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Principles of Gender-Specific Medicine

Principles of Gender-Specific Medicine
The Sex-Specific Biology in the Postgenomic Era

by Marianne J. Legato

  • Publisher : Academic Press
  • Release : 2022-08-15
  • Pages : 800
  • ISBN : 9780323885348
  • Language : En, Es, Fr & De
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Awarded with the 2018 Prose Award in Clinical Medicine, the third edition of Principles of Gender-Specific Medicine explored and described exciting new areas in biomedicine that integrated technology into the treatment of disease and the augmentation of human function. Novel topics such as the sex-specific aspects of space medicine, the development and the use of genderized robots and a discussion of cyborgs were included in the third edition, providing a preview of the expanding world of sex-specific physiology and therapeutics. This Fourth Edition is a continuation of the mission to trace the relevance of biological sex to normal function and to the experience of disease in humans. We are now twenty years into the postgenomic era. The investigation of how the genome produces the phenome has led to fascinating insights as well as yet unanswered questions. Principles of Gender-Specific Medicine, Fourth Edition, has a central theme: discuss advances in understanding the role of epigenetics in regulating gene expression in a dynamic, sex-specific way during human life. It explores the protean role of epigenetics in human physiology, the relevance of environmental experience to human function, the therapeutic promise of cutting-edge methodologies like gene manipulation, the preparation of humans for space travel, the use of artificial intelligence in detection and therapeutic decisions concerning disease states, the possibilities for technological support of not only compromised individuals but of the augmentation of human function, and an analysis of the benefits, limitations and issues that surround our current expectations of personalized medicine. Covers the most important developments in biomedical research in the past decade, with a thoughtful analysis of how they impact patient care Discusses the feasibility and usefulness of personalized medicine, the limits and promise of genetic editing, the basis for variation in sexual identity and how artificial intelligence and technology will affect basic human function as well as correcting disability Promotes and facilitates discussions about the ethics and governance issues that surround much of what science is now able to do at the most basic levels of human's physiology

Bridging Gaps Between Sex and Gender in Neurosciences

Bridging Gaps Between Sex and Gender in Neurosciences
A Book

by Annie Duchesne,Meng-Chuan Lai,Gillian Einstein,Belinda Pletzer,Marina A. Pavlova

  • Publisher : Frontiers Media SA
  • Release : 2020-07-14
  • Pages : 129
  • ISBN : 2889638650
  • Language : En, Es, Fr & De
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Handbook of Epigenetics

Handbook of Epigenetics
The New Molecular and Medical Genetics

by Trygve Tollefsbol

  • Publisher : Academic Press
  • Release : 2010-11-21
  • Pages : 638
  • ISBN : 9780123757104
  • Language : En, Es, Fr & De
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Epigenetics is considered by many to be the "new genetics" because of the overwhelming evidence of the contribution of non-genetic factors such as nutrition, environment, and chemical exposure on gene expression. The effects of epigenetics are vast, including tissue/organ regeneration, X-chromosome inactivation, and stem cell differentiation and genomic imprinting and aging. Aberrations of epigenetics influence many diseases for which clinical intervention is already in place, and many novel epigenetic therapies for cancer, immune disorders, neurological and metabolic disorders, and imprinting diseases are on the horizon. This comprehensive collection of reviews written by leaders in the field of epigenetics provides a broad view of this important and evolving topic. From molecular mechanisms and epigenetic technology to discoveries in human disease and clinical epigenetics, the nature and applications of the science will be presented for those with interests ranging from the fundamental basis of epigenetics to therapeutic interventions for epigenetic-based disorders. Contributions by leading international investigators involved in molecular research and clinical and therapeutic applications Integrates methods and biological topics with basic and clinical discoveries Includes coverage of new topics in epigenetics such as prions, regulation of long-term memory by epigenetics, metabolic aspects of epigenetics, and epigenetics of neuronal disorders

