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Spinal Cord Injury (SCI) Repair Strategies

Spinal Cord Injury (SCI) Repair Strategies
A Book

by Giuseppe Perale,Filippo Rossi

  • Publisher : Woodhead Publishing
  • Release : 2019-10-30
  • Pages : 346
  • ISBN : 0081028083
  • Language : En, Es, Fr & De
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Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. Covers current and future repair strategies for spinal cord injury repair Focuses on key research trends, clinics, biology and engineering Provides fundamentals on regenerative engineering and tissue engineering

Promoting Neuroplasticity to Repair the Injured Spinal Cord

Promoting Neuroplasticity to Repair the Injured Spinal Cord
A Book

by Nina Weishaupt

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 272
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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This thesis explores strategies to promote neuronal plasticity in a rat model of cervical spinal cord injury (SCI) in an effort to achieve improved recovery of skilled forelimb use. I focused on investigating how motor pathways disrupted by an SCI may connect to spared, lesion-bridging relay pathways to re-establish communication with target regions below the injury level. In chapter 2, I attempted to promote a detour for the cervically injured corticospinal tract (CST) via spared reticulospinal tract (RtST) axons with a combined treatment including the neurotrophins BDNF, NT-3 and rehabilitative training. Although anatomical evidence for the desired rewiring was not obtained, I found a synergistic effect of BDNF treatment and training on recovery of skilled forelimb reaching. No effect of NT-3 administered rostral to the SCI was evident. The experiment in chapter 3 was designed to answer the question whether NT-3-induced CST collateral growth rostral to an SCI can be facilitated by systemic immune activation. Results indicate that NT-3 expression can promote collateral growth from the injured CST, irrespective of immune activation. Since results from chapter 2 did not shed light on the previously suggested role of the RtST in recovery of hand/paw function after cervical SCI, I next examined whether the mostly spared RtST responds to SCI with changes in its anatomical projection pattern. While collateral projections were unchanged rostral to the SCI, I observed a marked withdrawal of collaterals from grey matter regions directly caudal to the SCI. Results from chapter 2 combined with previous reports indicate that task-specific training does often not translate into untrained tasks and may even result in undesired side effects. To elucidate the functional relationship between trained tasks further, I next investigated how training the primarily affected forelimb (PAF) and/or the less affected forelimb (LAF) after unilateral cervical SCI influences performance outcomes for each limb. Results point towards training tasks competitively recruiting available neuronal "hardware". This work identifies promising leads for promoting plasticity of important motor tracts after SCI, and also points out targets for optimization of strategies employed. These new insights contribute to the exploration of urgently needed repair strategies for SCI.

Journal of Rehabilitation Research and Development

Journal of Rehabilitation Research and Development
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2003
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Neurobiology of Spinal Cord Injury

Neurobiology of Spinal Cord Injury
A Book

by Robert G. Kalb,Stephen M. Strittmatter

  • Publisher : Springer Science & Business Media
  • Release : 1999-10-22
  • Pages : 284
  • ISBN : 1592592007
  • Language : En, Es, Fr & De
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Distinguished researchers review the latest scientific understanding of spinal cord injury (SCI), focusing on the mechanisms causing paralysis after spinal cord trauma, the molecular determinants of neural regeneration, and methods for improving damaged function. The authors examine the role of intracellular Ca2+ in neuronal death, the possibility of spinal learning, growth-promoting molecules for regenerating neurons, and the biochemistry and cell biology of microtubules. Among the treatment possibilities discussed are cell transplantation strategies beyond the use of fetal spinal cord tissue, remyelination in spinal cord demyelination models, high steroid therapy immediately after SCI, and the mixed use of anti- and proinflammatories. Comprehensive and highly promising, Neurobiology of Spinal Cord Injury summarizes and integrates the great progress that has been made in understanding and combating the paralysis that follows spinal cord injury.

Spinal Cord Injury Rehabilitation

Spinal Cord Injury Rehabilitation
A Book

by Edelle Field-Fote

  • Publisher : F.A. Davis
  • Release : 2009-03-26
  • Pages : 500
  • ISBN : 0803623194
  • Language : En, Es, Fr & De
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One of the world’s leading authorities in spinal cord injury, and a participant in the Human Brain Project brings you an evidenced-based guide to the state-of-the-art in spinal cord rehabilitation. She has assembled an expert team of clinicians, each with expertise in the content areas they address. Their work encompasses all of the new scientific knowledge and technological advances practitioners need to know to determine the most effective rehabilitation interventions for each patient and to attain maximum restoration of function in individuals with SCI.

