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Stem Cells and Aging

Stem Cells and Aging
A Book

by Surajit Pathak

  • Publisher : Academic Press
  • Release : 2021-03-01
  • Pages : 200
  • ISBN : 0128204133
  • Language : En, Es, Fr & De
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Stem Cells and Aging covers what is known about the effect of time and age on the basic units of life, which are the corresponding tissue-specific or adult stem cells. Even though the concept of stem cells was introduced nearly a century ago by Alexander Maximow, modern stem-cell research began in 1963 when James Till, Ernest McCullough and Lou Siminovitch established assays to detect hematopoietic stem cells. In fact, given the importance of the aging-associated diseases, scientists have developed a keen interest in understanding the aging process as they attempt to define the role of dysfunctional stem cells in the aging process. With an aging population worldwide, understanding these age-related stem cell changes at a basic biology level and at the level of their influences for regenerative medicine is of interest and importance. There is increasing evidence that the aging process can have much adverse effects on stem cells. In the modern era, one of the emerging fields in treating human diseases is stem cell research, as stem cells have the remarkable potential to treat a wide range of diseases. Nevertheless, understanding the molecular mechanism involved in aging and deterioration of stem cell function is crucial in developing effective new therapies for aging. Serves as an ideal reference to guide investigators toward valuable answers to the problems of our aging population Addresses the effect of time and age on human stem cells Includes chapters from contributors exploring the biology of stem cell aging around the globe

Stem Cells in Clinical Practice and Tissue Engineering

Stem Cells in Clinical Practice and Tissue Engineering
A Book

by Rakesh Sharma

  • Publisher : BoD – Books on Demand
  • Release : 2018-05-02
  • Pages : 352
  • ISBN : 1789230101
  • Language : En, Es, Fr & De
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Stem Cells in Clinical Practice and Tissue Engineering is a concise book on applied methods of stem cell differentiation and optimization using tissue engineering methods. These methods offer immediate use in clinical regenerative medicine. The present volume will serve the purpose of applied stem cell differentiation optimization methods in clinical research projects, as well as be useful to relatively experienced stem cell scientists and clinicians who might wish to develop their stem cell clinical centers or research labs further. Chapters are arranged in the order of basic concepts of stem cell differentiation, clinical applications of pluripotent stem cells in skin, cardiac, bone, dental, obesity centers, followed by tissue engineering, new materials used, and overall evaluation with their permitted legal status.

Adult Stem Cells in Aging, Diseases and Cancer

Adult Stem Cells in Aging, Diseases and Cancer
A Book

by K.L. Rudolph

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2014-12-22
  • Pages : 88
  • ISBN : 3318027324
  • Language : En, Es, Fr & De
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The functionality of adult tissue stem cells from various organ systems declines during aging. This publication summarizes novel molecular mechanisms responsible for the development of aging-associated deficiencies as discussed by leading experts during the 5th Else Kröner-Fresenius Symposium. It is the first book that explicitly focuses on molecular mechanisms of stem cell aging and its consequences for disease and cancer development including both cell-intrinsic mechanisms as well as aging-induced alterations in the stem cell niche and the systemic environment. Cutting-edge information on stem cells, aging, cancer, and disease make this publication of special interest to basic researchers in the respective fields. Further, it is also intended for medical doctors in the fields of geriatrics, internal medicine, and cancer as it provides a novel understanding of the evolution of tissue dysfunction, diseases and cancer as a consequence of aging.

Antiaging - Effect of Stem Cells on Aging and Stem Cell Aging

Antiaging - Effect of Stem Cells on Aging and Stem Cell Aging
A Book

by Jisook Moon

  • Publisher : Unknown Publisher
  • Release : 2015
  • Pages : 329
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Aging is defined broadly as the normal progressive process, consequently leading to growing vulnerability to disease and death. A major challenge lies in dissecting the underlying mechanisms of aging with conventional experiments due to the complexity of and multicontributions to the aging process, reflecting a need for investigation into it in various aspects. For this reason, the age process has currently been subjected to OMICS technologies including genomics, transcriptomics, proteomics, and metabolomics, allowing the exploration of age-related changes in a multifactorial manner. In addition, since age-dependent decline in stem cell function is almost identical to the biological age, stem cells have used to understand "aging" and to investigate key reverse factors for "antiaging". This suggests that a range of new approaches are needed to reveal the unknown biological basis for aging at a variety of different molecular levels using stem cells as a tool of normal aging process and can further apply fundamental aspects in biological aging and longevity.