Pharmacoepigenetics

Pharmacoepigenetics
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2019-06-04
  • Pages : 983
  • ISBN : 0128139404
  • Language : En, Es, Fr & De
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Pharmacoepigenetics, Volume Eleven provides a comprehensive volume on the role of epigenetics and epigenomics in drug discovery and development, providing a detailed, but accessible, view of the field, from basic principles, to applications in disease therapeutics. Leading international researchers from across academia, clinical settings and the pharmaceutical industry discuss the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, and treatment, current epigenetic drugs, and the application of epigenetic procedures in drug development. Throughout the book, chapter authors offer a balanced and objective discussion of the future of pharmacoepigenetics and its crucial contribution to the growth of precision and personalized medicine. Fully examines the influence of epigenetics and epigenomics in human pathology, epigenetic biomarkers for disease prediction, diagnosis, treatment, current epigenetic drugs and the application of epigenetic procedures in drug development Features chapter contributions from leading international researchers in academia, clinical settings and the pharmaceutical industry Instructs researchers, students and clinicians on how to better interpret and employ pharmacoepigenetics in drug development, efficiency and safety Provides a balanced and objective discussion of the future of pharmacoepigenetics and its crucial role in precision medicine

Gender, Sex and Children's Play

Gender, Sex and Children's Play
A Book

by Jacky Kilvington,Ali Wood

  • Publisher : Bloomsbury Publishing
  • Release : 2016-08-11
  • Pages : 208
  • ISBN : 1472523563
  • Language : En, Es, Fr & De
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Does gender, sex and sexuality influence children's play, and their learning? Can/should professionals try to influence children's gender and sexual concepts? Can/should professionals try to prevent gender stereotyping? These and other questions are explored in a lively and thought-provoking text that looks at why and how children inhabit or develop their gender and sexuality. Written in an approachable way and illustrated with case studies and linked to current research and theory, the book helps students, teachers and playworkers understand the debates about biology versus culture and social learning and how these impact on children's expression of gender and sexuality. Engaging the reader in a thorough reflection of their own views and approaches to the genderized and sexualized behaviour of children at play, this text is an invaluable guide for all those interested in the importance of play, gender and sexuality and how they relate to children's lives. Topics include: play and the behaviour of boys and girls within particular social contexts; play and girls' and boys' sexual behaviour and their associated feelings; play and children's self-concepts and expectations; the professional adult workers' role and the manifestation of genderized and/or sexualized play behaviour both in and outside a setting.

Biopolitics and Gender

Biopolitics and Gender
A Book

by Meredith W Watts Jr

  • Publisher : Routledge
  • Release : 2012-12-06
  • Pages : 220
  • ISBN : 1136548912
  • Language : En, Es, Fr & De
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Here is an important book for social scientists interested in the influence of gender on certain types of behavior. Several perspectives are presented on the general topic of biopolitics and gender, including the points of view of brain science, endocrinology, ethology, psychophysiology, and such conventional interests as political attitudes, socialization, participation, social structure, and political hierarchy. The varied and provocative ideas explored in this volume will broaden discussions of gender beyond an exclusive focus on sex links to oppression and discrimination.

