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Research in the Biomedical Sciences

Research in the Biomedical Sciences
Transparent and Reproducible

by Michael Curtis,Michael Williams

  • Publisher : Academic Press
  • Release : 2017-06-01
  • Pages : 356
  • ISBN : 9780128047255
  • Language : En, Es, Fr & De
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Research in the Biomedical Sciences: Transparent and Reproducible documents the widespread concerns related to reproducibility in biomedical research and provides a best practices guide to effective and transparent hypothesis generation, experimental design, reagent standardization (including validation and authentication), statistical analysis, and data reporting. The book addresses issues in the perceived value of the existing peer review process and calls for the need for improved transparency in data reporting. It reflects new guidelines for publication that include manuscript checklists, replication/reproducibility initiatives, and the potential consequences for the biomedical research community and societal health and well-being if training, mentoring, and funding of new generations of researchers and incentives for publications are not improved. This book offers real world examples, insights, and solutions to provide a thought-provoking and timely resource for all those learning about, or engaged in, performing and supervising research across the biomedical sciences. Provides a "big picture" perspective that includes the scope of the replicability issue and covers initiatives that have the potential to act as effective solutions Offers real world research context for transparent, replicable experimental design and execution and reporting of biomedical research with the potential to address aspects of the translational gap in drug discovery Highlights the importance of reproducibility and the necessary changes in biomedical and pharmaceutical research training and incentives to ensure sustainability

Research in Medical and Biological Sciences

Research in Medical and Biological Sciences
From Planning and Preparation to Grant Application and Publication

by Petter Laake,Haakon Breien Benestad

  • Publisher : Academic Press
  • Release : 2015-06-05
  • Pages : 512
  • ISBN : 0128001542
  • Language : En, Es, Fr & De
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Research in Medical and Biological Sciences covers the wide range of topics that a researcher must be familiar with in order to become a successful biomedical scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences, this publication discusses a broad range of topics that are common yet not traditionally considered part of formal curricula, including philosophy of science, ethics, statistics, and grant applications. The information presented in this book also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects. Covers the breadth of topics that a researcher must understand in order to be a successful experimental scientist Provides a broad scientific perspective that is perfect for students with various professional backgrounds Contains easily accessible, concise material about diverse methods Includes extensive online resources such as further reading suggestions, data files, statistical tables, and the StaTable application package Emphasizes the ethics and statistics of medical and biological sciences

Reporting and Publishing Research in the Biomedical Sciences

Reporting and Publishing Research in the Biomedical Sciences
Revised Edition

by Peush Sahni,Rakesh Aggarwal

  • Publisher : Springer
  • Release : 2018-02-25
  • Pages : 306
  • ISBN : 9811070628
  • Language : En, Es, Fr & De
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This book eases the task of converting your research work into a manuscript, and covers the recent developments in publishing that often stump the budding researchers. Few researchers in the biomedical sciences are trained in the essential skills of reporting their results. They seek help in writing a paper that will be acceptable for publication in the ‘right’ journal, and in presenting their results ‘effectively’ at a meeting. Besides covering the basic aspects of preparing manuscripts for publication, this book discusses best practices and issues relating to the publication of biomedical research. These include topics such as peer-review, authorship, plagiarism, conflicts of interest, publication misconduct, electronic publishing and open-access journals. The editors have more than two decades of experience in conducting workshops on writing scientific papers. They have brought together the expertise of 29 authors from seven countries to produce this one-stop guide to publishing research in biomedical sciences. This book is meant for young researchers who are beginning their careers and wish to hone their skills in understanding the rigors of research writing and publishing.

