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STRUCTURAL BIOLOGY IN IMMUNOLOGY

STRUCTURAL BIOLOGY IN IMMUNOLOGY
A Book

by Isaac Mills

  • Publisher : Unknown Publisher
  • Release : 2018
  • Pages : 129
  • ISBN : 9781684696260
  • Language : En, Es, Fr & De
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Structural Biology in Immunology

Structural Biology in Immunology
Structure/Function of Novel Molecules of Immunologic Importance

by Chaim Putterman,David Cowburn,Steven Almo

  • Publisher : Academic Press
  • Release : 2018-05-14
  • Pages : 186
  • ISBN : 0128033703
  • Language : En, Es, Fr & De
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Structural Biology in Immunology, Structure/Function of Novel Molecules of Immunologic Importance delivers important information on the structure and functional relationships in novel molecules of immunologic interest. Due to an increasingly sophisticated understanding of the immune system, the approach to the treatment of many immune-mediated diseases, including multiple sclerosis, systemic lupus erythematosus, rheumatoid arthritis, and inflammatory bowel disease has been dramatically altered. Furthermore, there is an increasing awareness of the critical role of the immune system in cancer biology. The improved central structure function relationships presented in this book will further enhance our ability to understand what defects in normal individuals can lead to disease. Describes novel/recently discovered immunomodulatory proteins, including antibodies and co-stimulatory or co-inhibitory molecules Emphasizes new biologic and small molecule drug design through the exploration of structure-function relationship Features a collaborative editorial effort, involving clinical immunologists and structural biologists Provides useful and practical insights on developing the necessary links between basic science and clinical therapy in immunology Gives interested parties a bridge to learn about computer modeling and structure based design principles

Structural Biology of the Complement System

Structural Biology of the Complement System
A Book

by Dimitrios Morikis,John D. Lambris

  • Publisher : CRC Press
  • Release : 2005-03-29
  • Pages : 370
  • ISBN : 0849350360
  • Language : En, Es, Fr & De
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Of recent, the structure of the complement system has received considerable attention, including the publication of several three-dimensional structures of complement proteins. This has led to the need for an authoritative resource to provide a complete overview of the basics, as well as an explanation of the cutting-edge work being accomplished in

Structural Immunology

Structural Immunology
A Book

by Tengchuan Jin,Qian Yin

  • Publisher : Springer Nature
  • Release : 2019-10-18
  • Pages : 226
  • ISBN : 9811393672
  • Language : En, Es, Fr & De
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This book presents a comprehensive overview of important immune molecules and their structure-function relationships. The immune system is highly complex, consisting of a network of molecules, cells, tissues and organs, and the immune reaction is involved in various physiological as well as pathological processes, including development, self-tolerance, infection, immunity, and cancer. Numerous molecules participate in immune recognition, inhibition and activation, and these important immune molecules can be roughly divided into cell surface receptors, intracellular receptors and intracellular signaling molecules. The study of how these immune molecules function at molecular level has laid the foundation for understanding the immune system. The book provides researchers and students with the latest research advances concerning the structural biology of key immune molecules/pathways, and offers immunologists essential insights into how these immune molecules function.

The B7-CD28 Family Molecules

The B7-CD28 Family Molecules
A Book

by Lieping Chen

  • Publisher : Springer Science & Business Media
  • Release : 2003-10-31
  • Pages : 141
  • ISBN : 9780306478420
  • Language : En, Es, Fr & De
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The B7-CD28 family molecules are probably the most intensively studied receptor-ligand systems in the field of immunology. This is evident from the explosive accumulation of literature, particularly in the last ten years. Recent years have witnessed rapid discoveries and characterization of new receptors and ligands in the family. These new pathways, although still in their infancy, have already brought much excitement to the field. However, until now, there has been no single volume to cover this entire area. This book was created to bring together state-of-the-art information and critical thinking from the leading investigators. This book covers significant territory of this rapidly moving field from structural biology and biochemical signalling to immunological functions and their potential applications in the treatment of human diseases. This is an excellent handbook and reference for immunologists, health professionals as well as medical students and graduate students in life science field.