Gender Dysphoria and Disorders of Sex Development

Gender Dysphoria and Disorders of Sex Development
Progress in Care and Knowledge

by Baudewijntje P.C. Kreukels,Thomas D. Steensma,Annelou L.C. de Vries

  • Publisher : Springer Science & Business Media
  • Release : 2013-07-01
  • Pages : 357
  • ISBN : 1461474418
  • Language : En, Es, Fr & De
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This book provides a state of the art review on the care and treatment of and current scientific knowledge on gender dysphoria (GD) and disorders of sex development (DSD). The book elucidates the history, the present situation, and the newest developments and future perspectives in both research on GD and DSD and the clinical management of individuals with GD and DSD of all ages. With contributions from a selection of leading scientists and established clinicians in the field of GD and DSD, this is a unique and comprehensive book focusing on the etiology and developmental trajectories of GD and DSD regarding gender identity development, psychiatric comorbidity, classification dilemmas, ethical dilemmas in treatment, influences of societal stigmatization, and discussion of the medical and psychological implications and outcomes of treatment, and providing treatment guidelines for individuals with GD and DSD (distinct guidelines each for children, adolescents, and adults). By presenting not only an historic overview and the current state of the art, but also challenges for the future, the book aims to demonstrate the need for further research and to stimulate the development and improvement of the clinical care of individuals with GD and DSD.​

Sex Differences in Neurology and Psychiatry

Sex Differences in Neurology and Psychiatry
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2020-09-30
  • Pages : 476
  • ISBN : 0444641246
  • Language : En, Es, Fr & De
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Sex Differences in Neurology and Psychiatry, Volume 175, addresses this important issue by viewing major neurological and psychiatric conditions through the lens of sexual dimorphism, providing an entirely novel approach to understanding vulnerability factors, as well as potential new treatment strategies in several common neuropsychiatric disorders. The handbook comprises four major sections: (1) Introduction to sex differences in neuroanatomy and neurophysiology, (2) Description of the impact of genetic, epigenetic, sex hormonal and other environmental effects on cerebral sex dimorphism, (3) Review of sex differences in neurologic disorders, and (4) Review of sex differences in psychiatric disorders. Explores sex differences in human neuroanatomy and neurophysiology Offers a pathway toward a gender-specific treatment of neurologic and psychiatric disorders Provides an overview of the genetics of sex hormones, human brain structure, and function, as well as the epigenetics, environment and social context

Early Life Adversity’s Impact on Brain and Body: Understanding Disrupted Circuits to Identify Preventive Strategies

Early Life Adversity’s Impact on Brain and Body: Understanding Disrupted Circuits to Identify Preventive Strategies
A Book

by Andreas Menke,Annamaria Cattaneo,Christiaan H. Vinkers

  • Publisher : Frontiers Media SA
  • Release : 2021-07-01
  • Pages : 129
  • ISBN : 2889669610
  • Language : En, Es, Fr & De
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Becoming Human

Becoming Human
Matter and Meaning in an Antiblack World

by Zakiyyah Iman Jackson

  • Publisher : NYU Press
  • Release : 2020-05-19
  • Pages : 320
  • ISBN : 1479830372
  • Language : En, Es, Fr & De
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Argues that blackness disrupts our essential ideas of race, gender, and, ultimately, the human Rewriting the pernicious, enduring relationship between blackness and animality in the history of Western science and philosophy, Becoming Human: Matter and Meaning in an Antiblack World breaks open the rancorous debate between black critical theory and posthumanism. Through the cultural terrain of literature by Toni Morrison, Nalo Hopkinson, Audre Lorde, and Octavia Butler, the art of Wangechi Mutu and Ezrom Legae, and the oratory of Frederick Douglass, Zakiyyah Iman Jackson both critiques and displaces the racial logic that has dominated scientific thought since the Enlightenment. In so doing, Becoming Human demonstrates that the history of racialized gender and maternity, specifically antiblackness, is indispensable to future thought on matter, materiality, animality, and posthumanism. Jackson argues that African diasporic cultural production alters the meaning of being human and engages in imaginative practices of world-building against a history of the bestialization and thingification of blackness—the process of imagining the black person as an empty vessel, a non-being, an ontological zero—and the violent imposition of colonial myths of racial hierarchy. She creatively responds to the animalization of blackness by generating alternative frameworks of thought and relationality that disrupt not only the racialization of the human/animal distinction found in Western science and philosophy but also by challenging the epistemic and material terms under which the specter of animal life acquires its authority. What emerges is a radically unruly sense of a being, knowing, feeling existence: one that necessarily ruptures the foundations of "the human."

