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Sirtuin Biology in Medicine

Sirtuin Biology in Medicine
Targeting New Avenues of Care in Development, Aging, and Disease

by Kenneth Maiese

  • Publisher : Academic Press
  • Release : 2021-03-04
  • Pages : 420
  • ISBN : 0128141190
  • Language : En, Es, Fr & De
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Sirtuin Biology in Medicine: Targeting New Avenues of Care in Development, Aging, and Disease provides a fascinating and in-depth analysis of sirtuins in the body during normal physiology as well during disease highlighting the targeting of sirtuin-controlled pathways for the development of innovative, efficacious, and safe therapeutic strategies for multiple disorders in the body that ultimately can affect lifespan extension. Sirtuins are expressed throughout the body, have broad biological effects, and can significantly impact both cellular survival and longevity during acute and long-term illnesses. These histone deacetylases play an intricate role in the pathology, progression, and treatment of several disease entities ranging from neurodegenerative disorders, cardiovascular disease, immune system dysfunction, reproductive dysfunction, endocrine disorders, gastrointestinal disease, drug dependency, and aging-related disorders. Implementing a translational medicine format, this unique reference highlights novel signaling pathways for sirtuins that promote stem cell proliferation, enhance cellular protection, modulate pathways of apoptosis and autophagy, and extend life span. Each chapter is presented with insightful detail that will be of interest and a comprehensive resource to audiences that include scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who discuss the broad role of sirtuins in health and disease Details the basic and clinical role of sirtuins for the development of new clinical treatments Summarizes the multidiscipline views and publications for the compelling discipline of sirtuins by covering systems throughout the body Serves as an important resource for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease
Cellular Pathways for Clinical Discovery

by Kenneth Maiese

  • Publisher : Academic Press
  • Release : 2021-03-19
  • Pages : 300
  • ISBN : 0128224673
  • Language : En, Es, Fr & De
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Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery fills a significant void that provides a unique resource for elucidating the most recent research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities. Scientists, physicians, students and pharmaceutical industry researchers from diverse backgrounds will use this reference as the "go-to resource” for both the biology and medical applications that focus upon sirtuins. As sirtuins play an intricate role in the pathology, progression and treatment of several disease entities ranging from metabolic disease and diabetes, cancer, cardiovascular disease, immune system dysfunction, to reproductive dysfunction, and aging-related disorders, this book provides an ideal update on the topic. Details the basic and clinical role of sirtuins and their broad applicability for sirtuin biology to be targeted for multiple medical disease entities Elucidates the research and advances on the biology of sirtuins, the application of these pathways upon cellular biology, and the translation of sirtuin pathways for the treatment of multiple disease entities Summarizes the multi-discipline views and publications for this diverse topic, covering cell development, cancer and metabolism

Sirtuins

Sirtuins
A Book

by Riekelt Houtkooper

  • Publisher : Springer
  • Release : 2016-11-19
  • Pages : 273
  • ISBN : 9789402409611
  • Language : En, Es, Fr & De
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The sirtuin family of proteins (SIRT1-7) received a lot of attention in recent years as they serve as metabolic sensors that control not only metabolism, but also aging and lifespan regulation. As such, sirtuins are strong targets for the treatment of age-related metabolic diseases, including obesity, diabetes, and cancer. Indeed, many research groups as well as pharmaceutical companies discovered food components and/or drugs that target the sirtuins and provide significant health benefits. This book focuses on various aspects of sirtuin biology, from basic biochemistry, via molecular function, to its role in (fighting) human disease.

Sirtuins in Health and Disease

Sirtuins in Health and Disease
A Book

by Weiping Zheng

  • Publisher : Academic Press
  • Release : 2018-01-27
  • Pages : 300
  • ISBN : 9780128122617
  • Language : En, Es, Fr & De
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Sirtuins in Health and Disease, Volume 154 presents the reactions catalyzed by sirtuins in terms of their unique coenzyme NAD+-dependent catalytic mechanisms, the ways to elucidate these mechanisms, and the design of the inhibitory compounds against the sirtuin-catalyzed reactions as potential therapeutic agents for human diseases. Sections cover the concepts and chemical tools in sirtuin research, SIRT4 and SIRT7, the regulatory effects of NAD metabolic pathways on sirtuin activity, sirtuins as modifiers of Huntington's Disease (HD) pathology, parasite sirtuins as targets for novel chemotherapeutic agents, targeting sirtuins - substrate specificity and inhibitor design, and chemical probes in sirtuin research. This book focuses on the outstanding issues in the sirtuin field and implications for future sirtuin research. Presents an excellent subject, excellent structural organization, and authoritative contributions from world-renowned scholars in the sirtuin field Provides the latest updates on sirtuins in health and disease

