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Sex and Gender Differences in Alzheimer's Disease

Sex and Gender Differences in Alzheimer's Disease
A Book

by Maria Teresa Ferretti,Annemarie Schumacher Dimech,Antonella Santuccione Chadha

  • Publisher : Academic Press
  • Release : 2021-08-05
  • Pages : 512
  • ISBN : 012819345X
  • Language : En, Es, Fr & De
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Sex and Gender Differences in Alzheimer’s Disease: The Women's Brain Project offers, for the first time, a critical overview of the evidence documenting sex and gender differences in AD neurobiology, biomarkers, clinical presentation, treatment, clinical trials and their outcomes and impact on caregivers. This knowledge is crucial for clinical development, digital health solutions, and as social and psychological support to AD families. Presents comprehensive and critical reviews of sex differences in Alzheimer’s disease Combines the knowledge and points-of-view of neuroscientists, medical doctors, psychologists and AI experts for a 360 degree view on the topic and its possible implications Edited by the Women’s Brain Project, the leading NGO in the field of sex differences in neuroscience

Cognitive Sex Differences in Normal and Pathological Aging

Cognitive Sex Differences in Normal and Pathological Aging
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 250
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Sex Differences in Physiology

Sex Differences in Physiology
A Book

by Gretchen Neigh,Megan Mitzelfelt

  • Publisher : Academic Press
  • Release : 2016-05-10
  • Pages : 236
  • ISBN : 0128026081
  • Language : En, Es, Fr & De
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Sex Differences in Physiology is an all-encompassing reference that details basic science research into sex differences in all physiological fields. It includes scientific discoveries concerning sex differences in cardiovascular, respiratory, renal, gastrointestinal, and musculoskeletal physiology. In addition, coverage of the development, endocrinology, neurophysiology, immunity, and metabolism is included, making this important reference a resource that will meet the needs of investigators interested in incorporating sex differences into their research programs, while also providing clinicians with the basis for providing the best sex-based medical treatment options available. Provides a sweeping, organ-by-organ review of currently observed sex differences in animal models and human disease Explains how sex differences influence physiology and disease Provides the critical knowledge on sex differences for better understanding of prevention and treatment of diseases

Sex and Gender Differences in Health and Disease

Sex and Gender Differences in Health and Disease
A Book

by Ricky L. Langley

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 358
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Ricky L. Langley is currently a medical epidemiologist for the North Carolina Department of Health and Human Services.

Sex and Gender Aspects in Clinical Medicine

Sex and Gender Aspects in Clinical Medicine
A Book

by Sabine Oertelt-Prigione,Vera Regitz-Zagrosek

  • Publisher : Springer Science & Business Media
  • Release : 2011-11-15
  • Pages : 204
  • ISBN : 9780857298324
  • Language : En, Es, Fr & De
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This book is a concise, easy to read professional text with a focus on practical aspects. All chapters include tables on sex/gender differences in symptoms and management and a series of suggestions to the novice in the field. Chapters are specialty-specific. The focus is not on women’s health, but the presentation of differences in clinical symptoms, management and outcomes in women and men. Gender Medicine strives to employ the knowledge about these differences to improve diagnosis, better understand pathogenesis and advance patient-oriented therapy.

Sex Differences in Alzheimer's Disease Pathologies and Symptoms

Sex Differences in Alzheimer's Disease Pathologies and Symptoms
A Novel Hypothesis: Circuitries and Plasticity Leading to Sex Differences During Alzheimer's Disease

by Miu Amaya

  • Publisher : CreateSpace
  • Release : 2013-12
  • Pages : 216
  • ISBN : 9781494785758
  • Language : En, Es, Fr & De
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A novel hypothesis describing brain circuitries and synaptic plasticity variations between genders thus leading to susceptibilities of Alzheimer's disease in females. A clear, concise and current exploration into sex differences in the pathogenesis and presentation of Alzheimer's disease during their respective presymptomatic, early symptomatic and late stages. Effects of emotions, trauma and stress impacts upon the brain environment are also explored, along with gender brain dimorphism, cardiovascular and disease risk predisposing one to Alzheimer's disease onsets. Prevention and treatments are further discussed.

