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Separation Methods in Drug Synthesis and Purification

Separation Methods in Drug Synthesis and Purification
A Book

by Klara Valko

  • Publisher : Elsevier
  • Release : 2000-10-13
  • Pages : 612
  • ISBN : 9780080541099
  • Language : En, Es, Fr & De
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Separation Methods in Drug Synthesis and Purification

Modern Thin-Layer Chromatography

Modern Thin-Layer Chromatography
A Book

by Nelu Grinberg

  • Publisher : CRC Press
  • Release : 1990-04-27
  • Pages : 504
  • ISBN : 9780824781385
  • Language : En, Es, Fr & De
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Provides chemists with an in-depth account of chromatographic phenomena and a detailed reference guide to the various choices in optimizing chromatographic separations of enantiomers. Clarifies how thin-layer chromatography differs from, but can be used as a pilot procedure for, high-performance liq

The British National Bibliography

The British National Bibliography
A Book

by Arthur James Wells

  • Publisher : Unknown Publisher
  • Release : 2000
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Journal of Chromatography

Journal of Chromatography
A.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Octanol-Water Partition Coefficients

Octanol-Water Partition Coefficients
Fundamentals and Physical Chemistry

by James Sangster

  • Publisher : John Wiley & Sons
  • Release : 1997-05-28
  • Pages : 178
  • ISBN : 9780471973973
  • Language : En, Es, Fr & De
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The octanol-water partition coefficient is a laboratory-measured property of a substance. It provides a thermodynamic measure of the tendency of the substance to prefer a non-aqueous or oily milieu rather than water (i.e. its hydrophilic/lipophilic balance). Partition coefficients are used extensively in medicinal chemistry, drug design, ecotoxicology and environmental chemistry. The partition coefficient is recognized by governmental and international agencies (U.S. Environmental Protection Agency, OECD) as a physical property of organic pollutants equal in importance to vapour pressure, water solubility and toxicity. Octanol-Water Partition Coefficients is a comprehensive and up-to-date survey of the thermodynamics of partitioning and of the octanol-water pair. In addition, all current methods of measurement are reviewed, strengths and weaknesses are noted and recommendations for particular applications are given. Current methods of calculation of partition coefficients are similarly surveyed and described. Five of the most popular computerized methods are tested for predictive accuracy for drugs, pollutants, aminoacids, etc. The book will be of interest not only to solution chemists, but to any chemists who use partition coefficients. It provides a thorough understanding of the fundamentals and offers clear guidance on the choice of methods of measurement and calculation. Contents: Introduction, Thermodynamics and Extrathermodynamics of Partitioning, Experimental Methods of Measurement, Discussion of Measurement Methods, Methods of Calculating Partitioning Coefficients, Discussion of LogKow Predictive Methods The Wiley Series in Solution Chemistry fills the increasing need to present authoritative, comprehensive and fully up-to-date accounts of the many aspects of solution chemistry. Internationally recognized experts from research or teaching institutions in various countries are invited to contribute to the series.

Comprehensive medicinal chemistry II

Comprehensive medicinal chemistry II
A Book

by John B. Taylor,D. J. Triggle

  • Publisher : Elsevier Science Ltd
  • Release : 2007
  • Pages : 7200
  • ISBN : 9780080445137
  • Language : En, Es, Fr & De
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The first edition of Comprehensive Medicinal Chemistry was published in 1990 and very well received. Comprehensive Medicinal Chemistry II is much more than a simple updating of the contents of the first edition. Completely revised and expanded, this new edition has been refocused to reflect the significant developments and changes over the past decade in genomics, proteomics, bioinformatics, combinatorial chemistry, high-throughput screening and pharmacology, and more. The content comprises the most up-to-date, authoritative and comprehensive reference text on contemporary medicinal chemistry and drug research, covering major therapeutic classes and targets, research strategy and organisation, high-throughput technologies, computer-assisted design, ADME and selected case histories. It is this coverage of the strategy, technologies, principles and applications of medicinal chemistry in a single work that will make Comprehensive Medicinal Chemistry II a unique work of reference and a single point of entry to the literature for pharmaceutical and biotechnology scientists of all disciplines and for many industry executives as well.Comprehensive Medicinal Chemistry II will be available online in 2007 via the proven platform ScienceDirect providing the user with enhanced features such as cross-referencing and dynamic linking. * Comprehensively reviews - for the first time in one single work - the strategies, technologies, principles and applications of modern medicinal chemistry * Provides a global and current perspective of today's drug discovery process and discusses the major therapeutic classes and targets * Includes a unique collection of case studies and personal assays reviewing the discovery and development of key drugs

Methods for Experimental Design

Methods for Experimental Design
Principles and Applications for Physicists and Chemists

by J.L. Goupy

  • Publisher : Elsevier
  • Release : 1993-05-05
  • Pages : 448
  • ISBN : 9780080868394
  • Language : En, Es, Fr & De
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A method for organizing and conducting scientific experiments is described in this volume which enables experimenters to reduce the number of trials run, while retaining all the parameters that may influence the result. The choice of ideal experiments is based on mathematical concepts, but the author adopts a practical approach and uses theory only when necessary. Written for experimenters by an experimenter, it is an introduction to the philosophy of scientific investigation. Researchers with limited time and resources at their disposal will find this text a valuable guide for solving specific problems efficiently. The presentation makes extensive use of examples, and the approach and methods are graphical rather than numerical. All calculations can be performed on a personal computer; readers are assumed to have no previous knowledge of the subject. The presentation is such that the beginner may acquire a thorough understanding of the basic concepts. However, there is also sufficient material to challenge the advanced student. The book is, therefore, suitable for both first and advanced courses. The many examples can also be used in detail for self-study or as a reference.

