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Spinal Cord Injury (SCI) Repair Strategies

Spinal Cord Injury (SCI) Repair Strategies
A Book

by Giuseppe Perale,Filippo Rossi

  • Publisher : Woodhead Publishing
  • Release : 2019-10-30
  • Pages : 346
  • ISBN : 0081028083
  • Language : En, Es, Fr & De
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Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Promoting Neuroplasticity to Repair the Injured Spinal Cord

Promoting Neuroplasticity to Repair the Injured Spinal Cord
A Book

by Nina Weishaupt

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 272
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay pathways to re-establish communication with target regions below the injury level. In chapter 2, I attempted to promote a detour for the cervically injured corticospinal tract (CST) via spared reticulospinal tract (RtST) axons with a combined treatment including the neurotrophins BDNF, NT-3 and rehabilitative training. Although anatomical evidence for the desired rewiring was not obtained, I found a synergistic effect of BDNF treatment and training on recovery of skilled forelimb reaching. No effect of NT-3 administered rostral to the SCI was evident. The experiment in chapter 3 was designed to answer the question whether NT-3-induced CST collateral growth rostral to an SCI can be facilitated by systemic immune activation. Results indicate that NT-3 expression can promote collateral growth from the injured CST, irrespective of immune activation. Since results from chapter 2 did not shed light on the previously suggested role of the RtST in recovery of hand/paw function after cervical SCI, I next examined whether the mostly spared RtST responds to SCI with changes in its anatomical projection pattern. While collateral projections were unchanged rostral to the SCI, I observed a marked withdrawal of collaterals from grey matter regions directly caudal to the SCI. Results from chapter 2 combined with previous reports indicate that task-specific training does often not translate into untrained tasks and may even result in undesired side effects. To elucidate the functional relationship between trained tasks further, I next investigated how training the primarily affected forelimb (PAF) and/or the less affected forelimb (LAF) after unilateral cervical SCI influences performance outcomes for each limb. Results point towards training tasks competitively recruiting available neuronal "hardware". This work identifies promising leads for promoting plasticity of important motor tracts after SCI, and also points out targets for optimization of strategies employed. These new insights contribute to the exploration of urgently needed repair strategies for SCI.

Neurobiology of Spinal Cord Injury

Neurobiology of Spinal Cord Injury
A Book

by Robert G. Kalb,Stephen M. Strittmatter

  • Publisher : Springer Science & Business Media
  • Release : 1999-10-22
  • Pages : 284
  • ISBN : 1592592007
  • Language : En, Es, Fr & De
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Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma
A Book

by Michael G. Fehlings,Brian Kwon,Alexander R. Vaccaro,F. Cumhur Oner

  • Publisher : Academic Press
  • Release : 2020-12-15
  • Pages : 400
  • ISBN : 9780128198353
  • Language : En, Es, Fr & De
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Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

Spinal Cord Injury

Spinal Cord Injury
A Book

by Joost Verhaagen,John W. McDonald III

  • Publisher : Newnes
  • Release : 2012-12-31
  • Pages : 656
  • ISBN : 0444535071
  • Language : En, Es, Fr & De
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Handbook of Clinical Neurology: Spinal Cord Injury summarizes advances in the clinical diagnosis, monitoring, prognostication, treatment, and management of spinal cord injuries. More specifically, it looks at new and important developments in areas such as high-resolution noninvasive neuroimaging, surgery, and electrical stimulation of motor, respiratory, bladder, bowel, and sexual functions. It also reviews the latest insights into spontaneous regeneration and recovery of function following rehabilitation, with emphasis on novel therapeutic strategies, such as gene therapy, transcranial stimulation, brain-machine interfaces, pharmacological approaches, molecular target discovery, and the use of olfactory ensheathing cells, stem cells, and precursor cells. Organized in five sections, the book begins with an overview of the development, maturation, biomechanics, and anatomy of the spinal cord before proceeding with a discussion of clinical diagnosis and prognosis as well as natural recovery, ambulation, and function following spinal cord injury. It then examines clinical neurophysiology in the prognosis and monitoring of traumatic spinal cord injury; medical, surgical and rehabilitative management of spinal cord trauma; and some new approaches for improving recovery in patients, including restoration of function by electrical stimulation, locomotor training, and the use of robotics. Other chapters cover cell transplantation, artificial scaffolds, experimental pharmacological interventions, and molecular and combinatorial strategies for repairing the injured spinal cord. This volume should be of interest to neuroscience and clinical neurology research specialists and practicing neurologists. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities

Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition

Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-07-22
  • Pages : 196
  • ISBN : 148166218X
  • Language : En, Es, Fr & De
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Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Diagnosis and Screening. The editors have built Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Diagnosis and Screening in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Spinal Cord Injury: New Insights for the Healthcare Professional: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Biomimetic Materials And Design

Biomimetic Materials And Design
Biointerfacial Strategies, Tissue Engineering And Targeted Drug Delivery

by Angela Dillow,Anthony Lowman

  • Publisher : CRC Press
  • Release : 2002-08-28
  • Pages : 696
  • ISBN : 0824743806
  • Language : En, Es, Fr & De
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Detailing techniques in wound healing and reconstruction, this reference describes the mechanisms and architecture of biological systems to formulate and design natural and synthetic compounds, degradable and non-degradable scaffolds, and targeted drug delivery devices. It offers strategies to control adhesive interactions, elicit specific cellular responses, and improve the biocompatibility, performance, and durability of prosthetic materials. Covering advances in the field, the book discusses the effect of topographical features on cell behaviors such as orientation, adhesion, migration, proliferation, and differentation.

Regenerative Biology of the Spine and Spinal Cord

Regenerative Biology of the Spine and Spinal Cord
A Book

by Rahul Jandial,Mike Y. Chen

  • Publisher : Springer Science & Business Media
  • Release : 2013-04-13
  • Pages : 215
  • ISBN : 1461440904
  • Language : En, Es, Fr & De
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Editors hope that Regenerative Biology of the Spine and Spinal Cord appeals to the nostalgic sentiments of investigators and intellectuals in that it can be held in hand and provide a broad survey of leading edge science. At the same time its chapters can be digitally acquired for those established in the field to refine particular knowledge interests or gaps. Most importantly, we ask the reader, whomever that may be, to peruse without prejudice as countless more chapters will have been written before total spinal regeneration is achieved.

Essentials of Spinal Cord Injury Medicine

Essentials of Spinal Cord Injury Medicine
A Book

by Yannis Dionyssiotis

  • Publisher : BoD – Books on Demand
  • Release : 2018-06-13
  • Pages : 166
  • ISBN : 1789232481
  • Language : En, Es, Fr & De
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Spinal cord injury is a severe condition leading to serious neurological dysfunctions and changes a person's life in a sudden way. Understanding the pathophysiology of spinal cord injury will improve the prognosis and reintegration to the society of spinal cord-injured subjects. The book Essentials in Spinal Cord Injury Medicine includes seven chapters with valuable information addressing hot topics related to spinal cord injury, ranging from pathophysiology, nontraumatic spinal cord injury, complications to exoskeletons, and research therapies with mesenchymal stem cells. The book could be a valued reference for physiatrists, neurosurgeons, orthopedic surgeons, neurologists and physical therapists.

Handbook of Innovations in Central Nervous System Regenerative Medicine

Handbook of Innovations in Central Nervous System Regenerative Medicine
A Book

by António Salgado

  • Publisher : Elsevier
  • Release : 2020-06-10
  • Pages : 710
  • ISBN : 0128180854
  • Language : En, Es, Fr & De
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Handbook of Innovations in CNS Regenerative Medicine provides a comprehensive overview of the CNS regenerative medicine field. The book describes the basic biology and anatomy of the CNS and how injury and disease affect its balance and the limitations of the present therapies used in the clinics. It also introduces recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies. Finally, the book presents successful cases of translation of basic research to first-in-human trials and the steps needed to follow this path. Areas such as cell transplantation approaches, bio and neuro-engineering, molecular/pharmacotherapy therapies and enabling technologies are key in regenerative medicine are covered in the book, along with regulatory and ethical issues. Describes the basic biology and anatomy of the CNS and how injury and disease affect its balance Discusses the limitations of present therapies used in the clinics Introduces the recent trends in different fields of CNS regenerative medicine, including cell transplantation, bio and neuro-engineering, molecular/pharmacotherapy therapies, and enabling technologies Presents successful cases of translation of basic research to first-in-human trials, along with the steps needed to follow this path