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation

Stem Cell Aging: Mechanisms, Consequences, Rejuvenation
A Book

by Hartmut Geiger,Heinrich Jasper,Maria Carolina Florian

  • Publisher : Springer
  • Release : 2015-07-06
  • Pages : 354
  • ISBN : 370911232X
  • Language : En, Es, Fr & De
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Aging of somatic stem cells reduces cell function and results in dysfunctional organs and tissues, making it an underlying cause of diseases associated with aging. It might even be the primary cause for age-associated attrition of tissue function in organs that heavily rely on stem cells for maintaining homeostasis, like the skin, blood and intestines. Understanding the molecular and cellular mechanisms involved is critical for developing approaches to attenuate stem cell aging and could pave the way for improved quality of life among the elderly. Written by highly prominent experts in the field, this book presents the current state of knowledge on these mechanisms. It offers insights into stem cell function, explains in detail the mechanisms of stem cell aging in model organisms as well as mammalian systems and describes related diseases and approaches to attenuating stem cell aging or achieving rejuvenation. The book is intended for all scientists and clinicians working with stem cells, aging mechanisms or age-related diseases.

Telomeres and Telomerase in Aging, Disease, and Cancer

Telomeres and Telomerase in Aging, Disease, and Cancer
Molecular Mechanisms of Adult Stem Cell Ageing

by K. Lenhard Rudolph

  • Publisher : Springer Science & Business Media
  • Release : 2007-11-07
  • Pages : 330
  • ISBN : 354073709X
  • Language : En, Es, Fr & De
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Telomere shortening represents one of the basic aspects of ageing and telomere dysfunction could contribute to the accumulation of DNA damage during ageing. This book summarizes evidence and data indicating that telomere dysfunction influences human ageing, diseases and cancer. The book describes our current knowledge on checkpoints that limit cellular lifespan and survival in response to telomere dysfunction. There is special focus on adult stem cells.

Progress in Stem Cell Transplantation

Progress in Stem Cell Transplantation
A Book

by Taner Demirer

  • Publisher : BoD – Books on Demand
  • Release : 2015-12-02
  • Pages : 208
  • ISBN : 9535122274
  • Language : En, Es, Fr & De
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This book documents the increased amount of stem cell-related research, basic and clinical applications as well as views for the future. The book covers a wide range of issues related to new developments and innovations in cell-based therapies discussed in basic and clinical chapters from authors around the world involved in stem cell studies and research. It thereby complements and extends the basic coverage of stem cells, such as mesenchymal stem cells, effect of stem cells on aging, cover hematopoietic stem cells, storage and cryopreservation, issues related to clinical applications such as haploidentical transplants and use of stem cells for the treatment of Huntingtons disease. Clearly, the treatment of various malignant and nonmalignant diseases depends heavily on stem cells, and this book is well positioned to provide comprehensive coverage of these developments.

Stem Cells and Aging

Stem Cells and Aging
Methods and Protocols

by Kursad Turksen

  • Publisher : Humana Press
  • Release : 2013-02-13
  • Pages : 179
  • ISBN : 9781627033169
  • Language : En, Es, Fr & De
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Over time, it has become clear that changes in stem cells do occur during aging, not only in their number but also in their relationship to their microenvironment and their functionality as reflected in changes to their metabolome. Stem Cells and Aging: Methods and Protocols brings together chapters from expert contributors with protocols critical for exploring the biology of stem cell aging, all of which is key for understanding these age-related stem cell changes at a basic biology level and at the level of their impacts for regenerative medicine. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and tips on troubleshooting and avoiding known pitfalls. Concise and easy to use, Stem Cells and Aging: Methods and Protocols serves as an ideal reference to guide investigators toward further valuable answers to the problems of our aging population.