Research Training in the Biomedical, Behavioral, and Clinical Research Sciences

Research Training in the Biomedical, Behavioral, and Clinical Research Sciences
A Book

by National Research Council,Policy and Global Affairs,Board on Higher Education and Workforce,Committee to Study the National Needs for Biomedical, Behavioral, and Clinical Research Personnel

  • Publisher : National Academies Press
  • Release : 2011-02-28
  • Pages : 206
  • ISBN : 0309209935
  • Language : En, Es, Fr & De
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Comprehensive research and a highly-trained workforce are essential for the improvement of health and health care both nationally and internationally. During the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various diseases and new insights that have led to more effective and targeted therapies. In spite of this program, the difficulty obtaining jobs after the postdoc period has discouraged many domestic students from pursuing graduate postdoc training. In the United States, more than 50 percent of the postdoc workforce is made up of individuals who obtained their Ph.D.s from other countries. Indeed, one can make a strong argument that the influx of highly trained and creative foreigners has contributed greatly to U.S. science over the past 70 years. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences discusses a number of important issues, including: the job prospects for postdocs completing their training; questions about the continued supply of international postdocs in an increasingly competitive world; the need for equal, excellent training for all graduate students who receive NIH funding; and the need to increase the diversity of trainees. The book recommends improvements in minority recruiting, more rigorous and extensive training in the responsible conduct of research and ethics, increased emphasis on career development, more attention to outcomes, and the requirement for incorporating more quantitative thinking in the biomedical curriculum.

A Guide to Methods in the Biomedical Sciences

A Guide to Methods in the Biomedical Sciences
A Book

by Ronald B. Corley

  • Publisher : Springer Science & Business Media
  • Release : 2006-01-16
  • Pages : 126
  • ISBN : 0387228454
  • Language : En, Es, Fr & De
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Thousands of methods have been developed in the various biomedical disciplines, and those covered in this book represent the basic, essential and most widely used methods in several different disciplines.

Large-Scale Biomedical Science

Large-Scale Biomedical Science
Exploring Strategies for Future Research

by National Research Council,Division on Earth and Life Studies,Institute of Medicine,National Cancer Policy Board,Committee on Large-Scale Science and Cancer Research

  • Publisher : National Academies Press
  • Release : 2003-07-19
  • Pages : 296
  • ISBN : 0309089123
  • Language : En, Es, Fr & De
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The nature of biomedical research has been evolving in recent years. Technological advances that make it easier to study the vast complexity of biological systems have led to the initiation of projects with a larger scale and scope. In many cases, these large-scale analyses may be the most efficient and effective way to extract functional information from complex biological systems. Large-Scale Biomedical Science: Exploring Strategies for Research looks at the role of these new large-scale projects in the biomedical sciences. Though written by the National Academies’ Cancer Policy Board, this book addresses implications of large-scale science extending far beyond cancer research. It also identifies obstacles to the implementation of these projects, and makes recommendations to improve the process. The ultimate goal of biomedical research is to advance knowledge and provide useful innovations to society. Determining the best and most efficient method for accomplishing that goal, however, is a continuing and evolving challenge. The recommendations presented in Large-Scale Biomedical Science are intended to facilitate a more open, inclusive, and accountable approach to large-scale biomedical research, which in turn will maximize progress in understanding and controlling human disease.

Reproducibility in Biomedical Research

Reproducibility in Biomedical Research
Epistemological and Statistical Problems

by Erwin B. Montgomery

  • Publisher : Academic Press
  • Release : 2019-03-14
  • Pages : 356
  • ISBN : 0128176725
  • Language : En, Es, Fr & De
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Reproducibility in Biomedical Research: Epistemological and Statistical Problems explores the ideas and conundrums inherent in scientific research. It explores factors of reproducibility, including logic, distinguishing productive from unproductive irreproducibility, the scientific method, and the use of statistics. In multiple examples and six detailed case studies, the book demonstrates the misuse of logic resulting in unproductive irreproducibility, allowing researchers to develop their own logic and planning abilities. Biomedical researchers, clinicians, administrators of scientific institutions and funding agencies, journal editors, philosophers of science and medicine will find the arguments and explorations a valuable addition to their libraries. Considers the meaning and purpose of reproducibility to help design research Reviews famous case studies of alleged irreproducibility to determine if these could be reproducible Provides a theoretical aspect to practical issues surrounding research design and conduct

