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Stress: Genetics, Epigenetics and Genomics

Stress: Genetics, Epigenetics and Genomics
Volume 4: Handbook of Stress

by George Fink

  • Publisher : Academic Press
  • Release : 2020-10-24
  • Pages : 344
  • ISBN : 0128131578
  • Language : En, Es, Fr & De
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This fourth volume in the Handbook of Stress series, Stress: Genetics, Epigenetics and Genomics, deals with the influence that genetics, epigenetics, and genomics have on the effects of and responses to stress. Chapters refer to epigenetic mechanisms that involve DNA methylation, histone modification, and/or noncoding RNA-associated gene activation or silencing. There is also coverage of epigenetic mechanisms in stress-related transgenerational transmission of characteristics, and how these may help explain heritability in some complex human diseases. The Handbook of Stress series, comprised of self-contained volumes that each focus on a specific stress area, covers the significant advances made since the publication of Elsevier’s Encyclopedia of Stress (2000 and 2007). Volume 4 is ideal for graduate students, post-doctoral fellows, faculty and clinicians interested in stress genetics, epigenetics and genomics involved in neuroendocrinology, neuroscience, biomedicine, endocrinology, psychology, psychiatry and the social sciences. Articles carefully selected by eminent stress researchers and prepared by contributors representing outstanding scholarship in the field, with each chapter fully vetted for reliable expert knowledge Richly illustrated with explanatory figures and tables Each chapter includes a boxed “Key points call out section Affordably priced, self-contained volume for readers specifically interested in stress genetics and epigenetics, removing the need to purchase the whole Handbook series

Stress and Epigenetics in Suicide

Stress and Epigenetics in Suicide
A Book

by Vsevolod Rozanov

  • Publisher : Academic Press
  • Release : 2017-02-13
  • Pages : 236
  • ISBN : 0128052864
  • Language : En, Es, Fr & De
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Stress and Epigenetics in Suicidediscusses the central role of epigenetic modifications in suicidal behavior. As early-life stress and an individual's ability to cope with such stressors, combined with psychological factors, social factors, and existential and cognitive factors can predispose young people to suicidal behavior and put them at added risk of suicidal behavior later in life, this book provides readers with an overview of the neurobiology of stress, an introduction to the epigenetic changes induced by stress, and an understanding of how vulnerability and resilience to stress are built. It integrates these mechanisms into a biobehavioral model of suicide based on epigenetic marks, gene-environment interactions, and other stressors. More importantly, it provides future direction for research and discusses potential interventions. This book is an ideal and trusted resource for researchers and clinicians who are interested in learning how the environment can affect behavior through genetics, and for those seeking the development of new methods for suicide prevention. Explores the neurobiology of stress and stress-related epigenetics, including discussion of the role of stress-induced epigenetic changes in behavioral, emotional, and cognitive mechanisms and whether these epigenetic marks are transgenerational Provides compelling biobehavioral models of suicide based on genetics, epigenetics, and behavioral adjustment Integrates social, psychological, and existential influences, giving readers a better understanding of the interdisciplinary nature of suicide risk factors Presents future directions for suicide-prevention strategies that incorporate recent research on genomics and stress resilience

Dog behaviour

Dog behaviour
Intricate picture of genetics, epigenetics, and human-dog relations

