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Structure and Function of the Extracellular Matrix

Structure and Function of the Extracellular Matrix
A Multiscale Quantitative Approach

by Bela Suki

  • Publisher : Academic Press
  • Release : 2021-12-06
  • Pages : 282
  • ISBN : 0128226056
  • Language : En, Es, Fr & De
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Structure and Function of the Extracellular Matrix: A Multiscale Quantitative Approach introduces biomechanics and biophysics with applications to understand the biological function of the extracellular matrix in health and disease. A general multiscale approach is followed by investigating behavior from the scale of single molecules, through fibrils and fibers, to tissues of various organ systems. Through mathematical models and structural information, quantitative description of the extracellular matrix function is derived with tissue specific details. The book introduces the properties and organization of extracellular matrix components and quantitative models of the matrix, and guides the reader through predicting functional properties. This book integrates evolutionary biology with multiscale structure to quantitatively understand the function of the extracellular matrix. This approach allows a fresh look into normal functioning as well as the pathological alterations of the extracellular matrix. Professor Suki’s book is written to be useful to undergraduates, graduate students, and researchers interested in the quantitative aspects of the extracellular matrix. Researchers working in mechanotransduction, respiratory and cardiovascular mechanics, and multiscale biomechanics of tendon, cartilage, skin, and bone may also be interested in this book. Examines the evolutionary origins and consequences of the extracellular matrix Delivers the first book to quantitatively treat the extracellular matrix as a multiscale system Presents problems and a set of computational laboratory projects in various chapters to aid teaching and learning Provides an introduction to the properties and organization of the extracellular matrix components

Structure and function of Collagen types

Structure and function of Collagen types
A Book

by Richard Maynes

  • Publisher : Elsevier
  • Release : 2012-12-02
  • Pages : 328
  • ISBN : 0323155715
  • Language : En, Es, Fr & De
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Structure and Function of Collagen Types is a collection of articles that reviews the different types of collagens (Type I to XI). Each article focuses on a particular type of collagen and written by leading investigators in the collagen field. The book begins with a review of the fibril forming collagens (types I, II, and III) and traces the early work on the structure of these collagens to our knowledge of the structure of the collagen genes. This chapter is followed by a detailed description of type IV (basement membrane) collagen. Chapter 3 addresses the biosynthesis and chain assembly of type V collagen. The evidence that type VI collagen is assembled to form tetramers is presented in chapter 4. The subsequent article shows that type VII collagens are assembled to form partially overlapping dimers. Chapter 6 presents the structure of type VIII collagen. Chapters 7, 8, and 9 discuss the structure and characteristics of collagens that are synthesized by cartilaginous tissues and these are designated as type IX, type X, and type XI. The final chapter reviews the recombinant DNA techniques used to investigate collagen structure and the possibility to recognize new collagen types from a cDNA library. Physiologists, cell biologists, and researchers in the field of collagen will find the text very insightful.

Extracellular Matrix

Extracellular Matrix
Structure and Function

by Anonim

  • Publisher : Unknown Publisher
  • Release : 1985
  • Pages : 436
  • ISBN : 9780845126233
  • Language : En, Es, Fr & De
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Extracellular Matrix

Extracellular Matrix
Structure and Function

by A. H. Reddi

  • Publisher : Unknown Publisher
  • Release : 1985-12
  • Pages : 462
  • ISBN : 9780471847687
  • Language : En, Es, Fr & De
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The Role of the Extracellular Matrix in Sertoli Cell Structure, Function and Differentiation

The Role of the Extracellular Matrix in Sertoli Cell Structure, Function and Differentiation
A Book

by Mark Anthony Hadley

  • Publisher : Unknown Publisher
  • Release : 1986
  • Pages : 470
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Cell Biology of Extracellular Matrix