Research Methodology in the Medical and Biological Sciences

Research Methodology in the Medical and Biological Sciences
A Book

by Petter Laake,Haakon Breien Benestad,Bjorn Reino Olsen

  • Publisher : Academic Press
  • Release : 2007-11-05
  • Pages : 512
  • ISBN : 9780080552897
  • Language : En, Es, Fr & De
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Providing easy-to-access information, this unique sourcebook covers the wide range of topics that a researcher must be familiar with in order to become a successful experimental scientist. Perfect for aspiring as well as practicing professionals in the medical and biological sciences it discusses a broad range of topics that are common, yet not traditionally considered part of formal curricula. The information presented also facilitates communication across conventional disciplinary boundaries, in line with the increasingly multidisciplinary nature of modern research projects. Perfect for students with various professional backgrounds providing a broad scientific perspective Easily accessible, concise material makes learning about diverse methods achievable in today's fast-paced world

Advancing the Nation's Health Needs

Advancing the Nation's Health Needs
NIH Research Training Programs

by National Research Council,Policy and Global Affairs,Board on Higher Education and Workforce,Committee for Monitoring the Nation's Changing Needs for Biomedical, Behavioral, and Clinical Personnel

  • Publisher : National Academies Press
  • Release : 2005-08-13
  • Pages : 186
  • ISBN : 0309094275
  • Language : En, Es, Fr & De
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This report is the twelfth assessment of the National Institutes of Health National Research Service Awards program. The research training needs of the country in basic biomedical, clinical, and behavioral and social sciences are considered. Also included are the training needs of oral health, nursing, and health services research. The report has been broadly constructed to take into account the rapidly evolving national and international health care needs. The past and present are analyzed, and predictions with regard to future needs are presented.

A Practical Guide to Biomedical Research

A Practical Guide to Biomedical Research
for the Aspiring Scientist

by Peter Agger,Robert S. Stephenson,J. Michael Hasenkam

  • Publisher : Springer
  • Release : 2017-10-27
  • Pages : 184
  • ISBN : 3319635824
  • Language : En, Es, Fr & De
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This book advises and supports novice researchers in taking their first steps into the world of scientific research. Through practical tips and tricks presented in a clear, concise and step-wise manner, the book describes the entire research process from idea to publication. It also gives the reader insight into the vast opportunities a research career can provide. The books target demographic is aspiring researchers within the biomedical professions, be it medical students, young doctors, nurses, engineers, physiotherapists etc. The book will help aspirational inexperienced researchers turn their intentions into actions, providing crucial guidance for successful entry into the field of biomedical research.

Career Options for Biomedical Scientists

Career Options for Biomedical Scientists
A Book

by Kaaren A. Janssen,Richard Sever

  • Publisher : Unknown Publisher
  • Release : 2014-04-30
  • Pages : 232
  • ISBN : 9781936113729
  • Language : En, Es, Fr & De
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Most people who do a PhD and postdoctoral work in the biomedical sciences do not end up as principal investigators in a research lab. Despite this, graduate courses and postdoctoral fellowships tend to focus almost exclusively on training for bench science rather than other career paths. This book plugs the gap by providing information about a wide variety of different careers that individuals with a PhD in the life sciences can pursue. Covering everything from science writing and grant administration to patent law and management consultancy, the book includes firsthand accounts of what the jobs are like, the skills required, and advice on how to get a foot in the door. It will be a valuable resource for all life scientists considering their career options and laboratory heads who want to give career advice to their students and postdocs.