by Ann-Sofie Sundman

  • Publisher : Linköping University Electronic Press
  • Release : 2019-04-17
  • Pages : 49
  • ISBN : 9176850722
  • Language : En, Es, Fr & De
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Dogs, Canis familiaris, share the lives of humans all over the world. That dogs, and the behavior of dogs, are of interest to many is therefore no surprise. In this thesis, the main aim has been to identify factors that affect dogs’ behaviours. The dog, Canis familiaris, is our first domesticated animal. Since domestication, various types of dogs have developed through adaptation to an environment shared with humans and through our selective breeding, resulting in a unique variation in morphology and behaviour. Although there is an individual variation in the behaviour of dogs, there is also a difference between breeds. Moreover, selection during the last decades has split some breeds into divergent types. Labrador and golden retrievers are divided into a common type, for show and companionship, and a field type, for hunting. By comparing the breed types, we can study the effects of recent selection. In Paper I, we investigate differences in general behavioural traits between Labrador and golden retriever and between common and field type within the two breeds by using results from the standardized behaviour test Dog Mentality Assessment. There were differences between breeds and types for all behavioural traits. However, there was also an interaction between breed and type. Thus, a common/field-type Labrador does not behave like a common/field-type golden retriever. Even though they have been selected for similar traits, the selection has affected the general behavioural traits differently in the two breeds. In paper II, we were interested in dogs’ human-directed social skills. Dogs have a high social competence when it comes to humans. Two experiments commonly used to study these skills are the problem-solving test, where dogs’ human-directed behaviours when faced with a problem are measured, and the pointing test, where dogs are tested on how well they understand human gestures. We compared the social skills of German shepherds and Labrador retrievers, and of common- and field-type Labradors. Labradors were more successful in the pointing test and German shepherds stayed closer to their owners during the problem solving. Among Labrador types, the field type had more human eye contact than the common type. Importantly, when comparing the two experiments, we found no positive correlations between the problem-solving test and the pointing test, suggesting that the two tests measure different aspects of human-directed social behaviour in dogs. A previous study has identified two suggestive genetic regions for human-directed social behaviours during the problem-solving test in beagles. In paper III, we show that these SNPs are also associated to social behaviours in Labrador and golden retrievers. Moreover, the Labrador breed types differed significantly in allele frequencies. This indicates that the two SNPs have been affected by recent selection and may have a part in the differences in sociability between common and field type. The behaviour of dogs cannot simply be explained by genetics, there is also an environmental component. In paper IV, we study which factors that affect long-term stress in dogs. Long-term cortisol can be measured by hair samples. We found a clear synchronization in hair cortisol concentrations between dogs and their owners. Neither dogs’ activity levels nor their behavioural traits affected the cortisol, however, the personality of the owners did. Therefore, we suggest that dogs mirror the stress level of their owners. The mediator between genes and the environment is epigenetics, and one epigenetic factor is DNA methylation. In paper V, we compared methylation patterns of wolves and dogs as well as dog breeds. Between both wolves and dogs and among dogs there were substantial differences in methylated DNA regions, suggesting that DNA methylation is likely to contribute to the vast variation among canines. We hypothesize that epigenetic factors have been important during domestication and in breed formation. In this thesis, I cover several aspects on how dogs’ behaviours can be affected, and paint an intricate picture on how genetics, epigenetics, and human-dog relations forms dog behaviour.

Dissecting the Mechanisms of Epigenetic Regulation in Plant Development and Stress

Dissecting the Mechanisms of Epigenetic Regulation in Plant Development and Stress
A Book

by Dean Michael Sanders

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 155
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The genomes of both plants and animals are under constant stress ranging from jumping genetic elements to UV irradiation. A fundamental question in the field of epigenetics is how chromatin landscapes are altered to generate adaptive responses. Epigenetic modifications allow heritable changes in the expression of a gene, without mutation of the underlying DNA sequences. My first project identified a novel epigenetic mechanism of regulating plant development involving a histone H3 mutation. Specifically, we found that a lysine-to-methionine mutation at the 36th amino acid of histone H3 (H3K36M) had a dominant negative affect on genome-wide H3K36 methylation leading to the misregulation of critical genes in the flowering and shoot branching pathways. These gene expression changes likely lead to the pleiotropic developmental defects that accompanied this mutation. Due to their sessile nature, plants are highly adaptive to the ever-changing environment. DNA methylation may contribute to adaptivity given its roles in gene expression and its heritability through meiotic generations in plants. My second project investigated the genetic, epigenetic, and physiological characteristics of a high altitude Tibetan accession of A. thaliana (Lhasa-0). Interestingly, Lhasa-0 is tolerant to multiple environmental stressors. This accession also had an uncommon frameshift mutation in the C-terminal of the chromomethylase-2 (CMT2) gene. This mutation was found to be responsible for a genome-wide reduction in CHH context DNA methylation (where H = A, T or C). Consistent with Lhasa-0's environmental tolerance, we found cmt2 mutants (Col-0 ecotype) were also tolerant to multiple stressors (UV-B, heat, and pathogen). These results suggest DNA methylation plays a role in tolerance to a broad range of stressors and inactivating CMT2 mutations may be adaptive for wild accessions. Relatedly, my third project aimed to screen DNA methylation mutants for basal thermotolerance. We found two genotypes with opposing effects on DNA methylation and thermotolerance. To elucidate the underlying molecular mechanisms, we performed time course transcriptome analysis and found that heat stress pathways are extremely robust and changes in DNA methylation do not drastically alter the heat stress transcriptome. We also performed time-course tandem mass spectrometry uncovering both heat-dependent and -independent genome-wide changes in histone modifications. Collectively, these projects shed new light on how chromatin and epigenetic modifications affect plant development and stress tolerance.

