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Synthetic Biology

Synthetic Biology
Metaphors, Worldviews, Ethics, and Law

by Joachim Boldt

  • Publisher : Springer
  • Release : 2015-11-26
  • Pages : 234
  • ISBN : 3658109882
  • Language : En, Es, Fr & De
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Assessing synthetic biology from a societal and ethical perspective is not only a matter of determining possible harms and benefits of synthetic biology applications. Synthetic biology also incorporates a specific technoscientific understanding of its research agenda and its research objects that has philosophical and ethical implications. This edited volume sets out to explore and evaluate these synthetic biology worldviews and it proposes appropriate governance measures. In addition, legal challenges are discussed.

Synthetic Biology — A Primer

Synthetic Biology — A Primer
Revised Edition

by Anonim

  • Publisher : World Scientific
  • Release : 2015-08-24
  • Pages : 196
  • ISBN : 1783268816
  • Language : En, Es, Fr & De
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Synthetic Biology — A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made. The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems. Examples of cutting-edge applications designed using synthetic biology principles are presented, including: the production of novel, microbial synthesis of pharmaceuticals and fine chemicalsthe design and implementation of biosensors to detect infections and environmental waste. The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research. Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology. Contents:List of ContributorsPrefaceIntroduction to BiologyBasic Concepts in Engineering BiologyFoundational TechnologiesMinimal Cells and Synthetic LifeParts, Devices and SystemsModelling Synthetic Biology SystemsApplications of Designed Biological SystemsiGEMThe Societal Impact of Synthetic BiologyAppendices:Proforma of Common Laboratory TechniquesGlossaryIndex Readership: Students, professionals, researchers in biotechnology and bioengineering. Keywords:Synthetic Biology;Engineering Principles;Biosociety;Biological Engineering;BiotechnologyKey Features:The book is written in a way that is accessible to students and researchers from different disciplinesThe authors are part of the internationally recognised Centre for Synthetic Biology and Innovation and are among the leaders in this field

Chemical Synthetic Biology

Chemical Synthetic Biology
A Book

by Pier Luigi Luisi,Cristiano Chiarabelli

  • Publisher : John Wiley & Sons
  • Release : 2011-02-10
  • Pages : 392
  • ISBN : 9781119990307
  • Language : En, Es, Fr & De
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Chemistry plays a very important role in the emerging field of synthetic biology. In particular, chemical synthetic biology is concerned with the synthesis of chemical structures, such as proteins, that do not exist in nature. With contributions from leading international experts, Chemical Synthetic Biology shows how chemistry underpins synthetic biology. The book is an essential guide to this fascinating new field, and will find a place on the bookshelves of researchers and students working in synthetic chemistry, synthetic and molecular biology, bioengineering, systems biology, computational genomics, and bioinformatics.

Synthetic Biology

Synthetic Biology
A Book

by Anton Glieder,Christian P. Kubicek,Diethard Mattanovich,Birgit Wiltschi,Michael Sauer

  • Publisher : Springer
  • Release : 2016-08-23
  • Pages : 368
  • ISBN : 9783319355153
  • Language : En, Es, Fr & De
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This book provides a comprehensive, up-to-date overview of the opportunities and challenges of the complex field of synthetic biology, which combines various scientific disciplines. The emerging field of synthetic biology employs biotechnological approaches to recreate and enhance basic biological structures, intracellular processes and whole organisms. The book addresses a broad range of topics, including redesigning complex metabolic pathways, DNA/RNA and protein engineering, as well as novel synthetic biomaterials. It discusses both “bottom up” and “top down” approaches and presents the latest genome engineering tools with predictions about how these could change our way of thinking and working. Since the use of synthetic biology raises a number of ethical questions, a chapter is devoted to public awareness and risk management.The book is of interest to scientists from both academia and industry, as well as PhD students and postdocs working in the field

Synthetic Biology Handbook

Synthetic Biology Handbook
A Book

by Darren N. Nesbeth

  • Publisher : CRC Press
  • Release : 2016-04-06
  • Pages : 318
  • ISBN : 1466568488
  • Language : En, Es, Fr & De
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The Synthetic Biology Handbook explains the major goals of the field of synthetic biology and presents the technical details of the latest advances made in achieving those goals. Offering a comprehensive overview of the current areas of focus in synthetic biology, this handbook: Explores the standardisation of classic molecular bioscience approaches Addresses the societal context and potential impacts of synthetic biology Discusses the use of legacy systems as tools for new product development Examines the design and construction of de novo cells and genetic codes Describes computational methods for designing genes and gene networks Thus, the Synthetic Biology Handbook provides an accurate sense of the scope of synthetic biology today. The handbook also affords readers with an opportunity to scrutinize the underlying science and decide for themselves what aspects of synthetic biology are most valuable to their research and practice.