Enhancing the Vitality of the National Institutes of Health

Enhancing the Vitality of the National Institutes of Health
Organizational Change to Meet New Challenges

by National Research Council,Institute of Medicine,Board on Health Sciences Policy,Division on Earth and Life Studies,Board on Life Sciences,Committee on the Organizational Structure of the National Institutes of Health

  • Publisher : National Academies Press
  • Release : 2003-07-29
  • Pages : 164
  • ISBN : 9780309167116
  • Language : En, Es, Fr & De
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The report says that important organizational changes are needed at the National Institutes of Health to ensure the agency meets future challenges effectively. In particular, the report advises NIH to devote additional resources to innovative interdisciplinary research that reflects its strategic objectives and cuts across all agency's institutes and centers. The report recommends that Congress should establish a formal process for determining how specific proposals for changes in the number of NIH agencies and centers should be addressed.

Reference Module in Biomedical Research

Reference Module in Biomedical Research
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2015-01-26
  • Pages : 329
  • ISBN : 9780128012383
  • Language : En, Es, Fr & De
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Reference Module in Biomedical Research

Biomedical Research Methodology

Biomedical Research Methodology
A Book

by Das Ranjan,Das PN

  • Publisher : Jaypee Brothers,Medical Publishers Pvt. Limited
  • Release : 2010-06-15
  • Pages : 258
  • ISBN : 9789350250174
  • Language : En, Es, Fr & De
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Knowledge generated from research in biomedical sciences plays a crucial role in the betterment of medical practice and health. It also has implications on policy decisions. It is for this reason that policy-makers at the national and international levels would like to see more of research. Most subspecialties within the broad area of biomedicine try to incorporate basic skills of research at the postgraduate level. However, in reality, the research acumen of the majority of postgraduates from various biomedical streams is deplorable. That is because, the subject of research per se finds lackadaisical handling by the specialties. And as a result, as if taking cue from Louis Pasteur’s words in the field of research, chance favors only the prepared mind, the research seeds, though floating constantly around us, fail to take roots in the minds of ill-prepared biomedical researchers. Society is thus deprived of benefits that could otherwise have accrued. Further, in the absence of trained researchers, all countries—developed as well as developing, are going to be affected. Training in biomedical research must, therefore, receive greater priority. The Global Forum for Health Research (2001) reported that the global investment in health research stood at an estimated US$ 75 billion, with 50% of it being spent by governments (developed : developing, 47 : 3), 42% by pharmaceutical industry, and 8% by the private not-for-profit sector. For all these reasons, building a career in biomedical research is certainly worth a proposition. According to a McKinsey Report (2007), biomedical researchers are going to be in great demand worldwide; 250,000 would be needed by 2010 with 50,000 in India alone. Few institutes formally train biomedical research professionals, while the majority of them are trained by the biomedical academic institutes. But, as mentioned previously, the quality of training on actual research remains very weak, even in institutions of respectable academic standards. That again calls for empowering the biomedical research trainees. One of the most important reasons of biomedical research training not being up to the mark is that, while this domain now requires the expertise of at least three specialties, namely, epidemiology, biostatistics and sociology, many institutes may not even have these specialists at all. For the debutant biomedical researcher, therefore, finding help from so many professionals may be an extremely challenging task if not a dream. Further, while most students of the medical sciences have had a brush with all these three specialty areas, yet the depth of it is not sufficient to be applied to research. In the context of other fields of biomedicine, students of some fields have better knowledge of biostatistics or sociology; but, then, epidemiology is an area which is generally left ignored. It is, therefore, pertinent that all professionals from the biomedical field including doctors and especially those at the postgraduate level be empowered in understanding research methodology as well as applying it on their own. Over the years, we have seen our postgraduate students struggle with their research project/thesis, and nothing has been more satisfying than trying to help our students understand difficult concepts and put those to use. That prompted us to do our bit to help them by documenting our experiences in a book. Even at the time when we were ourselves enrolled for postgraduate level research, we had searched for a short book on the techniques to be used for biomedical research. However, our search had proved futile then, and even now, nearly 20 years down the line there is probably not one title that can be used by entry-level researchers to guide them in their debut research work. With the above ideas in mind, we thought of writing this book, the primary audience of which is the postgraduate students of medical, dental, nursing and allied specialties. These young professionals have to plan and execute a research project and submit the thesis to be eligible for appearing in their university examinations. Needless to say, this book should also serve as a valuable resource book for others already working in the field of biomedical research. The content of the text of Biomedical Research Methodology is based on our own experiences as well as on the inputs received from our colleagues and inquisitive postgraduate students. The chapters have been ordered in a way to assist student researchers overcome the barriers they encounter, while conducting the research. We believe this book would prove to be highly resourceful in dealing with the practicalities of research, beginning from the very preliminary stages, through literature review, data analysis, right up to the final stage of writing the thesis and even getting the message out by publication. Our whole-hearted efforts for writing this book shall be successful only if it really benefits the target audience, and that shall be our reward as well. In spite of our best efforts, many errors might be there in the text. We shall be highly grateful and remain obliged to our esteemed readers for pointing out those to us. Constructive criticism on the content and its presentation is extremely necessary for the improvement of any work, and we welcome them for enriching our knowledge as well as for improvement of the book. Substantial contributors of these would certainly be credited through acknowledgement, if not anything more.