Spinal Cord Medicine, Second Edition

Spinal Cord Medicine, Second Edition
Principles and Practice

by Christopher M. Bono, MD,Diana D. Cardenas, MD, MHA,Frederick S. Frost, MD,Margaret C. Hammond, MD,Laurie B. Lindblom, MD,Inder Parkash, MD, MS, FRCS, FACS,Stevens A. Stiens, MD, MS,Robert M. Woolsey, MD

  • Publisher : Demos Medical Publishing
  • Release : 2010-03-19
  • Pages : 560
  • ISBN : 1935281771
  • Language : En, Es, Fr & De
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A Doody's Core Title 2012 The thoroughly revised Second Edition of this authoritative reference continues to define the standard of care for the field of spinal cord medicine. Encompassing all of the diseases and disorders that may a!ect the proper functioning of the spinal cord or spinal nerves, this comprehensive volume provides a state of the art review of the principles of care and best practices for restoring function and quality of life to patients with spinal cord injuries. Expert contributors from multiple disciplines cover topics ranging from acute medical and surgical management of specific problems to cutting-edge research, bladder, bowel and sexual dysfunction, neurologic and musculoskeletal issues, advanced rehabilitation techniques and technologies, functional outcomes, and psychosocial care. While comprehensive in scope, Spinal Cord Medicine offers practical guidance for physicians and other health care professionals involved in the management of individuals with SCI, multiple sclerosis, and other spinal cord disorders. The Second Edition has been completely updated to fully reflect current science and practice. Each section has been re-ordered to better present information and the Second Edition brings in many new authors and topics, more diagrams, illustrations, and tables to solidify concepts, and contains 18 entirely new chapters. Spinal Cord Medicine: Principles and Practice, Second Edition, reflects the breadth and depth of this multi-faceted specialty. Involving over 150 authors from more than 20 fields of medicine, it is a trusted reference for anyone who works with spinal cord patients and strives to deliver superior clinical care and improve outcomes.

Gene Therapy of the Central Nervous System: From Bench to Bedside

Gene Therapy of the Central Nervous System: From Bench to Bedside
A Book

by Michael G. Kaplitt,Matthew During

  • Publisher : Gulf Professional Publishing
  • Release : 2006
  • Pages : 355
  • ISBN : 9780123976321
  • Language : En, Es, Fr & De
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Few areas of biomedical research provide greater opportunities for radically new therapies for devastating diseases that have evaded treatment so far than gene therapy. This is particularly true for the brain and nervous system, where gene transfer has become a key technology for basic research and has recently been translated to human therapy in several landmark clinical trials. Gene Therapy of the Central Nervous System: From Bench to Bedside represents the first definitive volume on this subject. Edited by two pioneers of neurological gene therapy, this volume contains contributions by leaders who helped create this field and are expanding the promise of gene therapy for the future of basic and clinical neuroscience. Drawing upon this extensive collective experience, this book provides clear and informative reviews on a variety of subjects of interest to anyone exploring or using gene therapy for neurobiological applications in research and clinical praxis. * Presents gene transfer technologies with particular emphases upon novel vehicles, immunological issues and the role of gene therapy in stem cells * Discusses preclinical areas that are likely to translate into clinical studies in the near future, including epilepsy, pain and amyotrophic lateral sclerosis * Includes "insider" information on technological and regulatory issues which can often limit effective translation of even the most promising idea into clinical use

Advances in Nervous System Trauma Research and Treatment: 2013 Edition

Advances in Nervous System Trauma Research and Treatment: 2013 Edition
A Book

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2013-06-21
  • Pages : 254
  • ISBN : 148168342X
  • Language : En, Es, Fr & De
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Advances in Nervous System Trauma Research and Treatment: 2013 Edition is a ScholarlyEditions™ book that delivers timely, authoritative, and comprehensive information about Craniocerebral Trauma. The editors have built Advances in Nervous System Trauma Research and Treatment: 2013 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Craniocerebral Trauma in this book to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Advances in Nervous System Trauma Research and Treatment: 2013 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Practical Management of Head and Neck Injury