Systems Biology and Synthetic Biology

Systems Biology and Synthetic Biology
A Book

by Pengcheng Fu,Sven Panke

  • Publisher : John Wiley & Sons
  • Release : 2009-08-13
  • Pages : 672
  • ISBN : 9780470437971
  • Language : En, Es, Fr & De
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The genomic revolution has opened up systematic investigations and engineering designs for various life forms. Systems biology and synthetic biology are emerging as two complementary approaches, which embody the breakthrough in biology and invite application of engineering principles. Systems Biology and Synthetic Biology emphasizes the similarity between biology and engineering at the system level, which is important for applying systems and engineering theories to biology problems. This book demonstrates to students, researchers, and industry that systems biology relies on synthetic biology technologies to study biological systems, while synthetic biology depends on knowledge obtained from systems biology approaches.

Developing Biofuel Bioprocesses Using Systems and Synthetic Biology

Developing Biofuel Bioprocesses Using Systems and Synthetic Biology
A Book

by Sylvia M. Clay,Stephen S. Fong

  • Publisher : Springer Science & Business Media
  • Release : 2012-09-26
  • Pages : 68
  • ISBN : 1461455790
  • Language : En, Es, Fr & De
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Advances in technological and analytical methods have fostered rapid growth of systems biology and synthetic biology. There continues to be rapid changes and discoveries in both fields with a small number of recent peer-reviewed reviews indicating some of the relationships between systems biology and synthetic biology. This proposed SpringerBrief will cover core concepts of systems biology and synthetic biology and illustrate the implementation of associated research methodologies for an integrated approach to specifically address engineering microorganisms for biofuel production.​

Strange Natures

Strange Natures
Conservation in the Era of Synthetic Biology

by Kent H. Redford,William M. Adams

  • Publisher : Yale University Press
  • Release : 2021-06-22
  • Pages : 296
  • ISBN : 0300230974
  • Language : En, Es, Fr & De
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A groundbreaking examination of the implications of synthetic biology for biodiversity conservation Nature almost everywhere survives on human terms. The distinction between what is natural and what is human-made, which has informed conservation for centuries, has become blurred. When scientists can reshape genes more or less at will, what does it mean to conserve nature? The tools of synthetic biology are changing the way we answer that question. Gene editing technology is already transforming the agriculture and biotechnology industries. What happens if synthetic biology is also used in conservation to control invasive species, fight wildlife disease, or even bring extinct species back from the dead? Conservation scientist Kent Redford and geographer Bill Adams turn to synthetic biology, ecological restoration, political ecology, and de-extinction studies and propose a thoroughly innovative vision for protecting nature.

Synthetic Biology: A Very Short Introduction

Synthetic Biology: A Very Short Introduction
A Book

by Jamie A. Davies

  • Publisher : Oxford University Press
  • Release : 2018-06-14
  • Pages : 144
  • ISBN : 019252528X
  • Language : En, Es, Fr & De
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Synthetic biology is one of the 21st century's fastest growing fields of research, as important for technology as for basic science. Building on traditional genetic engineering, which was restricted to changing one or two genes, synthetic biology uses multi-gene modules and pathways to make very significant changes to what cells can do. Synthetic biologists aim to have an impact in fields as diverse as drug manufacture, biofuel production, tackling pollution, and medical diagnostics. Further ahead, synthetic biology may even make possible the long-standing goal of creating new life from non-living starting materials. This Very Short Introduction provides a concise explanation of what synthetic biology is, and how it is beginning to affect many fields of technology. Jamie Davies also discusses the considerable controversies surrounding synthetic biology, from questions over the assumption that engineering concepts can be applied to living systems easily, to scepticism over the claims for commercial promise, fears that the dangers of engineering life are worse than its benefits, and concerns over whether humans should be designing living systems at all. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Systems and Synthetic Biology

Systems and Synthetic Biology
A Book

by Vikram Singh,Pawan K. Dhar

  • Publisher : Springer
  • Release : 2014-12-15
  • Pages : 385
  • ISBN : 9401795142
  • Language : En, Es, Fr & De
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This textbook has been conceptualized to provide a detailed description of the various aspects of Systems and Synthetic Biology, keeping the requirements of M.Sc. and Ph.D. students in mind. Also, it is hoped that this book will mentor young scientists who are willing to contribute to this area but do not know from where to begin. The book has been divided into two sections. The first section will deal with systems biology – in terms of the foundational understanding, highlighting issues in biological complexity, methods of analysis and various aspects of modelling. The second section deals with the engineering concepts, design strategies of the biological systems ranging from simple DNA/RNA fragments, switches and oscillators, molecular pathways to a complete synthetic cell will be described. Finally, the book will offer expert opinions in legal, safety, security and social issues to present a well-balanced information both for students and scientists.