Encyclopedia of Molecular Biology

Encyclopedia of Molecular Biology
A Book

by John Kendrew

  • Publisher : Wiley
  • Release : 1995-10-05
  • Pages : 1192
  • ISBN : 9780865426214
  • Language : En, Es, Fr & De
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The growth of molecular biology and the spread of its influence in other disciplines has led to a proliferation of terminology which has, as yet, to be effectively defined and housed in one single, accessible reference source. Within one volume this unique reference work contains nearly 6,000 headwords covering all areas of molecular life science including cell biology, immunology, microbiology, neurobiology, structural biology, developmental biology and molecular medicine. The Encyclopedia houses two types of article entry. Short articles of up to 100 words offer a short definition which is fully cross-referenced to article length entries of between 1,000 - 3,000 words. This unique cross-reference system allows the reader to approach their subject at the required level of detail and sophistication

Chromatin Remodelling and Immunity

Chromatin Remodelling and Immunity
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2017-01-02
  • Pages : 318
  • ISBN : 0128123931
  • Language : En, Es, Fr & De
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Chromatin Remodelling and Immunity, Volume 106, the latest release in the Advances in Protein Chemistry and Structural Biology series is an essential resource for protein chemists. Each volume brings forth new information about protocols and analysis of proteins, with each thematically organized volume guest edited by leading experts in a broad range of protein-related topics. Provides cutting-edge developments in protein chemistry and structural biology Written by authorities in the field Targeted to a wide audience of researchers, specialists, and students

Signalling Networks in Cell Shape and Motility

Signalling Networks in Cell Shape and Motility
A Book

by Gregory R. Bock,Jamie A. Goode

  • Publisher : John Wiley & Sons
  • Release : 2005-10-31
  • Pages : 250
  • ISBN : 0470017651
  • Language : En, Es, Fr & De
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This book features contributions from experts in cell biology, genetics, neurobiology, immunology and structural biology. The unifying element is that they all study processes of cell shape change and motility. Several key questions in this field of research are discussed: What are the organising principles behind cell shape change? Are there ‘master switches’ present in every cell type? How are extracellular signals interpreted by the cell in order to activate intracellular mechanisms? What is the influence of the extracellular matrix on cell movement and internal signalling pathways? How do pathogens subvert cellular systems in order to stimulate or block their uptake? The book addresses all of these important questions. Data are presented on the key proteins that regulate cell shape: the GTP binding proteins of the Rho family. There are also extensive discussions of the potential applications of the data to clinical problems, particularly that of cell motility in cancer.

Mucosal Immune Defense: Immunoglobulin A

Mucosal Immune Defense: Immunoglobulin A
A Book

by Charlotte S. Kaetzel

  • Publisher : Springer Science & Business Media
  • Release : 2007-10-04
  • Pages : 433
  • ISBN : 0387722319
  • Language : En, Es, Fr & De
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Immune responses at mucosal surfaces play a major role in host mucosal defense against microbial pathogens and in the pathogenesis of acute and chronic mucosal inflammatory diseases. This volume draws on a broad spectrum of molecular biologic, biochemical, and immunogenetic approaches in combination with human and murine in vitro cell culture and in vivo model systems to address questions in mucosal immunity. Humans produce more immunoglobulin A (IgA) than all other antibody isotypes combined, most of which is rapidly transported into the external secretions bathing mucous membranes. It has been estimated that more than 3 grams of IgA are transported daily into mucosal secretions, carrying out a wide range of antimicrobial and anti-inflammatory functions. IgA is the second most abundant class of antibody in the bloodstream, contributing to systemic as well as secretory immunity. Recent advances in human genomics, gene regulation, structural biology, cell signaling, and immunobiology have greatly enhanced our understanding of this important class of antibody. This book is designed to serve as a concise reference of the present knowledge of the biology of IgA, including structure of IgA and its interaction with Fc receptors; epithelial transport of IgA; regulation of the mucosal IgA system; biological roles of IgA, including newly discovered functions; IgA-associated diseases, and therapeutic applications for IgA. Chapters have been contributed by internationally recognized leaders in the field of IgA research, representing 8 countries on 3 continents.