Practical Management of Head and Neck Injury
A Book

by Jeffrey Rosenfeld

  • Publisher : Elsevier Health Sciences
  • Release : 2012-10-31
  • Pages : 404
  • ISBN : 0729579565
  • Language : En, Es, Fr & De
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Category Winner 2013 - Tertiary Education (Wholly Australian) Student Resource, Australian Publishers Association – Australian Educational Publishing Awards 2013. Practical Management of Head and Neck Injury is a unique textbook which comprehensively covers the patient journey from injury to the rehabilitation phase. It includes diagnosis and management of head and neck injury with additional chapters on prognosis and special conditions including head injury in sport, the elderly, children, pregnant women, penetrating head injury, spine and spinal cord injury and brain death. It describes an integrated approach to care from all the relevant specialties with Australian, UK and US experts contributing to many chapters. The book will be of interest to junior doctors, specialist trainees and specialists in emergency medicine, surgery, neurosurgery, orthopaedics, ENT, maxillofacial surgery, neurology, ophthalmology, anaesthesia and intensive care as well as medical students, nurses, paramedics and remote and rural practitioners. The complete management of patients with head and neck trauma, from the accident scene through to rehabilitation Safe, practical tips to assist the non-neurosurgeon in managing head injuries and preventing secondary brain injury—a major concern for emergency and pre-hospital medical personnel All aspects of neck trauma covered, including the management of cervical spine injury Detailed discussion of topics such as the classification of brain injury, concussion in sport, head injuries in children and the elderly, penetrating head injuries and the prognosis of head injury The operative surgery of head and neck trauma outlined for the non-surgeon Contributions from a wide range of specialists, both from Australia and overseas Integration of neurosurgery with ear, nose and throat (ENT) surgery, maxillofacial surgery, ophthalmology and spinal orthopaedics Basic principles of relevant anatomy and pathophysiology, each covered in a separate chapter

Axon Growth and Regeneration:

Axon Growth and Regeneration:
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2012-12-31
  • Pages : 272
  • ISBN : 0124071694
  • Language : En, Es, Fr & De
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Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research. Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered. All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist Leading authors review state-of-the-art in their field of investigation and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist

Spinal Cord Injury: New Insights for the Healthcare Professional: 2012 Edition

Spinal Cord Injury: New Insights for the Healthcare Professional: 2012 Edition
ScholarlyBrief

by Anonim

  • Publisher : ScholarlyEditions
  • Release : 2012-12-10
  • Pages : 70
  • ISBN : 1464973989
  • Language : En, Es, Fr & De
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Spinal Cord Injury: New Insights for the Healthcare Professional / 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Spinal Cord Injury in a concise format. The editors have built Spinal Cord Injury: New Insights for the Healthcare Professional / 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Spinal Cord Injury in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Spinal Cord Injury: New Insights for the Healthcare Professional / 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.

Spine Surgery 2-Vol Set E-Book

Spine Surgery 2-Vol Set E-Book
Techniques, Complication Avoidance, and Management (Expert Consult - Online)

by Edward C. Benzel

  • Publisher : Elsevier Health Sciences
  • Release : 2012-05-14
  • Pages : 2248
  • ISBN : 1455723320
  • Language : En, Es, Fr & De
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Build a solid foundation of knowledge based on the fundamentals and employ step-by-step instruction from Spine Surgery. Edited by Edward C. Benzel, this best-selling medical reference explores the full spectrum of surgical techniques used in spine surgery and delivers the comprehensive, cutting-edge guidance you need to achieve successful outcomes. Online access, thorough updates, contributions by leading international authorities, an abundance of detailed illustrations, and procedural video clips provide everything you need to avoid and manage complex problems. Glean essential, up-to-date, need-to-know information in one comprehensive reference that explores the full spectrum of surgical techniques used in spine surgery. Hone your surgical skills and technique with intraoperative videos and more than 800 outstanding illustrations demonstrating each technique step by step. Grasp and apply the latest knowledge from more than 25 brand-new chapters, as well as extensive revisions or total rewrites to the majority of existing chapters to present all of the most up-to-date information available on every aspect of spine surgery including motion preservation technologies, endovascular management, back pain and psychosocial interactions, biomechanics, and more. Consult with the best. Renowned neurosurgery authority Edward C. Benzel leads an international team of accomplished neurosurgeons and orthopedic surgeons - many new to this edition - who provide dependable guidance and share innovative approaches to surgical techniques and complications management. Equip yourself to address increasing occurrences of pain among aging and physically active patients. Access the information you need, where you need it on your laptop or mobile device via expertconsult.com, with fully searchable text, a wealth of procedural videos, online updates from the experts, downloadable image gallery and links to PubMed.