Sirtuin Biology in Cancer and Metabolic Disease

Sirtuin Biology in Cancer and Metabolic Disease
Cellular Pathways for Clinical Discovery

by Kenneth Maiese

  • Publisher : Elsevier
  • Release : 2021-02-20
  • Pages : 300
  • ISBN : 0128224843
  • Language : En, Es, Fr & De
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Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students. Chapters are authored by internationally recognized experts who elucidate the intimate relationship between cancer and metabolic disease that intersects with sirtuin pathways Presents the basic and clinical role of sirtuins in regard to cancer and metabolic disease Summarizes the multidiscipline views and publications for this exciting field of sirtuins for the development of new clinical treatments for cancer and metabolic disease Provides a vital foundation for a broad audience of healthcare providers, scientists, drug developers, and students in both clinical and research settings

Introductory Review on Sirtuins in Biology, Aging, and Disease

Introductory Review on Sirtuins in Biology, Aging, and Disease
A Book

by Leonard Guarente,Raul Mostoslavsky,Aleksey Kazantsev

  • Publisher : Academic Press
  • Release : 2018-04-20
  • Pages : 220
  • ISBN : 012813500X
  • Language : En, Es, Fr & De
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Introductory Review on Sirtuins in Biology and Disease provides key insights for scientists and advanced students who need to understand sirtuins and the current research in this field. This book is ideal for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses. Sirtuins are a diverse family of proteins, with several members in mammals. The functional diversity of sirtuins is rather broad, and they have been implicated in various central biological processes. Thus, they are also highly relevant in the context of various human diseases, from cancer to neurodegeneration. Covers both the general and specific aspects of sirtuin proteins and their role in biology, aging and disease Presents a top quality collection of leading experts who contribute on a wide range of sirtuin-related topics Ideal resource for pharmaceutical companies as they develop novel targets using sirtuins for metabolic diseases, cancer and neurodegenerative illnesses

Epigenetics in Biology and Medicine

Epigenetics in Biology and Medicine
A Book

by Manel Esteller

  • Publisher : CRC Press
  • Release : 2008-09-17
  • Pages : 312
  • ISBN : 9781420007077
  • Language : En, Es, Fr & De
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Anomalous epigenetic patterns touch many areas of study including biomedical, scientific, and industrial. With perspectives from international experts, this resource offers an all-inclusive overview of epigenetics, which bridge DNA information and function by regulating gene expression without modifying the DNA sequence itself. Epigenetics, in its

Adaptation Biology and Medicine

Adaptation Biology and Medicine
|:

by Y Kawai

  • Publisher : ALPHA SCIENCE INTERNATIONAL LIMITED
  • Release : 2017-01-05
  • Pages : 480
  • ISBN : 8184876661
  • Language : En, Es, Fr & De
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Although the entire evolution of life is an adaptation right from the coming-together of the elements and reaching to human life as we know today, the realization of the adaptation biology as a discipline is relatively recent. Furthermore, subcellular basis of gradual adaptation of body systems in stressful conditions is still a greate mystery of biology. The present book attempts to fill that gap. It is known that such an adaptation not only increases tolerance of the body to that given stress but also to other challenges. A complete knowledge of this cross protection needs to be defined and exp;oited to improve patient care. The book includes chapters describing subcellular adaptations; adaptation to different stresses as well as to lifestyle and environment. Although for an easy reading the information has been grouped under the sub-heading: Current Trends, the book represents a common continuum of adaptations. The therapeutic value of the understanding of the science of adaptation has also been described in several chapters. Examples of cross adaptations are also provided, where repeated exposure to one stinulus may ptentialyy be used in the treatment as well as prophylaxis of different diseases.The present book will be of great interest to all biologists, physiologists, pharmacologists and physicians interested in the application of the biology of adaptation in the improvement of health.