Sex and Gender Differences in Pharmacology

Sex and Gender Differences in Pharmacology
A Book

by Vera Regitz-Zagrosek

  • Publisher : Springer Science & Business Media
  • Release : 2012-10-02
  • Pages : 602
  • ISBN : 3642307264
  • Language : En, Es, Fr & De
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This is the very first book to deal with sex and gender differences in drug therapy - an increasingly recognized medical need. It starts with an overview on S/G in clinical syndromes and a documentation of the medical and socioeconomic damage caused by gender specific adverse drug effects. Part I covers S/G differences in pharmacokinetics. Researchers will be satisfied by the detailed discussion of the mechanisms of S/G differences in drug effects that represents cutting edge science and includes interaction of drugs with sex hormones, genomic and epigenetic mechanisms. It also covers S/G in drug development, in animal models and clinical development and S/G in drug prescriptions. Part II targets S/G differences in drug effects in cardiovascular, pulmonary, CNS, neuromuscular, neuropsychiatric and metabolic diseases, in cancer, inflammation, and rheumatic diseases, in bacterial and retroviral infections, thrombosis, embolism. New drugs will be discussed.

Sex-Based Differences in Lung Physiology

Sex-Based Differences in Lung Physiology
A Book

by Patricia Silveyra,Xenia T. Tigno

  • Publisher : Springer Nature
  • Release : 2021-03-18
  • Pages : 490
  • ISBN : 303063549X
  • Language : En, Es, Fr & De
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This book provides an overview of the latest experimental work on sex-based differences in lung function and inflammation. Readers will learn how these differences relate to individual predispositions for the development of lung disease in men and women, and in different stages of their reproductive lives. Further, the book focuses on diseases that predominantly affect women or men, with an emphasis on the physiological mechanisms underlying their pathobiology. In turn, these findings are complemented by chapters on recent studies, which investigate how circulating sex hormone levels impact the lung’s innate immune response to environmental agents and air pollution. The pathogeneses of asthma and viral respiratory infection are also major focus areas. As an outlook, the book also discusses current and future research directions aimed at developing sex-specific therapies for lung disease. To examine these anatomical and physiological differences in the male and female respiratory systems, the authors employ a broad range of methods from molecular and clinical biology. Accordingly, the book will be a fascinating read for physiologists and clinicians alike.

Principles of Molecular Medicine

Principles of Molecular Medicine
A Book

by J. Larry Jameson

  • Publisher : Springer Science & Business Media
  • Release : 1998-07-13
  • Pages : 1127
  • ISBN : 1592597262
  • Language : En, Es, Fr & De
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Within the framework of clinical internal medicine, they will gain critical knowledge of the many powerful molecular biology-based developments now so rapidly enhancing our understanding of the pathophysiology of disease, improving the feasibility and accuracy of diagnostic testing, and opening novel therapeutic avenues, including gene therapy. Readers will also gain a fuller understanding of the role played by genetic defects in a host of diseases, among them peripheral neuropathies, Alzheimer's disease, arrhythmias, leukemias and lymphomas, cystic fibrosis, hepatitis, HIV, autoimmune disorders, polycystic kidney disease, schizophrenia, affective disorders, alcoholism, Huntington's disease, and many more.

Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans

Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2014-08-22
  • Pages : 326
  • ISBN : 0128003332
  • Language : En, Es, Fr & De
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Epigenetic Shaping of Sociosexual Interactions: From Plants to Humans is the first attempt to interpret the higher social functions of organisms. This volume covers an extraordinarily wide range of biological research and provides a novel framework for understanding human-specific brain functions. Covers an extraordinarily wide range of biological research Provides a novel framework for understanding human-specific brain functions.