Anticarbohydrate Antibodies

Anticarbohydrate Antibodies
From Molecular Basis to Clinical Application

by Paul Kosma,Sven Müller-Loennies

  • Publisher : Springer Science & Business Media
  • Release : 2011-11-27
  • Pages : 438
  • ISBN : 9783709108703
  • Language : En, Es, Fr & De
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Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. “Anticarbohydrate Antibodies – from molecular basis to clinical application” compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.

Structural Proteomics and Its Impact on the Life Sciences

Structural Proteomics and Its Impact on the Life Sciences
A Book

by Joel Sussman,Israel Silman

  • Publisher : World Scientific
  • Release : 2008
  • Pages : 572
  • ISBN : 9812772057
  • Language : En, Es, Fr & De
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The role played by structural proteomics in the first decade of the 21st century is equivalent to that played by the Human Genome Project in the last decade of the 20th century. The development of high-throughput technologies that permit the solution of hundreds of 3D structures of individual proteins, proteinOCoprotein complexes and proteinOCodrug complexes, just by one laboratory in a single year, will provide a knowledge base which will change the face of structural biology. This will have an immediate influence on medicinal chemistry and molecular pharmacology, as well as an increasing impact on such disciplines as neurobiology, developmental biology, immunology and molecular medicine.This book presents a state-of-the-art overview of the structural proteomics field, ranging from policy issues related to funding and goals, through the high-throughput procedures for protein production, to the solution of the structures of proteins and higher-order entities, via a multidisciplinary approach involving molecular biology, X-ray crystallography, NMR and electron microscopy, as well as bioinformatics analysis. This is the first book to provide such a comprehensive coverage of a rapidly evolving field.

Structural Proteomics and Its Impact on the Life Sciences

Structural Proteomics and Its Impact on the Life Sciences
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2021
  • Pages : 129
  • ISBN : 9814474061
  • Language : En, Es, Fr & De
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The Molecular Immunology of Complex Carbohydrates —2

The Molecular Immunology of Complex Carbohydrates —2
A Book

by Albert M. Wu

  • Publisher : Springer
  • Release : 2013-03-03
  • Pages : 640
  • ISBN : 9781461354697
  • Language : En, Es, Fr & De
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I organized this symposium, "Molecular Immunology of Complex Carbohydrates-2 (MICC-2)," at the Institute of Biological Chemistry, Academia Sinica, Taipei, Taiwan th between August 28-September 2, 1999, as a satellite meeting of the 15 International Glycoconjugate Conference (held August 22-27 in Tokyo, Japan). I also held a Taiwan Canada Glycobiology Workshop after this meeting at the Institutes of Biological Chemistry and Chemistry. To promote glycobiology in Taiwan, I offered a Complexs Carbohydrate & Medicine-2 workshop at the Glyco- Research Laboratory, College of Medicine, Chang Gung University, Kwei-san, Tao-yuan, Taiwan before the MICC-2 symposium. The lecture and poster materials of these three meetings are collected in these proceedings, which are divided into five Sections and two Appendixes. Section I, entitled "Protein-Carbohydrate Interactions of Plant and Animal Lectins," provides current concepts of lectin-carbohydrate interactions; classification of lectins, based on amino acid sequences, molecular structures, and lectin affinity for carbohydrates. However, the relationships between amino acid sequences and carbohydrate affinity of lectins have to be more thoroughly characterized. The reviews on animal lectins in this Section explore new areas of lectins. Section II, "Aspects of Structure and Antigenicity of Glycoconjugates," provides important information on structural concepts of glyco immunology. "Glycotope Expression (Glycosylation), Metabolism and Functions," which play important roles in life processes, are discussed in Section III. Four articles on advances in knowledge on structural roles of glycans and treatment of cancer are discussed in Section IV.