Handbook of the Biology of Aging

Handbook of the Biology of Aging
A Book

by Nicolas Musi,Peter Hornsby

  • Publisher : Academic Press
  • Release : 2021-01-19
  • Pages : 468
  • ISBN : 012816283X
  • Language : En, Es, Fr & De
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Handbook of the Biology of Aging, Ninth Edition, provides a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology. The book focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and metabolomics methodologies applied to aging related problems. Sections cover longevity pathways and interventions that modulate aging, innovative tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, and much more. Assists researchers in keeping abreast of research and clinical findings outside their subdiscipline Helps medical, behavioral and social gerontologists understand what basic scientists and clinicians are discovering Includes new chapters on genetics, evolutionary biology, bone aging, and epigenetic control Examines the diverse research being conducted in the study of the biology of aging

Sirtuins in Biology and Disease

Sirtuins in Biology and Disease
A Book

by Tiago F. Outeiro,Aleksey G. Kazantsev

  • Publisher : Frontiers E-books
  • Release : 2021
  • Pages : 329
  • ISBN : 9782889191178
  • Language : En, Es, Fr & De
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Sirtuins comprise a family of NAD+-dependent enzymes that have been shown to impact longevity in a number of eukaryotic organisms. Sir2 (Silent Information Regulator 2) was the first sirtuin protein discovered. The discovery that Sir2 requires NAD+ for its activity suggested a link between Sir2 activity and the phenomenon of caloric restriction in prolonging longevity. This link was strengthened by the observation that lifespan extension by caloric restriction requires Sir2 protein. Under conditions of caloric restriction, NAD+ levels are high, Sir2 is activated, and the rate of aging is decreased. These effects have been replicated in invertebrate organisms, where a close structural and functional homologue of Sir2 was found in C. elegans and Drosophila. The sirtuin-dependent effects on metabolism and ageing, observed in lower organisms, have ignited intensive investigation of their biological and therapeutic roles in mammals. There are seven known mammalian sirtuins, SIRTs 1-7, the most studied of which is SIRT1, a close structural and functional homologue of yeast Sir2. Enhancement of organismal longevity and other health-promoting effects of mammalian SIRT1 have frequently been attributed to the regulation of metabolism. A recognized molecular link between metabolism and aging stimulated a firestorm of investigations, aiming to combat metabolic and age-dependent human diseases. It has become clear, however, that the sirtuin family of proteins regulates a diverse repertoire of cellular functions in mammals. Mounting evidence implicating SIRT1 in important clinical indications, such as diabetes, cancer, cardiovascular dysfunction and neurodegenerative disease, suggest that modality as attractive therapeutic target. Subsequently, drug discovery and development, targeting sirtuin activation, has been intensified in the recent years. Despite rapid progress and accumulation of new data, the biological roles of other mammalian sirtuins have been less studied and remain poorly understood. There are several important questions that remain to be addressed. What are the functions of sirtuins in different cell types and tissues? Are all sirtuins involved in the regulation of metabolism and aging? What is the functional relationship between different sirtuins? What are the mechanisms of regulation of sirtuin activities? What is the role of sirtuins in disease and therapy? This issue aims to address these and other critical questions, relevant to Research Topic on sirtuin biology and therapeutics. To that end the issue solicits expert opinions of sirtuin research on structural biology, biochemistry, cell biology, animal genetics, pharmacology, medicinal chemistry and drug discovery, and on areas of investigation studying human conditions, like diabetes, cancer, cardio-vascular, and neutodegeneration. Of particular interest are the new methods and assays to study sirtuins in various organisms and developing sirtuin-based therapeutics. Furthermore, we propose to encourage contributors to discuss new concepts and paradigms, and to express their perspectives on the future development of the sirtuin research field. Altogether, we believe this issue provides a unique opportunity for comprehensive and diverse coverage of the topic, and will be of broad interest for the journal’s readership.

Issues in Pathology, Diagnostics, and Disease: 2011 Edition

Issues in Pathology, Diagnostics, and Disease: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 944
  • ISBN : 1464965439
  • Language : En, Es, Fr & De
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Issues in Pathology, Diagnostics, and Disease: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Pathology, Diagnostics, and Disease. The editors have built Issues in Pathology, Diagnostics, and Disease: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Pathology, Diagnostics, and Disease in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Pathology, Diagnostics, and Disease: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition

Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition
ScholarlyPaper

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-26
  • Pages : 22
  • ISBN : 1481632213
  • Language : En, Es, Fr & De
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Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition is a ScholarlyPaper™ that delivers timely, authoritative, and intensively focused information about Group III Histone Deacetylases in a compact format. The editors have built Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Group III Histone Deacetylases in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Group III Histone Deacetylases—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Using Medicine in Science Fiction

Using Medicine in Science Fiction
The SF Writer’s Guide to Human Biology

by H. G. Stratmann

  • Publisher : Springer
  • Release : 2015-09-14
  • Pages : 556
  • ISBN : 331916015X
  • Language : En, Es, Fr & De
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This book offers a clearly written, entertaining and comprehensive source of medical information for both writers and readers of science fiction. Science fiction in print, in movies and on television all too often presents dubious or simply incorrect depictions of human biology and medical issues. This book explores the real science behind such topics as how our bodies adapt to being in space, the real-life feasibility of common plot elements such as suspended animation and medical nanotechnology, and future prospects for improving health, prolonging our lives, and enhancing our bodies through technology. Each chapter focuses on a single important science fiction-related subject, combining concise factual information with examples drawn from science fiction in all media. Chapters conclude with a “Bottom Line” section summarizing the most important points discussed in the chapter and giving science fiction writers practical advice on how to incorporate them into their own creations, including a list of references for further reading. The book will appeal to all readers interested in learning about the latest ideas on a variety of science fiction-related medical topics, and offers an invaluable reference source for writers seeking to increase the realism and readability of their works. Henry G. Stratmann, MD, FACC, FACP is a cardiologist with board certifications in internal medicine, cardiology, and nuclear cardiology. Befor e entering private practice he became Professor of Medicine at St. Louis University School of Medicine and performed clinical medical research. Henry received a BA in chemistry from St. Louis University and his MD at Southern Illinois University School of Medicine. He is currently enrolled at Missouri State University to obtain a BS in physics with a minor in astronomy. His professional publications include being an author or coauthor of many research articles for medical journals, primarily in the field of nuclear cardiology. Henry is also a regular contributor of both stories and science fact articles to Analog Science Fiction and Fact.

Handbook of cholesterol

Handbook of cholesterol
Biology, function and role in health and diseases

by Ronald Ross Watson,Fabien De Meester

  • Publisher : Wageningen Academic Publishers
  • Release : 2016-02-08
  • Pages : 494
  • ISBN : 9086868215
  • Language : En, Es, Fr & De
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The handbook of cholesterol - biology, function and role in health and disease - gathers a substantial set of contributions supporting the modern view that dietary and blood cholesterols are safe or even beneficial in a balanced omega-6/3 fatty acids environment, whereas they may turn into unsafe or detrimental to health in a typical omega-6 fatty acid environment. Dietary and blood cholesterols, including LDL-cholesterol, are secondary risk factors which belong to the human omnivorous diet and physiology, which may represent clinical valid surrogates of the outcome, cardiovascular diseases. However, the primary risk factors, the omega-6/3 fatty acids, determine whether human health is in the safe evolutionary zone or not. Omega-6/3 fatty acids are essential to human physiology. They must be present and maintained in physiologically-defined essential amounts and balanced in blood and tissue lipid pools, through the diet. Chronic deviations from omega-6/3 fatty acids make LDL-cholesterol valid indicators of cardiovascular disease. The handbook takes preventive and acute approaches, based on biochemical and clinical evidence, to the management of cholesterol - a per se non-essential nutrient, yet an essential blood and tissue component. The reviews, especially when combined, will help understand the essentiality of dietary and blood cholesterol as (risk) factors in human health.

Translational Biology in Medicine

Translational Biology in Medicine
A Book

by M. Montano

  • Publisher : Elsevier
  • Release : 2014-12-08
  • Pages : 228
  • ISBN : 1908818654
  • Language : En, Es, Fr & De
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The recent emphasis in biomedical research on translational biology and personalized medicine is revolutionizing conceptual and experimental approaches to understanding and improving human health. Translational Biology in Medicine begins with an introduction to experimental model systems for disease, such as cell lines, primary cells, stem cells and animal models for disease, followed by a systematic description of genetic and genomic profiling and biomarker validation currently used in biomedical research. Examples of translation studies that have used these models and methods are presented, including studies in aging, tissue repair and chronic infection, each with an emphasis on how personalized medicine is transforming biomedicine. Bioethical considerations in translational study design and bioethical considerations in biomedical research are then covered, before concluding remarks, and a look towards the future of personalized medicine. Describes cellular and animal model systems used in translational research Discusses the use of blood, genetic and genomic biomarkers for disease Presents translational studies in aging, tissue repair and infectious disease biomedicine