Introduction in Synthetic Biology

Introduction in Synthetic Biology
About Modeling, Computation, and Circuit Design

by Mario Andrea Marchisio

  • Publisher : Springer
  • Release : 2018-06-27
  • Pages : 187
  • ISBN : 9789811087516
  • Language : En, Es, Fr & De
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The textbook is based on the lectures of the course “Synthetic Biology” for Master’s students in biology and biotechnology at the Harbin Institute of Technology. The goal of the textbook is to explain how to make mathematical models of synthetic gene circuits that will, later on, drive the circuit implementation in the lab. Concepts such as kinetics, circuit dynamics and equilibria, stochastic and deterministic simulations, parameter analysis and optimization are presented. At the end of the textbook, a chapter contains a description of structural motifs (e.g. positive and negative feedback loops, Boolean gates) that carry out specific functions and can be combined into larger networks. Moreover, several chapters show how to build up (an analyse, where possible) models for synthetic gene circuits with four different open-source software i.e. COPASI, XPPAUT, BioNetGeN, and Parts & Pools-ProMoT.

Positioning Synthetic Biology to Meet the Challenges of the 21st Century

Positioning Synthetic Biology to Meet the Challenges of the 21st Century
Summary Report of a Six Academies Symposium Series

by National Research Council,National Academy of Engineering,Division on Earth and Life Studies,Board on Life Sciences,Policy and Global Affairs,Committee on Science, Technology, and Law

  • Publisher : National Academies Press
  • Release : 2013-09-05
  • Pages : 80
  • ISBN : 0309225833
  • Language : En, Es, Fr & De
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Synthetic biology-unlike any research discipline that precedes it-has the potential to bypass the less predictable process of evolution to usher in a new and dynamic way of working with living systems. Ultimately, synthetic biologists hope to design and build engineered biological systems with capabilities that do not exist in natural systems-capabilities that may ultimately be used for applications in manufacturing, food production, and global health. Importantly, synthetic biology represents an area of science and engineering that raises technical, ethical, regulatory, security, biosafety, intellectual property, and other issues that will be resolved differently in different parts of the world. As a better understanding of the global synthetic biology landscape could lead to tremendous benefits, six academies-the United Kingdom's Royal Society and Royal Academy of Engineering, the United States' National Academy of Sciences and National Academy of Engineering, and the Chinese Academy of Science and Chinese Academy of Engineering-organized a series of international symposia on the scientific, technical, and policy issues associated with synthetic biology. Positioning Synthetic Biology to Meet the Challenges of the 21st Century summarizes the symposia proceedings.

Synthetic Biology

Synthetic Biology
Tools for Engineering Biological Systems

by Clyde A. Hutchinson, III,Daniel G. Gibson,J. Craig Venter,Hamilton O. Smith

  • Publisher : Perspectives Cshl
  • Release : 2017-04-30
  • Pages : 350
  • ISBN : 9781621821182
  • Language : En, Es, Fr & De
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Synthetic biology involves the rational design and construction of biological components and systemsfrom genetic elements and metabolic pathways to entirely new organisms. Progress in this field has been rapid, and it promises to significantly expand our capabilities in biotechnology, medicine, and agriculture. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology examines the tools and techniques employed by synthetic biologists, how these may be used to develop new drugs, diagnostic approaches, food sources, and clean energy, and what the field of synthetic biology has taught us about natural living systems. The contributors discuss advances in DNA synthesis and assembly, genome editing (e.g., CRISPR/Cas9), and artificial genetic systems. Progress in designing complex genetic switches and circuits, expanding the genetic code, modifying cellular organization, producing proteins using cell-free systems, and developing biodesign automation tools is also covered. The authors also explore ways to produce new organisms and products that have particular attributesfor example, microbial "molecular factories," synthetic organs and tissues, and plants with novel traits. This volume is an essential resource for molecular, cell, and systems biologists who seek to engineer living systems for human benefit.