Sex and Gender Differences in Pharmacology

Sex and Gender Differences in Pharmacology
A Book

by Vera Regitz-Zagrosek

  • Publisher : Springer Science & Business Media
  • Release : 2012-10-02
  • Pages : 602
  • ISBN : 3642307264
  • Language : En, Es, Fr & De
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This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Reviews on Biomarker Studies in Aging and Anti-Aging Research

Reviews on Biomarker Studies in Aging and Anti-Aging Research
A Book

by Paul C. Guest

  • Publisher : Springer Nature
  • Release : 2019-09-06
  • Pages : 274
  • ISBN : 3030256502
  • Language : En, Es, Fr & De
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Using both epidemiological and model organism approaches, we have gained new insights into the physiological and molecular aspects of aging, which has led to significant advancements in potential anti-aging strategies. Reviews on Biomarker Studies in Aging and Anti-Aging Research presents a series of reviews in various aspects of aging and age-related disease research along with several methods which have shown progress as potential anti-aging approaches. The book is aimed at researchers in the areas of aging and chronic disease, as well as to clinical scientists, physicians and major drug companies. It provides important information on disease mechanisms, and each chapter is presented in the context of the aging process, specific chronic diseases or different therapeutic areas.

Bridging Gaps Between Sex and Gender in Neurosciences

Bridging Gaps Between Sex and Gender in Neurosciences
A Book

by Annie Duchesne,Meng-Chuan Lai,Gillian Einstein,Belinda Pletzer,Marina A. Pavlova

  • Publisher : Frontiers Media SA
  • Release : 2020-07-14
  • Pages : 329
  • ISBN : 2889638650
  • Language : En, Es, Fr & De
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Sex Differences in Neurology and Psychiatry

Sex Differences in Neurology and Psychiatry
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2020-09-30
  • Pages : 476
  • ISBN : 0444641246
  • Language : En, Es, Fr & De
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Sex Differences in Neurology and Psychiatry, Volume 175, addresses this important issue by viewing major neurological and psychiatric conditions through the lens of sexual dimorphism, providing an entirely novel approach to understanding vulnerability factors, as well as potential new treatment strategies in several common neuropsychiatric disorders. The handbook comprises four major sections: (1) Introduction to sex differences in neuroanatomy and neurophysiology, (2) Description of the impact of genetic, epigenetic, sex hormonal and other environmental effects on cerebral sex dimorphism, (3) Review of sex differences in neurologic disorders, and (4) Review of sex differences in psychiatric disorders. Explores sex differences in human neuroanatomy and neurophysiology Offers a pathway toward a gender-specific treatment of neurologic and psychiatric disorders Provides an overview of the genetics of sex hormones, human brain structure, and function, as well as the epigenetics, environment and social context

An Investigation Into the Role of Iron, Copper, and Gender in a Transgenic Mouse Model of Alzheimer's Disease

An Investigation Into the Role of Iron, Copper, and Gender in a Transgenic Mouse Model of Alzheimer's Disease
A Book