The Developing Genome

The Developing Genome
An Introduction to Behavioral Epigenetics

by David S. Moore

  • Publisher : Oxford University Press, USA
  • Release : 2015
  • Pages : 308
  • ISBN : 0199922349
  • Language : En, Es, Fr & De
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Includes bibliographical references (pages 275-300) and index

Genome Stability

Genome Stability
From Virus to Human Application

by Igor Kovalchuk,Olga Kovalchuk

  • Publisher : Academic Press
  • Release : 2021-07-17
  • Pages : 760
  • ISBN : 0323856802
  • Language : En, Es, Fr & De
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Genome Stability: From Virus to Human Application, Second Edition, a volume in the Translational Epigenetics series, explores how various species maintain genome stability and genome diversification in response to environmental factors. Here, across thirty-eight chapters, leading researchers provide a deep analysis of genome stability in DNA/RNA viruses, prokaryotes, single cell eukaryotes, lower multicellular eukaryotes, and mammals, examining how epigenetic factors contribute to genome stability and how these species pass memories of encounters to progeny. Topics also include major DNA repair mechanisms, the role of chromatin in genome stability, human diseases associated with genome instability, and genome stability in response to aging. This second edition has been fully revised to address evolving research trends, including CRISPRs/Cas9 genome editing; conventional versus transgenic genome instability; breeding and genetic diseases associated with abnormal DNA repair; RNA and extrachromosomal DNA; cloning, stem cells, and embryo development; programmed genome instability; and conserved and divergent features of repair. This volume is an essential resource for geneticists, epigeneticists, and molecular biologists who are looking to gain a deeper understanding of this rapidly expanding field, and can also be of great use to advanced students who are looking to gain additional expertise in genome stability. A deep analysis of genome stability research from various kingdoms, including epigenetics and transgenerational effects Provides comprehensive coverage of mechanisms utilized by different organisms to maintain genomic stability Contains applications of genome instability research and outcomes for human disease Features all-new chapters on evolving areas of genome stability research, including CRISPRs/Cas9 genome editing, RNA and extrachromosomal DNA, programmed genome instability, and conserved and divergent features of repair

Epigenetics in Psychiatry

Epigenetics in Psychiatry
A Book

by Jacob Peedicayil,Dennis R. Grayson,Dimitri Avramopoulos

  • Publisher : Elsevier
  • Release : 2014-06-23
  • Pages : 664
  • ISBN : 0124171346
  • Language : En, Es, Fr & De
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Epigenetics in Psychiatry covers all major areas of psychiatry in which extensive epigenetic research has been performed, fully encompassing a diverse and maturing field, including drug addiction, bipolar disorder, epidemiology, cognitive disorders, and the uses of putative epigenetic-based psychotropic drugs. Uniquely, each chapter correlates epigenetics with relevant advances across genomics, transcriptomics, and proteomics. The book acts as a catalyst for further research in this potentially very important and useful area of psychiatry. The elucidation of basic principles of epigenetic biology points to the creation of more optimal and effective therapies for major classes of psychiatric disease. In this regard, epigenetic therapy, the use of drugs to correct epigenetic defects, may help in the pharmacotherapy of patients with these disorders. With time, such advances may eventually point to replacements for psychotropic drugs presently of symptomatic value and low efficacy. Moreover, there is evidence to suggest that other forms of treatment commonly used in the management of psychiatric disorders, like psychotherapy and electroconvulsive therapy, may also act by epigenetic mechanisms. Chapters review fascinating new areas of research across neuronal stem cells, cognitive disorders, and transgenerational epigenetics through drug addiction Relates broad advances in psychiatric epigenetics to a modern understanding of the genome, transcriptome, and protein Catalyzes knowledge discovery in both basic epigenetic biology and clinical application as epigenetic targets for drug discovery

Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome

Epigenetic pathways in PTSD: how traumatic experiences leave their signature on the genome
A Book

by Tania L Roth,David M Diamond,Karestan C Koenen

  • Publisher : Frontiers Media SA
  • Release : 2015-04-14
  • Pages : 158
  • ISBN : 2889194582
  • Language : En, Es, Fr & De
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This research topic focuses on epigenetic components of PTSD. Epigenetic mechanisms are a class of molecular mechanisms by which environmental influences, including stress, can interact with the genome to have long-term consequences for brain plasticity and behavior. Articles herein include empirical reports and reviews that link stress and trauma with epigenetic alterations in humans and animal models of early- or later-life stress. Themes present throughout the collection include: DNA methylation is a useful biomarker of stress and treatment outcome in humans; epigenetic programming of stress-sensitive physiological systems early in development confers an enhanced risk on disease development upon re-exposure to trauma or stress; and, long-lived fear memories are associated with epigenetic alterations in fear memory and extinction brain circuitry.

Epigenetics in Health and Disease

Epigenetics in Health and Disease
A Book

by Igor Kovalchuk,Olga Kovalchuk

  • Publisher : FT Press
  • Release : 2012-05-22
  • Pages : 608
  • ISBN : 0132599511
  • Language : En, Es, Fr & De
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This is the first comprehensive, authoritative, and easy-to-understand introduction to modern epigenetics. Authored by two active researchers in the field, it introduces key concepts one step at a time, enabling students at all levels to benefit from it. The authors begin by presenting a historical overview that places epigenetics in context, and makes it clear that the field is not (as some presume) completely new. Next, they introduce and explain key epigenetic mechanisms, and discuss the roles these mechanisms may play in inheritance, organism development, health and disease, behavior, evolution, ecology, and the interaction of individual organisms with their environments. Coverage includes: non-coding RNAs in each kingdom; allelic interactions; CRYSPR; gene silencing; epigenetics of germline and epigenetic memory; epigenetic regulation of genome stability and plant stress response; and much more. The authors conclude by offering significant new insights into how knowledge of epigenetics and epigenomics may promote the development of technologies and solutions in areas ranging from behavioral neuroscience to cancer treatment, toxicology to the development of hardier crops.

Quantitative Genetics, Genomics and Plant Breeding, 2nd Edition

Quantitative Genetics, Genomics and Plant Breeding, 2nd Edition
A Book

by Manjit S. Kang

  • Publisher : CABI
  • Release : 2020-04-01
  • Pages : 431
  • ISBN : 1789240212
  • Language : En, Es, Fr & De
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This book presents state-of-the-art, authoritative chapters on contemporary issues in the broad areas of quantitative genetics, genomics and plant breeding. Section 1 (Chapters 2 to 12) emphasizes the application of genomics, and genome and epigenome editing techniques, in plant breeding; bioinformatics; quantitative trait loci mapping; and the latest approaches of examining and exploiting genotype-environment interactions. Section 2 (Chapters 13 to 20) represents the intersection of breeding, genetics and genomics. This section describes the use of cutting-edge molecular breeding and quantitative genetics techniques in wheat, rice, maize, root and tuber crops and pearl millet. Overall, the book focuses on using genomic information to help evaluate traits that can combat biotic/abiotic stresses, genome-wide association mapping, high-throughput genotyping/phenotyping, biofortification, use of big data, orphan crops, and gene editing techniques. The examples featured are taken from across crop science research and cover a wide geographical base.

Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications

Epigenetics in Plants of Agronomic Importance: Fundamentals and Applications
Transcriptional Regulation and Chromatin Remodelling in Plants

by Raúl Alvarez-Venegas,Clelia De-la-Peña,Juan Armando Casas-Mollano

  • Publisher : Springer
  • Release : 2019-04-26
  • Pages : 415
  • ISBN : 3030147606
  • Language : En, Es, Fr & De
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Over the past few decades, chromatin modulation has emerged as an important regulator of gene expression. This second edition provides detailed information on the epigenetic mechanisms in plants, illustrating the value of this research in plants of agronomic importance. It examines recent advances regarding plants’ epigenetic regulation in response to abiotic and biotic types of stress; the epigenetic basis of plant immunity; evolution and functions of plant histones; epigenetic variation and plant breeding; and epigenome editing and crop improvement. The content is intended to promote the development of future biotechnologies to manipulate and selectively activate/inhibit proteins and metabolic pathways to counter pathogens, to treat important diseases, and to increase crop productivity. The development of new fields, like epigenome editing and RNA epigenetics, will certainly improve our understanding of currently known epigenetic modifications and their roles in e.g. host-pathogen interactions, crop productivity, and in response to environmental stimuli. This volume contains twelve new/revised chapters, written by an international team of experts on plant epigenetics, and addresses the needs of researchers and professionals in the fields of agronomics, crop breeding, epigenetics, plant biochemistry, plant developmental biology, and related disciplines.

Epigenetics of Aging and Longevity

Epigenetics of Aging and Longevity
Translational Epigenetics

by Alexey Moskalev,Alexander M. Vaiserman

  • Publisher : Academic Press
  • Release : 2017-11-17
  • Pages : 544
  • ISBN : 012811083X
  • Language : En, Es, Fr & De
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Epigenetics of Aging and Longevity provides an in-depth analysis of the epigenetic nature of aging and the role of epigenetic factors in mediating the link between early-life experiences and life-course health and aging. Chapters from leading international contributors explore the effect of adverse conditions in early-life that may result in disrupted epigenetic pathways, as well as the potential to correct these disrupted pathways via targeted therapeutic interventions. Intergenerational epigenetic inheritance, epigenetic drug discovery, and the role of epigenetic mechanisms in regulating specific age-associated illnesses—including cancer and cardiovascular, metabolic, and neurodegenerative diseases—are explored in detail. This book will help researchers in genomic medicine, epigenetics, and biogerontology better understand the epigenetic determinants of aging and longevity, and ultimately aid in developing therapeutics to extend the human life-span and treat age-related disease. Offers a comprehensive overview of the epigenetic nature of aging, as well as the impact of epigenetic factors on longevity and regulating age-related disease Provides readers with clinical and epidemiological evidence for the role of epigenetic mechanisms in mediating the link between early-life experiences, life-course health and aging trajectory Applies current knowledge of epigenetic regulatory pathways towards developing therapeutic interventions for age-related diseases and extending the human lifespan

Epigenetics in the post genomic era: Can behaviour change our genes?

Epigenetics in the post genomic era: Can behaviour change our genes?
Was Lamarck just a little bit right?

by Friederike Lange

  • Publisher : GRIN Verlag
  • Release : 2011-09-26
  • Pages : 9
  • ISBN : 3656014876
  • Language : En, Es, Fr & De
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Essay from the year 2011 in the subject Biology - Genetics / Gene Technology, grade: B2, University of Glasgow (Biology - Genetics), course: Genetics BA - Level 3, language: English, abstract: Traditionally, genomic research was focused on the investigation of DNA sequence which gives rise to the diversity of phenotypes found in nature. It was undoubted that the information which is given by the genomic sequence is the sole factor which is important for the outcome for each individual organism. But since a few decades, a new concept called epigenetics has arisen and shows that we have to modify our knowledge about genetics. “Epi” derives from Greek meaning “on” or “over” and implies that epigenetic mechanisms act on genes via altering the gene expression and regulation without modifying the actual DNA sequence. In epigenetics, we can find the reason why twins (who have the exact same gene sequence) can alter in their phenotype especially concerning their susceptibility to diseases (Fraga et al. 2005; Wong et al.; 2005). Furthermore, it has the potential to answer the question how phenotypic characteristics can alter between generations without a change in the underlying genetic material.

