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Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems

Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems
A Book

by Kamal Dua,Philip M. Hansbro,Ridhima Wadhwa,Mehra Haghi,Lisa G. Pont,Kylie A. Williams

  • Publisher : Academic Press
  • Release : 2020-08-04
  • Pages : 616
  • ISBN : 0128208880
  • Language : En, Es, Fr & De
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Targeting Chronic Inflammatory Lung Diseases Using Advanced Drug Delivery Systems explores the development of novel therapeutics and diagnostics to improve pulmonary disease management, looking down to the nanoscale level for an efficient system of targeting and managing respiratory disease. The book examines numerous nanoparticle-based drug systems such as nanocrystals, dendrimers, polymeric micelles, protein-based, carbon nanotube, and liposomes that can offer advantages over traditional drug delivery systems. Starting with a brief introduction on different types of nanoparticles in respiratory disease conditions, the book then focuses on current trends in disease pathology that use different in vitro and in vivo models. The comprehensive resource is designed for those new to the field and to specialized scientists and researchers involved in pulmonary research and drug development. Explores recent perspectives and challenges regarding the management and diagnosis of chronic respiratory diseases Provides insights into how advanced drug delivery systems can be effectively formulated and delivered for the management of various pulmonary diseases Includes the most recent information on diagnostic methods and treatment strategies using controlled drug delivery systems (including nanotechnology)

Advanced Drug Delivery Systems in the Management of Cancer

Advanced Drug Delivery Systems in the Management of Cancer
A Book

by Kamal Dua,Meenu Mehta,Terezinha de Jesus Andreoli Pinto,Lisa G. Pont,Kylie A. Williams,Michael Rathbone

  • Publisher : Elsevier
  • Release : 2021-06-24
  • Pages : 572
  • ISBN : 0323900798
  • Language : En, Es, Fr & De
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Advanced Drug Delivery Systems in the Management of Cancer discusses recent developments in nanomedicine and nano-based drug delivery systems used in the treatment of cancers affecting the blood, lungs, brain, and kidneys. The research presented in this book includes international collaborations in the area of novel drug delivery for the treatment of cancer. Cancer therapy remains one of the greatest challenges in modern medicine, as successful treatment requires the elimination of malignant cells that are closely related to normal cells within the body. Advanced drug delivery systems are carriers for a wide range of pharmacotherapies used in many applications, including cancer treatment. The use of such carrier systems in cancer treatment is growing rapidly as they help overcome the limitations associated with conventional drug delivery systems. Some of the conventional limitations that these advanced drug delivery systems help overcome include nonspecific targeting, systemic toxicity, poor oral bioavailability, reduced efficacy, and low therapeutic index. This book begins with a brief introduction to cancer biology. This is followed by an overview of the current landscape in pharmacotherapy for the cancer management. The need for advanced drug delivery systems in oncology and cancer treatment is established, and the systems that can be used for several specific cancers are discussed. Several chapters of the book are devoted to discussing the latest technologies and advances in nanotechnology. These include practical solutions on how to design a more effective nanocarrier for the drugs used in cancer therapeutics. Each chapter is written with the goal of informing readers about the latest advancements in drug delivery system technologies while reinforcing understanding through various detailed tables, figures, and illustrations. Advanced Drug Delivery Systems in the Management of Cancer is a valuable resource for anyone working in the fields of cancer biology and drug delivery, whether in academia, research, or industry. The book will be especially useful for researchers in drug formulation and drug delivery as well as for biological and translational researchers working in the field of cancer. Presents an overview of the recent perspectives and challenges within the management and diagnosis of cancer Provides insights into how advanced drug delivery systems can effectively be used in the management of a wide range of cancers Includes up-to-date information on diagnostic methods and treatment strategies using controlled drug delivery systems