Cumulated Index Medicus

Cumulated Index Medicus
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma

Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma
A Book

by Michael G. Fehlings,Brian Kwon,Alexander R. Vaccaro,F. Cumhur Oner

  • Publisher : Academic Press
  • Release : 2020-12-15
  • Pages : 400
  • ISBN : 9780128198353
  • Language : En, Es, Fr & De
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Neural Repair and Regeneration after Spinal Cord Injury and Spine Trauma provides readers with a comprehensive overview on the most up-to-date strategies to repair and regenerate the injured spinal cord following SCI and spine trauma. With contributions by international authors, chapters put regenerative approaches in context, allowing the reader to understand the challenges and future directions of regenerative therapies. Recent clinical trial advancements are thoroughly discussed, with the impact of trial findings addressed. Additionally, major ongoing clinical trials are included with thoughts from experts in the field. Recent clinical practice guidelines for the management of traumatic spinal cord injury are featured throughout. These guidelines are quickly being adopted as the standard of care worldwide, and the comprehensive information found within this book will place these recommendations in context with current knowledge surrounding spinal cord injury and spine trauma. Contains contributions by international authors Covers recent clinical trial advancements and findings and updates on ongoing trials Presents an overview of clinical practice guidelines for the management of traumatic spinal cord injury featured Provides the reader with insights regarding the translation of research from bench to bedside and the skills needed to understand the translational pathway using real-life examples

Dissertation Abstracts International

Dissertation Abstracts International
The sciences and engineering. B

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Neurotrauma and Critical Care of the Spine

Neurotrauma and Critical Care of the Spine
A Book

by Jack Jallo,Alexander R. Vaccaro

  • Publisher : Thieme
  • Release : 2018-03-21
  • Pages : 238
  • ISBN : 162623342X
  • Language : En, Es, Fr & De
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"This book is the most useful summary of present knowledge about epidemiology, pathophysiology, assessment and management of spinal cord injuries today. It is a great book that deserves a widespread distribution among spine surgeons and physicians involved in the treatment of spinal injuries." - European Journal of Orthopaedic Surgery & Traumatology Neurotrauma and Critical Care of the Spine, 2nd edition, by a distinguished critical care neurosurgeon, Jack Jallo, and a renowned spine surgeon, Alexander Vaccaro, incorporates salient components of the highly praised first edition. The updated text reflects cutting-edge discussion on spine injury management in a neurocritical care setting. Contributions from top experts in neurosurgery, orthopaedic surgery, neurology, critical care, cardiac and pulmonary care, and trauma surgery infuse this book with a well-rounded perspective. From the pre-hospital to intensive care setting, this unique reference provides a comprehensive, yet concise approach to the treatment of acute spinal cord injury and management of patients with chronic SCI. Chapters new to this edition include neurological assessment of spinal injury, clearing the cervical spine, management of concurrent TBI and spinal injury, blood pressure and oxygen management, temperature management, fluids and osmotherapy, pharmacology, autonomic dysreflexia, infection after SCI, and emerging therapies. Key Highlights, Evaluation and management of SCI in the athlete including different injury syndromes and the latest recommendations for "return to play" in less severe cases Management of pediatric spinal injuries in the NICU with illustrative cases Specialized topics include a comprehensive review of SCI pharmacology, recent medical advances, socioeconomic and quality-of-life considerations Nearly 100 high quality illustrations facilitate understanding of complex anatomy and techniques Summary tables provide a handy overview of injury type, causes, characteristics, and recommended imaging modalities The definitive guide on the management of cervical, cervicothoracic, and thoracolumbar injuries, this is essential reading for neurosurgeons, orthopaedic surgeons, trauma and emergency specialists, and residents in these specialties. Paired with Neurotrauma and Critical Care of the Brain, 2nd edition, this dynamic duo is the most up-to-date neurocritical care reference available today.