Plant Epigenetics and Epigenomics

Plant Epigenetics and Epigenomics
Methods and Protocols

by Charles Spillane,Peter McKeown

  • Publisher : Humana
  • Release : 2020-02-02
  • Pages : 272
  • ISBN : 9781071601785
  • Language : En, Es, Fr & De
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This second edition volume expands on the previous edition with a look at the latest techniques in plant epigenetics and epigenomic research. Chapters in this book cover topics such as whole genome methylome analysis; analysis of DNA methylation; chromatin analysis of metabolic gene clusters in plants; plant epigenetic stress memory induced by drought; small non-coding RNA analysis in seeds of forest tree species; and a discussion on epigenetics inheritance in plants. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and comprehensive, Plant Epigenetics and Epigenomics: Methods and Protocols, Second Edition is a valuable resource for both novice and expert researchers, and aims to advance this field of study by paving the way for integrating epigenetic mechanisms into models of plant function during development and evolution.

Evolution in Four Dimensions, revised edition

Evolution in Four Dimensions, revised edition
Genetic, Epigenetic, Behavioral, and Symbolic Variation in the History of Life

by Eva Jablonka,Marion J. Lamb,Anna Zeligowski

  • Publisher : MIT Press
  • Release : 2014-03-28
  • Pages : 563
  • ISBN : 0262525844
  • Language : En, Es, Fr & De
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A pioneering proposal for a pluralistic extension of evolutionary theory, now updated to reflect the most recent research.

Epigenetics of Lifestyle

Epigenetics of Lifestyle
A Book

by Marcelina Párrizas,Rosa Gasa,Perla Kaliman

  • Publisher : Bentham Science Publishers
  • Release : 2012-09-07
  • Pages : 174
  • ISBN : 1608052990
  • Language : En, Es, Fr & De
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Recent advances in the fields of genomics and bioinformatics have made it increasingly clear that genetic sequence alone cannot explain how the genome regulates the development and function of complex multicellular organisms both in health and disease. This inference has led to the expansion of epigenetics as a discipline. Epigenetics refers to the way in which the environment in the wide sense participates in the regulation of gene expression. Several studies show that the well-known beneficial role of a healthy lifestyle over a number of pathologies or as a pre-emptive therapy is at least in part exerted through epigenetic mechanisms, thus giving rise to a new paradigm of preventive medicine based on the concept of genetic plasticity. In Epigenetics of Lifestyle, several contributors provide a comprehensive view of how various facets of lifestyle, including nutrition, exercise, stress, addiction or social interactions, affect chromatin (the combination of DNA and proteins that make up the contents of a cell nucleus) - resulting in profound and long-lasting changes in gene function. In summary, Epigenetics of Lifestyle is a fresh approach towards epigenetics and presents the reader with significant research findings in epigenetics and lifestyle studies. This volume is a simplified source of information for both undergraduate and working professionals interested in lifestyle medicine and life sciences in general.

Advances in the Understanding of Biological Sciences Using Next Generation Sequencing (NGS) Approaches

Advances in the Understanding of Biological Sciences Using Next Generation Sequencing (NGS) Approaches
A Book

by Gaurav Sablok,Sunil Kumar,Saneyoshi Ueno,Jimmy Kuo,Claudio Varotto

  • Publisher : Springer
  • Release : 2015-07-16
  • Pages : 241
  • ISBN : 3319171577
  • Language : En, Es, Fr & De
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Provides a global view of the recent advances in the biological sciences and the adaption of the pathogen to the host plants revealed using NGS. Molecular Omic’s is now a major driving force to learn the adaption genetics and a great challenge to the scientific community, which can be resolved through the application of the NGS technologies. The availability of complete genome sequences, the respective model species for dicot and monocot plant groups, presents a global opportunity to delineate the identification, function and the expression of the genes, to develop new tools for the identification of the new genes and pathway identification. Genome-wide research tools, resources and approaches such as data mining for structural similarities, gene expression profiling at the DNA and RNA level with rapid increase in available genome sequencing efforts, expressed sequence tags (ESTs), RNA-seq, gene expression profiling, induced deletion mutants and insertional mutants, and gene expression knock-down (gene silencing) studies with RNAi and microRNAs have become integral parts of plant molecular omic’s. Molecular diversity and mutational approaches present the first line of approach to unravel the genetic and molecular basis for several traits, QTL related to disease resistance, which includes host approaches to combat the pathogens and to understand the adaptation of the pathogen to the plant host. Using NGS technologies, understanding of adaptation genetics towards stress tolerance has been correlated to the epigenetics. Naturally occurring allelic variations, genome shuffling and variations induced by chemical or radiation mutagenesis are also being used in functional genomics to elucidate the pathway for the pathogen and stress tolerance and is widely illustrated in demonstrating the identification of the genes responsible for tolerance in plants, bacterial and fungal species.