Handbook of Lung Targeted Drug Delivery Systems

Handbook of Lung Targeted Drug Delivery Systems
Recent Trends and Clinical Evidences

by Yashwant Pathak,Nazrul Islam

  • Publisher : CRC Press
  • Release : 2021-10-18
  • Pages : 690
  • ISBN : 1000450805
  • Language : En, Es, Fr & De
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Handbook of Lung Targeted Drug Delivery Systems: Recent Trends and Clinical Evidences covers every aspect of the drug delivery to lungs, the physiology and pharmacology of the lung, modelling for lung delivery, drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications. With the advent of nano sciences and significant development in the nano particulate drug delivery systems there has been a renewed interest in the lung as an absorption surface for various drugs. The emergence of the COVID-19 virus has brought lung and lung delivery systems into focus, this book covers new developments and research used to address the prevention and treatment of respiratory diseases. Written by well-known scientists with years of experience in the field this timely handbook is an excellent reference book for the scientists and industry professionals. Key Features: Focuses particularly on the chemistry, clinical pharmacology, and biological developments in this field of research. Presents comprehensive information on emerging nanotechnology applications in diagnosing and treating pulmonary diseases Explores drug devices focused on lung treatment, regulatory requirements, and recent trends in clinical applications Examines specific formulations targeted to pulmonary systems

Modeling and Control of Drug Delivery Systems

Modeling and Control of Drug Delivery Systems
A Book

by Ahmad Taher Azar

  • Publisher : Academic Press
  • Release : 2021-02-15
  • Pages : 408
  • ISBN : 0128211954
  • Language : En, Es, Fr & De
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Modeling and Control of Drug Delivery Systems provides comprehensive coverage of various drug delivery and targeting systems and their state-of-the-art related works, ranging from theory to real-world deployment and future perspectives. Various drug delivery and targeting systems have been developed to minimize drug degradation and adverse effect and increase drug bioavailability. Site-specific drug delivery may be either an active and/or passive process. Improving delivery techniques that minimize toxicity and increase efficacy offer significant potential benefits to patients and open up new markets for pharmaceutical companies. This book will attract many researchers working in DDS field as it provides an essential source of information for pharmaceutical scientists and pharmacologists working in academia as well as in the industry. In addition, it has useful information for pharmaceutical physicians and scientists in many disciplines involved in developing DDS, such as chemical engineering, biomedical engineering, protein engineering, gene therapy. Presents some of the latest innovations of approaches to DDS from dynamic controlled drug delivery, modeling, system analysis, optimization, control and monitoring Provides a unique, recent and comprehensive reference on DDS with the focus on cutting-edge technologies and the latest research trends in the area Covers the most recent works, in particular, the challenging areas related to modeling and control techniques applied to DDS

Nanotechnology and Drug Delivery, Volume Two

Nanotechnology and Drug Delivery, Volume Two
Nano-Engineering Strategies and Nanomedicines against Severe Diseases

by Jose L. Arias

  • Publisher : CRC Press
  • Release : 2016-04-21
  • Pages : 487
  • ISBN : 1482262738
  • Language : En, Es, Fr & De
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The recent introduction of nanomedicines in the drug therapy arena is revolutionizing the management of severe diseases. The key advance in the field is the optimization of the biological fate of drug molecules, thus improving the therapeutic effect while keeping to a very minimum the associated toxicity. Volume one of this book series, Nanoplatforms in Drug Delivery, established the basic aspects in the development of drug-loaded nanoplatforms, the so-called nanomedicines or nanodrugs, focusing on representative materials and strategies used in their formulation. Taking advantage of the advanced conceptualizations on nanomedicine engineering that were described in volume one, volume two, Nano-Engineering Strategies and Nanomedicines against Severe Diseases, analyzes in depth special features related to the formulation of nanoplatforms for oral, dental, topical and transdermal, pulmonary and nasal, ocular and otic, vaginal, and brain drug delivery and targeting. Particular aspects of nanomedicine engineering and in vivo fate associated with the routing of drug administration are given special attention. In addition, an up-to-date view is presented on the use of nanomedicines against severe diseases, such as cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, and metabolic diseases. The chapters analyze the key factors that need to be controlled to achieve the optimum therapeutic effect. Attention is further given to gene delivery and the recent concept of nanotheranosis.