Getting to Good

Getting to Good
Research Integrity in the Biomedical Sciences

by Arthur L. Caplan,Barbara K. Redman

  • Publisher : Springer
  • Release : 2018-07-23
  • Pages : 583
  • ISBN : 3319513583
  • Language : En, Es, Fr & De
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This book represents the first comprehensive, gold standard reader on research integrity in the biomedical sciences. Now more than ever, the responsible conduct of research (RCR) has become critically important as new technologies affect research practices in both positive and negative ways. Since learning to do science and practicing it brings researchers into contact with a vast array of ethical issues, it is critical to know the standards and how they are evolving. Indeed, research integrity requires scientists at all levels to operate ethically in a system that supports ethical practice. This unique, foundational text covers all the relevant areas -- subject protection, research misconduct and conflict of interest as well as newly quantified concerns about research bias and non-reproducibility, as well as other unique issues. Developed by renowned experts, this compelling title discusses the full range of practices and policies that should support research that is honestly produced and disseminated. It also specifically incorporates topics noted by the National Institutes of Health as essential and required for training in RCR. Getting to Good – Research Integrity in the Biomedical Sciences is a major contribution to the literature on bioethics and will serve as an invaluable resource for all researchers, students, administrators and professionals interested in research ethics and integrity.

Metabolomics for Biomedical Research

Metabolomics for Biomedical Research
A Book

by Jerzy Adamski

  • Publisher : Academic Press
  • Release : 2020-03-20
  • Pages : 266
  • ISBN : 0128127856
  • Language : En, Es, Fr & De
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Metabolomics for Biomedical Research brings together recent progress on study design, analytics, biostatistics and bioinformatics for the success of metabolomics research. Metabolomics represents a very interdisciplinary research prominent in the functional analyses of living systems; hence, this book focuses on translation and medical aspects. The book discusses topics such as biomarkers and their requirements to be used in medical research, with the parameters and approaches on how to validate their quality; and animal models and other approaches, as stem cells and organoid culture. Additionally, it explains how metabolomics may be applied in prediction of individual response to drug or disease progression. This book is a valuable source for researchers on systems biology and other members of biomedical field interested in metabolism-oriented studies for medical research. Focuses on metabolomics in translational and medical research Provides basics for, and concepts of, contemporary translational personalized medicine research with metabolomics Brings the major recent progresses on design, analytics, biostatistics and bioinformatics relating to the success of metabolomics research