Mattering

Mattering
Feminism, Science, and Materialism

by Victoria Pitts-Taylor

  • Publisher : NYU Press
  • Release : 2016-08-30
  • Pages : 313
  • ISBN : 1479833495
  • Language : En, Es, Fr & De
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Feminists today are re-imagining nature, biology, and matter in feminist thought and critically addressing new developments in biology, physics, neuroscience, epigenetics and other scientific disciplines. Mattering, edited by noted feminist scholar Victoria Pitts-Taylor, presents contemporary feminist perspectives on the materialist or ‘naturalizing’ turn in feminist theory, and also represents the newest wave of feminist engagement with science. The volume addresses the relationship between human corporeality and subjectivity, questions and redefines the boundaries of human/non-human and nature/culture, elaborates on the entanglements of matter, knowledge, and practice, and addresses biological materialization as a complex and open process. This volume insists that feminist theory can take matter and biology seriously while also accounting for power, taking materialism as a point of departure to rethink key feminist issues. The contributors, an international group of feminist theorists, scientists and scholars, apply concepts in contemporary materialist feminism to examine an array of topics in science, biotechnology, biopolitics, and bioethics. These include neuralplasticity and the brain-machine interface; the use of biometrical identification technologies for transnational border control; epigenetics and the intergenerational transmission of the health effects of social stigma; ADHD and neuropharmacology; and randomized controlled trials of HIV drugs.A unique and interdisciplinary collection, Mattering presents in grounded, concrete terms the need for rethinking disciplinary boundaries and research methodologies in light of the shifts in feminist theorizing and transformations in the sciences.

Neuroimaging of Pain

Neuroimaging of Pain
A Book

by Luca Saba

  • Publisher : Springer
  • Release : 2017-06-08
  • Pages : 508
  • ISBN : 3319480464
  • Language : En, Es, Fr & De
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Authored by world renowned scientists, this book expertly reviews all the imaging techniques and exciting new methods for the analysis of the pain, including novel tracers, biomarker, metabolomic and gene-array profiling, together with cellular, genetic, and molecular approaches. Recent advances in human brain imaging techniques have allowed a better understand of the functional connectivity in pain pathways, as well as the functional and anatomical alterations that occur in chronic pain patients. Modern imaging techniques have permitted rapid progress in the understanding of networks in the brain related to pain processing and those related to different types of pain modulation. Neuroimaging of Pain is designed to be a valuable resource for radiologists, neuroradiologists, neurologists and neuroscientists, working in hospitals and universities from junior trainees to consultants.

The Palgrave Handbook of Biology and Society

The Palgrave Handbook of Biology and Society
A Book

by Maurizio Meloni,John Cromby,Des Fitzgerald,Stephanie Lloyd

  • Publisher : Springer
  • Release : 2017-10-27
  • Pages : 941
  • ISBN : 1137528796
  • Language : En, Es, Fr & De
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This comprehensive handbook synthesizes the often-fractured relationship between the study of biology and the study of society. Bringing together a compelling array of interdisciplinary contributions, the authors demonstrate how nuanced attention to both the biological and social sciences opens up novel perspectives upon some of the most significant sociological, anthropological, philosophical and biological questions of our era. The six sections cover topics ranging from genomics and epigenetics, to neuroscience and psychology to social epidemiology and medicine. The authors collaboratively present state-of-the-art research and perspectives in some of the most intriguing areas of what can be called biosocial and biocultural approaches, demonstrating how quickly we are moving beyond the acrimonious debates that characterized the border between biology and society for most of the twentieth century. This landmark volume will be an extremely valuable resource for scholars and practitioners in all areas of the social and biological sciences. The chapter 'Ten Theses on the Subject of Biology and Politics: Conceptual, Methodological, and Biopolitical Considerations' is open access under a CC BY 4.0 license via link.springer.com. Versions of the chapters 'The Transcendence of the Social', 'Scrutinizing the Epigenetics Revolution', 'Species of Biocapital, 2008, and Speciating Biocapital, 2017' and 'Experimental Entanglements: Social Science and Neuroscience Beyond Interdisciplinarity' are available open access via third parties. For further information please see license information in the chapters or on link.springer.com.