Frailty and Sarcopenia

Frailty and Sarcopenia
Onset, Development and Clinical Challenges

by Yannis Dionyssiotis

  • Publisher : BoD – Books on Demand
  • Release : 2017-08-30
  • Pages : 254
  • ISBN : 9535134833
  • Language : En, Es, Fr & De
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Frailty is considered a multisystem impairment that makes an individual vulnerable to external or internal stressors. Sarcopenia, the age-dependent loss of muscle mass and function, is proposed as the biological substrate and the pathway whereby the consequences of physical frailty develop. These syndromes are associated with a negative impact in quality of life and can lead to the occurrence of disability, institutionalization, and even mortality. The book focuses upon all the related aspects of frailty and sarcopenia and the new advancements in the related treatments including complex issues and research. It includes high-quality chapters in all related aspects for the syndromes of sarcopenia and frailty, which adversely affect the function and overall effectiveness of the musculoskeletal system and interventions to promote rehabilitation.

Mesenchymal Stem Cell Therapy

Mesenchymal Stem Cell Therapy
A Book

by Lucas G. Chase,Mohan C Vemuri

  • Publisher : Springer Science & Business Media
  • Release : 2012-12-12
  • Pages : 456
  • ISBN : 1627032002
  • Language : En, Es, Fr & De
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Over the past decade, significant efforts have been made to develop stem cell-based therapies for difficult to treat diseases. Multipotent mesenchymal stromal cells, also referred to as mesenchymal stem cells (MSCs), appear to hold great promise in regards to a regenerative cell-based therapy for the treatment of these diseases. Currently, more than 200 clinical trials are underway worldwide exploring the use of MSCs for the treatment of a wide range of disorders including bone, cartilage and tendon damage, myocardial infarction, graft-versus-host disease, Crohn’s disease, diabetes, multiple sclerosis, critical limb ischemia and many others. MSCs were first identified by Friendenstein and colleagues as an adherent stromal cell population within the bone marrow with the ability to form clonogenic colonies in vitro. In regards to the basic biology associated with MSCs, there has been tremendous progress towards understanding this cell population’s phenotype and function from a range of tissue sources. Despite enormous progress and an overall increased understanding of MSCs at the molecular and cellular level, several critical questions remain to be answered in regards to the use of these cells in therapeutic applications. Clinically, both autologous and allogenic approaches for the transplantation of MSCs are being explored. Several of the processing steps needed for the clinical application of MSCs, including isolation from various tissues, scalable in vitro expansion, cell banking, dose preparation, quality control parameters, delivery methods and numerous others are being extensively studied. Despite a significant number of ongoing clinical trials, none of the current therapeutic approaches have, at this point, become a standard of care treatment. Although exceptionally promising, the clinical translation of MSC-based therapies is still a work in progress. The extensive number of ongoing clinical trials is expected to provide a clearer path forward for the realization and implementation of MSCs in regenerative medicine. Towards this end, reviews of current clinical trial results and discussions of relevant topics association with the clinical application of MSCs are compiled in this book from some of the leading researchers in this exciting and rapidly advancing field. Although not absolutely all-inclusive, we hope the chapters within this book can promote and enable a better understanding of the translation of MSCs from bench-to-bedside and inspire researchers to further explore this promising and quickly evolving field.

Exosomes, Stem Cells and MicroRNA

Exosomes, Stem Cells and MicroRNA
Aging, Cancer and Age Related Disorders

by Karl L. Mettinger,Pranela Rameshwar,Vinod Kumar

  • Publisher : Springer
  • Release : 2018-04-07
  • Pages : 152
  • ISBN : 3319744704
  • Language : En, Es, Fr & De
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This volume provides insight into the pivotal roles of stem cells, exosomes and other microvesicles in biofunction and molecular mechanisms and their therapeutic potential in translational nanomedicine. It further highlights evidence from recent studies as to how stem cell derived exosomes and microRNAs may restore and maintain tissue homeostasis, enable cells to recover critical cellular functions and begin repair regeneration. These early studies in animal models of aging also show evidence of improved immune, cardiovascular and cognitive functions as well as improved health span and life span. The use of exosomes from body fluids to define specific biomarkers for various tumors may also clear the path to patient-targeted treatments by developing exosome-derived microRNA based cancer therapeutics. It is essential reading for graduate students, research fellow and biomedical researchers in academia or the pharmaceutical or biotech industries.