PAIN – Novel targets and new technologies

PAIN – Novel targets and new technologies
A Book

by Susan Hua,Peter John Cabot

  • Publisher : Frontiers Media SA
  • Release : 2015-01-22
  • Pages : 95
  • ISBN : 2889193942
  • Language : En, Es, Fr & De
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The problem of clinical pain management is complex and far-reaching, as it encompasses many different types of pain, such as arthritis, musculoskeletal conditions, neuropathic pain, and visceral pain. It is widely known that many of the well-established analgesic pathways are centrally based, involving spinal and supraspinal sites. However, pain can also be effectively controlled by peripheral pathways. The analgesics market is growing and the driving forces are the aging population and need for better therapeutic benefits. There are various analgesic products that are available that can be administered by various routes, yet research is active in identifying new technologies for better drug targeting and novel targets to gain improved therapeutic efficiency. This e-Book “PAIN – novel targets and new technologies” has brought together experts in the field of pain at the physiological, pharmacological and pharmaceutical levels to discuss novel pain targets and new pain technologies across the various types of pain. This information is presented as novel research findings, short communications and review articles. The goal of this e-Book is to generate further collaborative discussion on the future and direction of pain therapies.

Immunity and Inflammation in Health and Disease

Immunity and Inflammation in Health and Disease
Emerging Roles of Nutraceuticals and Functional Foods in Immune Support

by Shampa Chatterjee,Wolfgang Jungraithmayr,Debasis Bagchi

  • Publisher : Academic Press
  • Release : 2017-08-31
  • Pages : 476
  • ISBN : 0128054026
  • Language : En, Es, Fr & De
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Immunity and Inflammation in Health and Disease: Emerging Roles of Nutraceuticals and Functional Foods in Immune Support provides a comprehensive description of the various pathways by which the vertebrate immune system works, the signals that trigger immune response and how fnew and novel nutraceuticals and functional foods, can be used to contain inflammation and also to boost immunity and immune health. Inflammation is a tool to fight pathogens and the vertebrate immune system has a very complex network of cells to achieve this. However inflammation that goes awry is also the leding cause of several diseases ranging from cardiovascular diseases to diabetes. This book covers the entire gamut from the various cellular players in the inflammation-immune response to its ramifications in terms of protection against pathogens as well as in onset of metabolic, aging and auto-immune related diseases. Finally, the balancing role of dietary nutrients between host defence and immune support is also showcased. The first three scetions explain the various components of the immune system and their modes of activation. The fourth section deals with the ramifications of a robust and execessive inflammatory response. The fifth section is focused on the association between nutrition and immunity and how deficiencies in certain nutrients may affect immunocompetence. The sixth section chapters represent a vision of paradigm shifts within the field and discusses possible future directions. This bool will be a valuable reference for researchers studying immune health either in academia, or in the nutraceutical or functional food industries. Product developers in nutraceutical, supplement, functional food, and health food companies will also appreciate the information presented here. Conceptualizes the key features in natural products which can boost immune function and immune health Explains the intricate mechanistic aspects and balance behind immune health Presents the pathophysiology of several diseases associated with immune system disruption

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes

Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes
A Book

by Vijay Mishra,Prashant Kesharwani,Mohd Cairul Iqbal Mohd Amin,Arun Iyer

  • Publisher : Academic Press
  • Release : 2017-05-23
  • Pages : 552
  • ISBN : 0128097183
  • Language : En, Es, Fr & De
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Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes provides an overview of the important aspects of nanomedicine in order to illustrate how to design and develop novel and effective drug delivery systems using nanotechnology. The book is organized into three sections, beginning with an introduction to nanomedicine and its associated issues. Section two discusses the latest technologies in nanomedicine, while the third section covers future developments and challenges in the field. By focusing on the design, synthesis, and application of a variety of nanocarriers in drug and gene delivery, this book provides pharmaceutical and materials science students, professors, clinical researchers, and industry scientists with a valuable resource aimed at tackling the challenges of delivering drugs and genes in a more targeted manner. Explores a wide range of promising approaches for the diagnosis and treatment of diseases using the latest advances in cutting-edge nanomedical technologies Contains contributions from world-renowned experts and researchers working in the area of nanomedicine and drug delivery Covers the associated challenges and potential solutions to working with nanotechnology in drug delivery Highlights crucial topics, such as biopharmaceutical and toxicity issues, quality by design, drug targeting, and more