Plant Epigenetics

Plant Epigenetics
A Book

by Nikolaus Rajewsky,Stefan Jurga,Jan Barciszewski

  • Publisher : Springer
  • Release : 2017-04-27
  • Pages : 536
  • ISBN : 3319555200
  • Language : En, Es, Fr & De
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This book presents, in 26 chapters, the status quo in epigenomic profiling. It discusses how functional information can be indirectly inferred and describes the new approaches that promise functional answers, collectively referred to as epigenome editing. It highlights the latest important advances in our understanding of the functions of plant epigenomics and new technologies for the study of epigenomic marks and mechanisms in plants. Topics include the deposition or removal of chromatin modifications and histone variants, the role of epigenetics in development and response to environmental signals, natural variation and ecology, as well as applications for epigenetics in crop improvement. Discussing areas ranging from the complex regulation of stress and heterosis to the precise mechanisms of DNA and histone modifications, it presents breakthroughs in our understanding of complex phenotypic phenomena.

Plant Epigenetics Coming of Age for Breeding Applications

Plant Epigenetics Coming of Age for Breeding Applications
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2018-11-21
  • Pages : 472
  • ISBN : 0128154047
  • Language : En, Es, Fr & De
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Epigenetics and Breeding, Volume 88, the latest release in the Advances in Botanical Research series, brings together the experiences and critical information teachers, researchers and managers must consider from both scientific and legal points-of-view as they relate to biotechnology. New chapters in this updated volume include sections on Epigenetic Mechanisms in Plants, Epigenomic Diversity and Applications to Breeding, Epigenetics in Breeding, EpiRILs: Lessons from Arabidopsis, Transposable Elements as a Tool for Plant Improvement, Epigenome Editing, Epigenetics and Grafting, Sexual and Non-sexual reproduction, Epigenetics in Cereals, and more. Encompasses various aspects of botanical research, including its historical background, current status, recent research outcomes and potential future developments Written by highly competent authors from all continents Provides data that is based on facts and written in a dispassionate and non-polemical tone

Genetic Enhancement of Crops for Tolerance to Abiotic Stress: Mechanisms and Approaches

Genetic Enhancement of Crops for Tolerance to Abiotic Stress: Mechanisms and Approaches
A Book

by Vijay Rani Rajpal,Deepmala Sehgal,Avinash Kumar,S.N. Raina

  • Publisher : Springer
  • Release : 2019-04-24
  • Pages : 268
  • ISBN : 3319919563
  • Language : En, Es, Fr & De
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Abiotic stresses such as drought (water deficit), extreme temperatures (cold, frost and heat), salinity (sodicity) and mineral (metal and metalloid) toxicity limit productivity of crop plants worldwide and are big threats to global food security. With worsening climate change scenarios, these stresses will further increase in intensity and frequency. Improving tolerance to abiotic stresses, therefore, has become a major objective in crop breeding programs. A lot of research has been conducted on the regulatory mechanisms, signaling pathways governing these abiotic stresses, and cross talk among them in various model and non-model species. Also, various ‘omics’ platforms have been utilized to unravel the candidate genes underpinning various abiotic stresses, which have increased our understanding of the tolerance mechanisms at structural, physiological, transcriptional and molecular level. Further, a wealth of information has been generated on the role of chromatin assembly and its remodeling under stress and on the epigenetic dynamics via histones modifications. The book consolidates outlooks, perspectives and updates on the research conducted by scientists in the abovementioned areas. The information covered in this book will therefore interest workers in all areas of plant sciences. The results presented on multiple crops will be useful to scientists in building strategies to counter these stresses in plants. In addition, students who are beginners in the areas of abiotic stress tolerance will find this book handy to clear their concepts and to get an update on the research conducted in various crops at one place