How and why We Age

How and why We Age
A Book

by Leonard Hayflick

  • Publisher : Unknown Publisher
  • Release : 1996-01-01
  • Pages : 377
  • ISBN : 9780345401557
  • Language : En, Es, Fr & De
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A cell biologist who has studied the aging process for thirty years answers the big questions about aging, dispels the myths, and discusses the desirability of living longer

The Stem Cell Niche during Ageing

The Stem Cell Niche during Ageing
A Book

by Susie Prof. Nilsson

  • Publisher : Academic Press
  • Release : 2020-08-22
  • Pages : 258
  • ISBN : 0128220201
  • Language : En, Es, Fr & De
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Advances in Stem Cells and Their Niches addresses stem cells during development, homeostasis, and disease/injury of the respective organs, presenting new developments in the field, including new data on disease and clinical applications. Video content illustrates such areas as protocols, transplantation techniques, and work with mice. Explores not only reviews of research, but also shares methods, protocols, and transplantation techniques Contains video content to illustrate such areas as protocols, transplantation techniques, and work with mice Each volume concentrates on one organ, making this a unique publication

Stem Cells in Development and Disease

Stem Cells in Development and Disease
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2014-01-15
  • Pages : 472
  • ISBN : 0123914353
  • Language : En, Es, Fr & De
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This new volume of Current Topics in Developmental Biology covers Stem Cells in Development and Disease. The chapters provide a comprehensive set of reviews covering such topics as the mechanisms of pluripotency in vivo and in vitro, hematopoietic stem cell development, intestinal stem cells and their defining niche, epithelial stem cells in adult skin, the mammary stem cell hierarchy, satellite cells, neural stem cells of the hippocampus, lung stem and progenitor cells in tissue homeostasis and disease, spermatogonial stem cell functions in physiological and pathological conditions, the origin, biology, and therapeutic potential of facultative adult hepatic progenitor cells, nephron progenitor cells, adult stem cell niches, cancer stem cells, pluripotency and cellular heterogeneity, and cellular mechanisms of somatic stem cell aging Covers the area of Stem Cells in Development and Disease International board of authors Provides a comprehensive set of reviews covering such topics as Intestinal Stem Cells, Nephron Stem Cells/Progenitors, Skin epithelial Stem Cells and Lung Stem Cells

Advances in Stem Cell Aging

Advances in Stem Cell Aging
A Book

by K. Lenhard Rudolph

  • Publisher : Karger Medical and Scientific Publishers
  • Release : 2012
  • Pages : 125
  • ISBN : 3318021709
  • Language : En, Es, Fr & De
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Up-to-date meeting report of the Else Kr ner-Fresenius Symposium on Adult Stem Cell Aging Adult stem cells are present in most postnatal tissues of mammals. Tissues with high rates of cell turnover depend on the functional capacity of stem cells for lifelong maintenance of tissue homeostasis. Adult stem cells are also required for the regeneration of tissues in response to injury as in, for example, the regeneration of skeletal muscle. In addition to its function in tissue homeostasis and regeneration, adult stem cells can represent the cell type of origin of various types of cancers including leukemia and colorectal cancer. Stem cells are the most long-lived cells in the proliferative compartment of mammalian tissues. Therefore, stem cells have an increased risk of acquiring mutations that could ultimately lead to the transformation of tissue stem cells. This publication presents the current knowledge in the field of stem cell aging, which was discussed at the Else Kr ner-Fresenius Symposium on Advances in Stem Cell Aging in 2011. It will be of special interest to scientists working on stem cell research, aging, regeneration, and cancer as well as physicians and scientists specializing in geriatric medicine, internal medicine, and surgery.

Stem Cells

Stem Cells
Biology and Application

by Mary Clarke,Jonathan Frampton

  • Publisher : Garland Science
  • Release : 2020-07-27
  • Pages : 450
  • ISBN : 1000062651
  • Language : En, Es, Fr & De
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Stem cell science, encompassing basic biology to practical application, is both vast and diverse. A full appreciation of it requires an understanding of cell and molecular biology, tissue structure and physiology, the practicalities of tissue engineering and bioprocessing, and the pathways to clinical implementation—including the ethical and regulatory imperatives that our society requires us to address. Expectation and debate have been driven by the allure of regenerative medicine using stem cells as a source of replacements for damaged or aged tissues. The potential of stem cell application goes far beyond this. Highly innovative uses of stem cells are emerging as possible therapies for cancers, treating acute damage in conditions such as stroke and myocardial infarction, and resolving a whole range of diseases. Stem Cells: Biology and Application presents the basic concepts underlying the fast-moving science of stem cell biology. This textbook is written for an advanced stem cell biology course. The target audience includes senior undergraduates, first year graduate students, and practitioners in molecular biology, biology, and biomedical engineering. Stem Cells provides a comprehensive understanding of these unique cells, highlighting key areas of research, associated controversies, case studies, technologies, and pioneers in the field.