Mucosal Delivery of Drugs and Biologics in Nanoparticles

Mucosal Delivery of Drugs and Biologics in Nanoparticles
A Book

by Pavan Muttil,Nitesh K. Kunda

  • Publisher : Springer Nature
  • Release : 2020-03-18
  • Pages : 277
  • ISBN : 3030359107
  • Language : En, Es, Fr & De
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Nanotechnology has revolutionized the approach to designing and developing novel drug delivery systems. The last two decades have seen a great interest in the use of nanotechnology to offer efficient ways of delivering new and existing drugs and macromolecules. The focus of this book is the application of nanotechnology to deliver drugs and biological agents by the mucosal routes of administration i.e. nasal, pulmonary, buccal, and oral routes. It provides an overview of nanotechnology in drug delivery with a description of different types of nanoparticles, methods of preparation and characterization, and functionalization for site-specific drug delivery. The emphasis is on the use of nanoparticles in treating various cancers and infectious diseases. It broadens the use of nanoparticles by including biologics, including vaccines and immunotherapies, apart from drugs and acknowledges the concerns around the potential toxicity of nanoparticles to the host; several chapters will discuss the biodistribution of these nanoparticles when mucosal routes of administration are employed. Further, the interaction of nanoparticles with the host’s immune cells is discussed. Moreover, it reviews the regulatory aspects of nanotechnology in product development, especially when delivered by the mucosal route of administration. Lastly, discusses the challenges and opportunities to manufacture nanoparticles on an industrial scale. This book is the first of its kind to focus on the design, development and delivery of nanoparticles when administered by different mucosal routes.

Nanopharmaceutical Advanced Delivery Systems

Nanopharmaceutical Advanced Delivery Systems
A Book

by Vivek Dave,Nikita Gupta,Srija Sur

  • Publisher : John Wiley & Sons
  • Release : 2020-12-29
  • Pages : 512
  • ISBN : 1119711681
  • Language : En, Es, Fr & De
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The book provides a single volume covering detailed descriptions about various delivery systems, their principles and how these are put in use for the treatment of multiple diseases. It is divided into four sections where the first section deals with the introduction and importance of novel drug delivery system. The second section deals with the most advanced drug delivery systems like microbubbles, dendrimers, lipid-based nanoparticles, nanofibers, microemulsions etc., describing the major principles and techniques of the preparations of the drug delivery systems. The third section elaborates on the treatments of diverse diseases like cancer, topical diseases, tuberculosis etc. The fourth and final section provides a brief informative description about the regulatory aspects of novel drug delivery system that is followed in various countries.

Polymeric Nanomaterials in Nanotherapeutics

Polymeric Nanomaterials in Nanotherapeutics
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2018-10-26
  • Pages : 558
  • ISBN : 0128139331
  • Language : En, Es, Fr & De
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Polymeric Nanomaterials in Nanotherapeutics describes how polymeric nanosensors and nanorobotics are used for biomedical instrumentation, surgery, diagnosis and targeted drug delivery for cancer, pharmacokinetics, monitoring of diabetes and healthcare. Key areas of coverage include drug administration and formulations for targeted delivery and release of active agents (drug molecules) to non-healthy tissues and cells. The book demonstrates how these are applied to dental work, wound healing, cancer, cardiovascular diseases, neurodegenerative disorders, infectious diseases, chronic inflammatory diseases, metabolic diseases, and more. Methods of administration discussed include oral, dental, topical and transdermal, pulmonary and nasal, ocular, vaginal, and brain drug delivery and targeting. Drug delivery topics treated in several subchapters includes materials for active targeting and cases study of polymeric nanomaterials in clinical trials. The toxicity and regulatory status of therapeutic polymeric nanomaterials are also examined. The book gives a broad perspective on the topic for researchers, postgraduate students and professionals in the biomaterials, biotechnology, and biomedical fields. Shows how the properties of polymeric nanomaterials can be used to create more efficient medical treatments/therapies Demonstrates the potential and range of applications of polymeric nanomaterials in disease prevention, diagnosis, drug development, and for improving treatment outcomes Accurately explains how nanotherapeutics can help in solving problems in the field through the latest technologies and formulations