Canadian Journal of Chemistry

Canadian Journal of Chemistry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2010
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Society for Neuroscience Abstracts

Society for Neuroscience Abstracts
Volume 27, 31st Annual Meeting, San Diego, Calif., November 10-15, 2001

by Society for Neuroscience. Meeting

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Peterson's Graduate Programs in the Biological Sciences 2008

Peterson's Graduate Programs in the Biological Sciences 2008
Book 3

by Peterson's

  • Publisher : Petersons
  • Release : 2007-12
  • Pages : 1239
  • ISBN : 9780768924060
  • Language : En, Es, Fr & De
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Lists over 3,700 graduate programs in 37 disciplines in the biological sciences

Science

Science
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2002
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Neuronal Differentiation Microenvironment is Essential for Spinal Cord Injury Repair

The Neuronal Differentiation Microenvironment is Essential for Spinal Cord Injury Repair
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2017
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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ABSTRACT: Spinal cord injury (SCI) often leads to substantial disability due to loss of motor function and sensation below the lesion. Neural stem cells (NSCs) are a promising strategy for SCI repair. However, NSCs rarely differentiate into neurons; they mostly differentiate into astrocytes because of the adverse microenvironment present after SCI. We have shown that myelin-associated inhibitors (MAIs) inhibited neuronal differentiation of NSCs. Given that MAIs activate epidermal growth factor receptor (EGFR) signaling, we used a collagen scaffold-tethered anti-EGFR antibody to attenuate the inhibitory effects of MAIs and create a neuronal differentiation microenvironment for SCI repair. The collagen scaffold modified with anti-EGFR antibody prevented the inhibition of NSC neuronal differentiation by myelin. After transplantation into completely transected SCI animals, the scaffold-linked antibodies induced production of nascent neurons from endogenous and transplanted NSCs, which rebuilt the neuronal relay by forming connections with each other or host neurons to transmit electrophysiological signals and promote functional recovery. Thus, a scaffold-based strategy for rebuilding the neuronal differentiation microenvironment could be useful for SCI repair.

Protective Strategies for Neurodegenerative Diseases

Protective Strategies for Neurodegenerative Diseases
A Book

by Debomoy K. Lahiri

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 356
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The incidence of age-related neurodegenerative diseases can be expected to rise dramatically in the future owing to an aging population. Consequently, finding the means of retarding the progression of such diseases becomes increasingly important. This volume focuses on research findings involving both nutritional and pharmacological strategies for slowing normal brain aging and its pathological variants such as Alzheimer's and Parkinson's diseases. Scientists well recognized for their molecular and mechanistic work in this area have contributed chapters to this volume. New concepts concerning neurodegenerative disease and its mitigation are also included in this volume, which is designed to promote the development of fresh research perspectives and therapeutic possibilities directed toward neuroprotection.

The Year in Neurology ...

The Year in Neurology ...
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Handbook of Biodegradable Polymeric Materials and Their Applications: Applications

Handbook of Biodegradable Polymeric Materials and Their Applications: Applications
A Book

by Surya Mallapragada,Balaji Narasimhan

  • Publisher : Unknown Publisher
  • Release : 2006
  • Pages : 313
  • ISBN : 9781588830555
  • Language : En, Es, Fr & De
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Tissue Engineering

Tissue Engineering
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2008
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Molecular Biology and Pharmacology of Tissue Repair

Molecular Biology and Pharmacology of Tissue Repair
Proceedings of the Esteve Foundation Symposium 12, Held Between 4 and 7 October 2006, S'Agaró (Girona), Spain

by Fundación Dr. Antonio Esteve. Symposium

  • Publisher : Elsevier Science Health Science Division
  • Release : 2007
  • Pages : 168
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Diseases associated with impaired tissue repair are common clinical problems. Therefore, the elucidation of the molecular basis of normal and impaired repair will help to define new therapeutic targets to alleviate and eventually cure these illnesses. Furthermore, recent studies have revealed remarkable similarities between tissue repair and cancer at the cellular and molecular level. Thus, the characterization of the mechanisms underlying normal repair processes will also enhance our knowledge on the pathogenesis of cancer and provide the basis for the development of novel cancer therapeutics. In recent years, our understanding on the molecular and cellular mechanisms involved in tissue repair has strongly increased, and some of the regulatory genes and signalling cascades have been identified. Furthermore, new strategies have been developed for the improvement of organ regeneration involving the use of growth factors or matrix proteins, stem cells and new biomaterials. MOLECULAR BIOLOGY AND PHARMACOLOGY OF TISSUE REPAIR summarizes the work of major experts in the tissue repair field. Similarities and differences in repair of different tissues and organs are reviewed, and the parallels between tissue repair and embryonic development, as well as between tissue repair and cancer are reported. Therefore, this volume will be of interest for basic scientists who work on embryonic development, tissue repair and cancer as well as for clinicians of different disciplines. Overview on repair of different tissues and organs Parallels between development and tissue repair Parallels between tissue repair and cancer

Nature Reviews

Nature Reviews
Neuroscience

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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