Chirality in Drug Research

Chirality in Drug Research
A Book

by Eric Francotte,Wolfgang Lindner

  • Publisher : John Wiley & Sons
  • Release : 2007-09-24
  • Pages : 370
  • ISBN : 3527608710
  • Language : En, Es, Fr & De
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Divided into the three main sections of synthesis, analysis and drug development, this handbook covers all stages of the drug development process, including large-scale synthesis and purification of chirally pure pharmaceuticals. The two editors from academia and a major pharmaceutical company have assembled an experienced, international team who provide first-hand practical advice and report previously unpublished data. In the first section, the isolation of chiral drugs from natural sources, their production in enzymatic processes and the resolution of racemic mixtures in preparative chromatography are outlined in separate chapters. For the section on qualitative and quantitative analysis, enantioselective chromatographic methods are presented as well as optical methods and CE-MS, while the final section deals with the pharmacology, pharmacokinetics and metabolic aspects of chiral drugs, devoting whole chapters to stereoselective drug binding and modeling chiral drug-receptor interactions. With its unique industry-relevant aspects, this is a must for medicinal and pharmaceutical chemists.

Genetic Engineering & Biotechnology News

Genetic Engineering & Biotechnology News
GEN.

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Journal of Analytical Chemistry of the USSR.

Journal of Analytical Chemistry of the USSR.
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1976
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Chiral Separation Techniques

Chiral Separation Techniques
A Practical Approach

by G. Subramanian

  • Publisher : Wiley-VCH
  • Release : 2001
  • Pages : 350
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This is a completely revised and updated sequel to 'A Practical Approach to Chiral Separations by Liquid Chromatography' by the same editor. The scope has been extended to further chiral separation techniques like electrophoresis, membrane separations, or biological assays. More emphasis is put on preparative separation techniques. From reviews of the previous edition: 'A team of experts from academic and industrial laboratories throughout the world have compiled their findings and experience to make this book an exceptionally timely and unique contribution to the field' European Journal of Drug Metabolism 'The dense mass of information contained in this book will make it a valuable resource ...' Chemical Engineering Research '... this is a worthwhile addition to the expanding chiral literature and the book should be of value to those working in this field' The Analyst

Chemical and Engineering News

Chemical and Engineering News
"news Edition" of the American Chemical Society

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1995
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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New Scientist

New Scientist
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1999
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Endocrinology Index

Endocrinology Index
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1973
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Analysis and Purification Methods in Combinatorial Chemistry

Analysis and Purification Methods in Combinatorial Chemistry
A Book

by Bing Yan

  • Publisher : John Wiley & Sons
  • Release : 2004-02-03
  • Pages : 480
  • ISBN : 9780471531999
  • Language : En, Es, Fr & De
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Quality measurement, control, and improvement in combinatorial chemistry Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable." To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering: * Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis * High-throughput analytical methods used to analyze the quality of libraries * High-throughput purification techniques * Analytical methods applied in post-synthesis and post-purification stages Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques. This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.

Separation and Purification of Materials

Separation and Purification of Materials
A Book

by Rolt Hammond

  • Publisher : Unknown Publisher
  • Release : 1958
  • Pages : 327
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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CJChE

CJChE
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2004-02
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Comprehensive Medicinal Chemistry II: Drug discovery technologies

Comprehensive Medicinal Chemistry II: Drug discovery technologies
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2007
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Synthesis and Applications of Isotopically Labelled Compounds

Synthesis and Applications of Isotopically Labelled Compounds
A Book

by D. C. Dean,C. N. Filer,K. E. McCarthy

  • Publisher : Wiley
  • Release : 2004-08-27
  • Pages : 522
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This volume provides an authoritative and comprehensive coverage of the most recent advances in the production, synthesis, analysis and applications of isotopically labelled compounds. It focuses especially on areas of significant growth since the immediately preceding Seventh International Isotope Society Meeting held in Dresden, Germany in June 2000. Contributions are drawn from major research groups around the world, providing valuable information to research community with interests in the following areas: New methodologies in the production of isotopes Novel synthetic and biosynthetic approaches to isotopically labelled compounds Analysis of isotopically labeled compounds Application of isotopically labelled compounds in medical, agricultural, nutritional and environmental research and development Investigation and elucidation or organic and bioorganic mechanisms and pathways Regulatory and safety perspectives The next Symposium in this series will be held at Edinburgh, Scotland in the summer of 2006.

Soviet Research in Pharmaceutical Chemistry

Soviet Research in Pharmaceutical Chemistry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1956
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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