Comparative Biology of Aging

Comparative Biology of Aging
A Book

by Norman S. Wolf

  • Publisher : Springer Science & Business Media
  • Release : 2010-01-08
  • Pages : 391
  • ISBN : 9789048134656
  • Language : En, Es, Fr & De
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determined by an inability to move in response to touch. C. elegans develop through four larval stages following hatching and prior to adulthood. Adult C. elegans are reproductive for about the rst week of adulthood followed by approximately two weeks of post-reproductive adulthood prior to death. Life span is most commonly measured in the laboratory by maintaining the worms on the surface of a nutrie- agar medium (Nematode Growth Medium, NGM) with E. coli OP50 as the bacterial food source (REF). Alternative culture conditions have been described in liquid media; however, these are not widely used for longevity studies. Longevity of the commonly used wild type C. elegans hermaphrodite (N2) varies ? from 16 to 23 days under standard laboratory conditions (20 C, NGM agar, E. coli OP50 food source). Life span can be increased by maintaining animals at lower ambient temperatures and shortened by raising the ambient temperature. Use of a killed bacterial food source, rather than live E. coli, increases lifespan by 2–4 days, and growth of adult animals in the absence of bacteria (axenic growth or bac- rial deprivation) increases median life span to 32–38 days [3, 23, 24]. Under both standard laboratory conditions and bacterial deprivation conditions, wild-derived C. elegans hermaphrodites exhibit longevity comparable to N2 animals [25].

The Molecular and Cellular Basis of Neurodegenerative Diseases

The Molecular and Cellular Basis of Neurodegenerative Diseases
Underlying Mechanisms

by Michael S. Wolfe

  • Publisher : Academic Press
  • Release : 2018-03-29
  • Pages : 560
  • ISBN : 0128113057
  • Language : En, Es, Fr & De
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The Molecular and Cellular Basis of Neurodegenerative Diseases: Underlying Mechanisms presents the pathology, genetics, biochemistry and cell biology of the major human neurodegenerative diseases, including Alzheimer’s, Parkinson’s, frontotemporal dementia, ALS, Huntington’s, and prion diseases. Edited and authored by internationally recognized leaders in the field, the book's chapters explore their pathogenic commonalities and differences, also including discussions of animal models and prospects for therapeutics. Diseases are presented first, with common mechanisms later. Individual chapters discuss each major neurodegenerative disease, integrating this information to offer multiple molecular and cellular mechanisms that diseases may have in common. This book provides readers with a timely update on this rapidly advancing area of investigation, presenting an invaluable resource for researchers in the field. Covers the spectrum of neurodegenerative diseases and their complex genetic, pathological, biochemical and cellular features Focuses on leading hypotheses regarding the biochemical and cellular dysfunctions that cause neurodegeneration Details features, advantages and limitations of animal models, as well as prospects for therapeutic development Authored by internationally recognized leaders in the field Includes illustrations that help clarify and consolidate complex concepts

Coenzymes: Advances in Research and Application: 2011 Edition

Coenzymes: Advances in Research and Application: 2011 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-01-09
  • Pages : 150
  • ISBN : 1464927383
  • Language : En, Es, Fr & De
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Coenzymes: Advances in Research and Application: 2011 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Enzymes and Coenzymes. The editors have built Coenzymes: Advances in Research and Application: 2011 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Enzymes and Coenzymes in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Coenzymes: Advances in Research and Application: 2011 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Issues in Life Sciences—Molecular Biology: 2012 Edition

Issues in Life Sciences—Molecular Biology: 2012 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-01-10
  • Pages : 925
  • ISBN : 1481645366
  • Language : En, Es, Fr & De
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Issues in Life Sciences—Molecular Biology / 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Molecular Biology. The editors have built Issues in Life Sciences—Molecular Biology: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Molecular Biology in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Issues in Life Sciences—Molecular Biology: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Handbook of the Biology of Aging

Handbook of the Biology of Aging
A Book

by Matt Kaeberlein,George Martin

  • Publisher : Academic Press
  • Release : 2015-08-20
  • Pages : 576
  • ISBN : 0124116205
  • Language : En, Es, Fr & De
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Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions