi- netic events constantly modulate stem cell behavior to evoke programming and reprogramming processes in normal tissue homeostasis during development. In any given cellular scenario, the regulatory networks can pose considerable complexity and yet exert an orderly control of stem cell differentiation during normal development. An aberration in these ?nely tuned processes during development usually results in a spectrum of diseases such as cancers and neurological disorders. Thisunderscorestheimminentneedforamorecompleteunderstandingofmolecular mechanisms underlying the regulatory circuitries required for stem cell maintenance. Overthepast3–5years,adiversegroupofbenchandphysicianscientistshaveprospectively enhanced our knowledge of stem cell biology. These studies are unveiling many unrecognized or previously unknown fundamentals of developmental biology.

Forefronts in Nephrology: Stem Cell and Regeneration of the Kidney, Karuizawwa, Japan January 20-22, 2005

Forefronts in Nephrology: Stem Cell and Regeneration of the Kidney, Karuizawwa, Japan January 20-22, 2005
A Book

by Matsuhiko Hayashi,Forefronts in Nephrology Stem Cell and Regeneration of the Kidney

  • Publisher : Unknown Publisher
  • Release : 2005
  • Pages : 496
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Encyclopedia of Tissue Engineering and Regenerative Medicine

Encyclopedia of Tissue Engineering and Regenerative Medicine
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-06-03
  • Pages : 1418
  • ISBN : 0128137002
  • Language : En, Es, Fr & De
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Encyclopedia of Tissue Engineering and Regenerative Medicine provides a comprehensive collection of personal overviews on the latest developments and likely future directions in the field. By providing concise expositions on a broad range of topics, this encyclopedia is an excellent resource. Tissue engineering and regenerative medicine are relatively new fields still in their early stages of development, yet they already show great promise. This encyclopedia brings together foundational content and hot topics in both disciplines into a comprehensive resource, allowing deeper interdisciplinary research and conclusions to be drawn from two increasingly connected areas of biomedicine. Provides a ‘one-stop’ resource for access to information written by world-leading scholars in the fields of tissue engineering and regenerative medicine Contains multimedia features, including hyperlinked references and further readings, cross-references and diagrams/images Represents the most comprehensive and exhaustive product on the market on the topic

Issues in Kidney Disease Research and Treatment: 2013 Edition

Issues in Kidney Disease Research and Treatment: 2013 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-05-01
  • Pages : 1055
  • ISBN : 1490109978
  • Language : En, Es, Fr & De
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Issues in Kidney Disease Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Nephrology. The editors have built Issues in Kidney Disease Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Nephrology in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Kidney Disease Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Clinical Regenerative Medicine in Urology

Clinical Regenerative Medicine in Urology
A Book

by Bup Wan Kim

  • Publisher : Springer
  • Release : 2017-09-14
  • Pages : 285
  • ISBN : 9811027234
  • Language : En, Es, Fr & De
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This multidisciplinary book provides up-to-date information on clinical approaches that combine stem or progenitor cells, biomaterials and scaffolds, growth factors, and other bioactive agents in order to offer improved treatment of urologic disorders including lower urinary tract dysfunction, urinary incontinence, neurogenic bladder, and erectile dysfunction. In providing clinicians and researchers with a broad perspective on the development of regenerative medicine technologies, it will assist in the dissemination of both regenerative medicine principles and a variety of exciting therapeutic options. After an opening section addressing current developments and future perspectives in tissue engineering and regenerative medicine, fundamentals such as cell technologies, biomaterials, bioreactors, bioprinting, and decellularization are covered in detail. The remainder of the book is devoted to the description and evaluation of a range of cell and tissue applications, with individual chapters focusing on the kidney, bladder, urethra, urethral sphincter, and penis and testis.

Brenner & [and] Rector's the Kidney

Brenner & [and] Rector's the Kidney
A Book

by Barry M. Brenner

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 2241
  • ISBN : 9781416031055
  • Language : En, Es, Fr & De
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