Recovery of Motor Function Following Spinal Cord Injury

Recovery of Motor Function Following Spinal Cord Injury
A Book

by Heidi Fuller,Monte Gates

  • Publisher : BoD – Books on Demand
  • Release : 2016-08-17
  • Pages : 330
  • ISBN : 9535124978
  • Language : En, Es, Fr & De
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Restoration of motor function following spinal cord injury is a complex and challenging task. By reviewing emerging cellular, pharmacological, rehabilitative, as well as surgical approaches, this book seeks to highlight promising therapeutic strategies for the repair and regeneration of motor circuitry. The multidisciplinary nature of these approaches illustrates various routes to bridging the gap between the bench and the bedside and to identify the challenges that must be overcome in order to bring about a viable therapeutic strategy for spinal cord injury patients.

Textbook of Neural Repair and Rehabilitation: Volume 1, Neural Repair and Plasticity

Textbook of Neural Repair and Rehabilitation: Volume 1, Neural Repair and Plasticity
A Book

by Michael E. Selzer,Michael Selzer,Stephanie Clarke,Leonardo Cohen,Pamela Duncan,Fred Gage

  • Publisher : Cambridge University Press
  • Release : 2006-02-16
  • Pages : 724
  • ISBN : 9780521856416
  • Language : En, Es, Fr & De
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Covers the basic sciences relevant to recovery of function following injury to the nervous system.

Neurotrauma and Critical Care of the Spine

Neurotrauma and Critical Care of the Spine
A Book

by Jack Jallo,Alexander R. Vaccaro

  • Publisher : Thieme
  • Release : 2018-03-21
  • Pages : 238
  • ISBN : 162623342X
  • Language : En, Es, Fr & De
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"This book is the most useful summary of present knowledge about epidemiology, pathophysiology, assessment and management of spinal cord injuries today. It is a great book that deserves a widespread distribution among spine surgeons and physicians involved in the treatment of spinal injuries." - European Journal of Orthopaedic Surgery & Traumatology Neurotrauma and Critical Care of the Spine, 2nd edition, by a distinguished critical care neurosurgeon, Jack Jallo, and a renowned spine surgeon, Alexander Vaccaro, incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on spine injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, orthopaedic surgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery infuse this book with a well-rounded perspective. From the pre-hospital to intensive care setting, this unique reference provides a comprehensive, yet concise approach to the treatment of acute spinal cord injury and management of patients with chronic SCI. Chapters new to this edition include neurological assessment of spinal injury, clearing the cervical spine, management of concurrent TBI and spinal injury, blood pressure and oxygen management, temperature management, fluids and osmotherapy, pharmacology, autonomic dysreflexia, infection after SCI, and emerging therapies. Key Highlights, Evaluation and management of SCI in the athlete including different injury syndromes and the latest recommendations for "return to play" in less severe cases Management of pediatric spinal injuries in the NICU with illustrative cases Specialized topics include a comprehensive review of SCI pharmacology, recent medical advances, socioeconomic and quality-of-life considerations Nearly 100 high quality illustrations facilitate understanding of complex anatomy and techniques Summary tables provide a handy overview of injury type, causes, characteristics, and recommended imaging modalities The definitive guide on the management of cervical, cervicothoracic, and thoracolumbar injuries, this is essential reading for neurosurgeons, orthopaedic surgeons, trauma and emergency specialists, and residents in these specialties. Paired with Neurotrauma and Critical Care of the Brain, 2nd edition, this dynamic duo is the most up-to-date neurocritical care reference available today.