Planning a Career in Biomedical and Life Sciences

Planning a Career in Biomedical and Life Sciences
Making Informed Choices

by Avrum I. Gotlieb

  • Publisher : Academic Press
  • Release : 2014-12-08
  • Pages : 144
  • ISBN : 0128025700
  • Language : En, Es, Fr & De
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Planning a Career in Biomedical and Life Sciences presents useful information, insights, and tips to those pursuing a career in the biomedical and life sciences. The book focuses on making educated choices during schooling, training, and job searching in both the academic and non-academic sectors. The premise of Planning a Career in Biomedical and Life Sciences is that by understanding the full path of a career in either the biomedical or life science fields, you can proactively plan your career, recognize any opportunities that present themselves, and be well prepared to address important aspects of your own professional development. Topics include choosing your training path, selecting the best supervisor/mentor, and negotiating a job offer. Provides strategies on evaluating biomedical and life sciences education and professional development opportunities in a thorough and systematic fashion. Discusses possible pitfalls and offers insight into how to navigate them successfully at various points of a scientist’s career. Offers valuable advice on how to make the best choices for yourself at any stage in your career.

Islam and Biomedical Research Ethics

Islam and Biomedical Research Ethics
A Book

by Mehrunisha Suleman

  • Publisher : Routledge
  • Release : 2020-07-08
  • Pages : 224
  • ISBN : 0429575424
  • Language : En, Es, Fr & De
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This book is a contribution to the nascent discourse on global health and biomedical research ethics involving Muslim populations and Islamic contexts. It presents a rich sociological account about the ways in which debates and questions involving Islam within the biomedical research context are negotiated - a perspective which is currently lacking within the broader bioethics literature. The book tackles some key understudied areas including: role of faith in moral deliberations within biomedical research ethics, the moral anxiety and frustration experienced by researchers when having to negotiate multiple moral sources and how the marginalisation of women, the prejudice and abuse faced by groups such as sex workers and those from the LGBT community are encountered and negotiated in such contexts. The volume provides a valuable resource for researchers and scholars in this area by providing a systematic review of ethical guidelines and a rich case-based account of the ethical issues emerging in biomedical research in contexts where Islam and the religious moral commitments of Muslims are pertinent. The book will be essential for those conducting research in low and middle income countries that have significant Muslim populations and for those in Muslim-minority settings. It will also appeal to researchers and scholars in religious studies, social sciences, philosophy, anthropology and theology, as well as the fields of biomedical ethics, Islamic ethics and global health..

The Common Marmoset in Captivity and Biomedical Research

The Common Marmoset in Captivity and Biomedical Research
A Book

by Robert P. Marini,Lynn M. Wachtman,Suzette D. Tardif,Keith Mansfield,James G. Fox

  • Publisher : Academic Press
  • Release : 2018-11-19
  • Pages : 570
  • ISBN : 012811830X
  • Language : En, Es, Fr & De
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The Common Marmoset in Captivity and Biomedical Research is the first text dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing information. Sponsored by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications of this important species. The common marmoset (Callithrix jacchus) has come of age in the scientific community as a behaviorally complex, cognitively advanced,small, prolific, and easily maintained nonhuman primate with many of the advantages of larger animals, such as macaques, but without the attendant physical and zoonotic risks. Marmosets are currently being used in diverse areas of inquiry, including vision and auditory research, infectious disease, cognitive neuroscience, behavior, reproductive biology, toxicology and drug development, and aging. The marmoset genome has been sequenced and there is currently an intensive effort to apply gene editing technologies to the species. The creation of transgenic marmosets will provide researchers with a small nonhuman primate model to study a number of poorly understood disorders, like autism. Presents a complete view of the marmoset, covering their biology and management, diseases and clinical applications, and research applications Includes contributions from renowned and international authors and editors Provides the first authoritative and comprehensive treatment of marmosets in biomedical research as part of the ACLAM Series

Radiobiology and Bio-medical Research

Radiobiology and Bio-medical Research
A Book

by K. P. Mishra

  • Publisher : Alpha Science Int'l Ltd.
  • Release : 2004
  • Pages : 208
  • ISBN : 9788173194849
  • Language : En, Es, Fr & De
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Radiobiology and Bio-Medical Research serves as an update in emerging areas of radiobiology and advanced medical science. Each chapter is written by experts and specialists with a view to provide an indepth account of biomedical research based on developing technologies in therapy and diagnosis. Book jacket.