Cell Biology of Extracellular Matrix
Second Edition

by E.D. Hay

  • Publisher : Springer Science & Business Media
  • Release : 2013-11-11
  • Pages : 468
  • ISBN : 1461537703
  • Language : En, Es, Fr & De
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In the ten-year interval since the first edition of this volume went to press, our knowledge of extracellular matrix (ECM) function and structure has enor mously increased. Extracellular matrix and cell-matrix interaction are now routine topics in the meetings and annual reviews sponsored by cell biology societies. Research in molecular biology has so advanced the number of known matrix molecules and the topic of gene structure and regulation that we won dered how best to incorporate the new material. For example, we deliberated over the inclusion of chapters on molecular genetics. We decided that with judicious editing we could present the recent findings in molecular biology within the same cell biology framework that was used for the first edition, using three broad headings: what is extracellular matrix, how is it made, and what does it do for cells? Maintaining control over the review of literature on the subject of ECM was not always an easy task, but we felt it was essential to production of a highly readable volume, one compact enough to serve the the student as an introduction and the investigator as a quick update on graduate the important recent discoveries. The first edition of this volume enjoyed con hope the reader finds this edition equally useful. siderable success; we D. Hay Elizabeth vii Contents Introductory Remarks 1 Elizabeth D. Hay PART I. WHAT IS EXTRACELLULAR MATRIX? Chapter 1 Collagen T. F. Linsenmayer 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 7 2. The Collagen Molecule . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 2. 1. Triple-Helical Domain(s) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .

Composition and Function of the Extracellular Matrix in the Human Body

Composition and Function of the Extracellular Matrix in the Human Body
A Book

by Francesco Travascio

  • Publisher : BoD – Books on Demand
  • Release : 2016-06-15
  • Pages : 374
  • ISBN : 9535124153
  • Language : En, Es, Fr & De
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The extracellular matrix (ECM) is an ensemble of non-cellular components present within all tissues and organs of the human body. The ECM provides structural support for scaffolding cellular constituents and biochemical and biomechanical support for those events leading to tissue morphogenesis, differentiation and homeostasis. Essential components of all ECMs are water, proteins and polysaccharides. However, their composition, architecture and bioactivity greatly vary from tissue to tissue in relation to the specific role the ECM is required to assume. This book overviews the role of the ECM in different tissues and organs of the human body.

Extracellular Matrix Organization, Structure, and Function

Extracellular Matrix Organization, Structure, and Function
A Book

by Dena Wiltz

  • Publisher : Unknown Publisher
  • Release : 2013
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Extracellular Matrix Organization, Structure, and Function.

The Extracellular Matrix: an Overview

The Extracellular Matrix: an Overview
A Book

by Robert Mecham

  • Publisher : Springer Science & Business Media
  • Release : 2011-02-16
  • Pages : 426
  • ISBN : 3642165559
  • Language : En, Es, Fr & De
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Knowledge of the extracellular matrix (ECM) is essential to understand cellular differentiation, tissue development, and tissue remodeling. This volume of the series “Biology of Extracellular Matrix” provides a timely overview of the structure, regulation, and function of the major macromolecules that make up the extracellular matrix. It covers topics such as collagen types and assembly of collagen-containing suprastructures, basement membrane, fibronectin and other cell-adhesive glycoproteins, proteoglycans, microfibrils, elastin, fibulins and matricellular proteins, such as thrombospondin. It also explores the concept that ECM components together with their cell surface receptors can be viewed as intricate nano-devices that allow cells to physically organize their 3-D-environment. Further, the role of the ECM in human disease and pathogenesis is discussed as well as the use of model organisms in elucidating ECM function.

Cell Surface and Extracellular Glycoconjugates

Cell Surface and Extracellular Glycoconjugates
Structure and Function

by Anonim

  • Publisher : Academic Press
  • Release : 2012-12-02
  • Pages : 314
  • ISBN : 0323138098
  • Language : En, Es, Fr & De
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This book serves as a much-needed guide for new investigators in the field of glycobiology as well as researchers in other disciplines attempting to define the role of glycoconjugates in their biological systems. Cell Surface and Extracellular Glycoconjugates: Structure and Function describes the determination of structure and function of glycoconjugates that occur on the cell surface and in molecules involved in cell-matrix interactions. The broad scope of thebook covers basic background and technical information in this rapidly expanding field. The text is specifically designed to inform researchers in diverse disciplines of the approaches and resources that can be employed to address problems in glycoconjugate biology. Includes coverage of the: * Structure of cell surface carbohydrates * Biosynthesis of glycoproteins * Biological signals associated with glycoproteins * Diversity of glycoprotein structure

Extracellular Matrix

Extracellular Matrix
Structure and Function : Proceedings of the Dow-UCLA Symposium, Held in Keystone, Colorado, April 22-29, 1984

by A. H. Reddi

  • Publisher : Unknown Publisher
  • Release : 1985
  • Pages : 436
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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The Structure, Function and Evolution of the Extracellular Matrix

The Structure, Function and Evolution of the Extracellular Matrix
A Systems-Level Analysis

by Lawrence Graham Cromar

  • Publisher : Unknown Publisher
  • Release : 2014
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Extracellular Matrix