Epigenetic Landscapes

Epigenetic Landscapes
Drawings as Metaphor

by Susan Merrill Squier

  • Publisher : Duke University Press
  • Release : 2017-11-03
  • Pages : 280
  • ISBN : 0822372606
  • Language : En, Es, Fr & De
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Devised in the 1940s by the biologist C. H. Waddington, the epigenetic landscape is a metaphor for how gene regulation modulates cellular development. As a scientific model, it fell out of use in the late 1960s but returned at the beginning of the twenty-first century with the advent of big-data genomic research because of its utility among scientists across the life sciences to think more creatively about and to discuss genetics. In Epigenetic Landscapes Susan Merrill Squier follows the model’s cultural trail, from its first visualization by the artist John Piper to its use beyond science. Squier examines three cases in which the metaphor has been imaginatively deployed to illustrate complex systems that link scientific and cultural practices: graphic medicine, landscape architecture, and bioArt. Challenging reductive understandings of epigenetics, Squier boldly reclaims the broader significance of the epigenetic landscape as a figure at the nexus of art, design, and science.

Epigenetics in Cardiovascular Disease

Epigenetics in Cardiovascular Disease
A Book

by Yvan Devaux,Emma Louise Robinson

  • Publisher : Academic Press
  • Release : 2021-03-06
  • Pages : 498
  • ISBN : 012822259X
  • Language : En, Es, Fr & De
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Epigenetics in Cardiovascular Disease, a new volume in the Translational Epigenetics series, offers a comprehensive overview of the epigenetics mechanisms governing cardiovascular disease development, as well as instructions in research methods and guidance in pursing new studies. More than thirty international experts provide an (i) overview of the epigenetics mechanisms and their contribution to cardiovascular disease development, (i) high-throughput methods for RNA profiling including single-cell RNA-seq, (iii) the role of nucleic acid methylation in cardiovascular disease development, (iv) epigenetic actors as biomarkers and drug targets, (v) and the potential of epigenetics to advance personalized medicine. Here, readers will discover strategies to combat research challenges, improve quality of their epigenetic research and reproducibility of their findings. Additionally, discussion of assay and drug development for personalized healthcare pave the way for a new era of understanding in cardiovascular disease. Offers a thorough overview of role of epigenetics mechanisms in cardiovascular disease Includes guidance to improve research plans, experimental protocols design, quality and reproducibility of results in new epigenetics research Explores biomarkers and drug targets of therapeutic potential to advance personalized healthcare Features chapter contributions from a wide range of international researchers in the field

The Plasticity of Sex

The Plasticity of Sex
The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior

by Marianne J. Legato

  • Publisher : Academic Press
  • Release : 2020-05-19
  • Pages : 318
  • ISBN : 0128159693
  • Language : En, Es, Fr & De
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The Plasticity of Sex: The Molecular Biology and Clinical Features of Genomic Sex, Gender Identity and Sexual Behavior provides a comprehensive view on the development of human sexuality. As there has been a crescendo of interest over the past several decades about the nature and diversity of human sexuality, this reference brings the evidence-based research into one place. The emergence of issues surrounding gender identity, genital ambivalence and the transition from one sex to another is striking, with the public and treating physicians alike clamoring for an evidence-based, comprehensive treatment of human sexuality and all its variations. This is a must-have reference for biomedical researchers in endocrinology, neuroscience, development biology, medical students, residents, and practicing physicians from all medical areas. Winner of the 2021 PROSE Award in Biomedicine from the Association of American Publishers! Discusses the role of biology in gender identity from research in genetics, endocrinology and neuroscience Addresses important health disparities and how to address them when treating the transgender patient Reviews evidence-based information on the biological basis and impact of environmental and hormonal factors at different life stages Outlines schema for treating variations in the sexuality and sexual function of the individual patient