by Caitlin Marie Groeber

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 75
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Age-related diseases are more prevalent due to increasing longevity, with this comes increasing dietary supplementation to maintain a healthy lifestyle. Alzheimer's disease (AD) is the primary cause of dementia and the sixth leading cause of death in the United States. Previous studies of transgenic AD mouse models have found that long-term dietary supplementation of zinc (Zn) impairs spatial memory, while copper (Cu) shows remediation of this impairment. Iron (Fe) shows a similar impairment in these tasks, but the potential effects of remediation by Cu have not been studied. In humans, being female is a risk factor for cognitive impairment in AD, therefore it is important to examine gender differences in AD. To examine the effect and interaction of Fe and Cu on cognitive function, male and female transgenic (Tg)CRND8 and wild-type (Wt) mice were administered enhanced drinking water for 5 months: Fe (10ppm FeNO3), Fe+Cu (10ppm FeNO3 + 0.2ppm CuNO3), Cu (0.2ppm CuNO3), and LW. Assessments included the novel object recognition task (NOR; discrimination task) and the Morris water maze (MWM; spatial memory). Histological analysis was conducted on the brain to examine the plaque load, metal content, ceruloplasmin levels, and amyloid levels in these mice. In NOR, Tg Fe+Cu-treated animals showed decreased object recognition compared to Tg LW animals, while Wt Fe+Cu-treated animals performed well. In MWM, only the Fe+Cu-treated animals did not have a decrease in latency and were significantly different from the LW, who were the fastest. Even in normal animals, high levels of Fe+Cu showed negative effects. CRND8 animals were impaired on all assessed measures of learning and memory (NOR and MWM) compared to Wt animals. Females and males perform differently in behavioral tasks dependent upon the type of task. The level of NOR differed between male and female Wt mice, but not Tg. This indicates that female Wt mice are better at this task than male Wt mice; however, once these animals develop signs of AD the difference between the sexes disappears. In contrast, in MWM, males swam faster to the platform than females, and spent less time around the edge of the pool. This was the most pronounced in Tg males compared to Tg females. Sex differences were seen across the varying behavioral tasks of learning and memory, emphasizing the importance of studying both sexes. Plaque load analysis indicated that Fe+Cu-treated and LW Tg animals had the highest plaque burden, while Cu-treated animals had the lowest plaque burden. Females had more plaque area than males, with female Fe+Cu animals showing the highest plaque load of all animals. This measurement of plaque burden may be not be a predictive measure of NOR, but it may be predictive of MWM and it may be due to location of plaque accumulation. The reason may be due to the brain regions required for the completion of the task; MWM depends on the hippocampus, while the hippocampus and entorhinal cortex are required for NOR. Fe+Cu animals had more severe impairments on discrimination and spatial tasks than LW, Fe, or Cu groups alone, which is in contrast to previous findings where Cu remediates impairments caused by Zn. This study showed that it is the balance of metals, not just an overload of a specific metal, which cause harm or not.

Hormones, Gender and the Aging Brain

Hormones, Gender and the Aging Brain
The Endocrine Basis of Geriatric Psychiatry

by Mary F. Morrison

  • Publisher : Cambridge University Press
  • Release : 2000-05-04
  • Pages : 359
  • ISBN : 9781139426459
  • Language : En, Es, Fr & De
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The significance of hormone action in psychiatry has been long studied, now including the psychiatric effects of hormones on the aging process. This clinical reference addresses the hormonal basis of mental disorders in older people. Hormones influence a wide range of states and conditions, from pain tolerance and anorexia to attention, mood, immunity, cardiovascular and cognitive function, schizophrenia and Alzheimer's disease. Written by an eminent team of psychiatrists, psychologists, geriatricians and neuropharmacologists, this book brings together established information and findings in four sections: • An overview of the basic science of neurosteroids • Sex difference and the roles that cortisol, thyroid hormone, and the sex steroids estrogen, progesterone, dehydroepiandrosterone and testosterone play in common mental disorders and pain sensitivity • Psychoneuroimmunology in relation to age • Sex differences and hormones in psychotropic drug metabolism in the elderly.

Gender: The Basics

Gender: The Basics
A Book

by Hilary M. Lips

  • Publisher : Routledge
  • Release : 2013-10-23
  • Pages : 260
  • ISBN : 1134682034
  • Language : En, Es, Fr & De
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Gender: The Basics is an engaging introduction which examines the impact of cultural, historical, biological, psychological and economic forces on qualities which have come to be defined as masculine or feminine. Highlighting that there is far more to gender than biological sex, it takes a global perspective to examine the interaction between gender and a wide range of topics including: • Relationships, intimacy and concepts of sexuality • The workplace and labour markets • Gender related violence and war • Public health, poverty and development • The ageing process Supporting theory with examples and case studies from a variety of contexts, suggestions for further reading and a detailed glossary, this text is an essential read for anyone approaching the study of gender for the first time.