Extracellular Matrix
Chemistry: Biology, and Pathobiology with Emphasis on the Liver

by Mark A. Zern,Lola M. Reid

  • Publisher : CRC Press
  • Release : 1993-04-01
  • Pages : 624
  • ISBN : 9780824788308
  • Language : En, Es, Fr & De
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Describing state-of-the-art research techniques for clinicians and introducing important clinical perspectives for basic scientists, this reference examines some significant areas of investigation into the biology of the extracellular matrix and its implications in human pathophysiology.;Focusing on the liver and providing a broad survey of the latest information available, Extracellular Matrix: discusses a wide range of models and organ systems; presents pathophysiological studies emphasizing hepatic disease, particularly the development of fibrosis and cirrhosis; furnishes structure and function analyses of the major extracellular matric components, including collagens, laminin, fibronectin, and proteoglycans; delineates the mechanisms leading to increased depositions of the matrix proteins during hepatic fibrogenesis; details new therapeutic approaches to liver disease; and more.;With authoritative contributions from more than 40 leading international experts representing five countries, Extracellular Matrix should be a useful reference for all scientists interested in matrix biology, chemistry, or pathobiology, especially gastroenterologists, hepatologists, pathologists, and graduate and medical school students in these disciplines.

The Structure and Function of Hyaluronan-binding Proteins in Extracellular Matrix Assembly

The Structure and Function of Hyaluronan-binding Proteins in Extracellular Matrix Assembly
A Book

by Nicholas T. Seyfried

  • Publisher : Unknown Publisher
  • Release : 2004
  • Pages : 324
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Structure and Function of Sites Within Fibronectin Required for Extracellular Matrix Assembly

Structure and Function of Sites Within Fibronectin Required for Extracellular Matrix Assembly
A Book

by Bradley Joseph Quade

  • Publisher : Unknown Publisher
  • Release : 1990
  • Pages : 234
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Extracellular Matrix Assembly and Structure

Extracellular Matrix Assembly and Structure
A Book

by Peter D. Yurchenco

  • Publisher : Academic Press
  • Release : 2013-10-22
  • Pages : 468
  • ISBN : 1483289427
  • Language : En, Es, Fr & De
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The complex and critical process of extracellular matrix (ECM) assembly is described in this book. Assembly may involve molecules interacting with molecules of the same matrix class, such as in collagen, or interactions between different ECM molecules, such as in basement membranes. The text shows how this is driven by structural information within the matrix monomer. This information will be of interest to cell, developmental, and molecular biologists, biochemists, biophysicists, and biomedical researchers involved in macromolecular assembly, biological macromolecules, and extracellular matrix. Addresses assembly of most of the known classes of extracellular matrix macromolecules Discusses higher order structures produced by ECM Gives important concepts in ECM and cell-matrix interactions, Protein structure and protein-protein interactions, Development and tissue remodeling

Mechanosensing and Mechanochemical Transduction in Extracellular Matrix

Mechanosensing and Mechanochemical Transduction in Extracellular Matrix
Biological, Chemical, Engineering, and Physiological Aspects

by Frederick H. Silver

  • Publisher : Springer Science & Business Media
  • Release : 2006-11-24
  • Pages : 292
  • ISBN : 0387281762
  • Language : En, Es, Fr & De
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This is the only single authored text on biological polymers available for bioengineering and biomedical engineering students. The book describes the structure of polymers and how these molecules are put together to make the tissues of the body and also their role in surgical implants and in structural diseases. It provides essential reading for biomedical engineers, biologists, physicians, health care professionals and other biomedical researchers who are interested in understanding how physical forces affect the biology, physiology and pathophysiology of humans. The author is an expert on the effect of mechanical forces on extracellular matrix.

Structure-function Relationship of the Cartilage Extracellular Matrix Assessed by Atomic Force Microscopy

Structure-function Relationship of the Cartilage Extracellular Matrix Assessed by Atomic Force Microscopy
A Book

by Carina Prein

  • Publisher : Unknown Publisher
  • Release : 2016
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Structure and Function of Fibulin-1

Structure and Function of Fibulin-1
An Extracellular Matrix and Plasma Glycoprotein

by Huan Trung Tran

  • Publisher : Unknown Publisher
  • Release : 1998
  • Pages : 348
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Evolution of Extracellular Matrix

Evolution of Extracellular Matrix
A Book

by Fred W. Keeley,Robert Mecham

  • Publisher : Springer Science & Business Media
  • Release : 2013-03-15
  • Pages : 290
  • ISBN : 3642360025
  • Language : En, Es, Fr & De
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The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.