Advanced Techniques in Soil Microbiology

Advanced Techniques in Soil Microbiology
A Book

by Ajit Varma,Ralf Oelmüller

  • Publisher : Springer Science & Business Media
  • Release : 2007-07-25
  • Pages : 427
  • ISBN : 3540708650
  • Language : En, Es, Fr & De
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This book presents a wide range of biotechnological methods for application in soil microbiology analysis, including all essential methods involving molecular biology, immunology, microbiology, and structural biology, such as transcriptome analysis, RNAi technology, molecular matchmaking, RAPD, T-RFLP and FT/MS. The techniques and procedures presented here offer practical guides for immediate use in the laboratory. This volume will be of use both to the first-timer and to the experienced scientist.

Advances in HIV-1 Assembly and Release

Advances in HIV-1 Assembly and Release
A Book

by Eric O. Freed

  • Publisher : Springer Science & Business Media
  • Release : 2013-07-12
  • Pages : 221
  • ISBN : 1461477298
  • Language : En, Es, Fr & De
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​Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.​

Structural Concepts in Immunology and Immunochemistry

Structural Concepts in Immunology and Immunochemistry
A Book

by Elvin Abraham Kabat

  • Publisher : Unknown Publisher
  • Release : 1968
  • Pages : 310
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Immune System

The Immune System
Fourth International Student Edition

by Parham, Peter

  • Publisher : W.W. Norton & Company
  • Release : 2014-10-01
  • Pages : 624
  • ISBN : 0815345275
  • Language : En, Es, Fr & De
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This text emphasizes the human immune system and presents concepts with a balanced level of detail to describe how the immune system works. Written for undergraduate, medical, veterinary, dental, and pharmacy students, it makes generous use of medical examples to illustrate points. This classroom-proven textbook offers clear writing, full-color illustrations, and section and chapter summaries that make the content accessible and easily understandable to students.

Advances in Immunology

Advances in Immunology
A Book

by Frederick W. Alt

  • Publisher : Academic Press
  • Release : 2020-05
  • Pages : 198
  • ISBN : 0128207396
  • Language : En, Es, Fr & De
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Advances in Immunology, Volume 146, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, with this release focusing on The design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies, T cells in latent viral infections, Preserving Immune Homeostasis with A20, Transcriptional control in the context of innate and adaptive lymphoid development, RAG and AID structural biology and the important insights it has generated for the V(D)J recombination and CSR/SHM fields, and more.

Encyclopedia of Life Sciences

Encyclopedia of Life Sciences
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2001
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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A fully searchable, working editorial site of articles by scientists and scientific historians in the fields of biochemistry and physiology, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neuroscience, microbiology and virology, plant science, structural biology, and science and society.

Targeting Notch in Cancer

Targeting Notch in Cancer
From the Fruit Fly to the Clinic

by Lucio Miele,Spyros Artavanis-Tsakonas

  • Publisher : Springer
  • Release : 2018-11-23
  • Pages : 389
  • ISBN : 149398859X
  • Language : En, Es, Fr & De
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The serendipitously discovered link between developmental biology and cancer, touched of an explosion of discoveries on the role of Notch in human malignancies, including every aspect of cancer biology, from control of differentiation, proliferation and apoptosis in transformed cells to angiogenesis, tumor-stroma interaction and anti-cancer immune responses. A number of observations have revealed that Notch even plays a role in the renewal of cancer stem cells and tumor initiating cells, which are thought to be a major cause of resistance to treatment. Targeting Notch in Cancer will provide researchers, oncologists, pharmacologists and students with a detailed understanding of the intricate cross-talk between Notch and other pathways of therapeutic interest so to better design rational drug combinations for specific diseases and disease subsets. Divided into two parts, Part I describes in detail what we know about the genetics, molecular biology, biochemistry and structural biology of Notch, as well as the role of Notch in such processes as angiogenesis and immune surveillance. Without insights gained from these basic studies, rational targeting of Notch in human disease would be impossible. Part II describes the role of Notch and ongoing experimental therapeutic efforts in the most important subtypes of human cancers, organized in a clinically oriented fashion by organs and systems affected