Aging and Aging-Related Diseases

Aging and Aging-Related Diseases
Mechanisms and Interventions

by Zhao Wang

  • Publisher : Springer
  • Release : 2018-09-19
  • Pages : 282
  • ISBN : 981131117X
  • Language : En, Es, Fr & De
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This book provides an overview of recent advances in the study of aging and aging related diseases, discussing the topics at individual, organ, tissue, cell, and molecular levels. It also presents studies on the biomarkers of aging and anti-aging interventions. Aging has been becoming a global health problem. However it was not possible to determine aging as we usually diagnose a disease because there are few biomarkers for age estimation. Since ancient times, people have been seeking anti-aging substances and methods for achieving immortality, while the scientific study of aging has only existed for 100 years. This book appeals to researchers both in institutes and in pharmaceutical companies interested in further studies in this field.

The Uniqueness of the Individual

The Uniqueness of the Individual
A Book

by P.B. Medawar

  • Publisher : Routledge
  • Release : 2019-08-31
  • Pages : 188
  • ISBN : 1000063844
  • Language : En, Es, Fr & De
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Originally published in 1957, The Uniqueness of the Individual is a collection of 9 essays published from the ten years preceding publication. The essays deal with some of the central problems of biology. These are among the questions put and answered from the standpoint of modern experimental biology. What is ageing and how is it measured? What theories have been held to account for it, and with what success? Did ageing evolve, and if so how? Is Lamarckism and adequate explanation of evolutionary process? Does evolution sometimes go wrong? Do human beings evolve in a way peculiar to themselves? Other essays touch upon the problems of scientific method and of growth and transformation. This book will be of interest to natural historians, evolutionists and anthropologists.

Models, Molecules and Mechanisms in Biogerontology

Models, Molecules and Mechanisms in Biogerontology
Physiological Abnormalities, Diseases and Interventions

by Pramod C. Rath

  • Publisher : Springer
  • Release : 2019-07-30
  • Pages : 436
  • ISBN : 9811335850
  • Language : En, Es, Fr & De
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This book examines the basic cellular and molecular mechanisms associated with aging. It comprehensively describes the genetic, epigenetic, biochemical and metabolic regulation of aging, as well as some important age-related diseases. Divided into two major sections, it takes readers through the various aspects of aging in a story-like manner and suggests various interventions for healthy aging, such as dietary restriction, regular exercise, nutrition and maintaining a balanced and a non-stressful lifestyle. It describes the implications of aging on the nervous system, metabolism, immunity and stem cells as well as care for the elderly. The book is an ideal companion for both new and established researchers in the field and is also useful for educators, clinicians and policy makers.

The Stem Cell Activation Diet

The Stem Cell Activation Diet
Your Complete Nutritional Guide to Fight Disease, Support Brain Health, and Slow the Effects of Aging

by Dana M Elia

  • Publisher : Simon and Schuster
  • Release : 2020-03-24
  • Pages : 192
  • ISBN : 1646040562
  • Language : En, Es, Fr & De
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Unleash your body’s natural ability to soothe chronic pain, heal injury, prevent diabetes and heart disease, lose weight, and more with this easy-to-use, science-backed fasting program. Stem cell activation is a quickly developing technique in healing and pain management, but it can be difficult to understand how it can benefit your specific needs. Can activating your body’s own existing stem cells help your particular injury, weight needs, or chronic issues? The answer is most likely “YES,” and this book will show you how. The Stem Cell Activation Diet provides all the information you need not only to assess if your stem cells can help you, but also to kick yours into gear to jump-start your healing. Learn how stem cell activation can help you: Heal from injury or surgery Prevent chronic issues like diabetes and heart disease Manage your pain Slow the effects of aging Support healthy cognitive function Written by a certified integrative dietitian and nutritionist, The Stem Cell Activation Diet will guide you to the dietary choices that are healthiest for your body to jump-start its natural regenerative process.