The Emergence of Life

The Emergence of Life
From Chemical Origins to Synthetic Biology

by Pier Luigi Luisi

  • Publisher : Cambridge University Press
  • Release : 2019-02-14
  • Pages : 478
  • ISBN : 9781108735506
  • Language : En, Es, Fr & De
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Addressing the emergence of life from a systems biology perspective, this new edition has undergone extensive revision, reflecting changes in scientific understanding and evolution of thought on the question 'what is life?'. With an emphasis on the philosophical aspects of science, including the epistemic features of modern synthetic biology, and also providing an updated view of the autopoiesis/cognition theory, the book gives an exhaustive treatment of the biophysical properties of vesicles, seen as the beginning of the 'road map' to the minimal cell - a road map which will develop into the question of whether and to what extent synthetic biology will be capable of making minimal life in the laboratory. Fully illustrated, accessibly written, directly challenging the reader with provocative questions, offering suggestions for research proposals, and including dialogues with contemporary authors such as Humberto Maturana, Albert Eschenmoser and Harold Morowitz, this is an ideal resource for researchers and students across fields including bioengineering, evolutionary biology, molecular biology, chemistry and chemical engineering.

Symposium on Opportunities and Challenges in the Emerging Field of Synthetic Biology Synthesis Report

Symposium on Opportunities and Challenges in the Emerging Field of Synthetic Biology Synthesis Report
Synthesis Report

by OECD

  • Publisher : OECD Publishing
  • Release : 2010-05-11
  • Pages : 48
  • ISBN : 9264086269
  • Language : En, Es, Fr & De
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The international symposium entitled “Opportunities and Challenges in the Emerging Field of Synthetic Biology” was held in July 2009 in Washington, DC under the auspices of the United States National Academies, the Organisation for Economic ...

Enzymes in Synthetic Biology

Enzymes in Synthetic Biology
A Book

by Anonim

  • Publisher : Academic Press
  • Release : 2018-08-30
  • Pages : 457
  • ISBN : 0128151498
  • Language : En, Es, Fr & De
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Volume 608 of the series Methods in Enzymology covers key aspects of enzyme discovery, engineering tools and platforms, and examples of applications in the enzymology of synthetic biology. Detailed methods for laboratory use of enzymes in synthetic biology applications Informative case history examples illustrating how enzyme and metabolic engineering are used to generate new products Emphasises latest developments in laboratory automation for the engineering of biology Covers many aspects of the design, build, test, learn cycle used in synthetic biology

Synthetic Biology

Synthetic Biology
Parts, Devices and Applications

by Christina Smolke

  • Publisher : John Wiley & Sons
  • Release : 2018-02-20
  • Pages : 1600
  • ISBN : 3527688080
  • Language : En, Es, Fr & De
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A review of the interdisciplinary field of synthetic biology, from genome design to spatial engineering. Written by an international panel of experts, Synthetic Biology draws from various areas of research in biology and engineering and explores the current applications to provide an authoritative overview of this burgeoning field. The text reviews the synthesis of DNA and genome engineering and offers a discussion of the parts and devices that control protein expression and activity. The authors include information on the devices that support spatial engineering, RNA switches and explore the early applications of synthetic biology in protein synthesis, generation of pathway libraries, and immunotherapy. Filled with the most recent research, compelling discussions, and unique perspectives, Synthetic Biology offers an important resource for understanding how this new branch of science can improve on applications for industry or biological research.

Synthetic Biology

Synthetic Biology
Advances in Molecular Biology and Medicine

by Robert Allen Meyers

  • Publisher : John Wiley & Sons
  • Release : 2015
  • Pages : 129
  • ISBN : 3527334823
  • Language : En, Es, Fr & De
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Synthetic Biology and Bioweapons

Synthetic Biology and Bioweapons
A Book

by Filippa Lentzos,Catherine Jefferson,Claire Marris

  • Publisher : World Scientific Publishing Europe Limited
  • Release : 2016-03-31
  • Pages : 180
  • ISBN : 9781783267651
  • Language : En, Es, Fr & De
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Developments in synthetic biology are raising significant security concerns: Will they enable the creation of dangerous viruses from scratch? Will scientific advances enable radically new pathogens not found in nature to be designed? Is synthetic biology breaking down the boundary between experts and non-experts to such an extent that anyone will be able to develop a biological weapon?Drawing on years of experience working with synthetic biologists, the established team of social scientists behind this book tackle these questions head on in their assessment of whether the misuse potential of synthetic biology is realistic or exaggerated.Through an accessible and engaging narrative that highlights key messages, questions for discussion and classroom exercises, readers are expertly led through the complex technical, historical, social, political and legal landscape at the intersection of synthetic biology and security.

Emerging Threats of Synthetic Biology and Biotechnology

Emerging Threats of Synthetic Biology and Biotechnology
Addressing Security and Resilience Issues

by Benjamin D. Trump

  • Publisher : Springer Nature
  • Release : 2021
  • Pages : 129
  • ISBN : 940242086X
  • Language : En, Es, Fr & De
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