Clinical Translation and Commercialisation of Advanced Therapy Medicinal Products

Clinical Translation and Commercialisation of Advanced Therapy Medicinal Products
A Book

by Tracy Tong Li Yu,Yves Bayon,Alain A. Vertes,Ivan Martin

  • Publisher : Frontiers Media SA
  • Release : 2021-01-21
  • Pages : 129
  • ISBN : 2889664147
  • Language : En, Es, Fr & De
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Dr. Yves Bayon is a Senior Principal Scientist at Medtronic and Dr. Alain Vertes is affiliated with NxR Biotechnologies GmbH. All other Topic Editors declare no competing interests with regards to the Research Topic subject.

Nanotechnology in Modern Animal Biotechnology

Nanotechnology in Modern Animal Biotechnology
Concepts and Applications

by Pawan Kumar Maurya,Sanjay Singh

  • Publisher : Elsevier
  • Release : 2019-07-20
  • Pages : 178
  • ISBN : 0128188243
  • Language : En, Es, Fr & De
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Nanotechnology in Modern Animal Biotechnology: Concepts and Applications discusses the advancement of nanotechnologies in almost every field, ranging from materials science, to food, forensic, agriculture and life sciences, including biotechnology and medicine. Nanotechnology is already being harnessed to address many of the key problems in animal biotechnology, with future applications covering animal biotechnology (e.g. animal nutrition, health, disease diagnosis, and drug delivery). This book provides the tools, ideas and techniques of nanoscale principles to investigate, understand and transform biological systems. Nanotechnology provides the ability to manipulate materials at atomic and molecular levels and also arrange atom-by-atom on a scale of ∼1–100 nm to create, new materials and devices with fundamentally new functions and properties arising due to their small scale. Details the basics of nanotechnology, along with comprehensive information on the state-of-the-art and future perspectives of nanotechnology in biosensors Provides recent perspectives and the challenges of nanomedicine Provides new insights into the role nanomaterials can play in curing various diseases Includes the most recent diagnostic methods, such as nanosensors

Liposome Technology

Liposome Technology
Interactions of Liposomes with the Biological Milieu

by Gregory Gregoriadis

  • Publisher : CRC Press
  • Release : 2006-09-12
  • Pages : 424
  • ISBN : 9780849397288
  • Language : En, Es, Fr & De
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Liposome Technology, Volume III: Interactions of Liposomes with the Biological Milieu, Third Edition, is a comprehensively updated and expanded new edition of a classic text in the field. Including step-by-step technical details, Volume III describes technologies for yielding liposomes that can function in a targeted fashion, and highlights methods for studying the interaction of liposomes within the biological environment to be applied in the detection, therapy, or prevention of disease. This source also offers critical discussions of the methodologies of each technology described so that readers can examine the benefits and limitations and compare it to other approaches.

Perspectives in Micro- and Nanotechnology for Biomedical Applications

Perspectives in Micro- and Nanotechnology for Biomedical Applications
A Book

by Juliana M Chan,Chenjie Xu

  • Publisher : World Scientific
  • Release : 2016-07-28
  • Pages : 312
  • ISBN : 1783269626
  • Language : En, Es, Fr & De
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Perspectives in Micro- and Nanotechnology for Biomedical Applications is an exciting new book that takes readers inside the fast-paced world of biomedical sciences fueled by advancements in nanotechnology, polymer chemistry and pharmacology. Guided by biotech researchers Chenjie Xu and Juliana Chan, an international ensemble of leading experts in the field cover topics ranging from classical chemical tools to nanoparticles as imaging probes and drug carriers, and combinatorial screens for new lipids and polymers. At the microscale it discusses advancements in hydrogels and platform technologies such as cell ghosts. This book provides a broad perspective into the basic principles and applications of today's most promising micro- and nanotechnologies, and is an up-to-date reference book for researchers. It is also suitable for undergraduate and graduate students, patent lawyers and investors who are interested in the latest innovations taking place in the biomedical sciences, many of which may dramatically improve the lives of millions of people.