How Sex and Gender Impact Clinical Practice

How Sex and Gender Impact Clinical Practice
An Evidence-Based Guide to Patient Care

by Marjorie R. Jenkins,Connie B. Newman

  • Publisher : Academic Press
  • Release : 2020-12-02
  • Pages : 360
  • ISBN : 0128167505
  • Language : En, Es, Fr & De
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How Sex and Gender Impact Clinical Practice: An Evidence-Based Guide to Patient Care enables primary care clinicians by providing a framework to understand differences and better care for patients in their practice. Each chapter covers a subspecialty in medicine and discusses the influence of sex hormones on disease, along with sex and gender-based differences in clinical presentation, physical examination, laboratory results, treatment regimens, comorbidities and prognosis. Illustrative case examples and practical practice points help each chapter come alive. A special chapter on communication differences between men and women assists clinicians in their conversations with patients. This book fills an important need by applying years of research findings to sex and gender specific medical care and demonstrating that an individualized approach to patient care will lead to improved detection, treatment and prevention of disease. Explores the effects of sex and gender on disease presentation, treatment and prognosis, and how these differences influence clinical decision-making Provides practical guidance that helps clinicians implement a more individualized approach to patient care Contains information on diseases in each major specialty, as well as chapters on communication, pharmacology and public health challenges

Cognitive Sex Differences in Normal and Pathological Aging

Cognitive Sex Differences in Normal and Pathological Aging
A Book

by Paula Kay Shear

  • Publisher : Unknown Publisher
  • Release : 1991
  • Pages : 250
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Encyclopedia of Gender and Society

Encyclopedia of Gender and Society
A Book

by Jodi O'Brien

  • Publisher : SAGE
  • Release : 2009
  • Pages : 976
  • ISBN : 1412909163
  • Language : En, Es, Fr & De
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Entries discuss the impact gender has had on cultural beliefs and practices, social and economic organizations, and individual lives.

Behavioral Pharmacology of the Cholinergic System

Behavioral Pharmacology of the Cholinergic System
A Book

by Mohammed Shoaib

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 329
  • ISBN : 3030560139
  • Language : En, Es, Fr & De
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Comprehensive Men's Mental Health

Comprehensive Men's Mental Health
A Book

by David Castle,David Coghill

  • Publisher : Cambridge University Press
  • Release : 2021-02-28
  • Pages : 256
  • ISBN : 1108740421
  • Language : En, Es, Fr & De
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A complete and accessible textbook covering current understandings about how mental health issues affect men, and the available treatments.

Sex and Gender in Acute Care Medicine

Sex and Gender in Acute Care Medicine
A Book

by Alyson J. McGregor,Esther K. Choo,Bruce M. Becker

  • Publisher : Cambridge University Press
  • Release : 2016-05-20
  • Pages : 329
  • ISBN : 1316688275
  • Language : En, Es, Fr & De
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Until the past decade, clinicians and researchers assumed that the medical evaluation and treatment of both women and men were the same. This archaic and dangerous notion persisted in spite of the clear anatomic and physiologic differences between the genders. Today, we fully understand that this paradigm is false. In all specialties of medicine, practitioners and researchers are beginning to consider the influence of sex and gender and how it should inform the care of their patients. This book focuses on the issue of sex and gender in the evaluation and treatment of patients specifically in the delivery of acute medical care. It serves as a guide both to clinicians interested in the impact of sex and gender on their practice and to researchers interested in the current state of the art in the field and critical future research directions.

Gender & Research

Gender & Research
Brussels, 8-9 November 2001

by Union européenne. Direction générale de la recherche,European Commission. Directorate General for Research

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 335
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Recoge : 1. "A lot done, a lot still to do" - 2. Ministerial round table - 3. First results from the Helsinki Group on women and science : policy review and indicators - 4. Gender impact assessment studies - 5. Benchmarking the progress of women in science - 6. Shaping gender in research - 7. Reaching out to schools and society at large - 8. Researching gender and science - 9. Beyond facts and figures : philosophical perspectives.