Inhalation Aerosols

Inhalation Aerosols
Physical and Biological Basis for Therapy, Third Edition

by Anthony J. Hickey,Heidi M. Mansour

  • Publisher : CRC Press
  • Release : 2019-03-21
  • Pages : 417
  • ISBN : 1351660519
  • Language : En, Es, Fr & De
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Inhalation aerosols continue to be the basis for successful lung therapy for several diseases, with therapeutic strategies and the range of technology significantly evolving in recent years. In response, this third edition takes a new approach to reflect the close integration of technology with its application. After briefly presenting the general considerations that apply to aerosol inhalation, the central section of the book uses the focus on disease and therapeutic agents to illustrate the application of specific technologies. The final integrated strategies section draws the major points from the applications for disease targets and drug products.

Handbook of Nanophysics

Handbook of Nanophysics
Nanomedicine and Nanorobotics

by Klaus D. Sattler

  • Publisher : CRC Press
  • Release : 2010-09-17
  • Pages : 887
  • ISBN : 9781420075496
  • Language : En, Es, Fr & De
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The tools of nanodiagnostics, nanotherapy, and nanorobotics are expected to revolutionize the future of medicine, leading to presymptomatic diagnosis of disease, highly effective targeted treatment therapy, and minimum side effects. Handbook of Nanophysics: Nanomedicine and Nanorobotics presents an up-to-date overview of the application of nanotechnology to molecular and biological processes, medical imaging, targeted drug delivery, and cancer treatment. Each peer-reviewed chapter contains a broad-based introduction and enhances understanding of the state-of-the-art scientific content through fundamental equations and illustrations, some in color. This volume shows how the materials, tools, and techniques of nanotechnology, such as enzymatic nanolithography, biomimetic approaches, and force spectroscopy, are currently used in biological applications, including living cell biochips, biosensors, protein recognition, and the analysis of biomolecules. Drawing on emerging toxicology research, it examines the impact and risks of nanomaterials on human health and the environment. Researchers at the forefront of the field cover tissue engineering, diagnostic, drug delivery, and therapeutic applications, including organs derived from nanomaterials, quantum dots and magnetic nanoparticles for imaging, pharmaceutical nanocarriers, targeted magnetic particles and biodegradable nanoparticles for drug delivery, and cancer treatment using gold nanoparticles. They also explain how cells and skin respond to these nanomaterials. In addition, the book investigates the next generation of nanotechnology research that is focused on nanorobotics and its potential in detecting and destroying cancer cells and detecting and measuring toxic chemicals. It considers the roles nanoheaters, nanomotors, and nanobatteries can play in this new technology. Nanophysics brings together multiple disciplines to determine the structural, electronic, optical, and thermal behavior of nanomaterials; electrical and thermal conductivity; the forces between nanoscale objects; and the transition between classical and quantum behavior. Facilitating communication across many disciplines, this landmark publication encourages scientists with disparate interests to collaborate on interdisciplinary projects and incorporate the theory and methodology of other areas into their work.

Lipid Nanoparticles as a Novel Strategy to Deliver Bioactive Molecules

Lipid Nanoparticles as a Novel Strategy to Deliver Bioactive Molecules
A Book

by Alan Talevi,Guillermo Raul Castro,Nelson Duran

  • Publisher : Frontiers Media SA
  • Release : 2021-04-13
  • Pages : 129
  • ISBN : 2889666972
  • Language : En, Es, Fr & De
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Chemistry and Industry

Chemistry and Industry
A Book

by Anonim

  • Publisher : Unknown Publisher
  • Release : 2009
  • Pages : 129
  • ISBN : 9876543210XXX
  • Language : En, Es, Fr & De
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Comprehensive Toxicology

Comprehensive Toxicology
A Book

by Anonim

  • Publisher : Elsevier
  • Release : 2010-06-01
  • Pages : 6448
  • ISBN : 0080468845
  • Language : En, Es, Fr & De
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An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version